Online citations, reference lists, and bibliographies.
← Back to Search

Mechanisms Of Polymer Degradation And Erosion.

A. Göpferich
Published 1996 · Materials Science, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
The most important features of the degradation and erosion of degradable polymers in vitro are discussed. Parameters of chemical degradation, which is the scission of the polymer backbone, are described such as the type of polymer bond, pH and copolymer composition. Examples are given how these parameters can be used to control degradation rates. Degradation leads finally to polymer erosion, the loss of material from the polymer bulk. The resulting changes in morphology, pH, oligomer and monomer properties as well as crystallinity are illustrated with selected examples. Finally, a brief survey on approaches to polymer degradation and erosion is given.
This paper references
10.1002/APP.1981.070261124
Aliphatic polyesters. I. The degradation of poly(ϵ‐caprolactone) in vivo
C. Pitt (1981)
10.1073/PNAS.86.20.7663
Ultrasound-enhanced polymer degradation and release of incorporated substances.
J. Kost (1989)
10.1021/BK-1994-0540
Polymers of biological and biomedical significance
S. Shalaby (1993)
10.1016/0009-2509(90)80116-V
Development and temporal evolution of erosion fronts in bioerodible controlled release devices
K. Zygourakis (1990)
10.1002/POL.1981.170190301
Stepwise thermal degradation of a polybenzimidazole foam
D. Chatfield (1981)
10.1002/JBM.820110507
Degradation rates of oral resorbable implants (polylactates and polyglycolates): rate modification with changes in PLA/PGA copolymer ratios.
R. Miller (1977)
10.1016/0378-5173(89)90068-9
The effect of the addition of low molecular weight poly(dl-lactide) on drug release from biodegradable poly(dl-lactide) drug delivery systems
R. Bodmeier (1989)
Controlled release : a quantitative treatment
L. Fan (1989)
10.1002/JPS.2600800815
Determination of specific rate constants of specific oligomers during polyester hydrolysis.
M. L. Maniar (1991)
10.1016/0168-3659(94)90263-1
Degradation of poly(d,l-lactic acid) microspheres: effect of molecular weight
T. Park (1994)
Lactic acid. Properties and chemistry of lactic acid and derivatives.
C. Holten (1971)
10.1021/MA00068A006
Modeling of Polymer Erosion
A. Göpferich (1993)
10.1021/MA00020A026
Stereocomplex formation between enantiomeric poly(lactic acid)s. 3. Calorimetric studies on blend films cast from dilute solution
H. Tsuji (1991)
10.1016/S0376-7388(00)80472-X
Diffusional release of a solute from a polymeric matrix — approximate analytical solutions
P. Lee (1980)
10.1002/AIC.690180234
Effect of geometry on the dissolution of pharmaceutical tablets and other solids: Surface detachment kinetics controlling
D. O. Cooney (1972)
10.1007/978-3-642-77563-5_6
Accelerated Degradation Test on Resorbable Polymers
B. Buchholz (1992)
10.1016/0142-9612(93)90066-B
Poly(L-lactide): a long-term degradation study in vivo. I. Biological results.
H. Pistner (1993)
10.1016/0168-3659(91)90027-B
MORE ABOUT THE DEGRADATION OF LA/GA – DERIVED MATRICES IN AQUEOUS MEDIA
M. Vert (1991)
10.1007/BFB0027551
Poly(Ortho Esters)
J. Heller (1993)
10.1016/0168-3659(85)90042-2
Controlled drug release from poly(ortho esters) — A surface eroding polymer☆
J. Heller (1985)
10.1007/978-1-4612-5186-6
Directed Drug Delivery
R. Borchardt (1985)
10.1007/978-3-642-77563-5
Degradation Phenomena on Polymeric Biomaterials
H. Planck (1992)
10.1016/0142-9612(93)90121-H
Poly(L-lactide): a long-term degradation study in vivo. Part III. Analytical characterization.
H. Pistner (1993)
10.1016/0169-409x(93)90027-2
Biodegradable Hydrogels for Drug Delivery
K. R. Kamath (1993)
10.1002/CHIN.199504317
Drug delivery from bioerodible polymers: systemic and intravenous administration
A. Göpferich (1994)
10.1016/0142-9612(84)90068-1
Modelling of drug release kinetics from a laminated device having an erodible drug reservoir.
