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Carrier Mediated Transport Of Amino Acids, Small Peptides, And Their Drug Analogs
P. Sinko, M. Hu, G. Amidon
Published 1987 · Chemistry
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Abstract The oral absorption of amino acids, small peptides and their analogs has been studied in rats using single pass intestinal perfusion. The experimental data was analyzed using a modified boundary layer method permitting the calculation of intrinsic membrane absorption parameters. Cefatrizine, l -Dopa, α-methyldopa, and l -PHE demonstrated concentration dependent absorption. Furthermore, the absorption of the amino acid analog, l -Dopa, was significantly inhibited by l -Leucine. Cefatrizine absorption was significantly inhibited by the peptide PHE-PHE (20 mM whereas the amino acid l -PHE (100 mM) did not inhibit its absorption. The results clearly demonstrate that l -Dopa and α-methyldopa oral absorption occurs via the amino acid pathway, while cefatrizine absorption occurs via the peptide pathway. These results indicate that nutrient pathways may function as a possible route for the oral delivery of selected drugs.
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