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How Is Myogenesis Initiated In The Embryo?

G. Cossu, S. Tajbakhsh, M. Buckingham
Published 1996 · Biology, Medicine

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Skeletal myoblasts are derived from paraxial mesoderm, but how myoblasts acquire their identity is still a matter of speculation. The characterization of molecular markers and, in some cases, the analysis of mutations in the corresponding genes, has now made it possible to ask specific questions about this process. Specification of somite cell fate depends on epigenetic factors. Adjacent tissues, such as the neural tube, notochord, dorsal ectoderm and lateral mesoderm, act either positively or negatively on the different myogenic precursor populations in the somite. Candidate molecules for this complex signalling activity include sonic hedgehog and the Wnt proteins as positive signals, and BMP4 as a possible inhibitor. Although it is generally assumed that induction is required, some observations suggest that embryonic cells might have a tendency to undergo myogenesis as a 'default' pathway. By analogy with Drosophila, where the neurogenic genes affect myogenesis, the vertebrate homologues of notch and its ligands could be candidate molecules for a repression or derepression mechanism. Similar studies with cultured muscle cells also implicate other HLH factors as potential inhibitors of the MyoD family and, hence, of inappropriate myogenesis.
This paper references
10.1111/j.1749-6632.1990.tb42374.x
Autonomous Expression of the Differentiation Programs of Cells in the Cardiac and Skeletal Myogenic Lineages a
H. Holtzer (1990)
Initial steps of myogenesis in somites are independent of influence from axial structures.
E. Bober (1994)
The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD.
R. Kopan (1994)
10.1016/0925-4773(95)00451-3
Complementary and combinatorial patterns of Notch gene family expression during early mouse development
R. Williams (1995)
10.1016/0925-4773(90)90132-6
The murine paired box gene, Pax7, is expressed specifically during the development of the nervous and muscular system
B. Jostes (1990)
Combinatorial signals from the neural tube, floor plate and notochord induce myogenic bHLH gene expression in the somite.
A. Münsterberg (1995)
10.1016/0092-8674(93)90621-V
MyoD or Myf-5 is required for the formation of skeletal muscle
M. Rudnicki (1993)
Regulation of Pax-3 expression in the dermomyotome and its role in muscle development.
M. Goulding (1994)
10.1006/DBIO.1995.1130
Myogenic specification of somites is mediated by diffusible factors.
N. Buffinger (1995)
Lineage restriction of the myogenic conversion factor myf-5 in the brain.
S. Tajbakhsh (1995)
10.1016/0925-4773(93)90096-G
Two molecules related to the VEGF receptor are expressed in early endothelial cells during avian embryonic development
A. Eichmann (1993)
10.1006/DBIO.1993.1258
Expression of the helix-loop-helix factor Id during mouse embryonic development.
S. Evans (1993)
Early expression of the myogenic regulatory gene, myf-5, in precursor cells of skeletal muscle in the mouse embryo.
M. Ott (1991)
Pax-3 expression in segmental mesoderm marks early stages in myogenic cell specification.
B. Williams (1994)
10.1016/S0092-8674(00)81291-X
Lateral and Axial Signals Involved in Avian Somite Patterning: A Role for BMP4
O. Pourquié (1996)
10.1016/0092-8674(94)90195-3
Notch is required for wingless signaling in the epidermis of Drosophila
J. Couso (1994)
10.1002/AJA.1002030302
Stages of embryonic development of the zebrafish
C. Kimmel (1995)
The neural tube/notochord complex is necessary for vertebral but not limb and body wall striated muscle differentiation.
P. M. Rong (1992)
10.1038/376768A0
Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
F. Bladt (1995)
10.1006/DBIO.1994.1273
M-twist is an inhibitor of muscle differentiation.
M. Hebrok (1994)
Expression of the fibroblast growth factor-5 gene in the mouse embryo.
O. Haub (1991)
10.1101/GAD.9.23.2911
Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite.
A. Münsterberg (1995)
Scleraxis: a basic helix-loop-helix protein that prefigures skeletal formation during mouse embryogenesis.
P. Cserjesi (1995)
10.1016/0092-8674(91)90183-Y
A role for the Drosophila neurogenic genes in mesoderm differentiation
V. Corbin (1991)
Mutations in a novel gene, myoblast city, provide evidence in support of the founder cell hypothesis for Drosophila muscle development.
E. Rushton (1995)
Myogenic specification in somites: induction by axial structures.
N. Buffinger (1994)
Myogenesis in paraxial mesoderm: preferential induction by dorsal neural tube and by cells expressing Wnt-1.
H. Stern (1995)
10.1016/0012-1606(86)90374-X
Neural control of early myogenic differentiation in cultures of mouse somites.
E. Vivarelli (1986)
10.1016/0092-8674(95)90294-5
Jagged: A mammalian ligand that activates notch1
C. Lindsell (1995)
The role of Pax-1 in axial skeleton development.
J. Wallin (1994)
Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta.
B. Bettenhausen (1995)
Notch1 is required for the coordinate segmentation of somites.
R. Conlon (1995)
10.1016/0012-1606(92)90214-2
Sequential activation of three myogenic regulatory genes during somite morphogenesis in quail embryos.
M. Pownall (1992)
10.1016/0092-8674(90)90214-Y
The protein Id: A negative regulator of helix-loop-helix DNA binding proteins
R. Benezra (1990)
10.1006/DBIO.1995.8028
Halves of epithelial somites and segmental plate show distinct muscle differentiation behavior in vitro compared to entire somites and segmental plate.
A. Gamel (1995)
10.1007/BF00304424
Early stages of chick somite development
B. Christ (2004)
10.1006/DBIO.1995.1009
Neural tube and notochord promote in vitro myogenesis in single somite explants.
H. Stern (1995)
10.1083/JCB.127.1.95
Somite subdomains, muscle cell origins, and the four muscle regulatory factor proteins
T. Smith (1994)
10.1016/0092-8674(94)90009-4
Patterning of mammalian somites by surface ectoderm and notochord: Evidence for sclerotome induction by a hedgehog homolog
C. Fan (1994)
Single cell analysis of mesoderm formation in the Xenopus embryo.
S. Godsave (1991)
10.1016/0092-8674(92)90508-A
Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development
M. Rudnicki (1992)
10.1038/336772A0
A community effect in animal development
J. Gurdon (1988)
Activation of different myogenic pathways: myf-5 is induced by the neural tube and MyoD by the dorsal ectoderm in mouse paraxial mesoderm.
G. Cossu (1996)
The prospero gene encodes a divergent homeodomain protein that controls neuronal identity in Drosophila.
Q. Chu-LaGraff (1991)
10.1016/S0168-9525(00)89106-4
Chasing tails in ascidians: developmental insights into the origin and evolution of chordates.
N. Satoh (1995)
10.1126/SCIENCE.1846704
The myoD gene family: nodal point during specification of the muscle cell lineage.
H. Weintraub (1991)



