Online citations, reference lists, and bibliographies.
← Back to Search

Neural Steroid Hormone Receptors

B. McEwen, J. Gerlach, V. Luine, I. Lieberburg
Published 1977 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Abstract (1) Cell nuclear and cytoplasmic receptors for estrogens, androgens, and glucocorticoids have been identified in brains and pituitary glands of vertebrates. With respect to topography, estradiol (E 2 ) receptors are localized primarily in the hypophysiotrophic area and amygdala; 5-α-dihydrotestosterone (DHT) receptors are found in hypothalamus and limbic regions in smaller amounts and more uniformly distributed than those for estradiol; and corticosterone receptors are found in the hippocampal formation, septum, entorhinal cortex and amygdala. (2) Where information is available, mainly for estrogen receptors, their neural topography shows a remarkable constancy among vertebrates. The neural topography of estrogen and glucocorticoid receptors of rat and rhesus monkey will be compared. (3) A complicating factor in the study of androgens interacting with the brain is the conversion of testosterone (T) in neural tissue to both estrogenic and androgenic metabolites. Two of the products, E 2 and DHT, are recovered attached to cell nuclear receptors in the rat brain, whereas only DHT and T itself are found in pituitary cell nuclei. Evidence from other laboratories suggests that interactions of E 2 and DHT or T with intracellular receptors each subserve different behavioral and neuroendocrine functions in the rat. (4) The topography of estrogen receptors in the rat brain provides an excellent opportunity for studying estrogen action on brain chemistry. Estrogen effects on monoamine oxidase, choline acetylase, and glucose-6-phosphate dehydrogenase activity will be described. The overall importance of the action of steroid hormones on gene expression will be briefly discussed.
This paper references
10.1016/b978-0-12-119284-6.x5001-5
The structure and function of nervous tissue
G. H. Bourne (1968)
10.1016/0006-8993(75)90404-7
The effects of gonadectomy and gonadal steroids on the activity of hypothalamic peptidases inactivating luteinizing hormone-releasing hormone (LH-RH)
E. C. Griffiths (1975)
10.1007/978-1-4684-2976-3_14
The Hippocampus and Hormonal Cyclicity
B. K. McGowan-Sass (1975)
10.1007/978-1-4615-7748-5_6
Isolation of Brain Cell Nuclei
B. McEwen (1972)
10.1111/j.1471-4159.1974.tb10744.x
OESTROGEN EFFECTS ON BRAIN AND PITUITARY ENZYME ACTIVITIES
V. Luine (1974)
10.1016/B978-0-12-119285-3.50011-8
5 – Sites of Steroid Binding and Action in the Brain
B. McEwen (1972)
10.1126/science.162.3857.1001
Estradiol-Concentrating Neurons: Topography in the Hypothalamus by Dry-Mount Autoradiography
W. Stumpf (1968)
10.1016/0006-8993(76)90928-8
Interactions in vivo and in vitro of corticoids and progesterone with cell nuclei and soluble macromolecules from rat brain regions and pituitary
B. McEwen (1976)
10.1016/0006-8993(75)90649-6
Brain cell nuclear retention of [3H]estradiol doses able to promote lordosis: temporal and regional aspects
B. McEwen (1975)
10.1016/0018-506X(75)90021-5
Androgen- and estrogen-induced copulatory behavior and inhibition of luteinizing hormone (LH) secretion in the male rat
D. Paup (1975)
10.1002/AJA.1001290209
Estrogen-neurons and estrogen-neuron systems in the periventricular brain.
W. Stumpf (1970)
10.1210/ENDO-97-6-1545
Blockade of testosterone-induced mounting behavior in the male rat with intracranial application of the aromatization inhibitor, androst-1,4,6,-triene-3,17-dione.
L. Christensen (1975)
10.1016/B978-0-12-571131-9.50012-8
The formation of estrogens by central neuroendocrine tissues.
F. Naftolin (1975)
10.1016/0006-8993(75)90703-9
Effect of gonadal hormones on enzyme activities in brain and pituitary of male and female rats
V. Luine (1975)
10.1002/CNE.901700302
Autoradiographic localization of hormone‐concentrating cells in the brain of the female rhesus monkey
D. Pfaff (1976)
10.1016/0304-4165(76)90176-8