A. Thombre (1984)
10.5254/1.3539991
Degradation of Polymers
L. A. Wall (1962)
10.1016/S0069-8040(08)70344-3
Chapter 2 Hydrolysis and Formation of Esters of Organic Acids
A. Kirby (1972)
10.1002/POLA.1993.080311004
The influence of microstructure and monomer properties on the erosion mechanism of a class of polyanhydrides
A. Göpferich (1993)
10.1163/156856292X00402
The development of polyanhydrides for drug delivery applications.
J. Tamada (1992)
10.1007/BF00700872
STRUCTURE – PROPERTY RELATIONSHIP IN THE CASE OF THE DEGRADATION OF MASSIVE ALIPHATIC POLY – (-HYDROXY ACIDS) IN AQUEOUS MEDIA, PART 1: DEGRADATION OF LACTIDE - GLYCOLIDE COPOLYMERS: PLA 37.5 GA 25 AND PLA 75 GA 25
S. Li (1990)
10.1016/0020-711x(92)90058-9
Biodegradable polymers as drug delivery systems
M. Chasin (1990)
10.1073/PNAS.90.2.552
Erosion kinetics of hydrolytically degradable polymers.
J. Tamada (1993)
10.1007/978-1-4612-5186-6_10
Biodegradable Poly(Ortho Esters) as Drug Delivery Forms
J. Heller (1985)
10.1016/0168-3659(88)90037-5
Chemically self-regulated drug delivery systems
J. Heller (1988)
10.1016/0141-3910(92)90154-W
Biodegradation of microbial polyesters in the marine environment
Yoshiharu Doi (1992)
10.1021/MA00020A027
Stereocomplex formation between enantiomeric poly(lactic acid)s. 4. Differential scanning calorimetric studies on precipitates from mixed solutions of poly(D-lactic acid) and poly(L-lactic acid)
H. Tsuji (1991)
10.1016/0168-3659(94)00064-2
Modeling monomer release from bioerodible polymers
Achim Go¨pferich (1995)
Controlled Release of Biologically Active Agents
R. W. Baker (1987)
10.1016/0142-9612(92)90152-E
Mechanical properties of biodegradable ligament augmentation device of poly(L-lactide) in vitro and in vivo.
O. Laitinen (1992)
10.1515/ci.2004.26.2.30b
Biodegradable polymers and plastics
M. Vert (1992)
10.1002/PI.1994.210330105
Crystalline oligomeric stereocomplex as an intermediate compound in racemic poly(DL-lactic acid) degradation
S. Li (1994)
Polyanhydrides as drug delivery systems
M. Chasin (1990)
10.1016/0142-9612(89)90063-X
In vitro and in vivo degradation of poly(D,L lactide/glycolide) type microspheres made by solvent evaporation method.
G. Spenlehauer (1989)
10.1007/BF00700871
Structure-property relationships in the case of the degradation of massive aliphatic poly-(α-hydroxy acids) in aqueous media
S. Li (1990)
10.1097/00000658-198201001-00009
A Comparison of the Effect of pH on the Biodegradation of Two Synthetic Absorbable Sutures
C. Chu (1982)
10.1021/MA00215A003
Morphological characterization of bioerodible polymers. 1. Crystallinity of polyanhydride copolymers
E. Mathiowitz (1990)
10.1016/0142-9612(91)90037-B
Physico-mechanical properties of degradable polymers used in medical applications: a comparative study.
I. Engelberg (1991)
10.1016/s0069-8040(03)80001-8
Comprehensive Chemical Kinetics
C. Bamford (1976)
10.1016/0032-3861(94)90953-9
Preparation and characterization of poly(l-lactic acid) foams
A. Mikos (1994)
10.1016/b978-0-12-074450-3.x5001-3
Controlled release of bioactive materials.
