Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Apomorphine-induced Relief Of The Akinetic-rigid Syndrome And Early Median Nerve Somatosensory Evoked Potentials (SEPs) In Parkinson's Disease.

F. Mauguière, E. Broussolle, J. Isnard
Published 1993 · Psychology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Among early cortical median nerve SEPs the frontal N30 potential is known to show amplitude reduction during execution of voluntary movements and to be abnormally reduced in parkinsonian patients. However, it is not clear whether N30 abnormalities are related to the severity of motor disability in Parkinson's disease. To address this question we studied median nerve SEPs, using a 16-channel montage, in 7 patients chronically treated with subcutaneous (s.c.) injections of apomorphine hydrochloride for spontaneous "on-off" motor fluctuations. We observed no significant changes in the latency, amplitude or scalp topography of early SEPs when comparing traces and maps obtained in the "off" condition and during the "on" phase induced by s.c. injection of apomorphine. The absence of any SEP changes, despite a clear-cut relief of the akinetic-rigid syndrome, suggests that early cortical SEPs, and in particular the frontal N30 potential, at least when recorded in a subject at rest, are not usable as an objective means to assess the severity or the fluctuations of motor disability in Parkinson's disease.
This paper references
10.1016/0168-5597(86)90022-5
Scalp topography and distribution of cortical somatosensory evoked potentials to median nerve stimulation.
S. Tsuji (1986)
10.1002/ANA.410300113
Focal capsular vascular lesions can selectively deafferent the prerolandic or the parietal cortex: Somatosensory evoked potentials evidence
F. Mauguière (1991)
10.1113/jphysiol.1973.sp010082
Input from muscle and cutaneous nerves of the hand and forearm to neurones of the precentral gyrus of baboons and monkeys
M. Wiesendanger (1973)
10.1016/0013-4694(77)90151-1
The scalp topography of human somatosensory and auditory evoked potentials.
G. Goff (1977)
10.1152/JN.1991.66.1.53
Cortical somatosensory evoked potentials. I. Recordings in the monkey Macaca fascicularis.
G. Mccarthy (1991)
10.1016/0013-4694(87)90056-3
Specific gating of the early somatosensory evoked potentials during active movement.
G. Cheron (1987)
10.1136/jnnp.52.4.544
Subcutaneous apomorphine in Parkinson's disease.
P. Pollak (1989)
10.1016/0304-3940(86)90383-6
The supplementary motor area modulates perturbation-evoked discharges of neurones in the precentral motor cortex
H. Hummelsheim (1986)
10.1093/BRAIN/106.2.271
Astereognosis and dissociated loss of frontal or parietal components of somatosensory evoked potentials in hemispheric lesions. Detailed correlations with clinical signs and computerized tomographic scanning.
F. Mauguière (1983)
10.1016/B978-0-444-81352-7.50030-3
Long latency reflexes of human arm muscles in health and disease.
J. Rothwell (1990)
10.1212/WNL.17.5.427
Parkinsonism: onset, progression, and mortality
M. Hoehn (1967)
10.1016/0140-6736(90)91531-E
Apomorphine test to predict dopaminergic responsiveness in parkinsonian syndromes
A. Hughes (1990)
10.1016/0013-4694(80)90007-3
Somatosensory evoked potentials to finger stimulation in healthy octogenarians and in young adults: wave forms, scalp topography and transit times of parietal and frontal components.
J. Desmedt (1980)
10.1016/0168-5597(92)90010-9
Mental movement simulation affects the N30 frontal component of the somatosensory evoked potential.
G. Cheron (1992)
10.1016/0013-4694(70)90096-9
Comparative study of sensory input to motor cortex in animals and man.
S. Goldring (1970)
10.1152/JN.1989.62.3.711
Human cortical potentials evoked by stimulation of the median nerve. II. Cytoarchitectonic areas generating long-latency activity.
