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Thermal Behaviour And Physicochemical Properties Of Naproxen In Mixtures With Polyvinylpyrrolidone

G. Bettinetti, P. Mura, F. Giordano, M. Setti
Published 1992 · Chemistry

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The thermal behaviour (DSC, TGA) of naproxen (NAP) and various grades of polyvinylpyrrolidone (PVP; Mr ≈ 10000, 25000, 40000 and 360000), and their mixtures was investigated. A profound modification of the NAP melting peak, observed in the DSC curves of simply blended systems (physical mixtures) with PVP, was attributed to a solid-state interaction. This interaction proved to be influenced by the composition of the mixture, the PVP average molecular weight and the type of manipulation of the sample (grinding, compaction, heating). The high dispersion of NAP within the PVP matrix probably gives rise to the formation of crystalline drug microaggregates (molecular clusters) responsible for the thermal behaviour. The chemical and physical stability (dissolution rate, crystallinity) of NAP was not significantly affected in the mixtures with PVP.
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This paper is referenced by
Formulation and Evaluation of Gliclazide Tablets Containing PVP-K30 and Hydroxypropyl-β-cyclodextrin Solid Dispersion
M. Varma (2012)
Interactions between naproxen and maltoheptaose, the non-cyclic analog ofβ-cyclodextrin
G. Bettinetti (1996)
The influence of polyvinylpyrrolidone on naproxen complexation with hydroxypropyl-beta-cyclodextrin.
P. Mura (2001)
Thermal behavior of naproxen and ketoprofen nonsteroidal anti-inflammatory drugs
R. S. Medeiros (2020)
Interação do diclofenaco com fosfatidilcolina de soja e lipossomas unilamelares liofilizados
L. B. Lopes (2006)
An evaluation of the dissolution behaviour of poorly soluble acidic and basic drugs in biorelevant media.
Utpal Shah (2006)
Preparation, characterization and dissolution studies of fast release diclofenac sodium tablets from PVP solid dispersions.
M. C. Lamas (2010)
Interaction of naproxen with α-, β-, and γ-hydroxypropyl cyclodextrins in solution and in the solid state
F. Melani (1995)
Development of Meloxicam-Loaded Electrospun Polyvinyl Alcohol Mats as a Transdermal Therapeutic Agent
T. Ngawhirunpat (2009)
Utilization of differential scanning calorimetry as a screening technique to determine the compatibility of ketoprofen with excipients
P. Mura (1995)
Interaction of sodium diclofenac with freeze-dried soya phosphatidylcholine and unilamellar liposomes
L. B. Lopes (2007)
Drug-loaded electrospun mats of poly(vinyl alcohol) fibres and their release characteristics of four model drugs
P. Taepaiboon (2006)
Assessment of solid-state interactions of naproxen with amorphous cyclodextrin derivatives by DSC.
G. Bettinetti (2002)
Interaction of naproxen with noncrystalline acetyl β- and acetyl γ-cyclodextrins in the solid and liquid state
G. Bettinetti (2002)
Formulation, Evaluation and Characterization of Solid Dispersions of Pioglitazone Hydrochloride
N. Jahnavi (2013)
Preparation, characterization and dissolution studies of fast release diclofenac sodium tablets from PVP solid dispersions
M. C. Lamas (2010)
Formulation, Evaluation and Characterization of Solid Dispersions of Pioglitazone
N. Jahnavi (2013)
Formulation, Physicochemical Evaluation, and Dissolution Studies of Carbamazepine Solid Dispersions
M. Varma (2012)
Compatibility study between ibuproxam and pharmaceutical excipients using differential scanning calorimetry, hot-stage microscopy and scanning electron microscopy.
P. Mura (1998)
Comparison of the effect of chitosan and polyvinylpyrrolidone on dissolution properties and analgesic effect of naproxen.
N. Zerrouk (2004)
Physicochemical Properties of Solid Dispersions of Gliclazide in Polyvinylpyrrolidone K90
S. Biswal (2009)
Comparison of the effect of tromethamine and polyvinylpyrrolidone on dissolution properties and analgesic effect of nimesulide
H. Abdelkader (2008)
Thermoanalytical study of some anti-inflammatory analgesic agents
G. Bannach (2010)
Interactions of naproxen with vinylpyrrolidone and β-cyclodextrin: a fluorimetric study1
I. Vélaz (1997)
Drug complexation and physicochemical properties of vinylpyrrolidone-N, N′-dimethylacrylamide copolymers
A. Queiroz (2004)
Thermal Behavior of Paracetamol-Polymeric Excipients Mixtures
F. Giordano (2002)
Studies on the intercalation of naproxen into layered double hydroxide and its thermal decomposition by in situ FT-IR and in situ HT-XRD
M. Wei (2004)
Increased Solubility, Dissolution and Physicochemical Studies of Curcumin- Polyvinylpyrrolidone K-30 Solid Dispersions
N. Kaewnopparat (2009)
Dissolution kinetics for coprecipitates of diflunisal with PVP K30
C. Rodríguez-Espinosa (2010)
Gelatine enhances drug dispersion in alginate bilayer film via the formation of crystalline microaggregates.
H. Thu (2013)
Interaction between naproxen and chemically modified β-cyclodextrins in the liquid and solid state
P. Mura (1995)
Gamma radiation assisted modification on electrical properties of Polyvinyl Pyrrolidone/Polyethylene Oxide blend doped by copper oxide nanoparticles
M. J. Tommalieh (2021)
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