R. Baker (1980)
10.1002/PI.4980230310
Synthesis and properties of biodegradable aliphatic polyesters
J. Dahlmann (1990)
Predicting drug release from cylindric polyanhydride matrix discs
A. Göpferich (1995)
10.1177/088391159400900105
An Investigation of Poly(lactic acid) Degradation
Xichen Zhang (1994)
10.1016/0168-3659(87)90020-4
Modification of the rates of chain cleavage of poly(ϵ-caprolactone) and related polyesters in the solid state
C. Pitt (1987)
10.1021/BK-1994-0540.CH002
Tissue Engineering Using Synthetic Biodegradable Polymers
C. Vacanti (1993)
10.1007/BF00701077
Structure-property relationships in the case of the degradation of massive poly(α-hydroxy acids) in aqueous media
S. Li (1990)
10.1002/JPS.2600781016
Use of liquid chromatography and mass spectroscopy to select an oligomer representative of polyester hydrolysis pathways.
M. L. Maniar (1989)
10.1021/MA00027A020
Experimental approach to elucidate the mechanism of ultrasound-enhanced polymer erosion and release of incorporated substances
L.-S. Liu (1992)
10.1073/PNAS.90.9.4176
Controlled release of polypeptides from polyanhydrides.
E. Ron (1993)
10.1016/0264-410X(92)90094-Z
Parameters affecting the immunogenicity of microencapsulated tetanus toxoid.
I. Esparza (1992)
10.1126/SCIENCE.8128245
Biodegradable long-circulating polymeric nanospheres.
R. Gref (1994)
10.1016/B978-0-12-074450-3.50005-X
THEORY AND PRACTICE OF CONTROLLED DRUG DELIVERY FROM BIOERODIBLE POLYMERS
J. Heller (1980)
10.1016/S0006-3495(89)82788-2
Transport rates of proteins in porous materials with known microgeometry.
W. Saltzman (1989)
10.1002/PEN.760290106
Laboratory simulation of space and salt water environmental effects on polymers
A. Garton (1989)
10.1023/A:1015801216466
Molecular Weight Changes in Polymer Erosion
A. D’Emanuele (2004)
10.1126/SCIENCE.2218494
New methods of drug delivery.
R. Langer (1990)
10.1016/0168-3659(89)90047-3
The acceleration of degradation-controlled drug delivery from polyester microspheres
Y. Cha (1989)
Comparative measurements of nanoparticle degradation velocity using an accelerated hydrolysis test
K. H. Wallis (1993)
10.1016/0167-7799(92)90194-Z
Responsive polymer systems for controlled delivery of therapeutics.
J. Kost (1992)
10.1002/JBM.820190806
Bioerodible polyanhydrides as drug-carrier matrices. I: Characterization, degradation, and release characteristics.
K. Leong (1985)
10.1177/088391158600100405
Review : Biodegradability of Synthetic Polymers Used for Medical and Pharmaceutical Applications: Part 1— Principles of Hydrolysis Mechanisms
T. S. Pierre (1986)
10.1016/0168-3659(87)90008-3
The effect of copolymerized 9,10-dihydroxystearic acid on erosion rates of poly(ortho esters) and its use in the delivery of levonorgestrel
J. Heller (1987)
10.1016/0267-6605(92)90078-8
Mechanisms of biodegradation of implantable polymers.
D. Williams (1992)
10.1021/MA00037A024
Stereocomplex formation between enantiomeric poly(lactic acids). 5. Calorimetric and morphological studies on the stereocomplex formed in acetonitrile solution
H. Tsuji (1992)
10.1016/S0140-6736(77)90420-2
POLYGLYCOLIC ACID SUTURES
A. Fowler (1977)
10.1023/A:1018942118148
Determinants of Release Rate of Tetanus Vaccine from Polyester Microspheres
M. Alonso (2004)
10.1002/MASY.19920530134
Reactions of atomic oxygen [O(3P)] with polymer films
M. A. Golub (1992)
Drug carriers in biology and medicine
G. Gregoriadis (1979)
10.1007/978-3-642-69376-2
Polymer Degradation and Stabilization
W. Hawkins (1984)
10.1021/MA00084A004
Incorporation of Benzocyclobutene into Polystyrene Allowing Postpolymerizer Chain Extension/Branching
S. Delassus (1994)
10.1021/MA00170A034
Stereocomplex formation between enantiomeric poly(lactides)
Y. Ikada (1987)
10.1021/MA00010A013
Stereocomplex formation between enantiomeric poly(lactic acid)s. 2. Stereocomplex formation in concentrated solutions
H. Tsuji (1991)
Tissue engineering : Frontiers in biotechnology
R. Langer (1993)
10.1016/0142-9612(87)90034-2
Resorbable materials of poly(L-lactide). VI. Plates and screws for internal fracture fixation.
