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Familial Lipoprotein Lipase-activity Deficiency: Study Of Total Body Fatness And Subcutaneous Fat Tissue Distribution.

L. O. Brun, C. Gagné, P. Julien, A. Tremblay, S. Moorjani, C. Bouchard, P. Lupien
Published 1989 · Biology, Medicine

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Total body fatness and subcutaneous fat tissue distribution were evaluated in 19 hyperchylomicronemic patients. Eleven were males, aged 10 to 57 years, and eight were females, aged 13 to 46 years. Familial lipoprotein-lipase-activity deficiency was diagnosed by the absence of lipoprotein-lipase activity in the plasma withdrawn ten and 20 minutes after intravenous injection of ten units of heparin per kilogram of body weight. The 19 patients had skin-fold measurements for evaluation of subcutaneous fat distribution. Fifteen also underwent body density measurements by underwater weighing. Percent body fat was calculated from body density. These anthropometric data were plotted against the regression curves of 1638 normal controls of both sexes (aged 10 to 54 years) for fat tissue weight, percent body fat, subcutaneous fat/total fat mass ratio and trunk/extremity skin-fold ratio. Impairments in the process of building fat tissue reserves could not be shown in the 19 hyperchylomicronemic patients, in spite of the absence of lipoprotein-lipase activity in their postheparin plasma. It is hypothesized that normal fat tissue mass in these patients could be due partly to de novo synthesis of fatty acids by adipocytes, hydrolysis of plasma triglycerides by hepatic lipase, and/or contribution of a specific fat-tissue lipase to the catabolism of plasma triglyceride-rich lipoproteins.
This paper references
10.1172/JCI111040
Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution.
M. Krotkiewski (1983)
10.1172/JCI103182
The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum.
R. Havel (1955)
10.1111/j.1365-2362.1984.tb01174.x
Hazards in subgroups of human obesity
P. Björntorp (1984)
10.3181/00379727-159-40338
Influence of Dietary Fat, Fasting, and Acute Premature Weaning on in Vivo Rates of Fatty Acid Synthesis in Lactating Mice 1
D. Romsos (1978)
Adaptive changes in enzyme activity and metabolic pathways in adipose tissue from meal-fed rats.
G. Leveille (1966)
10.1016/0002-9343(60)90137-6
A simplified closed circuit helium dilution method for the determination of the residual volume of the lungs
G. Meneely (1960)
10.1056/NEJM197806082982301
Hypertriglyceridemia associated with deficiency of apolipoprotein C-II.
W. Breckenridge (1978)
10.1055/S-0028-1093706
Effect of fat cell size, restrictive diet and diabetes on lipoprotein lipase release by human adipose tissue.
B. Guy-grand (1975)
10.3181/00379727-167-41224
Reduced Organ Growth When Hyperphagia Is Prevented in Genetically Obese (fa/fa) Zucker Rats 1
M. Cleary (1981)
Evaluation and regulation of body build and composition
A. R. Behnke (1974)
10.1172/JCI111675
Regulation of lipoprotein lipase in primary cultures of isolated human adipocytes.
P. Kern (1985)
10.1016/S0140-6736(78)92465-0
INCREASED ADIPOSE-TISSUE LIPOPROTEIN-LIPASE ACTIVITY IN MODERATELY OBESE MEN AFTER WEIGHT REDUCTION
R. Schwartz (1978)
10.1016/0020-711X(81)90177-4
Tissue lipoprotein lipase activity and its action in lipoprotein metabolism.
A. Cryer (1981)
10.1111/J.0954-6820.1977.TB16851.X
Lipoprotein lipase activity in adipose tissue and in postheparin plasma in human obesity.
M. R. Taskinen (1977)
10.1016/B978-1-4831-9942-9.50008-5
Practical methods for plasma lipoprotein analysis.
F. Hatch (1968)
10.1139/Y84-240
Lipogenesis and lipoprotein lipase in human adipose tissue: reproducibility of measurements and relationships with fat cell size.
R. Savard (1984)
10.1016/B978-1-4832-3110-5.50011-X
The gross composition of the body.
