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DNA Fragmentation In Focal Cortical Freeze Injury Of Rats

T. Tominaga, S. Kure, T. Yoshimoto
Published 1992 · Biology, Medicine

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This study examined the appearance of double-strand DNA breaks in rat brain after a focal cortical freeze injury in vivo. DNA fragments of oligonucleosome size appeared 3 h after the injury, and increased in a time-dependent manner. At 24 h, the amount of DNA fragmentation reached a maximum and then declined. When nuclei from freeze-injured brain tissue were incubated with Ca2+ in vitro, increased endonuclease activity, which can cause DNA fragmentation, was found. These findings indicate that the activation of a Ca(2+)-dependent endonuclease may be involved in the evolution of freeze-traumatized brain tissue.
This paper references
10.1016/0076-6879(89)70039-2
Preparation of nucleosomes and chromatin.
R. Kornberg (1989)
10.1089/DNA.1991.10.133
Development of an apoptosis endonuclease assay.
M. M. Compton (1991)
10.1096/fasebj.3.7.2497041
Calcium‐activated DNA fragmentation kills immature thymocytes
D. McConkey (1989)
10.1016/0003-9861(89)90119-7
Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration.
D. McConkey (1989)
10.1038/284555A0
Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
A. Wyllie (1980)
10.1093/OXFORDJOURNALS.JBCHEM.A133175
Purification and characterization of the Ca2+ plus Mg2+-dependent endodeoxyribonuclease from calf thymus chromatin.
M. Nakamura (1981)
Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.
J. Cohen (1984)
10.1016/s0021-9258(18)77327-4
DNA fragmentation induced in macrophages by gliotoxin does not require protein synthesis and is preceded by raised inositol triphosphate levels.
P. Waring (1990)
10.1016/0006-291X(74)90662-7
Isolation and purification of calcium and magnesium dependent endonuclease from rat liver nuclei.
R. Ishida (1974)
10.1016/S0074-7696(08)62312-8
Cell death: the significance of apoptosis.
A. Wyllie (1980)
10.1016/0076-6879(89)70051-3
Digestion of nucleosomes with deoxyribonucleases I and II.
L. Lutter (1989)
10.1016/s0021-9258(18)83363-4
Calcium-activated DNA fragmentation in rat liver nuclei.
D. P. Jones (1989)
10.1111/j.1471-4159.1984.tb12710.x
Induction of Brain Ornithine Decarboxylase During Recovery from Metabolic, Mechanical, Thermal, or Chemical Injury
G. Dienel (1984)
10.1016/s0021-9258(18)47561-8
Identification of a glucocorticoid-induced nuclease in thymocytes. A potential "lysis gene" product.
M. M. Compton (1987)



