← Back to Search
Receptor-effector Coupling By G Proteins.
L. Birnbaumer, J. Abramowitz, A. M. Brown
Published 1990 · Biology, Medicine
Download PDFAnalyze on Scholarcy
The primary structure of G proteins as deduced from purified proteins and cloned subunits is presented. When known, their functions are discussed, as are recent data on direct regulation of ionic channels by G proteins. Experiments on expression of alpha subunits, either in bacteria or by in vitro translation of mRNA synthesized from cDNA are presented as tools for definitive assignment of function to a given G protein. The dynamics of G protein-mediated signal transduction are discussed. Key points include the existence of two superimposed regulatory cycles in which upon activation by GTP, G proteins dissociate into alpha and beta gamma and their dissociated alpha subunits hydrolyze GTP. The action of receptors to catalyze rather than regulate by allostery the activation of G proteins by GTP is emphasized, as is the role of subunit dissociation, without which receptors could not act as catalysts. To facilitate the reading of this review, we have presented the various subtopics of this rapidly expanding field in sections 1-1X, each of which is organized as a self-contained sub-chapter that can be read independently of the others.
This paper references
Splice variants of the alpha subunit of the G protein Gs activate both adenylyl cyclase and calcium channels.
R. Mattera (1989)
The GTP-binding protein, Go9 regulates neuronal calcium channels
J. Hescheler (1987)
Angiotensin increases inositol trisphosphate and calcium in vascular smooth muscle.
R. Alexander (1985)
Similar effects of substance P and related peptides on salivation and on phosphatidylinositol turnover in rat salivary glands.
M. Hanley (1980)
Hysteretic activation of adenylyl cyclases. I. Effect of Mg ion on the rate of activation by guanine nucleotides and fluoride.
R. Iyengar (1981)
Acetylcholine hyperpolarizes central neurones by acting on an M2 muscarinic receptor
T. M. Egan (1986)
Chapter 14 Cyclic-Nucleotide Metabolism in Vertebrate Photoreceptors: A Remarkable Analogy and an Unraveling Enigma
M. Bitensky (1981)
Isolation, sequence analysis, and intron-exon arrangement of the gene encoding bovine rhodopsin
J. Nathans (1983)
Presence of both beta1- and beta2-adrenergic receptors in a single cell type.
V. Homburger (1981)
Guanine nucleotides modulate the binding affinity of the oligopeptide chemoattractant receptor on human polymorphonuclear leukocytes.
C. Koo (1983)
Molecular cloning of a new human G protein Evidence for two Giα‐like protein families
J. Didsbury (1987)
Carbachol and oxytocin stimulate the generation of inositol phosphates in the guinea pig myometrium
S. Marc (1986)
Stimulation and inhibition of adenylyl cyclases mediated by distinct regulatory proteins
J. Hildebrandt (1983)
Isolation and characterization of cGMP phosphodiesterase from bovine rod outer segments.
W. Baehr (1979)
Activation of phospholipase C and prostaglandin synthesis by [arginine]vasopressin in cultures.
J. Pfeilschifter (1984)
Effects of cholecystokinin on adenylate cyclase activity in dispersed pancreatic acinar cells.
B. Long (1977)
Two different adenylyl cyclases in brain distinguished by monoclonal antibodies.
S. Mollner (1988)
Isolation of GTP-binding proteins from myeloid HL-60 cells. Identification of two pertussis toxin substrates.
R. J. Uhing (1987)
Escherichia coli thioredoxin confers processivity on the DNA polymerase activity of the gene 5 protein of bacteriophage T7.
S. Tabor (1987)
Adenyl cyclase in fat cells. 1. Properties and the effects of adrenocorticotropin and fluoride.
L. Birnbaumer (1969)
The kyotorphin (tyrosine-arginine) receptor and a selective reconstitution with purified Gi, measured with GTPase and phospholipase C assays.
H. Ueda (1989)
Reconstitution of the purified porcine atrial muscarinic acetylcholine receptor with purified porcine atrial inhibitory guanine nucleotide binding protein.
M. R. Tota (1987)
The mammalian beta 2-adrenergic receptor: reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system.
R. Cerione (1984)
Secretagogue-induced formation of inositol phosphates in rat exocrine pancreas. Implications for a messenger role for inositol trisphosphate.
R. Rubin (1984)
Activation of Adenyl Cyclase by Glucagon in Cat and Human Heart
G. Levey (1969)
β‐Subunits of the human liver Gs/Gi signal‐transducing proteins and those of bovine retinal rod cell transducin are identical
J. Codina (1986)
Identification of a gamma subunit associated with the adenylyl cyclase regulatory proteins Ns and Ni.
J. Hildebrandt (1984)
Stimulation of choleragen enzymatic activities by GTP and two soluble proteins purified from bovine brain.
S. C. Tsai (1988)
Regulation of hormone-receptor coupling to adenylyl cyclase. Effects of GTP and GDP.
R. Iyengar (1980)
Reconstitution of catecholamine-stimulated adenylate cyclase activity using three purified proteins.
D. C. May (1985)
Odorant- and guanine nucleotide-stimulated phosphoinositide turnover in olfactory cilia.
T. Huque (1986)
Sequence of the alpha subunit of photoreceptor G protein: homologies between transducin, ras, and elongation factors.
M. Lochrie (1985)
Protein kinase C phosphorylates the inhibitory guanine-nucleotide-binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase.
T. Katada (1985)
The role of hormone receptors and GTP-regulatory proteins in membrane transduction
M. Rodbell (1980)
Direct hyperpolarizing action of baclofen on hippocampal pyramidal cells
N. Newberry (1984)
Gonadotropin-releasing hormone stimulates phosphatidylinositol labeling and prostaglandin E production in Leydig cells.
J. Molcho (1984)
Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol.
M. Berridge (1983)
The G protein β2 complementary DNA encodes the β35 subunit
B. Gao (1987)
Direct activation of mammalian atrial muscarinic potassium channels by GTP regulatory protein Gk.
A. Yatani (1987)
Identification of the GTP-binding protein encoded by Gi3 complementary DNA.
P. Goldsmith (1988)
Action of cholecystokinin and cholinergic agents on membrane-bound calcium in dispersed pancreatic acinar cells.
H. T. Shelby (1976)
Choleragen-stimulated release of guanyl nucleotides from turkey erythrocyte membranes.
D. Burns (1982)
The interaction of nucleotides with pertussis toxin. Direct evidence for a nucleotide binding site on the toxin regulating the rate of ADP-ribosylation of Ni, the inhibitory regulatory component of adenylyl cyclase.
R. Mattera (1986)
Characterization of transducin from bovine retinal rod outer segments. II. Evidence for distinct binding sites and conformational changes revealed by limited proteolysis with trypsin.
B. Fung (1983)
The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Properties and function of the purified protein.
T. Katada (1984)
Acetylglyceryl ether phosphorylcholine. A potent activator of hepatic phosphoinositide metabolism and glycogenolysis.
S. Shukla (1983)
Purification of a beta 35 form of the beta gamma complex common to G-proteins from human placental membranes.
