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Age-related Decrease In Sympathetic Sprouting Is Primarily Due To Decreased Target Receptivity: Implications For Understanding Brain Aging

K. Crutcher
Published 1990 · Biology, Medicine

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Aging of the nervous system is characterized by reduced anatomical plasticity. The cause of this decreased plasticity is not known because it is usually not possible to distinguish between extrinsic and intrinsic factors that affect neuronal growth. One example of age-related reduced neuronal plasticity that is amendable to such analysis is the growth of sympathetic axons into the rat hippocampal formation following septal denervation. This sprouting response can be elicited throughout the lifespan of the rat but is drastically reduced in aged animals. The age-related reduction in ingrowth could theoretically be due to decreased receptivity of the target (reduced trophic support or increased inhibition of growth), decreased responsivity of the sympathetic neurons or a combination of both factors. In order to test the relative contributions of the age of the target tissue and the age of the sympathetic neurons to the reduced growth observed in aged animals, superior cervical ganglia were transplanted from young animals into old animals (y/o) and from old animals into young animals (o/y) as well as autologously within the same animals (y/y and o/o). The extent of sympathetic ingrowth and the survival of transplanted neurons were assessed with fluorescence histochemical methods. The extent of ingrowth was significantly greater in young hosts compared with old hosts regardless of the age of the donor. In addition, the survival of transplanted neurons was greater in younger hosts than in aged hosts regardless of donor age. These results indicate that sympathetic ingrowth is reduced in aging primarily because of decreased receptivity of the hippocampal target tissue.
This paper references
10.1016/0006-8993(89)91507-2
Age-related alterations in noradrenergic input to the hippocampal formation: structural and functional studies in intraocular transplants
M. Eriksdotter-Nilsson (1989)
10.1159/000112359
Transplantation of CNS fragments into the brain of shiverer mutant mice: extensive myelination by implanted oligodendrocytes. I. Immunohistochemical studies.
F. Lachapelle (1983)
10.1016/0014-4886(80)90006-0
Effects of aging on nerve sprouting and regeneration
A. Pestronk (1980)
10.1016/0014-4886(81)90257-0
Axonal sprouting at the neuromuscular junction of adult and aged rats
G. Fagg (1981)
10.1523/JNEUROSCI.05-10-02809.1985
Neurotrophic activity in the adult rat hippocampal formation: regional distribution and increase after septal lesion
F. Collins (1985)
10.1016/0006-8993(81)91004-0
In vivo evidence for a hippocampal adrenergic neuronotrophic factor specifically released on septal deafferentation
A. Bjo¨rklund (1981)
10.1016/0006-291X(87)90600-0
Loss of nerve growth factor receptors in sympathetic ganglia from aged mice.
Y. Uchida (1987)
10.1016/0165-0270(80)90029-1
An improved approach to histofluorescence using the SPG method for tissue monoamines
J. D. L. Torre (1980)
10.1016/0006-8993(86)91471-X
Effect of age and muscle type on regeneration of neuromuscular synapses in mice
W. G. Hopkins (1986)
10.1016/0306-4522(84)90174-X
Fetal locus coeruleus transplanted into the transected spinal cord of the adult rat: Some observations and implications
J. Commissiong (1984)
10.1002/GLIA.440020309
Trauma‐induced proliferation of astrocytes in the brains of young and aged rats
K. Topp (1989)
10.1016/0006-8993(81)90648-X
Does the Mauthner cell conform to the criteria of the command neuron concept?
M. K. Rock (1981)
10.1083/JCB.106.4.1281
Two membrane protein fractions from rat central myelin with inhibitory properties for neurite growth and fibroblast spreading
P. Caroni (1988)
10.1016/0014-4886(79)90221-8
Sprouting of sympathetic nerves in the absence of afferent input
K. Crutcher (1979)
10.1126/SCIENCE.7375941
Sexual dimorphism in extent of axonal sprouting in rat hippocampus.
R. Loy (1980)
10.1126/SCIENCE.6879196
Aged rats: recovery of motor impairments by intrastriatal nigral grafts.
N. H. Gage (1983)
10.1126/SCIENCE.6539949
Intrahippocampal septal grafts ameliorate learning impairments in aged rats.
