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Lipoprotein Lipase Of Adipose Tissue And Skeletal Muscle In Human Obesity: Response To Glucose And To Semistarvation.

M. R. Taskinen, E. Nikkilä
Published 1981 · Biology, Medicine

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Abstract Obesity is frequently associated with elevated plasma levels of triglyceride and very low density lipoproteins (VLDL). It is possible that this could be at least partly attributed to defective removal of triglycerides from circulation. Therefore, we studied the response of tissue lipoprotein lipase (LPL) activity to stimulation by glucose and to suppression by caloric deficiency in subjects with simple obesity and in nonobese controls. A five-hour intravenous infusion of glucose increased the LPL activity in both adipose tissue and skeletal muscle. The average rise was 2.5-fold in nonobese subjects but only 1.8-fold in obese patients (p
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