This paper is referenced by
10.1139/G07-012
Screen for new mutations on the 2nd chromosome involved in indirect flight muscle development in Drosophila melanogaster.
Sajesh Babu (2007)
The cellular mechanism by which the dermomyotome contributes to the second wave of myotome development.
N. Kahane (1998)
10.1101/GAD.1117603
The initial somitic phase of Myf5 expression requires neither Shh signaling nor Gli regulation.
L. Teboul (2003)
10.1002/dvdy.20671
Mohawk is a novel homeobox gene expressed in the developing mouse embryo
D. M. Anderson (2006)
10.1002/dvg.22796
In vivo cell tracking of mouse embryonic myoblasts and fast fibers during development
L. Guerrero (2014)
10.1083/JCB.153.5.1133
Circulating Skeletal Stem Cells
S. Kuznetsov (2001)
10.1083/JCB.153.4.F9
A New Role for Ion Channels in Myoblast Fusion
E. Cooper (2001)
10.1016/S0168-9525(99)01750-3
Patterning the C. elegans embryo: moving beyond the cell lineage.
M. Labouesse (1999)
10.1016/S0955-0674(00)00159-9
Genes that control the development of migrating muscle precursor cells.
C. Birchmeier (2000)
10.1002/dvdy.10215
T‐box binding site mediates the dorsal activation of myf‐5 in Xenopus gastrula embryos
G. F. Lin (2003)
10.1016/S0925-4773(98)00036-7
The generation and interpretation of positional information within the vertebrate myotome
P. Currie (1998)
10.1016/S0304-419X(96)00036-4
Interdependence between muscle differentiation and cell-cycle control.
R. Maione (1997)
10.1006/DBIO.1997.8605
Genetic interactions in zebrafish midline development.
M. Halpern (1997)
10.1242/bio.20121958
Fss/Tbx6 is required for central dermomyotome cell fate in zebrafish
S. Windner (2012)
10.1016/j.stem.2012.04.001
Tissue-specific stem cells: lessons from the skeletal muscle satellite cell.
A. Brack (2012)
The Effect of Pax3 Over-expression on Myoblast Function
Erik Brijs (2009)
Sonic hedgehog is required for survival of both myogenic and chondrogenic somitic lineages.
M. Teillet (1998)
p27Kip1 is expressed transiently in developing myotomes and enhances myogenesis.
S. Zabludoff (1998)
10.1006/DBIO.2001.0511
Muscle development and lineage-specific expression of CiMDF, the MyoD-family gene of Ciona intestinalis.
T. H. Meedel (2002)
10.1016/B978-012597951-1/50009-3
7 – Somitogenesis: Segmentation of the Paraxial Mesoderm and the Delineation of Tissue Compartments
A. Gossler (2002)
Onto-phylogenetic aspect of myotomal myogenesis in Chordata.
L. Kiełbówna (2004)
10.1002/dvdy.21873
The homeobox gene Mohawk represses transcription by recruiting the sin3A/HDAC co‐repressor complex
D. M. Anderson (2009)
10.1201/B16777-19
Vascularization of Muscle
T. Criswell (2014)
Promoting notochord fate and repressing muscle development in zebrafish axial mesoderm.
S. Amacher (1998)
10.1016/S0092-8674(00)80894-6
Somite Development: Constructing the Vertebrate Body
S. Tajbakhsh (1998)
10.1016/j.febslet.2007.11.047
A soluble and active form of Wnt‐3a protein is involved in myogenic differentiation after cholesterol depletion
D. Portilho (2007)
10.1007/s004270050274
Differential expression of two nonallelic MyoD genes in developing and adult myotomal musculature of the trout (Oncorhynchus mykiss)
J. M. Delalande (1999)
10.14418/wes01.3.38
Segmentation Genes and the Development of Skeletal Muscle Progenitors in Zebrafish
Stefanie Elisabeth Windner (2015)
10.1016/J.YDBIO.2004.02.013
An enhancer directs differential expression of the linked Mrf4 and Myf5 myogenic regulatory genes in the mouse.
T. Chang (2004)
10.1002/(SICI)1097-0177(199911)216:3<219::AID-DVDY1>3.0.CO;2-J
Early development of the myotome in the mouse
S. Venters (1999)
10.1242/jcs.088898
Cellular self-organization by autocatalytic alignment feedback
M. Junkin (2011)
10.1046/J.1432-0436.2001.680407.X
The skeletal muscle satellite cell: stem cell or son of stem cell?
P. Zammit (2001)
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