This paper is referenced by
10.1016/0304-3940(96)12839-1
Ultrastructural morphological changes are not characteristic of apoptotic cell death following focal cerebral ischaemia in the rat
M. V. L. Campagne (1996)
10.1097/00002826-200109000-00002
Acute Spinal Cord Injury, Part I: Pathophysiologic Mechanisms
R. J. Dumont (2001)
10.1161/01.STR.26.8.1478
Ischemic delayed neuronal death. A mitochondrial hypothesis.
K. Abe (1995)
10.1016/S0301-0082(98)00047-1
Cold injury in mice: a model to study mechanisms of brain edema and neuronal apoptosis
K. Murakami (1999)
10.1016/S0306-4522(97)00197-8
Occurrence of apoptosis following cold injury-induced brain edema in mice
K. Murakami (1997)
10.1385/0-89603-540-9:217
Neurons: Necrotic vs Apoptotic Changes
K. Abe (1999)
10.1016/S0304-3940(99)00327-4
Release of mitochondrial cytochrome c and DNA fragmentation after cold injury-induced brain trauma in mice: possible role in neuronal apoptosis
Y. Morita-Fujimura (1999)
10.1111/j.1750-3639.1994.tb00821.x
Evidence of Nuclear DNA Fragmentation Following Hypoxia‐Ischemia in the Infant Rat Brain, and Transient Forebrain Ischemia in the Adult Gerbil
I. Ferrer (1994)
10.1152/PHYSREV.1999.79.4.1431
Ischemic cell death in brain neurons.
P. Lipton (1999)
10.1111/j.1460-9568.1995.tb01158.x
NMDA and Kainate Induce Internucleosomal DNA Cleavage Associated With Both Apoptotic and Necrotic Cell Death in the Neonatal Rat Brain
M. L. Lookeren Campagne (1995)
10.1097/00004647-199906000-00006
Inhibition of Interleukin-1β Converting Enzyme Family Proteases (Caspases) Reduces Cold Injury-Induced Brain Trauma and DNA Fragmentation in Mice
Y. Morita-Fujimura (1999)
10.1006/hbeh.2000.1572
Hippocampal Anatomy and Water Maze Performance Are Affected by Neonatal Cryoanesthesia in Rats of Both Sexes
J. Nuñez (2000)
10.1038/labinvest.3700325
Increased angiopoietin2 expression is associated with endothelial apoptosis and blood–brain barrier breakdown
S. Nag (2005)
10.1159/000047089
Effect of Graded Hypoxia on Cerebral Cortical Genomic DNA Fragmentation in Newborn Piglets
W. Akhter (2001)
10.1016/S0145-2126(99)00098-3
Detection of apoptosis in acute promyelocytic leukemia cells in vivo during differentiation-induction with all-trans retinoic acid in combination with chemotherapy.
A. Sato (1999)
10.1007/s11064-009-0032-7
Mechanism of Post-Translational Modification by Tyrosine Phosphorylation of Apoptotic Proteins During Hypoxia in the Cerebral Cortex of Newborn Piglets
M. Delivoria-Papadopoulos (2009)
10.1016/j.neuroscience.2006.05.005
Hypoxia-induced Bax and Bcl-2 protein expression, caspase-9 activation, DNA fragmentation, and lipid peroxidation in mitochondria of the cerebral cortex of newborn piglets: The role of nitric oxide
O. Mishra (2006)
10.14670/HH-22.235
Immunohistochemical characterization of Fas (CD95) and Fas Ligand (FasL/CD95L) expression in the injured brain: relationship with neuronal cell death and inflammatory mediators.
M. Grosjean (2007)
10.1006/exnr.1999.7071
Temporal Profile of Apoptotic-like Changes in Neurons and Astrocytes Following Controlled Cortical Impact Injury in the Rat
J. K. Newcomb (1999)
10.1002/(SICI)1098-2302(199812)33:4<295::AID-DEV1>3.0.CO;2-L
The size of the splenium of the rat corpus callosum: influence of hormones, sex ratio, and neonatal cryoanesthesia.
J. Nuñez (1998)
10.1016/J.LEUKRES.2003.12.017
Alteration in the cellular response to retinoic acid of a human acute promyelocytic leukemia cell line, UF-1, carrying a patient-derived mutant PML-RARalpha chimeric gene.
A. Sato (2004)
10.1016/0006-8993(96)00222-3
DNA fragmentation and nuclear endonuclease activity in rat brain after severe closed head injury
S. Pravdenkova (1996)
10.1016/j.brainres.2006.05.021
Effect of nitric oxide synthase inhibition during post-hypoxic reoxygenation on Bax and Bcl-2 protein expression and DNA fragmentation in neuronal nuclei of newborn piglets
O. Mishra (2006)
10.1046/j.1365-2990.1999.00206.x
Distinct phases of cryogenic tissue damage in the cerebral cortex of wild‐type and c‐fos deficient mice
Steinbach (1999)
10.1016/0006-8993(93)90768-I
Endonuclease activation following focal ischemic injury in the rat brain
T. Tominaga (1993)
10.1016/S0166-2236(96)80039-7
Apoptotic features of selective neuronal death in ischemia, epilepsy and gpI20 toxicity
C. Charriaut-Marlangue (1996)
10.1023/A:1009653126347
Ultrastructural Morphology of Neuronal Death Following Reversible Focal Ischemia in the Rat
D. Aggoun-Zouaoui (2004)
10.1007/978-1-59259-479-5
Cerebral Ischemia
W. Walz (1999)
10.1007/s11064-009-0031-8
Mechanism of Increased Tyrosine (Tyr99) Phosphorylation of Calmodulin During Hypoxia in the Cerebral Cortex of Newborn Piglets: The Role of nNOS-Derived Nitric Oxide
O. Mishra (2009)
10.1016/S0006-8993(02)03342-5
Nitric oxide-mediated expression of Bax protein and DNA fragmentation during hypoxia in neuronal nuclei from newborn piglets
A. Zubrow (2002)
10.1016/S0006-8993(00)02375-1
Reduction of the DNA base excision repair protein, XRCC1, may contribute to DNA fragmentation after cold injury-induced brain trauma in mice
M. Fujimura (2000)
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