Online citations, reference lists, and bibliographies.
← Back to Search

Effect Of Calcitonin Gene-related Peptide On Delayed Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage In Rabbits.

S. Imaizumi, H. Shimizu, I. Ahmad, T. Kaminuma, M. Tajima, T. Yoshimoto
Published 1996 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
BACKGROUND Calcitonin gene-related peptide (CGRP) is an intrinsic vasodilatory substance contained in perivascular nerve fibers of intracranial arteries. It is suggested that CGRP plays a role in cerebral vasospasm after subarachnoid hemorrhage (SAH). METHOD An experimental SAH was produced by intracisternal injection of arterial blood in rabbits. The animals were treated with intrathecal administration of CGRP solution 3 days after SAH. The degree of vasospasm and the effect of CGRP were evaluated angiographically by measuring the basilar artery diameter. RESULTS The basilar artery constricted to 73.0% of the pre-SAH values 3 days after SAH. Fifteen minutes after injection of 10(-10) mol/kg CGRP, the basilar artery dilated to 117.1% (n = 8), which was significantly larger than 67.1% in the vehicle group (n = 8) (p < 0.01). The significant vasodilatory effect of CGRP, compared with the vehicle group, lasted for 6 hours. CONCLUSIONS Intrathecal administration of CGRP has therapeutic potential for treating cerebral vasospasm.
This paper references
10.1136/JNNP.54.7.657
Hemiageusia: an unusual presentation of multiple sclerosis.
A. Pascual-Leone (1991)
10.1016/0304-3940(85)90166-1
Perivascular peptides relax cerebral arteries concomitant with stimulation of cyclic adenosine monophosphate accumulation or release of an endothelium-derived relaxing factor in the cat
L. Edvinsson (1985)
10.1038/jcbfm.1990.111
Involvement of Perivascular Sensory Fibers in the Pathophysiology of Cerebral Vasospasm following Subarachnoid Hemorrhage
L. Edvinsson (1990)
10.3171/JNS.1992.76.1.0099
Endothelin-1 of canine basilar artery in vasospasm.
I. Yamaura (1992)
Calcitonin gene-related peptide stimulates adenylate cyclase and relaxes intracerebral arterioles.
R. Edwards (1991)
10.3171/JNS.1992.77.5.0740
Is vasospasm related to proliferative arteriopathy?
R. Pluta (1992)
10.1161/01.STR.16.4.595
Subarachnoid haemorrhage in the rat: angiography and fluorescence microscopy of the major cerebral arteries.
T. Delgado (1985)
10.1227/00006123-199203000-00004
The permeability change of major cerebral arteries in experimental vasospasm.
T. Ohta (1992)
10.3171/JNS.1986.65.1.0080
The effects of HA compound calcium antagonists on delayed cerebral vasospasm in dogs.
M. Takayasu (1986)
10.3171/JNS.1987.66.6.0915
Effect of subarachnoid hemorrhage on endothelium-dependent vasodilation.
T. Nakagomi (1987)
10.1152/AJPHEART.1979.237.3.H381
Vasodilation of cat cerebral arterioles by prostaglandins D2, E2, G2, and I2.
E. Ellis (1979)
10.1038/jcbfm.1987.126
Calcitonin Gene-Related Peptide and Cerebral Blood Vessels: Distribution and Vasomotor Effects
L. Edvinsson (1987)
10.1002/ANA.410210503
Peptide‐containing nerve fibers in human cerebral arteries: Immunocytochemistry, radioimmunoassay and in vitro pharmacology
L. Edvinsson (1987)
10.3171/JNS.1988.68.5.0757
Effect of removal of the endothelium on vasocontraction in canine and rabbit basilar arteries.
T. Nakagomi (1988)
10.1089/NEU.1990.7.121
Effect of experimental subarachnoid hemorrhage on CSF eicosanoids in the rat.
D. d'Avella (1990)
10.1016/0090-3019(87)90280-1
Angiographic evidence of basilar artery constriction in the rabbit: a new model of vasospasm.