T. Evans (1987)
Cloning and expression of a rat D2 dopamine receptor cDNA
James R. Bunzow (1988)
Primary structure of the α‐subunit of bovine adenylate cyclase‐inhibiting G‐protein deduced from the cDNA sequence
Toshihide Nukada (1986)
Family of G protein α chains: amphipathic analysis and predicted structure of functional domains
S. Masters (1986)
Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.
P. Sternweis (1984)
[3H]GDP release from rat and hamster adipocyte membranes independently linked to receptors involved in activation or inhibition of adenylate cyclase. Differential susceptibility to two bacterial toxins.
T. Murayama (1984)
Adenyl cyclase in fat cells. 3. Stimulation by secretin and the effects of trypsin on the receptors for lipolytic hormones.
M. Rodbell (1970)
Characterization of transducin from bovine retinal rod outer segments. Mechanism and effects of cholera toxin-catalyzed ADP-ribosylation.
S. Navon (1984)
Reconstitution of resolved muscarinic cholinergic receptors with purified GTP-binding proteins.
V. Florio (1985)
Epinephrine inhibits adenylate cyclase and stimulates a GTPase in human platelet membranes vis α‐adrenoceptors
K. Aktories (1981)
Transient and steady state kinetics of the interaction of guanyl nucleotides with the adenylyl cyclase system from rat liver plasma membranes. Interpretation in terms of a simple two-state model.
L. Birnbaumer (1980)
The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart
D. Logothetis (1987)
Selection of a variant lymphoma cell deficient in adenylate cyclase.
H. Bourne (1975)
Gonadotropin-Releasing Hormone Stimulates Phospholipid Labeling in Cultured Granulosa Cells
Z. Naor (1982)
Chemotactic factor causes rapid decreases in phosphatidylinositol,4,5-bisphosphate and phosphatidylinositol 4-monophosphate in rabbit neutrophils.
M. Volpi (1983)
Purification and properties of the inhibitory guanine nucleotide regulatory unit of brain adenylate cyclase.
E. Neer (1984)
Studies on receptor-mediated activation of adenylyl cyclases. II. Nucleotide and nucleoside regulation of the activities of the beef renal medullary adenylyl cyclase and their stimulation by neurohypophyseal hormones.
L. Birnbaumer (1974)
Beta-adrenergic inhibition of cardiac sodium channels by dual G-protein pathways.
B. Schubert (1989)
Identification of receptor contact site involved in receptor–G protein coupling
K. Sullivan (1987)
Bimodal regulation of adenylate cyclase
D. M. Cooper (1982)
Kappa opiate agonists inhibit Ca2+ influx in rat spinal cord-dorsal root ganglion cocultures. Involvement of a GTP-binding protein.
B. Attali (1989)
Calcitonin gene-related peptide and cyclic AMP stimulate phosphoinositide turnover in skeletal muscle cells. Interaction between two second messenger systems.
Ralph Laufer (1989)
Angiotensin II‐induced stimulation of voltage‐dependent Ca2+ currents in an adrenal cortical cell line.
J. Hescheler (1988)
Identification and characterization of leukotriene D4 receptors and signal transduction processes in rat basophilic leukemia cells.
H. Sarau (1987)
Identification by molecular cloning of two forms of the α‐subunit of the human liver stimulatory (Gs) regulatory component of adenylyl cyclase
R. Mattera (1986)
The protein cofactor necessary for ADP-ribosylation of Gs by cholera toxin is itself a GTP binding protein.
R. Kahn (1986)
Receptor-coupled activation of phosphoinositide-specific phospholipase C by an N protein.
C. D. Smith (1986)
Histamine Stimulation of Inositol 1‐Phosphate Accumulation in Lithium‐Treated Slices from Regions of Guinea Pig Brain
P. Daum (1984)
Regulation of calcium currents by a GTP analogue: Potentiation of (−)-baclofen-mediated inhibition
R. H. Scott (1986)
Control of aldosterone production by angiotensin II is mediated by two guanine nucleotide regulatory proteins.
W. Hausdorff (1987)
Mechanism of action of gonadotropin-releasing hormone. Involvement of phospholipid turnover in luteinizing hormone release.
Z. Naor (1981)
Expression of cDNAs for G proteins in Escherichia coli. Two forms of Gs alpha stimulate adenylate cyclase.
M. Graziano (1987)
The stimulatory effect of prostaglandin E2 on adenyl cyclase in the bovine corpus luteum
J. M. Marsh (1970)
The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and the inhibition of adenylate cyclase in S49 lymphoma cyc- and wild type membranes.
T. Katada (1984)
ADP-ribosylation of transducin by pertussis toxin.
P. Watkins (1985)
Membrane-dependent guanine nucleotide binding and GTPase activities of soluble protein from bovine rod cell outer segments.
W. Godchaux (1979)
Specificity of the functional interactions of the beta-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles.
R. Cerione (1985)
Activation of myocardial adenyl cyclase by histamine in guinea pig, cat, and human heart.
I. Klein (1971)
Characterization of peptide YY receptors in the brain.
A. Inui (1989)
Multiple roles of erythrocyte supernatant in the activation of adenylate cyclase by Vibrio cholerae toxin in vitro.
D. Gill (1976)
USE OF LIVER ADENYL CYCLASE FOR ASSAY OF GLUCAGON IN HUMAN GASTRO-INTESTINAL TRACT AND PANCREAS.
M. Makman (1964)
Somatogenic receptors of rat liver: regulation by insulin.
R. Baxter (1980)
Dopamine inhibits adenylate cyclase in human prolactin-secreting pituitary adenomas
P. Camilli (1979)
Histamine-sensitive adenylate cyclase in mammalian brain
LINDA R. Hegstrand (1976)
Solubilization of the vasopressin receptor from rat liver plasma membranes. Evidence for a receptor X GTP-binding protein complex.
T. FitzGerald (1986)
Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes
T. Bonner (1988)
The STE4 and STE18 genes of yeast encode potential β and γ subunits of the mating factor receptor-coupled G protein
M. Whiteway (1989)
Changes in membrane currents in bullfrog atrium produced by acetylcholine.
W. Giles (1976)
Hormonal inhibition of adenylate cyclase. alpha 2 Adrenergic receptors promote release of [3H]guanylylimidodiphosphate from platelet membranes.
T. Michel (1982)
Neuropeptide Y inhibits cardiac adenylate cyclase through a pertussis toxin-sensitive G protein.
S. Kassis (1987)
Mouse neuroblastoma adenylate cyclase. Adenosine and adenosine analogues as potent effectors of adenylate cyclase activity.
A. Blume (1975)
Pertussis toxin inhibits enkephalin stimulation of GTPase of NG108-15 cells.
D. Burns (1983)
Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein.
C. D. Smith (1985)
Identification of a new GTP-binding protein. A Mr = 43,000 substrate for pertussis toxin.