F. Gage (1984)
10.1007/978-1-4613-2705-9_4
Morphological Aspects of Brain Damage in Aging
Stephen W. Scheff (1984)
10.1002/CNE.902050305
Lesion‐induced synaptogenesis in the dentate gyrus of aged rats: II. Demonstration of an impaired degeneration clearing response
S. F. Hoff (1982)
10.1002/JNR.490190106
Migration of cultured fetal spinal cord astrocytes into adult host cervical cord and medulla following transplantation into thoracie spinal cord
W. Goldberg (1988)
10.1016/0006-8993(84)91321-0
Synaptic density and axonal sprouting in rat hippocampus: stability in adulthood and decline in late adulthood
J. R. Mcwilliams (1984)
10.1146/ANNUREV.PH.48.030186.002311
Neural grafting in the aged rat brain.
F. Gage (1986)
10.1016/0197-4580(87)90004-2
Persistence of sympathetic ingrowth fibers in aged rat hippocampus
R. Booze (1987)
10.1016/0197-4580(81)90005-1
Changes in noradrenergic neurotransmission in rat cerebellum during aging
J. Marwaha (1981)
10.1002/JNR.490170410
Transplant‐derived astrocytes migrate into host lumbar and cervical spinal cord after implantation of El4 fetal cerebral cortex into adult thoracic spinal cord
W. Goldberg (1987)
10.1016/0047-6374(88)90069-3
Morphometric studies on pre- and paravertebral sympathetic neurons in the rat: Changes with age
D. Baker (1988)
10.1016/0006-8993(89)90057-7
Rapid migration of grafted cortical astrocytes from suspension grafts placed in host thoracic spinal cord
J. J. Bernstein (1989)
10.1016/0006-8993(85)90364-6
Effects of nerve growth factor and heart cell conditioned medium on neurite regeneration of aged sympathetic neurons in culture
Y. Uchida (1985)
10.1146/ANNUREV.NE.07.030184.001431
Intracerebral neural implants: neuronal replacement and reconstruction of damaged circuitries.
A. Björklund (1984)
10.1016/0006-8993(87)90826-2
Age-related changes in cerebellar noradrenergic pre- and postsynaptic mechanisms: intrinsic vs extrinsic determinants evaluated with brain grafts in oculo
A. Granholm (1987)
10.1093/BRAIN/97.1.481
Lipoprotein pigments--their relationship to ageing in the human nervous system. I. The lipofuscin content of nerve cells.
D. Mann (1974)
10.1016/0006-8993(83)90785-0
Regulation of hippocampal sympathetic ingrowth: Role of afferent input
R. Madison (1983)
10.1016/0006-8993(88)91270-X
Age-related variations in plasticity of rat basal forebrain cholinergic neurons after cortical lesions
P. H. Stephens (1988)
10.1016/0304-3940(83)90449-4
Survival and differentiation of oligodendrocytes from neural tissue transplanted into new-born mouse brain
M. Gumpel (1983)
10.1038/329065A0
Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor
W. Fischer (1987)
10.1016/0014-4886(89)90007-1
Tissue sections from the mature rat brain and spinal cord as substrates for neurite outgrowth in vitro: Extensive growth on gray matter but little growth on white matter
K. Crutcher (1989)
10.1016/0896-6273(88)90212-7
Antibody against myelin associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matter
P. Caroni (1988)
10.1016/0006-8993(86)90745-6
Hippocampal sympathetic ingrowth in rats and guinea pigs: quantitative morphometry and topographical differences
R. Booze (1986)
10.1002/JNR.490200107
Fetal cortical astrocytes migrate from cortical homografts throughout the host brain and over the glia limitans
W. Goldberg (1988)
10.1016/0304-3940(78)90171-4
Growth of vascular sympathetic axons into the hippocampus after lesions of the septo-hippocampal pathway: a pitfall in brain lesion studies
F. Stenevi (1978)
Synapse repair in the hippocampus: the effects of aging.
C. Cotman (1983)
10.1016/0006-8993(81)90893-3
Regeneration of the septohippocampal pathways in adult rats is promoted by utilizing embryonic hippocampal implants as bridges
L. F. Kromer (1981)
10.1126/SCIENCE.715443
Decrease in adrenergic axon sprouting in the senescent rat.
S. Scheff (1978)
10.1016/0047-6374(79)90124-6
Compensatory synapse growth in aged animals after neuronal death
C. Cotman (1979)
10.1159/000211047
The influence of age on the course of reinnervation of muscle.
