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Human Aging And Disease.

R. Kohn
Published 1963 · Medicine

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Abstract Human aging is characterized by a logarithmic increase in death rate due to a large number of diseases; by a decrease in efficiency of homeostatic mechanisms and by chemical and physical changes at tissue, cell, and molecular levels. Increasing debility and disease most likely result from decreased efficiency of homeostasis and from tissue changes responsible for the latter. The probable importance of basic age-related changes in connective tissue and the vascular system is emphasized. Reasons for using human tissue in the study of human aging and postulates useful in relating basic change to debility are presented.
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