R. Iyengar (1987)
The yeast SCG1 gene: A Gα-like protein implicated in the a- and α-factor response pathway
C. Dietzel (1987)
Mode of coupling between the beta-adrenergic receptor and adenylate cyclase in turkey erythrocytes.
A. Tolkovsky (1978)
Primary structure of the α-subunit of transducin and its relationship to ras proteins
T. Tanabe (1985)
Activation of two signal-transduction systems in hepatocytes by glucagon
M. Wakelam (1986)
Pharmacological inhibition of the M‐current
P. Adams (1982)
Effects of angiotensin II on phosphatidylinositol and polyphosphoinositide turnover in rat kidney. Mechanism of prostaglandin release.
J. Benabe (1982)
The regulatory component of adenylate cyclase. Purification and properties of the turkey erythrocyte protein.
E. Hanski (1981)
Angiotensin II inhibits adenylate cyclase from adrenal cortex glomerulosa zone
J. Marie (1983)
Islet-activating protein. A modifier of receptor-mediated regulation of rat islet adenylate cyclase.
T. Katada (1981)
Origin and blockade of the synaptic responses of curarized sympathetic ganglia
R. Eccles (1961)
Phosphatidylcholine breakdown in rat liver plasma membranes. Roles of guanine nucleotides and P2-purinergic agonists.
H. Irving (1987)
An α40 subunit of a GTP-Binding protein immunologically related to G0 mediates a dopamine-induced decrease of Ca2+ current in snail neurons
R. Harris-Warrick (1988)
Trends in the Development of Baculovirus Expression Vectors
V. A. Luckow (1988)
Vasopressin and angiotensin induce inositol lipid breakdown in rat adenohypophysial cells in primary culture
G. Guillon (1987)
An M2 muscarinic receptor subtype coupled to both adenylyl cyclase and phosphoinositide turnover.
A. Ashkenazi (1987)
Serotonin 5-HT1 receptors mediate inhibition of cyclic AMP production in neurons.
S. Weiss (1986)
A single GTP-binding protein regulates K+-channels coupled with dopamine, histamine and acetylcholine receptors
K. Sasaki (1987)
Relationships within the family of GTP-binding proteins isolated from bovine central nervous system.
D. Roof (1985)
Glucagon and epinephrine stimulation of adenyl cyclase in isolated rat liver plasma membranes.
G. Marinetti (1969)
Identification of a family of muscarinic acetylcholine receptor genes.
T. Bonner (1987)
Coupling of the guanine nucleotide regulatory protein to chemotactic peptide receptors in neutrophil membranes and its uncoupling by islet-activating protein, pertussis toxin. A possible role of the toxin substrate in Ca2+-mobilizing receptor-mediated signal transduction.
F. Okajima (1985)
Inhibition of hamster fat cell adenylate cyclase by prostaglandin E1 and epinephrine: Requirement for GTP and sodium ions
K. Aktories (1979)
The G protein-gated atrial K+ channel is stimulated by three distinct GIα-subunits
A. Yatani (1988)
Adenyl cyclase. IV. The effects of neurohormones on the formation of adenosine 3',5'-phosphate by preparations from brain and other tissues.
L. M. Klainer (1962)
Purification and characterization of the human platelet alpha 2-adrenergic receptor.
J. Regan (1986)
Characterization by two-dimensional peptide mapping of the gamma subunits of Ns and Ni, the regulatory proteins of adenylyl cyclase, and of transducin, the guanine nucleotide-binding protein of rod outer segments of the eye.
J. Hildebrandt (1985)
The role of the guanine nucleotide exchange reaction in the regulation of the beta-adrenergic receptor and in the actions of catecholamines and cholera toxin on adenylate cyclase in turkey erythrocyte membranes.
P. Lad (1980)
POLYPEPTIDE AND PROTEIN HORMONES
R. T. Coutts (1966)
The alpha subunit of the GTP binding protein activates muscarinic potassium channels of the atrium.
E. Cerbai (1988)
Isolation and structure of a rhodopsin gene from D. melanogaster
C. Zuker (1985)
Catecholamine-stimulated GTPase activity in turkey erythrocyte membranes.
D. Cassel (1976)
Identification of specific transducin alpha subunits in retinal rod and cone photoreceptors.
C. L. Lerea (1986)
Serotonin increases the production of inositol phosphates and mobilises calcium via the 5-HT2 receptor in A7r5 smooth muscle cells
V. Doyle (2004)
Molecular cloning and sequence determination of a cDNA coding for the α‐subunit of a Go‐type protein of Xenopus laevis oocytes
J. Olate (1989)
Complex formation between metarhodopsin II and GTP‐binding protein in bovine protoreceptor membranes leads to a shift of the photoproduct equilibrium
D. Emeis (1982)
Adenyl cyclase in fat cells. II. Hormone receptors.
L. Birnbaumer (1969)
The impact of streptozotocin-induced diabetes mellitus on cyclic nucleotide regulation of skeletal muscle amino acid metabolism in the rat.
A. Garber (1980)
Characterization of transducin from bovine retinal rod outer segments. Participation of the amino-terminal region of T alpha in subunit interaction.
S. Navon (1987)
Receptor-mediated inhibition of adenylate cyclase and stimulation of arachidonic acid release in 3T3 fibroblasts. Selective susceptibility to islet-activating protein, pertussis toxin.
T. Murayama (1985)
Angiotensin II receptors and inhibitory actions in Leydig cells.
A. Khanum (1988)
Studies on the hepatic alpha 1-adrenergic receptor. Modulation of guanine nucleotide effects by calcium, temperature, and age.
C. Lynch (1985)
Reticulocyte lysates synthesize an active alpha subunit of the stimulatory G protein Gs.
J. Olate (1988)
The distribution of the components of the cyclic GMP cycle in retina.
S. J. Berger (1980)
Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor
T. Kubo (1986)
Pertussis toxin-catalyzed ADP-ribosylation of transducin. Cysteine 347 is the ADP-ribose acceptor site.
R. E. West (1985)
Enkephalin-mediated inhibition of forskolin-stimulated rabbit luteal adenylyl cyclase activity.
J. Abramowitz (1983)
Inhibition of adenylate cyclase by angiotensin II in rat renal cortex.
E. Woodcock (1982)
Zum Mechanismus der Membranwirkung des Acetylcholin an der Herzmuskelfaser
W. Trautwein (2004)
Reconstitution of somatostatin and muscarinic receptor mediated stimulation of K+ channels by isolated GK protein in clonal rat anterior pituitary cell membranes.
A. Yatani (1987)
Guanine nucleotides and monovalent cations increase agonist affinity of prostaglandin E2 receptors in hamster adipocytes.
R. Grandt (1982)
Interaction of porcine vasoactive intestinal peptide with dispersed pancreatic acinar cells from the guinea pig. Structural requirements for effects of vasoactive intestinal peptide and secretin on cellular adenosine 3':5'-monophosphate.
P. Robberecht (1976)
Purification of the catalyst of adenylate cyclase.
