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Receptor-effector Coupling By G Proteins.

L. Birnbaumer, J. Abramowitz, A. M. Brown
Published 1990 · Biology, Medicine

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The primary structure of G proteins as deduced from purified proteins and cloned subunits is presented. When known, their functions are discussed, as are recent data on direct regulation of ionic channels by G proteins. Experiments on expression of alpha subunits, either in bacteria or by in vitro translation of mRNA synthesized from cDNA are presented as tools for definitive assignment of function to a given G protein. The dynamics of G protein-mediated signal transduction are discussed. Key points include the existence of two superimposed regulatory cycles in which upon activation by GTP, G proteins dissociate into alpha and beta gamma and their dissociated alpha subunits hydrolyze GTP. The action of receptors to catalyze rather than regulate by allostery the activation of G proteins by GTP is emphasized, as is the role of subunit dissociation, without which receptors could not act as catalysts. To facilitate the reading of this review, we have presented the various subtopics of this rapidly expanding field in sections 1-1X, each of which is organized as a self-contained sub-chapter that can be read independently of the others.
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Parallel inactivation of α2‐adrenergic agonist binding and Ni by alkaline treatment
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Rhodopsin-enhanced GTPase activity of the inhibitory GTP-binding protein of adenylate cyclase.
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Cholera toxin inhibits prostaglandin E1 but not adrenaline‐induced stimulation of GTP hydrolysis in human platelet membranes
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Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase.
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Bradykinin stimulation of inositol polyphosphate production in porcine aortic endothelial cells.
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Purification of the beta-adrenergic receptor. Identification of the hormone binding subunit.
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Turkey erythrocyte membranes as a model for regulation of phospholipase C by guanine nucleotides.
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Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism.
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Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium.
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Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production
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Odorant-sensitive adenylate cyclase may mediate olfactory reception
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Reconstitution of catecholamine-stimulated binding of guanosine 5'-O-(3-thiotriphosphate) to the stimulatory GTP-binding protein of adenylate cyclase.
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A role for Ni in the hormonal stimulation of adenylate cyclase
R. Cerione (1985)
Involvement of guanine nucleotide-binding protein in the gating of Ca2+ by receptors
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Stimulation of adenosine 3',5'-monophosphate production by growth hormone-releasing factor and its inhibition by somatostatin in anterior pituitary cells in vitro.
L. Bilezikjian (1983)
Sucrose-gap recordings of nerve-evoked potentials in mammalian parasympathetic ganglia
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The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. IV. Effects of guanylnucleotides on binding of 125I-glucagon.
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