Please confirm you are human (Sign Up for free to never see this)
← Back to Search
Ultraterminal Sprouting In Innervated And Partially Denervated Adult And Aged Rat Muscle
Published 1990 · Biology, Medicine
Save to my Library
Download PDFAnalyze on Scholarcy
End plates from the extensor digitorum longus, soleus and diaphragm muscles of adult (10-month-old) and aged (25-month-old) rats were examined to determine whether aging affects the frequency of occurrence of ultraterminal sprouting, a form of terminal sprouting commonly associated with muscle denervation. There was a significant increase in the fraction of end plates exhibiting ultraterminal sprouts in the extensor digitorum longus muscle only; the number increased from 5.5% in 10-month-old animals to 23.0% in 25-month-old animals. To see whether age also influences the sprouting response to denervation, extensor digitorum longus muscles from 10-and 25-month-old animals were partially denervated by severing spinal nerve L5, and end plates were examined 4-7 and 10-14 days following denervation. Denervation induced a more profound increase in the percentage of end plates exhibiting ultraterminal sprouting in the 10- compared with 25-month-old animals. However, sprouting remained significantly greater in the 25- compared with the 10-month-old animals. Furthermore, following denervation the average ultraterminal sprout length was significantly greater in the 25- compared with the 10-month-old animals. There was no correlation between the extent of muscle denervation and the percentage of end plates exhibiting ultraterminal sprouts. End plates with ultraterminal sprouts had larger areas and contained fewer nerve terminal branches than end plates without these sprouts. It is suggested that the limited response to partial denervation in the 25-month-old extensor digitorum longus muscles may indicate that the aged extensor digitorum longus has already approached the maximum capacity for sprouting.
This paper references
Neural cell adhesion molecule (N-CAM) accumulates in denervated and paralyzed skeletal muscles.
J. Covault (1985)
Filopodia, lamellipodia and retractions at mouse neuromuscular junctions
N. Robbins (1988)
Progression of age changes in mature mouse motor nerve terminals and its relation to locomotor activity
N. Robbins (1985)
Expression of several adhesive macromolecules (N-CAM, L1, J1, NILE, uvomorulin, laminin, fibronectin, and a heparan sulfate proteoglycan) in embryonic, adult, and denervated adult skeletal muscle
J. Sanes (1986)
Postnatal growth of motor nerve terminals in muscles of the mouse
W. G. Hopkins (1985)
Differential changes in the end-plate architecture of functionally diverse muscles during aging.
J. Rosenheimer (1985)
Motor nerve terminal outgrowth and acetylcholine receptors: inhibition of terminal outgrowth by alpha-bungarotoxin and anti-acetylcholine receptor antibody
A. Pestronk (1985)
Neurite outgrowth on cryostat sections of innervated and denervated skeletal muscle
J. Covault (1987)
Histochemical composition, contraction speed and fatiguability of rat soleus motor units.
E. Kugelberg (1973)
Sprouting and degeneration of mammalian motor axons in normal and de-afferentated skeletal muscle
D. Barker (1966)
Nodal and terminal sprouting from motor nerves in fast and slow muscles of the mouse.
M. C. Brown (1980)
Aging rat neuromuscular junnctions: A morphometric study of cholinesterase‐stained whole mounts and ultrastructure
C. Cardasis (1987)
Synaptic rearrangements and alterations in motor unit properties in neonatal rat extensor digitorum longus muscle.
R. Balice-Gordon (1988)
ACCELERATION AND RETARDATTON OF THE PROCESS OF AXON-SPROUTTNG IN PARTIALLY DENERVATED MUSCLES *
H. Hoffman (1952)
Histochemistry: Theoretical and Applied
A. G. Pearse (1953)
Selective effects of skeletal muscle extract fractions on motoneuron development in vitro
R. Smith (1986)
Persistence of nerve sprouting with features of synapse remodelling in soleus muscles of adult mice
A. Wernig (1984)
Suppression of sprouting at the neuromuscular junction by immune sera
M. Gurney (1984)
Motor nerve sprouting.
M. C. Brown (1981)
Axonal sprouting at the neuromuscular junction of adult and aged rats
G. Fagg (1981)
Sprouting and regression of neuromuscular synapses in partially denervated mammalian muscles.
M. C. Brown (1978)
Synapse replacement in the nervous system of adult vertebrates.
C. Cotman (1981)
Source of the stimulus for nerve terminal sprouting in partially denervated muscle
S. Pockett (1982)
Effect of age and muscle type on regeneration of neuromuscular synapses in mice
W. G. Hopkins (1986)
Acetylcholine storage, release and leakage at the neuromuscular junction of mature adult and aged rats.
D. O. Smith (1984)
Reinnervation of partially denervated rat soleus muscle.
W. Thompson (1978)
Control of contractile properties within adaptive ranges by patterns of impulse activity in the rat
R. Westgaard (1988)
The organization and development of compartmentalized innervation in rat extensor digitorum longus muscle.
