Online citations, reference lists, and bibliographies.
← Back to Search

[Aspirin-induced Asthma].

A. Szczeklik
Published 1986 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Share
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
Abstract Eighteen patients with asthma and aspirin hypersensitivity have been challenged with increasing doses of aspirin, fenoprofen, ibuprofen, and dextropropoxyphene. Low doses of the first three drugs induced bronchoconstriction in all the patients as evidenced by fall in peak expiratory flow and appearance of clinical symptoms. There were no reactions to therapeutic doses of dextropropoxyphene. Aspirin, fenoprofen, and ibuprofen, but not dextropropoxyphene, inhibited prostaglandin synthetase activity in three different microsomal preparations, i.e., in bovine seminal vesicles, in rabbit brain and, in rabbit kidney medulla. Expected in vivo antienzymic potency of a drug, calculated from experiments using rabbit brain microsomes, corresponded roughly with its potency to induce bronchoconstriction in the challenge tests. An individual pattern of sensitivity to threshold doses of prostaglandin, synthetase inhibitors was demonstrated for each patient. The results obtained suggest that precipitation of asthmatic attacks by nonsteroidal anti-inflammatory drugs is mediated through inhibition of prostaglandin biosynthesis. The degree of enzymic inhibition, which is sufficient to precipitate bronchoconstriction, is an individual hallmark. Knowing the threshold dose for any of prostaglandin synthetase inhibitors in a patient, one can predict the threshold doses for the rest of aspirin-like drugs in this particular patient.
This paper references
PROSTAGLANDINS AND RELATED FACTORS: XIX. THIN-LAYER CHROMATOGRAPHY OF PROSTAGLANDINS.
K. Gréen (1964)
10.7326/0003-4819-66-3-568
Bronchial asthma induced by indomethacin.
N. Vanselow (1967)
10.1016/0021-8707(67)90076-7
Concerning the nature of intolerance to aspirin.
M. Samter (1967)
10.1038/2181135A0
Prostaglandins released by the Spleen
N. Gilmore (1968)
10.1016/0021-8707(70)90040-7
Presidential message. The need to re-evaluate acetylsalicylic acid (aspirin).
R. Farr (1970)
10.1038/NEWBIO231232A0
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.
J. Vane (1971)
10.1016/0091-6749(72)90014-0
Aspirin intolerance in asthma. Detection by oral challenge.
J. R. McDonald (1972)
10.1038/NEWBIO238104A0
Effects of anti-inflammatory drugs on prostaglandin biosynthesis.
R. Flower (1972)
10.1073/PNAS.70.12.3830
Effects of bradykinin and indomethacin on cyclic GMP and cyclic AMP in lung slices.
J. Stoner (1973)
10.1038/NEWBIO245084A0
Prostaglandin regulation of airway smooth muscle tone.
J. Orehek (1973)
10.1080/21548331.1973.11707951
Intolerance to Aspirin
M. Samter (1973)
10.1136/bmj.1.5847.193
Bronchial Hyperreactivity to Prostaglandin F2α and Histamine in Patients with Asthma
A. Mathé (1973)
Release and metabolism of prostaglandins in lung tissue.
Piper Pj (1974)
10.1016/0090-6980(74)90022-7
Fenoprofen: inhibitor of prostaglandin synthesis.
P. Ho (1974)
10.1056/NEJM197410032911406
Products containing aspirin.
E. Leist (1974)
10.1016/0090-6980(74)90100-2
Hypothesis: Inhibition of E prostaglandin-sensitive adenyl cyclase as the mechanism of morphine analgesia.
H. Collier (1974)
10.1016/S0140-6736(74)90075-0
Increased plasma levels of 15-keto-13,14-dihydro-prostaglandin F2X after allergen-provoked asthma in man.
K. Gréen (1974)
ヒトにおけるアレルゲン誘発ぜん息後の15‐ケト‐13,14‐ジヒドロ‐プロスタグランジンF2αの血しょう値上昇
K. Gréen (1974)
Drugs which inhibit prostaglandin biosynthesis.
R. Flower (1974)
10.1136/bmj.1.5949.67
Relationship of inhibition of prostaglandin biosynthesis by analgesics to asthma attacks in aspirin-sensitive patients.
A. Szczeklik (1975)
10.1111/j.2042-7158.1975.tb09414.x
Generation of prostaglandin E‐like material by the guinea‐pig trachea contracted by histamine
L. Grodzińska (1975)
10.7326/0003-4819-82-2-286
Aspirin Sensitivity: Other Drugs
R. Gryglewski (1975)
10.1016/0014-2999(75)90206-X
β-Adrenoceptors involved in inhibition of histamine release from sensitized guinea-pig lung
E. Malta (1975)