J. Leenslag (1987)
10.1016/0142-9612(84)90037-1
The in vivo and in vitro degradation of poly(glycolic acid) suture material as a function of applied strain.
N. D. Miller (1984)
Strategies for the design of biodegradable polymer systems: manipulation of polyhydroxybutyrate-based materials
M. Yasin (1993)
10.1021/MA00195A018
Solid-state and solution stability of poly(anhydrides) and poly(esters)
A. Domb (1989)
10.1021/MA00089A031
Morphological changes resulting from the hydrolytic degradation of stereocopolymers derived from L- and DL-lactides
S. Li (1994)
Biomedical polymers : designed-to-degrade systems
S. Shalaby (1994)
10.1016/0142-9612(84)90022-X
Drug delivery from catalysed erodible polymeric matrices of poly(ortho ester)s.
C. Shih (1984)
10.1080/07366578308079439
Chemical and Physical Structure of Polymers as Carriers for Controlled Release of Bioactive Agents: A Review
R. Langer (1983)
Ester formation and hydrolysis, and related reactions
C. Bamford (1972)
A guidebook to mechanism in organic chemistry
Peter Sykes (1970)
10.1016/0168-3659(91)90011-2
Base-induced polymer hydrolysis in poly (β-hydroxybutyrate/β-hydroxyvalerate) matrices
S. Yoshioka (1991)
10.1002/AIC.690411012
Modeling of polymer erosion in three dimensions: Rotationally symmetric devices
A. Göpferich (1995)
10.1021/MA00077A010
Morphological characterization of bioerodible polymers. 3. Characterization of the erosion and intact zones in polyanhydrides using scanning electron microscopy
E. Mathiowitz (1993)
10.1111/j.2042-7158.1991.tb03547.x
Salt Formation of Lactic Acid Oligomers as Matrix for Sustained Release of Drugs
R. Wada (1991)
10.1016/0168-3659(92)90076-4
Blends of PVA and PGLA: control of the permeability and degradability of hydrogels by blending
G. Pitt (1992)
10.1557/PROC-331-79
Design of Bioerodible Devices with Optimal Release Characteristics
K. Zygourakis (1993)
10.1021/bk-1976-0033.ch003
Controlled Release from Erodible Slabs, Cylinders, and Spheres
H. Hopfenberg (1976)
10.1007/BF01457654
Effects of higher-order structure of poly(3-hydroxybutyrate) on its biodegradation. II. Effects of crystal structure on microbial degradation
H. Nishida (1993)
Polymers as controlled drug delivery devices for the treatment of malignant brain tumors
H. Brem (1993)
10.1038/354291A0
Electrically credible polymer gel for controlled release of drugs
I. C. Kwon (1991)
10.1001/ARCHSURG.1970.01340220162027
Polyglycolic acid sutures. Laboratory and clinical evaluation of a new absorbable suture material.
J. B. Herrmann (1970)



This paper is referenced by
10.1002/APP.21411
Physical properties and enzymatic hydrolysis of poly(L‐lactide)–TiO2 composites
N. Fukuda (2005)
10.1002/jbm.b.31611
Bone repair by cell-seeded 3D-bioplotted composite scaffolds made of collagen treated tricalciumphosphate or tricalciumphosphate-chitosan-collagen hydrogel or PLGA in ovine critical-sized calvarial defects.
K. Haberstroh (2010)
10.5772/35128
Biodegradation of Pre-Aged Modified Polyethylene Films
B. Nowak (2012)
10.1080/15421406.2016.1255509
L-ascorbic acid release from polymeric matrixes based on blends of chitosan, collagen and hyaluronic acid
B. Kaczmarek (2016)
10.1016/j.carbpol.2018.03.067
Degradation properties of chitosan microspheres/poly(L-lactic acid) composite in vitro and in vivo.
Zhenzhao Guo (2018)
10.3390/polym10050489
A Novel Delivery System for the Controlled Release~of Antimicrobial Peptides: Citropin 1.1 and Temporin A
U. Piotrowska (2018)
10.1080/10426500290095557
Correlation Between In Vitro Release and In Vivo Immune Response from Biodegradable Polymer Particles Entrapping Tetanus Toxoid
R. Raghuvanshi (2002)
10.1002/1097-4636(20010305)54:3<335::AID-JBM40>3.0.CO;2-4
Polylactide implants and bacterial contamination: an animal study.