T. Allison (1989)
10.1016/0168-5597(91)90134-J
Gating of the early components of the frontal and parietal somatosensory evoked potentials in different sensory-motor interference modalities.
G. Cheron (1991)
10.1152/JN.1978.41.5.1107
Spatial organization of precentral cortex in awake primates. I. Somatosensory inputs.
Y. Wong (1978)
10.1002/MDS.870060109
Motor and sensory evoked potentials in progressive supranuclear palsy
G. Abbruzzese (1991)
10.1016/0168-5597(89)90049-X
Centrifugal and centripetal mechanisms involved in the 'gating' of cortical SEPs during movement.
S. J. Jones (1989)
10.1016/0168-5597(86)90012-2
Separate generators with distinct orientations for N20 and P22 somatosensory evoked potentials to finger stimulation?
M. Deiber (1986)
10.1016/0168-5597(92)90069-N
Unmasking of cortical SEP components by changes in stimulus rate: a topographic study.
L. García Larrea (1992)
10.1016/B978-0-407-02295-9.50012-6
Fluctuations of disability in Parkinson's disease – clinical aspects
C. Marsden (1981)
10.1152/JN.1981.45.3.467
Submodality distribution in sensorimotor cortex of the unanesthetized monkey.
J. Tanji (1981)
10.3171/JNS.1969.31.2.0117
Origin of somatosensory evoked scalp responses in man.
P. Stohr (1969)
10.1016/0168-5597(92)90005-V
The N30 component of somatosensory evoked potentials in patients with dystonia.
J. A. Reilly (1992)
10.1016/0013-4694(90)90151-9
Responses of monkey precentral neurones to passive movements and phasic muscle stretch: relevance to man.
J. Colebatch (1990)
10.1136/jnnp.46.1.35
The behaviour of the long-latency stretch reflex in patients with Parkinson's disease
J. Rothwell (1983)
10.1016/0168-5597(87)90036-0
Non-invasive evaluation of input-output characteristics of sensorimotor cerebral areas in healthy humans.
P. Rossini (1987)
10.1001/ARCHNEUR.1992.00530260044017
Supplementary and primary sensory motor area activity in Parkinson's disease. Regional cerebral blood flow changes during finger movements and effects of apomorphine.
O. Rascol (1992)
10.1016/0013-4694(62)90110-4
Recovery functions of somatosensory evoked responses in man.
T. Allison (1962)
10.1016/0006-8993(75)90167-5
Evidence for abnormal long-loop reflexes in rigid Parkinsonian patients
W. Tatton (1975)
10.1016/S0140-6736(88)91193-2
SUBCUTANEOUS APOMORPHINE IN PARKINSONIAN ON-OFF OSCILLATIONS
C. Stibe (1988)
10.1136/jnnp.53.11.1004
Comparison of motor response to apomorphine and levodopa in Parkinson's disease.
P. Kempster (1990)
10.1038/238140A0
Servo Action in Human Voluntary Movement
C. D. Marsden (1972)
Evoked potentials III
C. Barber (1987)
10.1016/B978-0-444-81352-7.50012-1
Physiology and clinical applications of hand muscle reflexes.
G. Deuschl (1990)
10.1016/0168-5597(89)90058-0
Abnormalities of short-latency somatosensory evoked potentials in parkinsonian patients.
P. Rossini (1989)
10.1212/WNL.42.3.614
Cerebral venous thrombosis in Behçet's disease
B. Wechsler (1992)
10.1212/WNL.32.5.514
The mysterious motor function of the basal ganglia
C. Marsden (1982)
10.1113/jphysiol.1981.sp013601
Functional properties of monkey motor cortex neurones receiving afferent input from the hand and fingers
R. Lemon (1981)
10.1001/ARCHNEUR.1960.03840090124020
Handbook of Physiology.
F. Plum (1960)
10.1016/0168-5597(85)90030-9
Color imaging of parietal and frontal somatosensory potential fields evoked by stimulation of median or posterior tibial nerve in man.