This paper is referenced by
10.1080/15376516.2020.1727597
Effects of COX inhibitors on responsiveness of the tracheal tract to acetylcholine and histamine and their relationship with LTC4 and PGE2 levels of bronchoalveolar lavage fluid in allergic Guinea pigs
A. Rassouli (2020)
10.1016/j.ejphar.2017.12.005
Prostaglandin D2 generation from human lung mast cells is catalysed exclusively by cyclooxygenase‐1
B. Baothman (2018)
10.1016/B978-0-12-801238-3.64240-X
Chemical- and Drug-Induced Asthma
Brita Kilburg-Basnyat (2018)
Systemic prostaglandin E2 production in patients with chronic idiopathic urticaria does not discriminate between positive and negative aspirin challenge
L. Mastalerz (2016)
Clinical Responses and Serum Prostaglandin
Sheldon L. Spector (2015)
10.2165/00003495-198325060-00001
Asthma and Anti-inflammatory Drugs
A. Szczeklik (2012)
10.2165/00003495-198020060-00002
Antirheumatic Drugs: Clinical Pharmacology and Therapeutic Use
G. Craig (2012)
Adverse events of glucocorticoid pulse therapy in inflammatory diseases: a meta-analysis
N. Smits (2011)
10.1111/j.1398-9995.2010.02352.x
Conversion of Th17‐type into Th2‐type inflammation by acetyl salicylic acid via the adenosine and uric acid pathway in the lung
H. Moon (2010)
Aspirin Induced Asthma- a Review
Unnati Gohil (2010)
10.1111/j.1365-2222.2010.03558.x
Iloprost has potent anti‐inflammatory properties on human monocyte‐derived dendritic cells
T. Müller (2010)
10.3349/ymj.2009.50.6.744
Update on Recent Advances in the Management of Aspirin Exacerbated Respiratory Disease
N. Palikhe (2009)
10.1586/1744666X.5.1.97
Role of infections in the induction and development of asthma: genetic and inflammatory drivers
Qun Wu (2009)
10.3858/emm.2010.42.1.005
Aspirin attenuates the anti-inflammatory effects of theophylline via inhibition of cAMP production in mice with non-eosinophilic asthma
Hyung-geun Moon (2009)
10.1111/j.1365-2222.2008.03155.x
BSACI guidelines for the management of drug allergy
R. Mirakian (2009)
10.1007/978-4-431-98349-1_20
Diagnosis of Aspirin Sensitivity in Aspirin Exacerbated Respiratory Disease
M. L. Kowalski (2009)
10.1111/j.1365-2222.2008.02989.x
Involvement of 15‐lipoxygenase and prostaglandin EP receptors in aspirin‐triggered 15‐hydroxyeicosatetraenoic acid generation in aspirin‐sensitive asthmatics
M. Jędrzejczak-Czechowicz (2008)
Prostacyclin among prostanoids.
R. Gryglewski (2008)
10.1097/PAF.0b013e318185a00a
Fatal Adverse Reaction to Ketorolac Tromethamine in Asthmatic Patient
C. Campobasso (2008)
10.1111/j.1365-2710.2008.00961.x
What do we know about the genetics of aspirin intolerance?
N. Palikhe (2008)
10.1007/s10875-008-9190-7
Association of Four-locus Gene Interaction with Aspirin-intolerant Asthma in Korean Asthmatics
Seung-Hyun Kim (2008)
10.1016/j.clinthera.2007.12.021
A review of ibuprofen and acetaminophen use in febrile children and the occurrence of asthma-related symptoms.
D. Kanabar (2007)
10.1097/01.fpc.0000239977.61841.fe
Association between polymorphisms in prostanoid receptor genes and aspirin-intolerant asthma
S. Kim (2007)
10.1016/J.DLD.2006.08.001
Respiratory symptoms in patients with inflammatory bowel disease and the impact of dietary salicylates.
P. Sivagnanam (2007)
Not for Sale or Commercial Distribution
M. Ravalia (2007)
10.1002/MED.20071
Cysteinyl‐leukotrienes and their receptors in asthma and other inflammatory diseases: Critical update and emerging trends
V. Capra (2007)
10.2165/00044011-200727020-00004
Retrospective Evaluation of Adverse Drug Reactions Induced by Nonsteroidal Anti-Inflammatory Drugs
L. Gallelli (2007)
10.1111/j.1398-9995.2006.00979.x
ALOX5 promoter genotype, asthma severity and LTC4 production by eosinophils
O. Kalayci (2006)
10.1016/J.JPEDS.2005.12.023
Evidence-based protocols for oral NSAID challenges.
D. Stevenson (2006)
Production of PGE 2 by bovine cultured airway smooth muscle cells and its inhibition by cyclooxygenase inhibitors
F. Delamere (2006)
10.1016/B0-12-370879-6/00035-1
ASTHMA | Aspirin-Intolerant
A. Sampson (2006)
10.1007/BF00587792
Participation of prostaglandins in pathogenesis of aspirin-sensitive asthma
A. Szczeklik (2004)
See more
Semantic Scholar Logo Some data provided by SemanticScholar