Z. Drahota (1961)
10.1016/0006-8993(81)90889-1
Sympathetic noradrenergic sprouting in response to central cholinergic denervation: A histochemical study of neuronal sprouting in the rat hippocampal formation
K. Crutcher (1981)
10.1016/0165-3806(85)90102-6
Neuronotrophic factors for mammalian brain neurons: injury induction in neonatal, adult and aged rat brain.
S. Whittemore (1985)
10.1152/PHYSREV.1981.61.3.684
Synapse replacement in the nervous system of adult vertebrates.
C. Cotman (1981)
10.1016/0306-4522(84)90070-8
An autoradiographic study of neuronal development, vascularization and glial cell migration from hippocampal transplants labelled in intermediate explant culture
R. M. Lindsay (1984)
10.1002/CNE.902370109
Evidence for sprouting specificity following medial septal lesions in the rat
K. Crutcher (1985)
10.1016/0014-4886(79)90188-2
Slowing of the rate of axonal regeneration during growth and maturation
M. Black (1979)
10.1016/0006-8993(77)90744-2
Experimental reinnervation of the rat hippocampus by grafted sympathetic ganglia I. Axonal regeneration along the hippocampal fimbria
A. Bjo¨rklund (1977)
10.1093/GERONJ/32.1.3
Patterns of astroglial hypertrophy and neuronal degeneration in the hippocampus of ages, memory-deficient rats.
P. Landfield (1977)
10.1016/S0163-1047(82)90234-5
Rapid forgetting in aged rats.
S. Zornetzer (1982)
10.1016/0197-4580(84)90084-8
Spatial learning and motor deficits in aged rats
F. Gage (1984)
10.1073/PNAS.83.9.3027
Loss of perforated synapses in the dentate gyrus: morphological substrate of memory deficit in aged rats.
Y. Geinisman (1986)
10.1016/0006-8993(88)91103-1
Transplantation of norepinephrine neurons into aged rats improves performance of a learned task
T. J. Collier (1988)
10.1016/0006-8993(80)90227-9
Decline in reactive fiber growth in the dentate gyrus of aged rats compared to young adult rats following entorhinal cortex removal
S. Scheff (1980)
10.1016/0047-6374(79)90126-X
Age pigments, cell loss and hippocampal function
K. Brizzee (1979)
10.1016/0047-6374(76)90003-8
Decrease in the number of synapses in the senescent brain: A quantitative electron microscopic analysis of the dentate gyrus molecular layer in the rat
Y. Geinisman (1976)
10.1016/0169-328X(87)90044-1
Decreased level of nerve growth factor (NGF) and its messenger RNA in the aged rat brain.
L. Lärkfors (1987)
10.1159/000123862
Elevated corticosterone levels. A possible cause of reduced axon sprouting in aged animals.
S. DeKosky (1984)
10.1523/JNEUROSCI.08-07-02381.1988
Oligodendrocytes and CNS myelin are nonpermissive substrates for neurite growth and fibroblast spreading in vitro
M. Schwab (1988)
10.1016/0165-0173(87)90013-0
Sympathetic sprouting in the central nervous system: a model for studies of axonal growth in the mature mammalian brain
K. Crutcher (1987)



This paper is referenced by
10.1016/0197-4580(94)90029-9
Increased NGF-like activity in young but not aged rat hippocampus after septal lesions
S. A. Scott (1994)
The regulation of axonal growth in the mature mammalian nervous system.
K. Crutcher (1990)
10.1155/NP.1997.73
Fetal Dopaminergic Neurons Transplanted to the Normal Striatum of Neonatal or Adult Rats and to the Denervated Striatum of Adult Rats
V. Sable (1997)
10.1016/0165-1838(95)00111-5
Can the neurotrophic hypothesis explain degeneration and loss of plasticity in mature and ageing autonomic nerves?
I. Gavazzi (1996)
10.1159/000022077
Tests Used to Assess the Cognitive Abilities of Aged Rats: Their Relation to Each Other and to Hippocampal Morphology and Neurotrophin Expression
R. McLay (1999)
10.3171/JNS.1996.84.3.0487
Superior cervical ganglion regenerating axons through peripheral nerve grafts and reversal of behavioral deficits in hemiparkinsonian rats.