J. Desmedt (1985)
10.1016/S0987-7053(05)80118-2
Attenuation of the early anterior negativity of median nerve somatosensory evoked potential in the MPTP-treated monkey
M. Onofrj (1990)
10.1093/BRAIN/108.2.463
The anatomical basis of symptomatic hemidystonia.
C. Marsden (1985)
10.1093/BRAIN/110.2.451
Localization, timing and specificity of gating of somatosensory evoked potentials during active movement in man.
L. Cohen (1987)
10.4324/9780203397244
The Nervous System
M. Taussig (1991)
10.1098/rspb.1976.0082
Afferent input to movement-related precentral neurones in conscious monkeys
R. Lemon (1976)
10.1212/WNL.37.7.1250
Diurnal responsiveness to apomorphine
S. Gancher (1987)
10.1016/0168-5597(91)90122-E
Mapping study of somatosensory evoked potentials during selective spatial attention.
L. Garcia-Larrea (1991)
10.1016/S0140-6736(88)91755-2
SUBCUTANEOUS APOMORPHINE IN PARKINSON'S DISEASE
W. Poewe (1988)
10.1016/0168-5597(91)90055-3
Brain excitability and long latency muscular arm responses: non-invasive evaluation in healthy and parkinsonian subjects.
P. Rossini (1991)
10.1016/0168-5597(87)90065-7
Bit-mapped color imaging of human evoked potentials with reference to the N20, P22, P27 and N30 somatosensory responses.
J. Desmedt (1987)
10.1016/0169-2607(85)90040-9
Sequential colour mapping system of brain potentials.
M. H. Giard (1985)
10.1016/B978-0-444-81352-7.50032-7
Loss of parietal and frontal somatosensory evoked potentials in hemispheric deafferentation.
F. Mauguière (1990)
10.1016/0013-4694(81)91430-9
Non-cephalic reference recording of early somatosensory potentials to finger stimulation in adult or aging normal man: differentiation of widespread N18 and contralateral N20 from the prerolandic P22 and N30 components.
J. Desmedt (1981)
10.1016/0168-5597(90)90065-L
Bit-mapped somatosensory evoked potentials and muscular reflex responses in man: comparative analysis in different experimental protocols.
P. Rossini (1990)



This paper is referenced by
10.1007/BF03080146
Klinisch neurologische toepasbaarheid van multikanaals-eeg
Wilma Wassenberg (2010)
10.1038/nrneurol.2013.224
Pathophysiology of somatosensory abnormalities in Parkinson disease
A. Conte (2013)
10.1109/10.301728
Statistical analysis of topographic maps of short-latency somatosensory evoked potentials in normal and parkinsonian subjects
F. Babiloni (1994)
10.1002/(SICI)1097-4598(199602)19:2<191::AID-MUS11>3.0.CO;2-Y
Somatosensory evoked potentials during the ideation and execution of individual finger movements
P. Rossini (1996)
10.1016/S0987-7053(01)00248-9
Age-related changes of evoked potentials
M. Onofrj (2001)
10.1016/j.neuroimage.2010.08.060
Frontal phasic and oscillatory generators of the N30 somatosensory evoked potential
Ana-Maria Cebolla (2011)
10.1002/MDS.870100112
The abnormality of N30 somatosensory evoked potential in idiopathic Parkinson's disease is unrelated to disease stage or clinical scores and insensitive to dopamine manipulations
M. Onofrj (1995)
10.1002/(SICI)1097-4598(199907)22:7<910::AID-MUS15>3.0.CO;2-V
Different contribution of joint and cutaneous inputs to early scalp somatosensory evoked potentials
D. Restuccia (1999)
10.1212/WNL.47.1.306-b
Cerebellar timing process
R. Seitz (1996)
Possible role of the basal ganglia in the generation of the N30 potential of the median nerve somatosensory evoked potentials.