M. Smigel (1986)
STIMULATION OF RAT GASTRIC ADENYLATE CYCLASE BY HISTAMINE AND HISTAMINE ANALOGUES AND BLOCKADE BY BURIMAMIDE
J. McNEILL (1974)
Suppression of insulin release by galanin and somatostatin is mediated by a G-protein. An effect involving repolarization and reduction in cytoplasmic free Ca2+ concentration.
T. Nilsson (1989)
Molecular basis for two forms of the G protein that stimulates adenylate cyclase.
J. Robishaw (1986)
Hormone‐stimulated GTPase activity in rat pancreatic plasma membranes
M. Lambert (1979)
The stimulation of adenosine 3,5-monophosphate production by antidiuretic factors.
E. Brown (1963)
Primary structure of the α‐subunit of bovine adenylate cyclase‐stimulating G‐protein deduced from the cDNA sequence
T. Nukada (1986)
Growth factor-like action of phosphatidic acid
W. Moolenaar (1986)
Thyrotropin-releasing hormone rapidly activates the phosphodiester hydrolysis of polyphosphoinositides in GH3 pituitary cells. Evidence for the role of a polyphosphoinositide-specific phospholipase C in hormone action.
T. Martin (1983)
Adenylate cyclase assembled in vitro: cholera toxin substrates determine different patterns of regulation by isoproterenol and guanosine 5'-triphosphate.
H. Kaslow (1979)
Site of G protein binding to rhodopsin mapped with synthetic peptides from the alpha subunit.
H. Hamm (1988)
Inhibition by glucagon of the calcium pump in liver plasma membranes.
S. Lotersztajn (1984)
A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.
A. De Léan (1980)
Studies on the mechanism of inhibition of hepatic cAMP accumulation by vasopressin
N. G. Morgan (1983)
Thyrotropin-releasing hormone activates a Ca2+-dependent polyphosphoinositide phosphodiesterase in permeable GH3 cells. GTP gamma S potentiation by a cholera and pertussis toxin-insensitive mechanism.
T. Martin (1986)
Neurotensin-mediated inhibition of cyclic AMP formation in neuroblastoma N1E115 cells: involvement of the inhibitory GTP-binding component of adenylate cyclase.
J. Bozou (1986)
Alpha i-3 cDNA encodes the alpha subunit of Gk, the stimulatory G protein of receptor-regulated K+ channels.
J. Codina (1988)
GTP hydrolysis by pure Ni, the inhibitory regulatory component of adenylyl cyclases.
T. Sunyer (1984)
Activation of phospholipases A2 and C in pig aortic endothelial cells synthesizing prostacyclin.
S. Hong (1982)
A G protein couples serotonin and GABAB receptors to the same channels in hippocampus.
R. Andrade (1986)
Adenosine 3′,5′-Monophosphate (Cyclic AMP) as the Mediator of the Actions of Melanocyte Stimulating Hormone (MSH) and Norepinephrine on the Frog Skin1
K. Abe (1969)
Stimulation of phosphatidic acid and phosphatidylinositol labeling in luteal cells by luteinizing hormone releasing hormone.
P. Leung (1983)
Stimulation of prostaglandin accumulation by luteinizing hormone-releasing hormone (LHRH) and LHRH analogs in rat granulosa cells in vitro.
M. R. Clark (1980)
Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs.
H. Itoh (1988)
Effects of lipolytic and antilipolytic substances on adenosine 3',5'-monophosphate levels in isolated fat cells.
R. W. Butcher (1968)
Association of a solubilized prostaglandin E2 receptor from renal medulla with a pertussis toxin-reactive guanine nucleotide regulatory protein.
T. Watanabe (1986)
The 35- and 36-kDa beta subunits of GTP-binding regulatory proteins are products of separate genes.
T. Amatruda (1988)
Islet-activating protein, pertussis toxin: a probe for functions of the inhibitory guanine nucleotide regulatory component of adenylate cyclase
M. Ui (1984)
Adenosine receptor-mediated inhibition of rat cerebral cortical adenylate cyclase by a GTP-dependent process.
D. M. Cooper (1980)
Effect of lhrh on incorporation of [32p]-orthophosphate into phosphatidylinositol by dispersed anterior pituitary cells
G. Snyder (1982)
Functional homology between signal-coupling proteins. Cholera toxin inactivates the GTPase activity of transducin.
M. Abood (1982)
Newly identified brain potassium channels gated by the guanine nucleotide binding protein Go.
A. VanDongen (1988)
Mode of regulation of the ACh-sensitive K-channel by the muscarinic receptor in rabbit atrial cells
M. Soejima (2004)
G proteins: transducers of receptor-generated signals.
A. Gilman (1987)
Inositol trisphosphate formation and calcium mobilization in Swiss 3T3 cells in response to platelet-derived growth factor.
M. Berridge (1984)
Stimulatory effects of LH, FSH and prostaglandins upon cyclic 3',5'-AMP levels in porcine granulosa cells.
J. Kolena (1972)
Modulation of ovarian adenylate cyclase response to gonadotropins following luteinization of the rat ovary.
C. Lee (1977)
Purification of the muscarinic acetylcholine receptor from porcine brain.
K. Haga (1985)
Sidedness of reconstituted calcium channels from muscle transverse tubules as determined by D600 and D890 blockade.
H. Affolter (1986)
gamma-aminobutyric acid B receptors are negatively coupled to adenylate cyclase in brain, and in the cerebellum these receptors may be associated with granule cells.
W. Wojcik (1984)
Guanine nucleotide regulation of a mammalian myocardial muscarinic receptor system. Evidence for homo- and heterotropic cooperativity in ligand binding analyzed by computer-assisted curve fitting.
R. Mattera (1985)
Effects of substance P on inositol triphosphate accumulation, on contractile responses and on arachidonic acid release and prostaglandin biosynthesis in rabbit iris sphincter muscle.
S. Y. Yousufzai (1986)
Role of Ni in coupling angiotensin receptors to inhibition of adenylate cyclase in hepatocytes.
B. Pobiner (1985)
Mechanism of action of monoclonal antibodies that block the light activation of the guanyl nucleotide-binding protein, transducin.
H. Hamm (1987)
Molecular cloning and expression of a fifth muscarinic acetylcholine receptor.
C. Liao (1989)
Angiotensin II and dopamine modulate both cAMP and inositol phosphate productions in anterior pituitary cells. Involvement in prolactin secretion.
A. Enjalbert (1986)
Reconstitution of a hormone-sensitive adenylate cyclase system. The pure beta-adrenergic receptor and guanine nucleotide regulatory protein confer hormone responsiveness on the resolved catalytic unit.
R. Cerione (1984)
Human Gi protein α‐subunit: deduction of amino acid structure from a cloned cDNA
J. Didsbury (1987)
Chromatographic resolution and immunologic identification of the alpha 40 and alpha 41 subunits of guanine nucleotide-binding regulatory proteins from bovine brain.
S. Mumby (1988)
Mechanisms of slow postsynaptic potentials
H. Hartzell (1981)
Rapid accumulation of inositol phosphates in isolated rat superior cervical sympathetic ganglia exposed to V1-vasopressin and muscarinic cholinergic stimuli.