R. Balice-Gordon (1988)
Scanning and light microscopic study of age changes at a neuromuscular junction in the mouse
M. A. Fahim (1983)
Age-related increase in soluble and cell surface-associated neurite-outgrowth factors from rat muscle
J. Rosenheimer (1990)
Sprouting of active nerve terminals in partially inactive muscles of the rat.
W. Betz (1980)
Decreased sprouting and degeneration of nerve terminals of active muscles in aged rats.
D. O. Smith (1982)
Denervation increases a neurite-promoting activity in extracts of skeletal muscle
C. E. Henderson (1983)
Muscle-specific decrease in presynaptic calcium dependence and clearance during neuromuscular transmission in aged rats.
D. O. Smith (1988)
Effects of aging on nerve sprouting and regeneration
A. Pestronk (1980)
Acetylcholine Synthesis and Release in the Extensor Digitorum Longus Muscle of Mature and Aged Rats
D. O. Smith (1990)
Firing patterns of motor units in normal rats
R. Hennig (1985)
Growth and degeneration of motor end-plates in normal cat hind limb muscles.
Tuffery Ar (1971)
Changes in motor innervation and cholinesterase localization induced by botulinum toxin in skeletal muscle of the mouse: differences between fast and slow muscles.
L. Duchen (1970)
This paper is referenced by
Effects of Aging on Swallowing
J. Robbins (2006)
Effects of exercise training on neuromuscular junction morphology and pre- to post-synaptic coupling in young and aged rats
M. Deschenes (2016)
Skeletal muscle weakness due to deficiency of CuZn-superoxide dismutase is associated with loss of functional innervation.
L. Larkin (2011)
Role of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) in denervation-induced atrophy in aged muscle: facts and hypotheses
G. Gouspillou (2013)
Differences in age-related alterations in muscle contraction properties in rat tongue and hindlimb.
N. Connor (2008)
Nodal and terminal sprouting by regenerating nerve in vitamin E-deficient rats
R. Cuppini (1993)
PDFlib PLOP: PDF Linearization, Optimization, Protection Page inserted by evaluation version
A. W. Linnane (2001)
Role of the nervous system in sarcopenia and muscle atrophy with aging: strength training as a countermeasure
P. Aagaard (2010)
Remodeling of Neuromuscular Junctions in Aged Rat Genioglossus Muscle
Sarah H Hodges (2004)
Sarcopenia: Aging-Related Loss of Muscle Mass and Function.
L. Larsson (2019)
Properties of single motor units in medial gastrocnemius muscles of adult and old rats.
V. Kadhiresan (1996)
Oral, pharyngeal and esophageal motor function in aging
J. Robbins (2006)
Morphological correlates of physiological responses in partially denervated mouse muscle during aging
M. Fahim (1993)
Effect of Deficits in Laryngeal Sensation on Laryngeal Muscle Biochemistry
H. Nagai (2005)
A Novel Egr-1-Agrin Pathway and Potential Implications for Regulation of Synaptic Physiology and Homeostasis at the Neuromuscular Junction
R. MacDonald (2017)
Changes in acetylcholine receptor distribution and binding properties at the neuromuscular junction during aging
D. O. Smith (1990)
Age‐related changes in the structure and function of mammalian neuromuscular junctions
S. Willadt (2018)
Age‐associated Changes in the Innervation of Muscle Fibers and Changes in the Mechanical Properties of Motor Units
A. R. Luff (1998)
Effect of tongue exercise on protrusive force and muscle fiber area in aging rats.
N. Connor (2009)
Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise
G. Valdez (2010)
Factors affecting denervation-like changes at the neuromuscular junction during aging
J. L. Rosenheimer (1990)
Muscle fatigue in old animals. Unique aspects of fatigue in elderly humans.
Faulkner Ja (1995)
Sarcoglycan Alpha Mitigates Neuromuscular Junction Decline in Aged Mice by Stabilizing LRP4
K. Zhao (2018)
Neuromuscular Junction as an Entity of Nerve-Muscle Communication
Elisa Lepore (2019)
Muscle Fatigue in Old Animals
J. Faulkner (1995)
Age-associated alterations of the neuromuscular junction
Youngmok C. Jang (2011)
The role of laminins in the organization and function of neuromuscular junctions.
R. Rogers (2017)
GDNF content and NMJ plasticity in slow and fast twitch myofibers follows recruitment in exercise
A. Gyorkos (2014)
Implication des cellules gliales dans la modulation de l’activité synaptique à la jonction neuromusculaire sénescente
Ayman Moustaine (2019)
Neuromuscular Junction Changes in Aged Rat Thyroarytenoid Muscle
N. Connor (2002)
Effect of exercise on stability of chronically enlarged motor units
S. L. Tam (2002)
Enlargement of motoneuron peripheral field following partial denervation with or without dorsal rhizotomy
R. Cuppini (1998)See more