W. Siri (1956)
10.1111/j.1365-2362.1979.tb00896.x
Synthesis of fatty acids and cholesterol by liver, adipose tissue and intestinal mucosa from obese and control patients
A. Angel (1979)
10.1002/CBF.290050304
Lipases operative at the fat cell surface: Attempt at an integrated approach
A. Vérine (1987)
10.1210/JCEM-59-6-1176
Insulin responsiveness of adipose tissue lipoprotein lipase is delayed but preserved in obesity.
C. Sadur (1984)
10.1016/0021-9150(79)90101-1
Heterozygous familial hypercholesterolemia. Relationship between plasma lipids, lipoproteins, clinical manifestations and ischaemic heart disease in men and women.
C. Gagné (1979)
10.1016/0002-9343(84)90102-5
C-II anapolipoproteinemia and severe hypertriglyceridemia. Report of a rare case with absence of C-II apolipoprotein isoforms and review of the literature.
K. Saku (1984)
Immunocytochemical localization of the functional fraction of lipoprotein lipase in the perfused heart.
M. E. Pedersen (1983)
10.1083/JCB.51.1.1
SITES OF LIPOPROTEIN LIPASE ACTIVITY IN ADIPOSE TISSUE PERFUSED WITH CHYLOMICRONS
E. J. Blanchette-Mackie (1971)
10.1172/JCI108185
Determinants of human adipose tissue lipoprotein lipase. Effect of diabetes and obesity on basal- and diet-induced activity.
O. Pykälistö (1975)
Familial lipoprotein lipase deficiency and related disorders of chylomicron metabolism.
E. Nikkila (1983)
Synthesis of hepatic lipase in liver and extrahepatic tissues.
M. Doolittle (1987)
Human biology: A guide to field methods;
J. S. Weiner (1969)
10.1146/ANNUREV.BI.49.070180.003315
Lipolytic enzymes and plasma lipoprotein metabolism.
P. Nilsson-ehle (1980)
The lipoprotein-lipase activity of adipose tissue from different sites in obese women and relationship to cell size.
H. Lithell (1978)
10.1051/RND:19850216
Lipoprotein lipase and the uptake of lipids by adipose cells during development.
A. Cryer (1985)
10.1152/AJPENDO.1980.238.3.E284
Development of obesity in Zucker obese (fafa) rat in absence of hyperphagia.
M. Cleary (1980)
10.1016/0026-0495(80)90106-7
Heterogeneity of primary lipoprotein lipase deficiency.
J. Brunzell (1980)
10.1016/0026-0495(75)90017-7
Fatty acid synthesis by human adipose tissue.
M. Patel (1975)
Insulin and adipose tissue lipoprotein lipase activity in humans.
J. Brunzell (1981)
Measurements of lipoprotein lipase activity
P. N. Ehle (1987)
10.1172/JCI110171
Increase of adipose tissue lipoprotein lipase activity with weight loss.
R. Schwartz (1981)
Familial chylomicronemia due to a circulating inhibitor of lipoprotein lipase activity.
J. Brunzell (1983)
Zucker fafa rats maintain their obese body composition ten months after jejunoileal bypass surgery.
M. R. Greenwood (1982)
Body composition in adopted and biological siblings.
C. Bouchard (1985)
Primary lipoprotein-lipase-activity deficiency: clinical investigation of a French Canadian population.
C. Gagné (1989)



This paper is referenced by
10.1080/17482970601069185
Regulation of fatty acid transport and storage: influence of acylation-stimulating protein
K. Cianflone (2006)
10.1017/S0007114598001585
Lipoprotein lipase and the disposition of dietary fatty acids.
B. Fielding (1998)
10.1007/978-3-642-00300-4_13
The Ins and Outs of Adipose Tissue
T. Olivecrona (2009)
10.1111/j.1399-0004.1992.tb03664.x
Prevalence, geographical distribution and genealogical investigations of mutation 188 of lipoprotein lipase gene in the French Canadian population of Québec
J. Bergeron (1992)
10.1093/JN/133.6.1866
Weight gain in gonadectomized normal and lipoprotein lipase-deficient male domestic cats results from increased food intake and not decreased energy expenditure.
M. L. Kanchuk (2003)
10.2460/AJVR.2001.62.264
Maternal expression of functional lipoprotein lipase and effects on body fat mass and body condition scores of mature cats with lipoprotein lipase deficiency.