E. Bone (1984)
Multiple receptors for dopamine
J. Kebabian (1979)
Vasoactive intestinal polypeptide increases inositol phospholipid breakdown in the rat superior cervical ganglion
S. Audigier (1986)
Structure of the GDP domain of EF-Tu and location of the amino acids homologous to ras oncogene proteins.
F. Jurnak (1985)
The mammalian beta 2-adrenergic receptor: purification and characterization.
J. Benovic (1984)
Modulation of adenylate cyclase of human platelets by phorbol ester. Impairment of the hormone-sensitive inhibitory pathway.
K. Jakobs (1985)
Elementary currents through Ca2+ channels in Guinea pig myocytes
A. Cavalié (2004)
On the relationship between formylmethionyl-leucyl-phenylalanine stimulation of arachidonyl phosphatidylinositol turnover and lysosomal enzyme secretion by rabbit neutrophils.
R. Rubin (1981)
Effects of Ca++ and prostaglandin E1 on vasopressin activation of renal adenyl cyclase.
F. Marumo (1971)
Synaptic delay in the heart: an ionophoretic study.
I. Hill-Smith (1978)
Novel S49 lymphoma variants with aberrant cyclic AMP metabolism.
M. Salomon (1981)
Luteinizing hormone increases inositol trisphosphate and cytosolic free Ca2+ in isolated bovine luteal cells.
J. S. Davis (1987)
Direct demonstration of adrenocorticotropin-induced changes in cytoplasmic free calcium with aequorin in adrenal glomerulosa cell.
I. Kojima (1986)
Role of calcium and cAMP in the action of adrenocorticotropin on aldosterone secretion.
I. Kojima (1985)
A role for Gi in control of thrombin receptor-phospholipase C coupling in human platelets.
M. F. Crouch (1988)
Regulation of beta-adrenergic receptors by guanyl-5'-yl imidodiphosphate and other purine nucleotides.
R. Lefkowitz (1976)
Regulation of glucagon receptor binding. Lack of effect of Mg and preferential role for GDP.
F. Rojas (1985)
Angiotensin II and alpha-adrenergic agonists inhibit rat liver adenylate cyclase.
S. Jard (1981)
Insulation of the conduction pathway of muscle transverse tubule calcium channels from the surface charge of bilayer phospholipid
R. Coronado (1986)
Effects of somatostatin on the hepatic adenylate cyclase system in the rat.
F. Vinicor (1977)
Hormone receptor-mediated stimulation of adenylyl cyclase systems. Nucleotide effects and analysis in terms of a simple two-state model for the basic receptor-affected enzyme.
R. Iyengar (1980)
A quantitative analysis of beta-adrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modeling of ligand binding data.
R. Kent (1980)
Rapid decrease of phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets.
M. Billah (1982)
Pertussis toxin attenuates atrial natriuretic factor-mediated inhibition of adenylate cyclase. Involvement of inhibitory guanine nucleotide regulatory protein.
M. Anand-Srivastava (1987)
Ns and Ni, the stimulatory and inhibitory regulatory components of adenylyl cyclases. Purification of the human erythrocyte proteins without the use of activating regulatory ligands.
J. Codina (1984)
Simultaneous inhibitions of inositol phospholipid breakdown, arachidonic acid release, and histamine secretion in mast cells by islet-activating protein, pertussis toxin. A possible involvement of the toxin-specific substrate in the Ca2+-mobilizing receptor-mediated biosignaling system.
T. Nakamura (1985)
Stimulation of inositol trisphosphate and diacylglycerol production in renal tubular cells by parathyroid hormone.
K. Hruska (1987)
Purification of a protein cofactor required for ADP-ribosylation of the stimulatory regulatory component of adenylate cyclase by cholera toxin.
R. Kahn (1984)
Carboxyl terminal domain of Gs alpha specifies coupling of receptors to stimulation of adenylyl cyclase.
S. Masters (1988)
Agonist-specific effects of guanine nucleotides on alpha-adrenergic receptors in human platelets.
B. S. Tsai (1979)
Glucagon receptors in -cells. Binding of 125 I-glucagon and activation of adenylate cyclase.
I. Goldfine (1972)
Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin
R. A. Dixon (1986)
Neurotensin stimulates inositol phospholipid hydrolysis in rat brain slices
M. Goedert (1984)
Detection of alpha-transducin in retinal rods but not cones.
G. Grunwald (1986)
Distinct subunits for the regulation and catalytic activity of aspartate transcarbamylase.
J. Gerhart (1965)
Hormone-sensitive adenylyl cyclases. Useful models for studying hormone receptor functions in cell-free systems.
L. Birnbaumer (1973)
Prostacyclin activation of adenylyl cyclase in rabbit corpus luteum membranes: comparison with 6-keto prostaglandin F1 alpha and prostaglandin E1.
J. Abramowitz (1979)
The rapid formation of inositol phosphates in human platelets by thrombin is inhibited by prostacyclin.
S. Watson (1984)
Uncoupling of cardiac muscarinic and β-adrenergic receptors from ion channels by a guanine nucleotide analogue
Gerda E. Breitwieser (1985)
Trigger and amplification mechanisms in visual phototransduction.
M. Chabre (1985)
The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. V. An obligatory role of guanylnucleotides in glucagon action.
M. Rodbell (1971)
Hysteretic activation of adenylyl cyclases. II. Mg ion regulation of the activation of the regulatory component as analyzed by reconstitution.
R. Iyengar (1981)
Effect of glucagon on rat heart adenyl cyclase.
F. Murad (1969)
A Drosophila melanogaster G protein alpha subunit gene is expressed primarily in embryos and pupae.
N. Provost (1988)
Effects of guanine nucleotides and Mg on human erythrocyte Ni and Ns, the regulatory components of adenylyl cyclase.
J. Codina (1984)
Recombinant alpha i-3 subunit of G protein activates Gk-gated K+ channels.
R. Mattera (1989)
Solubilization and characterization of the beta-adrenergic receptor binding sites of frog erythrocytes.
M. Caron (1976)
The somatostatin receptor is directly coupled to adenylate cyclase in GH4C1 pituitary cell membranes.
B. D. Koch (1984)
Thyroliberin stimulates rapid hydrolysis of phosphatidylinositol 4,5-bisphosphate by a phosphodiesterase in rat mammotropic pituitary cells. Evidence for an early Ca2+-independent action.
M. Rebecchi (1983)
Thyrotropin (TSH)-releasing hormone decreases phosphatidylinositol and increases unesterified arachidonic acid in thyrotropic cells: possible early events in stimulation of TSH secretion.
R. Kolesnick (1984)
ACTH stimulation of adenyl cyclase in adrenal homogenates.
O. D. Taunton (1967)
Characterization of the dopamine-responsive adenylate cyclase of bovine parathyroid cells and its relationship to parathyroid hormone secretion.
M. Attie (1980)
Phospholipid methylation affects immunoglobulin E-mediated histamine and arachidonic acid release in rat leukemia basophils.
