Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Sequence Of A Second Human KDEL Receptor.

M. Lewis, H. Pelham
Published 1992 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Retention of luminal endoplasmic reticulum (ER) proteins is mediated via a conserved carboxy-terminal tetrapeptide that serves as a signal for their retrieval from subsequent compartments of the secretory pathway. The signal is recognized by a receptor molecule that is believed to cycle between the Golgi apparatus and the ER. This receptor in Saccharomyces cerevisiae is encoded by the ERD2 gene, and a human cDNA homologue of the gene has been isolated. Binding of ligand by the product of this gene results in a shift of its steady-state location from Golgi to ER, suggesting that retrograde transport has been triggered. Here we report the identification of a related human protein with similar properties. This indicates that there are at least two distinct genes in humans that encode functional KDEL receptors.
This paper references
10.1093/NAR/15.20.8125
An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs.
M. Kozak (1987)
10.1083/JCB.111.2.369
Recycling of proteins from the Golgi compartment to the ER in yeast
N. Dean (1990)
10.1016/0092-8674(90)90698-E
ERD2, a yeast gene required for the receptor-mediated retrieval of luminal ER proteins from the secretory pathway
J. C. Semenza (1990)
10.1146/ANNUREV.CB.05.110189.000245
Control of protein exit from the endoplasmic reticulum.
H. Pelham (1989)
10.1038/348162A0
A human homologue of the yeast HDEL receptor
M. Lewis (1990)
10.1016/0092-8674(92)90476-S
Ligand-induced redistribution of a human KDEL receptor from the Golgi complex to the endoplasmic reticulum
M. Lewis (1992)
10.1016/B978-0-12-372180-8.50008-1
4 – RACE: RAPID AMPLIFICATION OF cDNA ENDS
M. Frohman (1990)
10.1016/0092-8674(90)90699-F
The ERD2 gene determines the specificity of the luminal ER protein retention system
M. Lewis (1990)
10.1016/0968-0004(87)90011-9
Coordinated regulation of a set of genes by glucose and calcium ionophores in mammalian cells
A. Lee (1987)
10.1002/j.1460-2075.1988.tb03005.x
Sorting of soluble ER proteins in yeast.
H. Pelham (1988)
10.1016/0092-8674(87)90086-9
A C-terminal signal prevents secretion of luminal ER proteins
S. Munro (1987)
10.1016/0022-2836(92)90571-Z
Changing the specificity of the sorting receptor for luminal endoplasmic reticulum proteins.
J. C. Semenza (1992)
10.1016/0968-0004(90)90303-S
The retention signal for soluble proteins of the endoplasmic reticulum.
H. Pelham (1990)



This paper is referenced by
10.1091/MBC.11.10.3469
Identification of a novel saturable endoplasmic reticulum localization mechanism mediated by the C-terminus of a Dictyostelium protein disulfide isomerase.
J. Monnat (2000)
10.1074/jbc.273.4.2467
Identification of Amino Acids in the Binding Pocket of the Human KDEL Receptor*
A. Scheel (1998)
10.1016/j.nano.2012.09.002
KDEL peptide gold nanoconstructs: promising nanoplatforms for drug delivery.
Guankui Wang (2013)
10.1016/J.BBAPAP.2006.09.002
Proteomic inventory of "anchorless" proteins on the colon adenocarcinoma cell surface.
H. Tjalsma (2006)
10.1016/j.cbpb.2013.12.006
RNA interference mediated knockdown of the KDEL receptor and COPB2 inhibits digestion and reproduction in the parasitic copepod Lepeophtheirus salmonis.
C. Tröße (2014)
10.1016/j.febslet.2009.10.053
The KDEL receptor: New functions for an old protein
Mirco Capitani (2009)
10.4489/KJM.2007.35.1.001
Effect of Mutation in α-COP, A Subunit of the COPI Vesicle, on Cell Wall Biogenesis in Fungi
Hwan-Hee Lee (2007)
10.1177/10454411980090040301
Protein N-glycosylation: molecular genetics and functional significance.
M. Kukuruzinska (1998)
Toxoplasma gondii Apicomplexan Parasite Receptor for Retrograde Transport in the
Stacy L. Pfluger (2004)
10.1074/jbc.M111799200
The Cytoplasmic Tail of α1,3-Galactosyltransferase Inhibits Golgi Localization of the Full-length Enzyme*
J. Milland (2002)
Peptides and Peptide-9 ElO : Interactions with mycTGN 3 & KDEL Receptors , and Oligosaccharyltransferase In Vitro
Gero Miesenb (2002)
10.1016/B978-012088394-3/50005-2
CHAPTER 2 – Translation and Posttranslational Processing of Gastrointestinal Peptides
C. Gariepy (2006)
ERD2 proteins mediate ER retention of the HNEL signal of LRP's receptor-associated protein (RAP).
G. Bu (1997)
10.1016/0304-4157(96)00003-2
The secretory pathway: mechanisms of protein sorting and transport.
C. Harter (1996)
10.1083/JCB.127.1.21
Retrieval of HDEL proteins is required for growth of yeast cells
F. Townsley (1994)
10.1016/j.neuroscience.2011.06.008
The KDEL receptor induces autophagy to promote the clearance of neurodegenerative disease-related proteins
P. Wang (2011)
10.1096/fj.02-0942fje
I ntrabody‐based strategies for inhibition of vascular endothelial growth factor receptor‐2: effects on apoptosis, cell growth, and angiogenesis
Yurong Yang Wheeler (2003)
Knockdown surface expression of p75 neurotrophin receptor with ER retained intrabody in mammalian cells
Congcong Zhang (2010)
10.3748/wjg.v21.i25.7621
Recent developments in the pathophysiology of irritable bowel syndrome.
M. El-Salhy (2015)
Mechanism of pFGE and FGE Retention in Endoplasmic Reticulum
S. Gande (2007)
10.1105/tpc.12.5.739
Protein Recycling from the Golgi Apparatus to the Endoplasmic Reticulum in Plants and Its Minor Contribution to Calreticulin Retention
S. Pagny (2000)
10.1016/0955-0674(93)90127-C
The modification and assembly of proteins in the endoplasmic reticulum.
J. Gaut (1993)
10.1007/s10571-019-00715-2
KDELR2 Promotes Glioblastoma Tumorigenesis Targeted by HIF1a via mTOR Signaling Pathway
Zhangyuan Liao (2019)
10.1002/9783527610754.SF19
Protein Folding in the Endoplasmic Reticulum
Y. Shen (2008)
10.1007/978-3-319-07761-1_9
Small G Proteins: Arf Family GTPases in Vesicular Transport
F. Adolf (2014)
Golgi pH and glycosylation
Antti Rivinoja (2009)
10.1002/mc.22871
Protein interactions of FAM134B with EB1 and APC/beta‐catenin in vitro in colon carcinoma
Farhadul Islam (2018)
10.1007/s004250000360
Characterization and expression of the Douglas-fir luminal binding protein (PmBiP)
B. S. Forward (2000)
10.2217/fon-2016-0050
ROS1 fusions in cancer: a review.
A. Uguen (2016)
10.1016/j.brainres.2018.03.028
Novel Drosophila model for mitochondrial diseases by targeting of a solute carrier protein SLC25A46
Kojiro Suda (2018)
Rolle der -COP-Untereinheit im frühen sekretorischen Pfad
Zentrum Biochemie (2015)
10.4161/psb.21217
Plant ERD2s self-interact and interact with GTPase-activating proteins and ADP-ribosylation factor 1
Guoyong Xu (2012)
See more
Semantic Scholar Logo Some data provided by SemanticScholar