R. Backus (2001)
10.1093/JN/136.12.2980
Adipose fatty acid composition and rate of incorporation of alpha-linolenic acid differ between normal and lipoprotein lipase-deficient cats.
B. C. Veltri (2006)
10.1038/sj.ijo.0801506
The role of lipoprotein lipase in adipose tissue development and metabolism
R. Zechner (2000)
10.23938/ASSN.0812
[Adipose tissue: a storage and secretory organ].
M. Moreno (2002)
10.1073/PNAS.94.19.10261
Lipoprotein lipase controls fatty acid entry into adipose tissue, but fat mass is preserved by endogenous synthesis in mice deficient in adipose tissue lipoprotein lipase.
P. Weinstock (1997)
10.1007/978-3-642-78426-2
Principles and Treatment of Lipoprotein Disorders
D. Blankenhorn (1994)
10.1007/978-3-642-78426-2_6
Lipoprotein Lipase and Hepatic Lipase
T. Olivecrona (1990)
10.3989/GYA.043209
El tejido adiposo: algo ms que un reservorio de energa
B. AlfonsoValenzuela (2009)
10.5897/AJBR2017.0926
Regulatory role of 3-iodothyronamine in tissue-specific fatty acid uptake in mice
Neda Eskandarzade (2017)
10.1159/000059582
The adipsin-acylation-stimulating protein pathway and microenvironmental metabolic regulation.
A. Sniderman (1997)
10.1016/S1569-2558(03)33017-6
Triacylglycerol metabolism in adipose tissue
K. Frayn (2003)
Regional differences in triacylglycerol synthesis in adipose tissue and in cultured preadipocytes.
M. Maslowska (1993)
10.1016/S0009-8981(99)00099-6
Regulation of Plasma fatty acid metabolism.
J. Saleh (1999)
10.1074/jbc.M113.469270
Adipose-specific Lipoprotein Lipase Deficiency More Profoundly Affects Brown than White Fat Biology*
I. Garcia-Arcos (2013)
10.1172/JCI15972
Endothelial lipase provides an alternative pathway for FFA uptake in lipoprotein lipase-deficient mouse adipose tissue.
D. Kratky (2005)
10.1016/j.bbalip.2008.12.015
Effect of plasma triglyceride metabolism on lipid storage in adipose tissue: studies using genetically engineered mouse models.
Peter J. Voshol (2009)
10.1016/0163-7258(96)00005-8
Molecular pathobiology of the human lipoprotein lipase gene.
V. Murthy (1996)
10.1016/j.bbalip.2011.10.006
Lipase maturation factor 1: a lipase chaperone involved in lipid metabolism.
M. Péterfy (2012)
El tejido adiposo: órgano de almacenamiento y órgano secretor Adipose tissue: a storage and secretory organ
M. Moreno (2002)
10.1210/EDRV-14-1-72
Genetic and nongenetic determinants of regional fat distribution.
C. Bouchard (1993)
10.1074/jbc.272.27.17182
Induced Mutant Mice Expressing Lipoprotein Lipase Exclusively in Muscle Have Subnormal Triglycerides yet Reduced High Density Lipoprotein Cholesterol Levels in Plasma*
S. Levak-Frank (1997)
10.1172/JCI118319
Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice. Mild hypertriglyceridemia with impaired very low density lipoprotein clearance in heterozygotes.
P. Weinstock (1995)
10.1161/01.ATV.0000085040.58340.36
VLDL Induces Adipocyte Differentiation in ApoE-Dependent Manner
T. Chiba (2003)
10.1201/9781420039108.ch4
Fatty acids, white adipose tissue development, and adipocyte differentiation.
G. Ailhaud (2001)
10.1194/jlr.M011155
Lipase maturation factor 1 is required for endothelial lipase activity[S]
O. Ben-Zeev (2011)
10.1097/00041433-200210000-00002
Lipoprotein lipase: the regulation of tissue specific expression and its role in lipid and energy metabolism
Karina Preiss-Landl (2002)
10.1186/1476-511X-13-136
Apolipoprotein E synthesized by adipocyte and apolipoprotein E carried on lipoproteins modulate adipocyte triglyceride content
Y. Li (2014)
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