K. Baker (1987)
10.3171/JNS.1974.40.4.0451
Cerebral arterial spasm. 3. In vivo intracisternal production of spasm by serotonin and blood and its reversal by phenoxybenzamine.
G. Allen (1974)
10.1111/j.1476-5381.1989.tb12652.x
Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase
T. Asano (1989)
10.3171/JNS.1987.66.5.0741
Changes of neuropeptide immunoreactivity in cerebrovascular nerve fibers after experimentally produced SAH. Immunohistochemical study in the dog.
Y. Uemura (1987)
10.3171/JNS.1990.72.5.0792
Vascular relaxation properties of calcitonin gene-related peptide and vasoactive intestinal polypeptide in subarachnoid hemorrhage.
K. Nozaki (1990)
10.3109/02688699008992720
Calcitonin gene-related peptide-LI in subarachnoid haemorrhage in man. Signs of activation of the trigemino-cerebrovascular system?
R. Juul (1990)
10.3171/JNS.1989.71.4.0558
Relaxant effect of calcitonin gene-related peptide on cerebral arterial spasm induced by experimental subarachnoid hemorrhage in dogs.
K. Nozaki (1989)
EFFECT OF CALCITONIN-GENE-RELATED PEPTIDE IN PATIENTS WITH DELAYED POSTOPERATIVE CEREBRAL-ISCHEMIA AFTER ANEURYSMAL SUBARACHNOID HEMORRHAGE
I. Bailey (1992)
10.1111/j.1600-0404.1991.tb04658.x
Neuropeptide Y and vasoactive intestinal peptide in experimental subarachnoid hemorrhage: immunocytochemistry, radioimmunoassay and pharmacology
L. Edvinsson (1991)
10.1227/00006123-198911000-00008
Arterial wall changes in cerebral vasospasm.
J. Findlay (1989)
10.3171/JNS.1986.65.4.0531
Cerebral perivascular nerves in subarachnoid hemorrhage. A histochemical and immunohistochemical study.
H. Hara (1986)
10.1227/00006123-199203000-00006
Time course of changes in concentration of intracellular free calcium in cultured cerebrovascular smooth muscle cells exposed to oxyhemoglobin.
Y. Takanashi (1992)
10.1016/0140-6736(90)90473-I
Effect of calcitonin-gene-related peptide on postoperative neurological deficits after subarachnoid haemorrhage
F. Johnston (1990)
10.1227/00006123-198612000-00007
Electron microscopy of simian cerebral arteries after subarachnoid hemorrhage and after the injection of horseradish peroxidase.
F. Espinosa (1986)
10.1227/00006123-199204000-00010
Effect of intrathecal superoxide dismutase and catalase on oxyhemoglobin-induced vasospasm in monkeys.
R. Macdonald (1992)
10.1016/S0140-6736(85)90059-5
CALCITONIN GENE-RELATED PEPTIDE: POTENT VASODILATOR AND MAJOR PRODUCT OF CALCITONIN GENE
S. Girgis (1985)
10.3171/JNS.1989.70.1.0108
Release of endothelium-derived relaxing factor after subarachnoid hemorrhage.
P. Kim (1989)
10.1016/0090-3019(91)90088-Q
Cerebral vasospasm following subarachnoid hemorrhage: effect of calcitonin gene-related peptide on middle cerebral artery velocities using transcranial Doppler sonography.
A. Naylor (1991)



This paper is referenced by
10.1097/00006123-199611000-00020
Prevention of cerebral vasospasm by calcitonin gene-related peptide slow-release tablet after subarachnoid hemorrhage in monkeys.
T. Inoue (1996)
10.1007/978-3-540-70995-4_2
Cardiovascular Activity
H. G. Vogel (2008)
10.1016/j.jns.2014.04.020
Biomarkers of vasospasm development and outcome in aneurysmal subarachnoid hemorrhage
A. Rodríguez-Rodríguez (2014)
10.1097/00006123-199706000-00026
Rapid reversal of endothelin-1-induced cerebral vasoconstriction by intrathecal administration of nitric oxide donors.
