Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Attentional Influence On The P50 Component Of The Auditory Event-related Brain Potential.

Y. Guterman, R. Josiassen, T. R. Bashore
Published 1992 · Psychology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
To determine if attentional factors influence the suppression of the auditory P50 in a conditioning-testing paradigm, known as the 'sensory gating' effect, we tested 10 healthy young adults in four experimental conditions. The first condition was the traditional passive conditioning-testing paradigm in which a pair of identical auditory clicks is administered at an interstimulus interval fixed at 500 ms. The effect of interest is a reduction of P50 amplitude in response to the second stimulus. In the next condition, the second stimulus could be one of two possible frequencies and subjects were required to count one and to ignore the other. The third and fourth experimental conditions involved a motor response. In the third condition, subjects were required to make a unimanual button press to the occurrence of the second stimulus. In the fourth condition, subjects were required to discriminate among two possible second stimuli, and make a unimanual button press to the occurrence of the designated stimulus. Subjects also completed four matched blocks of single stimulus (i.e., unpaired) presentations to provide a baseline for assessing the effect of the warning stimulus on the evoked response. We found, in agreement with previous results, that passive exposure to the paired stimuli produced a suppression of P50 amplitude to the second stimulus. However, we also found that suppression of P50 amplitude was not evident when subjects selectively counted the designated stimuli, and was reduced in magnitude when a simple motor response was required and when a selective motor response was based on stimulus discrimination. In addition, we observed that the amplitude of the P50 was larger with unpaired single stimuli than it was either with the first or second stimulus of a pair, regardless of processing demands. Furthermore, variations in processing demands did not affect P50 amplitude when a single stimulus was presented. This pattern of results suggests that the 'sensory gating' effect is not a simple 'hard-wired' inhibitory phenomenon. Rather, it may be one manifestation of an attention regulation process that is activated by a warning stimulus and has either inhibitory or excitatory effects on neural transmission, determined by variations in processing demands. Presentation of a warning stimulus may have an additional, unselective suppressing effect, operating independently of this attention regulating process.
This paper references
10.1016/0006-3223(90)90443-6
Sensory gating deficits in psychiatric impatients: Relation to catecholamine metabolites in different diagnostic groups
N. Baker (1990)
10.1017/S0140525X00026121
The Maltese cross: A new simplistic model for memory
D. Broadbent (1984)
10.3758/BF03326801
Early selective attention effects on cutaneous and acoustic blink reflexes
S. Hackley (1983)
PEARL II: portable laboratory computer system for psychophysiological assessment using event related brain potentials.
E. Heffley (1985)
10.1016/0920-9964(91)90007-E
Gating of auditory response in schizophrenics and normal controls: Effects of recording site and stimulation interval on the P50 wave
H. Nagamoto (1991)
10.1016/0013-4694(83)90252-3
The cognitive P40, N60 and P100 components of somatosensory evoked potentials and the earliest electrical signs of sensory processing in man.
J. Desmedt (1983)
10.1016/0165-1781(86)90102-2
Gating of auditory evoked responses in normal college students
M. Waldo (1986)
10.1126/science.182.4108.177
Electrical Signs of Selective Attention in the Human Brain
S. Hillyard (1973)
10.1037/0033-295X.84.1.1
Controlled and Automatic Human Information Processing: 1. Detection, Search, and Attention.
W. Schneider (1977)
10.1016/0013-4694(74)90155-2
Human auditory evoked potentials. I. Evaluation of components.
T. Picton (1974)
10.1016/0165-1781(90)90099-Q
Sensory physiology and catecholamines in schizophrenia and mania
L. Adler (1990)
10.1111/J.1469-8986.1987.TB00311.X
The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure.
R. Näätänen (1987)
10.1017/S0140525X00078407
The role of attention in auditory information processing as revealed by event-related potentials and other brain measures of cognitive function
R. Näätänen (1990)
10.1037/10037-000
Perception and communication
D. Broadbent (1958)
10.1111/J.1469-8986.1982.TB02536.X
Somatosensory evoked potential changes with a selective attention task.
R. Josiassen (1982)
10.1016/0006-3223(90)90419-3
Sensory gating in normals and schizophrenics: A failure to find strong P50 suppression in normals
N. Kathmann (1990)
10.1016/0013-4694(83)90135-9
A new method for off-line removal of ocular artifact.
G. Gratton (1983)
10.1037/H0027242
Strategies and models of selective attention.
A. Treisman (1969)
10.1109/TAU.1973.1162525
A computer program for designing optimum FIR linear phase digital filters
J. McClellan (1973)
Mechanisms of early selective attention in auditory and visual modalities.
S. Hillyard (1987)
10.1111/J.1469-8986.1983.TB00891.X
Brain event-related potentials as indicators of early selective processes in auditory target localization.
W. McCallum (1983)
10.1037/014068
Attention and Performance II.
J. Brožek (1971)
10.2307/3150757
Design and Analysis: A Researcher's Handbook
G. Keppel (1973)
10.1093/SCHBUL/13.4.669
Neurobiological studies of sensory gating in schizophrenia.