P. Mainil-Varlet (2001)
10.1002/JBM.A.30083
Poly(anhydride-ester) fibers: role of copolymer composition on hydrolytic degradation and mechanical properties.
Kenya Whitaker-Brothers (2004)
10.1016/S0142-9612(03)00597-0
Study of the initial stages of drug release from a degradable matrix of poly(d,l-lactide-co-glycolide).
Alexis Frank (2004)
10.1109/DTIP.2008.4753004
Fabrication of nanostructured PLGA scaffolds using anodic aluminum oxide templates
Cheng-Chih Hsueh (2008)
10.1002/jbm.a.31967
Effect of dynamic 3-D culture on proliferation, distribution, and osteogenic differentiation of human mesenchymal stem cells.
M. Stiehler (2009)
10.1007/S10856-007-3292-2
In vitro and in vivo degradation of poly(l-lactide-co-glycolide) films and scaffolds
E. Pamuła (2008)
10.1533/9781845695033.1.3
An overview of bioresorbable materials
K. Burg (2008)
10.1002/JBM.A.20044
Biodegradable poly(ether-ester) multiblock copolymers for controlled release applications.
R. van Dijkhuizen-Radersma (2003)
10.1533/9780857098825.3.656
Resin-based ceramic matrix composite materials in dentistry
H. Mirmohammadi (2014)
10.1002/MASY.200690092
Molecular Dynamics of PGA Bioabsorbable Polymer During Isothermal Cold Crystallization
G. Kortaberria (2006)
Geis-Gerstorfer Impact of artificial ageing process on the wear resistance of dental materials
J. Geis-Gerstorfer (2005)
10.1021/acsomega.8b00534
Hybrid Polyester Self-Immolative Polymer Nanoparticles for Controlled Drug Release
Michael T. Gambles (2018)
10.1002/mabi.201000023
Microparticles for drug delivery based on functional polycaprolactones with enhanced degradability: loading of hydrophilic and hydrophobic active compounds.
C. Vaida (2010)
10.1016/j.jmbbm.2010.12.006
Mechanical study of PLA-PCL fibers during in vitro degradation.
A. Vieira (2011)
10.1016/j.ijpharm.2020.119339
The Effect of PLGA Molecular Weight Differences on Risperidone Release from Microspheres.
Moe Kohno (2020)
10.1111/j.1365-2591.2011.01869.x
Evaluation of cytotoxic and genotoxic effects of two resin-based root-canal sealers and their components on human leucocytes in vitro.
A. Baraba (2011)
10.1016/j.foodres.2020.109625
Bio-based active food packaging materials: Sustainable alternative to conventional petrochemical-based packaging materials
M. Asgher (2020)
10.1111/eos.12705
Suboptimal light curing and direct exposure to water of two contemporary composites: degree of conversion, sorption, solubility, and Knoop hardness.
Aksel W Wikant (2020)
10.1016/j.jmbbm.2015.07.026
Effects of aging procedures on the molecular, biochemical, morphological, and mechanical properties of vacuum-formed retainers.
H. Ahn (2015)
10.1016/j.pharma.2017.09.002
PLGA-based monolithic filaments prepared by hot-melt extrusion: In-vitro comparative study.
R. Kamel (2018)
10.1002/9781118675748.ch4
Drug‐Eluting Stents
A. Seidlitz (2019)
10.1016/J.SNA.2017.05.007
A remotely operated drug delivery system with dose control
Y. Yi (2017)
10.1016/J.PROGPOLYMSCI.2017.02.004
Lifetime prediction of biodegradable polymers
B. Laycock (2017)
10.1039/C6NJ02539K
Design and synthesis of new s-triazine polymers and their application as nanoparticulate drug delivery systems
S. N. Khattab (2016)
10.1021/bm401715z
Cross-linked, biodegradable, cytocompatible salicylic acid based polyesters for localized, sustained delivery of salicylic acid: an in vitro study.
Yashoda Chandorkar (2014)
See more
Semantic Scholar Logo Some data provided by SemanticScholar