R. Pallini (1996)
10.1016/S0197-4580(01)00238-X
Plasticity of aged perivascular axons following exogenous NGF: analysis of catecholamines
A. K. Dickason (2002)
10.1523/JNEUROSCI.14-05-03048.1994
In vivo infusion of NGF induces the organotypic regrowth of perivascular nerves following their atrophy in aged rats
T. Andrews (1994)
10.1002/(SICI)1096-9861(19960129)365:1<69::AID-CNE6>3.0.CO;2-H
Sympathetic nerve trajectories to rat orbital targets: Role of connective tissue pathways
P. Smith (1996)
10.1016/S0301-0082(97)00071-3
Plasticity in adult and ageing sympathetic neurons
T. Cowen (1998)
10.1016/S1566-0702(01)00373-3
Aging and neuronal plasticity: lessons from a model
K. Crutcher (2002)
10.1016/0304-3940(95)11449-7
Collateral sprouting and responsiveness to nerve growth factor of ageing neurons
I. Gavazzi (1995)
10.1002/CNE.903340312
NGF can induce a ‘young’ pattern of reinnervation in transplanted cerebral blood vessels from ageing rats
I. Gavazzi (1993)
10.1016/S0165-3806(97)00014-X
Decreased receptivity of pathway connective tissue to sympathetic nerve ingrowth in the developing rat.
J. Hiebert (1997)
Intracerebral Grafting: A Tool for the Neurobiologist Review
F. Gage (1991)
10.1007/BF02284823
Age-related changes in the morphology of preganglionic neurons projecting to the rat hypogastric ganglion
M. A. Dering (1996)
10.1016/B978-0-12-474993-1.50008-0
Anatomical Correlates of Neuronal Plasticity
K. Crutcher (1991)
10.1002/(SICI)1096-9861(19960422)368:1<33::AID-CNE3>3.0.CO;2-L
Target‐specific differences in the dendritic morphology and neuropeptide content of neurons in the rat SCG during development and aging
T. Andrews (1996)
10.1016/0006-8993(95)01364-4
Sympathetic sprouting reverses decreases in membrane-associated activity of protein kinase C following septohippocampal denervation of the rat hippocampus
Prabhu V. Ayyagari (1996)
10.1016/0891-0618(92)90019-M
Serotonergic fibres degenerating in the aging rat brain or sprouting from grafted fetal neurons are not affected by the neurotrophic ACTH analogue Org 2766
M. G. P. A. V. Luijtelaar (1992)
10.1016/j.neurobiolaging.2005.08.005
Sympathetic neuroaxonal dystrophy in the aged rat pineal gland
R. Schmidt (2006)
10.1016/0306-4522(91)90381-W
Morphological, neurochemical, and behavioral studies on serotonergic denervation and graft-induced reinnervation of the rat hippocampus
M. G. P. A. V. Luijtelaar (1991)
10.1016/S0197-4580(00)00155-X
Sympathetic neurite growth on central nervous system sections is region-specific and unaltered by aging
D. Pettigrew (2000)
10.1007/BF01275527
Nerve growth factor enhances the dendritic arborization of sympathetic ganglion cells undergoing atrophy in aged rats
T. Andrews (1994)
10.1089/ten.1996.2.183
Nerve growth factor delivery and cell aggregation enhance choline acetyltransferase activity after neural transplantation.
C. E. Krewson (1996)
10.1016/0197-4580(91)90072-R
Hippocampal NGF levels are not reduced in the aged Fischer 344 rat
K. Crutcher (1991)
10.1016/S0197-4580(98)00073-6
Uninjured aged sympathetic neurons sprout in response to exogenous NGF in vivo
L. Isaacson (1998)
10.1016/B978-012351830-9/50066-4
64 – The Aged Sympathetic Nervous System
G. Kuchel (2001)
10.1016/S0306-4522(97)00154-1
Distribution and levels of [125I]IGF-I, [125I]IGF-II and [125I]insulin receptor binding sites in the hippocampus of aged memory-unimpaired and -impaired rats
S. Dore (1997)
10.1016/B978-012705070-6/50007-X
Fetal Neuronal Grafting for CNS Regeneration: General Principles
J. Kordower (1999)
10.1007/BF01181534
Pathologic alterations in pre- and postsynaptic elements in aged mouse sympathetic ganglia
R. Schmidt (1995)
10.1097/00006123-199311000-00017
Spinal Cord Transection in Adult Rats
E. Fernández (1993)
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