F. Crews (1980)
The effect of intracellular cyclic nucleotides and calcium on the action potential and acetylcholine response of isolated cardiac cells
W. Trautwein (2004)
Light- and GTP-regulated interaction of GTPase and other proteins with bovine photoreceptor membranes
H. Kühn (1980)
Mode of coupling between hormone receptors and adenylate cyclase elucidated by modulation of membrane fluidity
G. Rimon (1978)
Neurotransmitters decrease the calcium component of sensory neurone action potentials
K. Dunlap (1978)
ADP ribosylation of the specific membrane protein of C6 cells by islet-activating protein associated with modification of adenylate cyclase activity.
T. Katada (1982)
Pertussis toxin blocks both cyclic AMP-mediated and cyclic AMP-independent actions of somatostatin. Evidence for coupling of Ni to decreases in intracellular free calcium.
B. D. Koch (1985)
Guanine nucleotide inhibition of cyc- S49 mouse lymphoma cell membrane adenylyl cyclase.
J. Hildebrandt (1982)
Arachidonic acid metabolites as intracellular modulators of the G protein-gated cardiac K+ channel
Y. Kurachi (1989)
Adenylate cyclase inhibition by hormones
J. Bockaert (1983)
Stimulation of a low Km GTPase by inhibitors of adipocyte adenylate cyclase.
K. Aktories (1982)
Bradykinin-induced changes in phosphatidyl inositol turnover in cultured rabbit papillary collecting tubule cells.
J. Shayman (1985)
Is there a basis for distinguishing two types of P2-purinoceptor?
G. Burnstock (1985)
The light-activated GTP-dependent cyclic GMP phosphodiesterase complex of bovine retinal rod outer segments. Dark resolution of the catalytic and regulatory proteins.
R. Kohnken (1981)
Shift in the relation between flash‐induced metarhodopsin I and metarhodopsin II within the first 10% rhodopsin bleaching in bovine disc membranes
D. Emeis (1981)
Amino acid sequence of retinal transducin at the site ADP-ribosylated by cholera toxin.
C. van Dop (1984)
Characterization of VIP‐sensitive adenylate cyclase in guinea pig brain
M. Deschodtlanckman (1977)
Primary structure and biochemical properties of an M2 muscarinic receptor.
E. Peralta (1987)
cDNA eloping of bovine substance-K receptor through oocyte expression system
Y. Masu (1987)
H1-histaminergic activation stimulates inositol-1-phosphate accumulation in chromaffin cells.
E. Noble (1986)
The calcium signal and phosphatidylinositol breakdown in 2H3 cells.
M. Beaven (1984)
The agonist-specific effect of magnesium ion on binding by beta-adrenergic receptors in S49 lymphoma cells. Interaction of GTP and magnesium in adenylate cyclase activation.
S. J. Bird (1978)
Biphasic effects of prostaglandin E2 on the human fat cell adenylate cyclase.
H. Kather (1979)
Effects of Mg2+ and the beta gamma-subunit complex on the interactions of guanine nucleotides with G proteins.
T. Higashijima (1987)
G-protein distribution in canine cardiac sarcoplasmic reticulum and sarcolemma: comparison to rabbit skeletal muscle membranes and to brain and erythrocyte G-proteins.
N. M. Scherer (1987)
The genomic clone G-21 which resembles a β-adrenergic receptor sequence encodes the 5-HT1A receptor
A. Fargin (1988)
Effects of angiotensin-II and potassium on phospholipid metabolism in the adrenal zona glomerulosa.
R V Farese (1981)
Synaptic excitation and inhibition resulting from direct action of acetylcholine on two types of chemoreceptors on individual amphibian parasympathetic neurones
H. Hartzell (1977)
Rapid binding of guanosine 5'-O-(3-thiotriphosphate) to an apparent complex of beta-adrenergic receptor and the GTP-binding regulatory protein Gs.
D. C. May (1988)
The relationship of epinephrine and glucagon to liver phosphorylase. III. Reactivation of liver phosphorylase in slices and in extracts.
T. Rall (1956)
Mammalian alpha 1-adrenergic receptor. Purification and characterization of the native receptor ligand binding subunit.
J. Lomasney (1986)
The influence of bound GDP on the kinetics of guanine nucleotide binding to G proteins.
K. Ferguson (1986)
A nucleotide regulatory site for somatostatin inhibition of adenylate cyclase in S49 lymphoma cells
K. Jakobs (1983)
Enkephalin opens potassium channels on mammalian central neurones
J. Williams (1982)
The effect of gonadotropins on testicular adenyl cyclase.
F. Murad (1969)
D-2 dopamine receptor-mediated inhibition of adenylate cyclase activity in the intermediate lobe of the rat pituitary gland requires guanosine 5'-triphosphate.
T. Cote (1982)
Molecular genetics of human color vision: the genes encoding blue, green, and red pigments.
J. Nathans (1986)
Molecular cloning of complementary DNA for the alpha subunit of the G protein that stimulates adenylate cyclase.
B. Harris (1985)
Two polyphosphatidylinositide metabolites control two K+ currents in a neuronal cell
Haruhiro Higashida (1986)
Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles.
R. Cerione (1986)
Corticotropin-releasing factor stimulates adenylate cyclase activity in the anterior pituitary gland
F. Labrie (1982)
Substance P induced hydrolysis of inositol phospholipids in guinea-pig ileum and rat hypothalamus.
S. Watson (1983)
Effects of vasoactive intestinal peptide, secretin, and related peptides on rat colonic transport and adenylate cyclase activity.
D. Waldman (1977)
An agonist-specific effect of guanine nucleotides on binding to the beta adrenergic receptor.
M. Maguire (1976)
Hormone-stimulated polyphosphoinositide breakdown in rat liver plasma membranes. Roles of guanine nucleotides and calcium.
R. J. Uhing (1986)
Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin
G. Bokoch (1984)
Resolution of some components of adenylate cyclase necessary for catalytic activity.
E. Ross (1977)
The human genome encodes at least three non‐allellic G proteins with αi‐type subunits
W. Suki (1987)
G-protein βγ-subunits activate the cardiac muscarinic K+-channel via phospholipase A2
D. Kim (1989)
Studies on receptor-mediated activation of adenylyl cyclases. III. Regulation by purine nucleotides of the activation of adenylyl cyclases from target organs for prostaglandins, luteinizing hormone, neurohypophyseal hormones and catecholamines. Tissue- and hormone-dependent variations.
L. Birnbaumer (1974)
Evidence for interdependent action of glucagon and nucleotides on the hepatic adenylate cyclase system.
M. Rodbell (1974)
Cyclic AMP‐independent, dual regulation of voltage‐dependent Ca2+ currents by LHRH and somatostatin in a pituitary cell line.
W. Rosenthal (1988)
Renal Adenyl Cyclase: Anatomically Separate Sites for Parathyroid Hormone and Vasopressin
L. Chase (1968)
The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution, activity, and properties of the 35,000-dalton (beta) subunit.
J. Northup (1983)
The relationship between alpha 1-adrenergic receptor occupation and the mobilization of intracellular calcium.