J. Thomas (1997)
10.3389/fendo.2012.00135
Role of calcitonin gene-related peptide in cerebral vasospasm, and as a therapeutic approach to subarachnoid hemorrhage
S. Kokkoris (2012)
10.1111/j.1440-1681.1998.tb02337.x
SUBARACHNOID HAEMORRHAGE: WHAT HAPPENS TO THE CEREBRAL ARTERIES?
C. Sobey (1998)
10.3171/JNS.2002.97.1.0136
Posttreatment with adenovirus-mediated gene transfer of calcitonin gene-related peptide to reverse cerebral vasospasm in dogs.
M. Satoh (2002)
10.1097/00004647-199810000-00001
Role of Potassium Channels in Regulation of Cerebral Vascular Tone
F. Faraci (1998)
10.1161/01.ATV.21.1.28
Potassium channel function in vascular disease.
C. Sobey (2001)
10.1097/00008506-200407000-00009
Changes of Endothelin and Calcitonin Gene-Related Peptide During Desflurane Anesthesia in Patients Undergoing Intracranial Aneurysm Clipping
T. Wang (2004)
10.1016/B978-012464161-7/50008-1
Chapter 6 – Pharmacology
R. Macdonald (2001)
10.1016/j.ejphar.2019.172726
Fremanezumab inhibits vasodilatory effects of CGRP and capsaicin in rat cerebral artery - Potential role in conditions of severe vasoconstriction.
A. Grell (2019)
10.1016/S0168-3659(97)00178-8
Prevention of cerebral vasospasm by vasodilatory peptide maxadilan following subarachnoid hemorrhage in rabbits.
T. Kaminuma (1998)
10.1152/PHYSREV.1998.78.1.53
Regulation of the cerebral circulation: role of endothelium and potassium channels.
F. Faraci (1998)
10.1002/jnr.21823
Pathogenesis of cerebral vasospasm following aneurysmal subarachnoid hemorrhage: Putative mechanisms and novel approaches
A. Kolias (2009)
10.1634/stemcells.2004-0032
Engineering Ex Vivo–Expanded Marrow Stromal Cells to Secrete Calcitonin Gene–Related Peptide Using Adenoviral Vector
W. Deng (2004)
19 CGRP: a Multifunctional Neuropeptide
A. Russo (2006)
10.1016/j.wneu.2011.02.032
How large is the typical subarachnoid hemorrhage? A review of current neurosurgical knowledge.
R. Whitmore (2012)
10.1161/01.RES.87.9.818
Gene transfer of calcitonin gene-related peptide prevents vasoconstriction after subarachnoid hemorrhage.
K. Toyoda (2000)
10.3892/etm.2017.5423
Effect of recombinant adeno-associated virus expressing calcitonin gene-related peptide on chick embryo umbilical artery vasospasm model
Y. Yuan (2018)
10.1007/978-3-642-27728-3_10-1
Effects on Blood Supply and on Arterial and Venous Tonus
M. Gralinski (2014)
10.3389/fneur.2017.00357
Alpha Calcitonin Gene-Related Peptide Increases Cerebral Vessel Diameter in Animal Models of Subarachnoid Hemorrhage: A Systematic Review and Meta-analysis
Liam M. C. Flynn (2017)
10.1016/j.brainres.2014.08.012
Protective effect of stellate ganglion block on delayed cerebral vasospasm in an experimental rat model of subarachnoid hemorrhage
N. Hu (2014)
10.2741/E209
Intranasal delivery of calcitonin gene-related peptide reduces cerebral vasospasm in rats.
B. Sun (2010)
10.1046/j.1440-1681.2001.03550.x
Cerebrovascular Dysfunction After Subarachnoid Haemorrhage: Novel Mechanisms And Directions For Therapy
C. Sobey (2001)
10.1007/s12028-018-0650-5
Delayed Cerebral Ischemia After Subarachnoid Hemorrhage: Experimental-Clinical Disconnect and the Unmet Need
F. Oka (2019)
Semantic Scholar Logo Some data provided by SemanticScholar