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DOI: 10.1016/0024-3205(71)90353-5

Respiratory Activity And Cytochrome Content Of Liver Mitochondria From Diabetic Rats.

T. Matsubara, Y. Uemura-Ishikawa, Y. Tochino
Published 1971 · Biology, Medicine

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Abstract Respiratory and phosphorylating activities, and cytochrome content were determined in liver mitochondria from chronically (mildly) diabetic rats. Diabetes was induced by the administration of a law dose of alloxan and the animals showed typical diabetic changes in the activities of glucokinase and glucose-6-phosphatase. Diabetic mitochondria showed a depressed respiratory rate while the P : O ratio was within the normal range. Respiratory cytochromes were also decreased in diabetic liver mitochondria, while depressed levels were restored by the successive administration of insulin.
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