G. Amitai (1984)
Chapter 5 First Stage of Amplification in the Cyclic-Nucleotide Cascade of Vision
L. Stryer (1981)
Molecular characterization of a functional cDNA encoding the serotonin 1c receptor.
D. Julius (1988)
Purification of heterotrimeric GTP-binding proteins from brain: identification of a novel form of Go.
P. Goldsmith (1988)
A G protein directly regulates mammalian cardiac calcium channels.
A. Yatani (1987)
Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor.
B. Kobilka (1987)
Highly potent and selective ligands for histamine H3-receptors
J. Arrang (1987)
Pertussis toxin blocks the somatostatin-induced inhibition of growth hormone release and adenosine 3',5'-monophosphate accumulation.
M. Cronin (1983)
Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells
D. Piomelli (1987)
A new GTP‐binding protein in brain tissues serving as the specific substrate of islet‐activating protein, pertussis toxin
T. Katada (1987)
Catecholamine-stimulated GTPase cycle. Multiple sites of regulation by beta-adrenergic receptor and Mg2+ studied in reconstituted receptor-Gs vesicles.
D. R. Brandt (1986)
Adenyl cyclase. III. The effect of catecholamines and choline esters on the formation of adenosine 3',5'-phosphate by preparations from cardiac muscle and liver.
F. Murad (1962)
Hepatic alpha 1-adrenergic receptors show agonist-specific regulation by guanine nucleotides. Loss of nucleotide effect after adrenalectomy.
M. Goodhardt (1982)
Calcitonin gene‐related peptide elevates cyclic AMP levels in chick skeletal muscle: possible neurotrophic role for a coexisting neuronal messenger.
R. Laufer (1987)
Expression of Gs alpha in Escherichia coli. Purification and properties of two forms of the protein.
M. Graziano (1989)
Colony-stimulating factor 1-induced Na+ influx into human monocytes involves activation of a pertussis toxin-sensitive GTP-binding protein.
K. Imamura (1988)
Treatment of rabbit neutrophils with phorbol esters results in increased ADP‐ribosylation catalyzed by pertussis toxin and inhibition of the GTPase stimulated by fMet‐Leu‐Phe
T. Matsumoto (1986)
Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism
P. Rosoff (1988)
The effect of GTP and Mg2+ on the GTPase activity and the fluorescent properties of Go.
T. Higashijima (1987)
The effect of activating ligands on the intrinsic fluorescence of guanine nucleotide-binding regulatory proteins.
T. Higashijima (1987)
Thyrotropin-releasing hormone and GTP activate inositol trisphosphate formation in membranes isolated from rat pituitary cells.
R. Straub (1986)
Prostaglandins increase GTP hydrolysis by membranes from human mononuclear cells.
A. Bitonti (1980)
Direct evidence for involvement of a guanine nucleotide-binding protein in chemotactic peptide-stimulated formation of inositol bisphosphate and trisphosphate in differentiated human leukemic (HL-60) cells. Reconstitution with Gi or Go of the plasma membranes ADP-ribosylated by pertussis toxin.
A. Kikuchi (1986)
Hormonal regulation of pituitary GH3 cell K+ channels by Gk is mediated by its α‐subunit
J. Codina (1987)
Potentiation by thrombin of the secretion of serotonin from permeabilized platelets equilibrated with Ca2+ buffers. Relationship to protein phosphorylation and diacylglycerol formation.
R. Haslam (1984)
G proteins: a family of signal transducers.
L. Stryer (1986)
Progress in Clinical and Biological Research
J. F. Smyth (1982)
Activation mechanism of rod outer segment cyclic GMP phosphodiesterase. Release of inhibitor by the GTP/GTP-binding protein.
A. Yamazaki (1983)
The alpha subunit of the GTP binding protein Gk opens atrial potassium channels.
J. Codina (1987)
A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants.
M. Trahey (1987)
Distinct primary structures, ligand‐binding properties and tissue‐specific expression of four human muscarinic acetylcholine receptors.
E. Peralta (1987)
Stimulation by vasopressin and alpha-catecholamines of phosphatidylinositol formation in isolated rat liver parenchymal cells.
M. Tolbert (1980)
The regulatory components of adenylate cyclase and transducin. A family of structurally homologous guanine nucleotide-binding proteins.
D. Manning (1983)
Primary structure of the β‐subunit of bovine transducin deduced from the cDNA sequence
K. Sugimoto (1985)
The stimulatory G protein of adenylyl cyclase, Gs, also stimulates dihydropyridine-sensitive Ca2+ channels. Evidence for direct regulation independent of phosphorylation by cAMP-dependent protein kinase or stimulation by a dihydropyridine agonist.
A. Yatani (1988)
Postsynaptic serotonin-sensitive adenylate cyclase in the central nervous system. I. Development and distribution of serotonin and dopamine-sensitive adenylate cyclases in rat and guinea pig brain.
A. Enjalbert (1978)
7‐O‐hemisuccinyl‐deacetyl forskolin—sepharose: a novel affinity support for purification of adenylate cyclase
T. Pfeuffer (1982)
Mechanism of guanine nucleotide regulatory protein-mediated inhibition of adenylate cyclase. Studies with isolated subunits of transducin in a reconstituted system.
R. Cerione (1986)
Bradykinin and angiotensin II activation of arachidonic acid deacylation and prostaglandin E2 formation in rabbit kidney. Hormone-sensitive versus hormone-insensitive lipid pools of arachidonic acid.
M. Schwartzman (1981)
Dual actions of phorbol esters on cytosolic free Ca2+ concentrations and reconstitution with ionomycin of acute thyrotropin-releasing hormone responses.
P. Albert (1985)
A new GTP-binding protein in differentiated human leukemic (HL-60) cells serving as the specific substrate of islet-activating protein, pertussis toxin.
M. Oinuma (1987)
ADP-ribosylation of the specific membrane protein by islet-activating protein, pertussis toxin, associated with inhibition of a chemotactic peptide-induced arachidonate release in neutrophils. A possible role of the toxin substrate in Ca2+-mobilizing biosignaling.
F. Okajima (1984)
A mutation that prevents GTP-dependent activation of the α chain of Gs
R. T. Miller (1988)
Kinetics of activation of phospholipase C by P2Y purinergic receptor agonists and guanine nucleotides.
J. Boyer (1989)
The stimulatory effect of luteinizing hormone on adenosine 3',5'-monophosphate accumulation in corpus luteum slices.
J. M. Marsh (1966)
Mechanisms of muscarinic receptor action on Go in reconstituted phospholipid vesicles.
V. Florio (1989)
A monoclonal antibody to the alpha subunit of Gk blocks muscarinic activation of atrial K+ channels.
A. Yatani (1988)
GTP-binding proteins mediate transmitter inhibition of voltage-dependent calcium channels
G. Holz (1986)
GTP-binding proteins couple cardiac muscarinic receptors to a K channel
Paul J. Pfaffinger (1985)
Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase
S. Cockcroft (1985)
Human pancreatic tumor growth hormone-releasing factor stimulates anterior pituitary adenylate cyclase activity, adenosine 3',5'-monophosphate accumulation, and growth hormone release in a calmodulin-dependent manner.