R. Freedman (1987)
10.1016/0001-6918(69)90065-1
On the speed of mental processes.
F. C. Donders (1969)
Neurophysiological evidence for a defect in inhibitory pathways in schizophrenia: comparison of medicated and drug-free patients.
R. Freedman (1983)
Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia.
L. Adler (1982)



This paper is referenced by
Three types of sensory gating : exploring interrelationships, individual differences, and implications
C. A. Yadon (2007)
10.1027//0269-8803.17.1.23
P50 Gating is Not Affected by Selective Attention
K. Kho (2003)
10.1037/a0018265
Attentional modulation of the P50 suppression deficit in recent-onset and chronic schizophrenia.
C. Yee (2010)
Respiratory sensory gating indices of inspiratory mechanical stimulus elicited cortical neural activation in humans
Pei-Ying S. Chan (2008)
10.1177/155005940003100207
Reduction of Auditory P50 Gating Response in Marihuana Users: Further Supporting Data
G. Patrick (2000)
10.1016/j.pscychresns.2002.12.001
Memory impairment and auditory evoked potential gating deficit in schizophrenia
M. H. Hsieh (2004)
10.1027/0269-8803/A000042
Relevance of attention in auditory sensory gating paradigms in schizophrenia A pilot study.
K. Gjini (2011)
10.1101/186304
Impaired conscious access and abnormal attentional amplification in schizophrenia
L. Berkovitch (2017)
10.3389/fphys.2010.00167
Cortical Gating of Oropharyngeal Sensory Stimuli
K. Wheeler-Hegland (2011)
10.1001/ARCHPSYC.1996.01830120052009
Inhibitory gating of an evoked response to repeated auditory stimuli in schizophrenic and normal subjects. Human recordings, computer simulation, and an animal model.
R. Freedman (1996)
10.1016/j.neuropsychologia.2004.04.022
Time course and hemispheric lateralization effects of complex pitch processing: evoked magnetic fields in response to rippled noise stimuli
I. Hertrich (2004)
10.1016/S1566-2772(03)00018-5
Sensory gating deficits in schizophrenia: can we parse the effects of medication, nicotine use, and changes in clinical status?
G. Light (2003)
10.1016/S0165-1781(01)00226-8
Gating of the vertex somatosensory and auditory evoked potential P50 and the correlation to skin conductance orienting response in healthy men
S. Arnfred (2001)
10.1016/j.clinph.2016.03.013
The relevance of attention in schizophrenia P50 paired stimulus studies
A. Dalecki (2016)
10.1027/0269-8803/A000229
Auditory Sensory Gating and the Big Five Personality Factors
C. A. Yadon (2019)
10.1016/S0006-3223(97)00161-3
A Parametric Study of the N40 Auditory Evoked Response in Rats
N. Boutros (1997)
10.1016/S0920-9964(98)00075-9
P50 abnormalities in schizophrenia: relationship to clinical and neuropsychological indices of attention
R. J. Erwin (1998)
10.1016/j.schres.2007.07.019
Reduced P50 suppression is associated with the cognitive disorganisation dimension of schizotypy
L. Evans (2007)
10.1007/978-0-387-72639-7_9
Electrophysiology of Attention
R. Cohen (2014)
10.1016/j.neuroimage.2015.07.001
Detecting tones in complex auditory scenes
Anette S. Giani (2015)
10.1016/S0304-3940(97)00403-5
A left temporal lobe impairment of auditory information processing in schizophrenia: an event-related potential study
U. Schall (1997)
10.1080/13803395.2016.1176995
Electrophysiological approaches to noise sensitivity
D. Shepherd (2016)
Effects of Stimuli Intensity and Frequency on Auditory P50 and N100 Sensory Gating
Yolanda Tri (2010)
10.1016/j.neubiorev.2005.04.002
Event-related potentials, cognition, and behavior: A biological approach
B. Kotchoubey (2006)
10.1046/j.1468-2982.2003.00434.x
What Kind of Habituation is Impaired in Migraine Patients?
M. Siniatchkin (2003)
10.1016/j.nicl.2018.03.010
Impaired conscious access and abnormal attentional amplification in schizophrenia
L. Berkovitch (2018)
10.1111/J.1469-8986.1995.TB02097.X
Effects of sound intensity on a midlatency evoked response to repeated auditory stimuli in schizophrenic and normal subjects.
J. Griffith (1995)
Auditory event-related potentials in attention-deficit hyperactivity disorder: developmental and clinical aspects
S. Johnstone (1999)
10.1016/S1388-2457(01)00578-8
The effect of state on sensory gating: comparison of waking, REM and non-REM sleep
M. Kisley (2001)
Neurocognitive signatures of auditory and visual sensory gating
Laura Jones (2016)
10.1111/ejn.12043
Affect‐specific modulation of the N1m to shock‐conditioned tones: magnetoencephalographic correlates
Ann-Kathrin Bröckelmann (2013)
10.1111/J.1469-8986.2006.00408.X
P50 sensitivity to physical and psychological state influences.
P. White (2006)
See more
Semantic Scholar Logo Some data provided by SemanticScholar