S. Beniczky (2007)
10.1016/0168-5597(94)00292-M
Median nerve somatosensory evoked potentials. Apomorphine-induced transient potentiation of frontal components in Parkinson's disease and in parkinsonism.
P. Rossini (1995)
10.1212/WNL.45.5.989
The frontal N30 component of the median‐derived SEP in patients with predominantly unilateral Parkinson's disease
P. Garcia (1995)
10.1016/0753-3322(96)82620-5
Apomorphine in patients with Parkinson's disease.
D. Muguet (1995)
10.1016/S0246-0378(07)46691-X
Potentiels évoqués en neurologie : réponses pathologiques et indications
F. Mauguière (2007)
10.1111/j.1468-1331.1997.tb00296.x
SEPs N30 amplitude in Parkinson's disease and in pharmacologically induced rigidity: relationship with the clinical status
P. Stanzione (1997)
10.1016/S1634-7072(07)70547-0
Potenziali evocati in neurologia: risposte patologiche e indicazioni
F. Mauguière (2007)
10.1016/j.braindev.2006.05.002
Topographic MN-SSEPs (N18, N20 and N30) might characterize underlying CNS involvements in representative types of cerebral palsy
Y. Tomita (2006)
10.3233/BEN-1996-93-406
Somatosensory evoked potentials and dopaminergic responsiveness to apomorphine and levodopa in parkinsonian patients.
M. Miranda (1996)
10.1016/S0022-510X(99)00067-2
Parkinson’s disease and lower limb somatosensory evoked potentials: Apomorphine-induced relief of the akinetic-rigid syndrome and vertex P37-N50 potentials
M. Tinazzi (1999)
10.1016/S0168-5597(98)00055-0
Parallel processing of sensory inputs: an evoked potentials study in Parkinsonian patients implanted with thalamic stimulators
A. Insola (1999)
10.1016/S0987-7053(00)00235-5
Abnormality of N30 somatosensory evoked potentials in Parkinson’s disease: a multidisciplinary approach
S. Bostantjopoulou (2000)
10.1016/S1388-2457(02)00335-8
Abnormal gating of somatosensory inputs in essential tremor
D. Restuccia (2003)
10.11251/OJJSCN1969.34.295
正中神経刺激による短潜時体性感覚誘発電位 (MN-SSEPs)
福田 千佐子 (2002)
10.1016/j.neucli.2010.04.002
Excitability of the lower-limb area of the motor cortex in Parkinson's disease
F. Vacherot (2010)
10.1016/S0987-7053(05)80074-7
BIT-mapped somatosensory evoked potentials in the fragile X syndrome
R. Ferri (1994)
10.1002/MDS.870120309
Sensory and motor evoked potentials in multiple system atrophy: A comparative study with Parkinson's disease
G. Abbruzzese (1997)
10.1007/BF00230430
A neuromagnetic study of movement-related somatosensory gating in the human brain
R. Kristeva-Feige (2004)
10.1007/s00221-006-0409-7
Predictive and reactive control of grasping forces: on the role of the basal ganglia and sensory feedback
D. A. Nowak (2006)
10.1016/S1388-2457(03)00068-3
The selective gating of the N30 cortical component of the somatosensory evoked potentials of median nerve is different in the mesial and dorsolateral frontal cortex: evidence from intracerebral recordings
P. Kaňovský (2003)
10.1016/0168-5597(94)90133-3
Somatosensory evoked potentials at rest and during movement in Parkinson's disease: evidence for a specific apomorphine effect on the frontal N30 wave.
G. Cheron (1994)
10.1016/S1388-2457(00)00497-1
Deficits in sensorimotor control during precise hand movements in Huntington's disease
M. Schwarz (2001)
10.1016/S0022-510X(00)00383-X
Somatosensory evoked potentials in progressive supranuclear palsy
M. Kofler (2000)
See more
Semantic Scholar Logo Some data provided by SemanticScholar