G. Schettini (1984)
A monoclonal antibody to guanine nucleotide binding protein inhibits the light-activated cyclic GMP pathway in frog rod outer segments
H. Hamm (1984)
Reconstitution of Excitable Cell Membrane Structure in Vitro
P. R. Müller (1962)
Parallel inactivation of α2‐adrenergic agonist binding and Ni by alkaline treatment
M. H. Kim (1985)
Rhodopsin-enhanced GTPase activity of the inhibitory GTP-binding protein of adenylate cyclase.
Y. Kanaho (1984)
Inhibition of platelet adenylate cyclase by 1-O-alkyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine (platelet-activating factor).
R. Haslam (1982)
Cholera toxin inhibits prostaglandin E1 but not adrenaline‐induced stimulation of GTP hydrolysis in human platelet membranes
K. Aktories (1982)
Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase.
G. Bokoch (1984)
5-Hydroxytryptamine stimulates inositol phosphate production in a cell-free system from blowfly salivary glands. Evidence for a role of GTP in coupling receptor activation to phosphoinositide breakdown.
I. Litosch (1985)
Bradykinin stimulation of inositol polyphosphate production in porcine aortic endothelial cells.
T. Lambert (1986)
Purification of the beta-adrenergic receptor. Identification of the hormone binding subunit.
R. Shorr (1981)
Turkey erythrocyte membranes as a model for regulation of phospholipase C by guanine nucleotides.
T. K. Harden (1987)
Hormonal regulation of testicular luteinizing hormone receptors. Effects on cyclic AMP and testosterone responses in isolated Leydig cells.
T. Tsuruhara (1977)
Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism.
S. Bocckino (1987)
Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium.
D. Jones (1987)
Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production
M. Wakelam (1986)
Odorant-sensitive adenylate cyclase may mediate olfactory reception
U. Pace (1985)
Reconstitution of catecholamine-stimulated binding of guanosine 5'-O-(3-thiotriphosphate) to the stimulatory GTP-binding protein of adenylate cyclase.
T. Asano (1984)
A role for Ni in the hormonal stimulation of adenylate cyclase
R. Cerione (1985)
Involvement of guanine nucleotide-binding protein in the gating of Ca2+ by receptors
B. Gomperts (1983)
Stimulation of adenosine 3',5'-monophosphate production by growth hormone-releasing factor and its inhibition by somatostatin in anterior pituitary cells in vitro.
L. Bilezikjian (1983)
Sucrose-gap recordings of nerve-evoked potentials in mammalian parasympathetic ganglia
W. Griffith (1981)
The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. IV. Effects of guanylnucleotides on binding of 125I-glucagon.
M. Rodbell (1971)
This paper is referenced by
Pharmacological Implications of Adenosine 2A and Dopamine Type 2 Receptor Heteromerization
Candice Hatcher-Solis (2020)
The diagnostic significance of the induced acrosome reaction
C. Jonge (1994)
G-protein-coupled receptors in HL-60 human leukemia cells.
J. F. Klinker (1996)
Right Ventricular Infundibular β-Adrenoceptor Complex in Tetralogy of Fallot Patients
L. Sun (1997)
Effects of adenosine on cAMP production during early development in the optic tectum of chicks
C. Tasca (1995)
G Protein Activation Stimulates Phospholipase D Signaling in Plants.
T. Munnik (1995)
The mechanisms of aquaporin control in the renal collecting duct.
E. Klussmann (2000)
Binding properties of a selective tritiated vasopressin V2 receptor antagonist, [H]-SR 121463.
C. Serradeil-Le Gal (2000)
Diabetes attenuates the response of the lumbospinal noradrenergic system to idazoxan
M. Bitar (2000)
Agonist regulation of D(2) dopamine receptor/G protein interaction. Evidence for agonist selection of G protein subtype.
Y. Cordeaux (2001)
Bioinformatics: from genome to drug targets
S. Dahl (2002)
An ultra-HTS process for the identification of small molecule modulators of orphan G-protein-coupled receptors.
A. Cacace (2003)
Activation of a pertussis toxin-sensitive, inhibitory G-protein is necessary for steroid-mediated oocyte maturation in spotted seatrout.
M. Pace (2005)
Effects of arachidonic acid on A-type potassium currents in smooth muscle cells of the guinea pig.
N. Nagano (1997)
The Relationship of Goα Subunit Deamidation to the Tissue Distribution, Nucleotide Binding Properties, and βγ Dimer Interactions of Goα Subunit Isoforms
W. McIntire (1999)
Epidermal Growth Factor Receptor Signaling in Rat Pancreatic Acinar Cells
D. Stryjek-Kaminska (1995)
Membrane signaling systems
C. Smith (1995)
Lipophilic beta-adrenoceptor antagonists and local anesthetics are effective direct activators of G-proteins.
A. Hagelüken (1994)
ADP-Ribosylation of Signal-Transducing Guanine Nucleotide Binding Proteins by Cholera and Pertussis Toxin
P. Gierschik (1994)
Histamine release from basophils in childhood: Age dependency and inhibition by pertussis infection and pertussis toxin
M. Griese (2005)
Cibacron blue-induced enhancement of agonist binding to cholecystokinin (CCK) receptors in solubilized pancreatic membranes.
Daniel S. Yuan (1993)
Functional alterations of G-proteins in diabetic rat retina: a possible explanation for the early visual abnormalities in diabetes mellitus
A. Kowluru (2004)
Activating mutations in the NH2‐ and COOH‐terminal moieties of the Gsα subunit have dominant phenotypes and distinguishable kinetics of adenylyl cyclase stimulation
S. Gupta (1991)
'Crosstalk': a pivotal role for protein kinase C in modulating relationships between signal transduction pathways.
M. Houslay (1991)
Postmortem cerebral cortex Gs α-subunit levels are elevated in bipolar affective disorder
L. Young (1991)
Modulatory actions of the neuropeptide FMRFamide on synaptic transmission in Helisoma neurons
H. Man-Son-Hing (1991)
Caractérisation et étude d'un élément régulateur du gène codant pour le récepteur à la vasopressine de type 2
Nicolas Debrand (2009)
Genetically acquired diabetes: adipocyte guanine nucleotide regulatory protein expression and adenylate cyclase regulation.
D. Strassheim (1991)
Ca2+ oscillations induced by histamine H1 receptor stimulation in HeLa cells: Fura-2 and patch clamp analysis.
R. Sauvé (1991)
Muscarinic Cholinergic Stimulation of Exogenous Phosphatidylinositol Hydrolysis Is Regulated by Guanine Nucleotides in Rabbit Brain Cortical Membranes
H. R. Carter (1991)
Dose-dependency in spatial dynamics of [Ca2+]c in pancreatic acinar cells.
Y. Habara (1991)
Signalling in the Activation of Immunologically Relevant Cells
K. E. Nye (1994)See more