Differences between cytosol receptor complexes with corticosterone and dexamethasone in hippocampal tissue from rat brain.
E. D. de Kloet (1976)
10.1016/S0015-0282(16)34143-7
Stimulation of l-Cystine-Aminopeptidase Activity by Hormonal Steroids and Steroid-Analogs in the Hypothalamus and Other Tissues of the Female Rat*
H. Heil (1971)
10.1016/c2013-0-04207-7
Steroid-cell interactions
R. King (1974)
10.1210/ENDO-91-5-1372
Testosterone metabolism in target tissues: effects of testosterone and dihydrotestosterone injection and hypothalamic implantation on serum LH in ovariectomized rats.
C. Beyer (1972)
10.1016/0304-4165(76)90175-6
A putative glucocorticoid receptor and a transcortin-like macromolecule in pituitary cytosol.
E. D. de Kloet (1976)
10.1016/0006-8993(77)90513-3
Effect of 17 ß-estradiol on hypothalamic tyrosine hydroxylase activity
V. Luine (1977)
10.1210/ENDO-100-2-598
5alpha-Dihydrotestosterone (DHT) receptors in rat brain and pituitary cell nuclei.
I. Lieberburg (1977)
10.1159/000122411
Glucocorticoid binding to adenohypophysis receptors and its physiological role.
B. Koch (1975)
10.1016/0039-128X(72)90115-8
Control of LH and FSH secretion in the male: Evidence that aromatization of androgens to estradiol is not required for inhibition of gonadotropin secretion.
R. Swerdloff (1972)
10.1210/ENDO-100-2-588
Brain Cell Nuclear Retention of Testosterone Metabolites, 5α-Dihydrotestosterone and Estradiol-17β, in Adult Rats
I. Lieberburg (1977)
10.1210/ENDO-89-5-1158
Effect of 5-alpha-dihydrotestosterone on gonadotropin secretion and estrous behavior in the female Wistar rat.
C. Beyer (1971)
10.1677/JOE.0.0590605
Sex differences and hormonal control of testosterone metabolism in rat pituitary and brain.
C. Denef (1973)
10.1159/000122397
Effects of estrogen on neuronal excitability in the hippocampal-septal-hypothalamic system.
K. Kubo (1975)
10.1210/ENDO-96-3-598
Differences in corticosterone and dexamethasone binding to rat brain and pituitary.
R. de Kloet (1975)
10.1016/0006-8993(76)90463-7
Cells in regions of rhesus monkey brain and pituitary retain radioactive estradiol, corticosterone and cortisol differentially
J. Gerlach (1976)
10.1159/000121978
Effect of ovariectomy on the oxidative activity of the hypothalamus and of the limbic system of the rat.
O. Schiaffini (1971)
10.1002/CNE.901510204
Atlas of estradiol‐concentrating cells in the central nervous system of the female rat
D. Pfaff (1973)
10.1159/000122020
Succinic-dehydrogenase and cytochrome-oxidase activity in the hypothalamus during the sexual cycle in rats.
J. Moguilevsky (1971)
10.1677/JOE.0.0510241
THE COMPARATIVE ACTIONS OF TESTOSTERONE PROPIONATE AND 5α-ANDROSTAN17β-OL-3-ONE PROPIONATE ON THE REPRODUCTIVE BEHAVIOUR, PHYSIOLOGY AND MORPHOLOGY OF MALE RATS
Feder Hh (1971)
10.1159/000122144
Glucose oxidation in the hypothalamus during the sexual cycle in rats: influence of castration.
P. Scacchi (1973)
10.1210/ENDO-95-4-984
Intrahypothalamic implants of testosterone or estradiol and resumption of masculine sexual behavior in long-term castrated male rats.
L. Christensen (1974)
10.1016/0006-8993(75)90704-0
Effect of gonadal steroids on activities of monoamine oxidase and choline acetylase in rat brain
V. Luine (1975)
10.1016/0018-506X(72)90024-4
Intracerebral androgens and sexual behavior in the male rat
P. Johnston (1972)



This paper is referenced by
10.1016/B978-0-12-040001-0.50016-1
chapter 9 – Aging and Brain Plasticity1
G. Lynch (1981)
10.1007/BF01153681
Disturbance of neuroendocrine regulation of sexual behavior of male rats with streptozotocin diabetes
T. V. El'tseva (2005)
10.1080/11250008009438710
Evolution of the hypothalamo-hypophysial regulation in tetrapods
A. Fasolo (1980)
10.3389/fnbeh.2010.00187
Hippocampal Testosterone Relates to Reference Memory Performance and Synaptic Plasticity in Male Rats
K. Schulz (2010)
10.1080/13825580600802893
Effects of Hormone Replacement Therapy and Aging on Cognition: Evidence for Executive Dysfunction
D. J. Wegesin (2007)
10.1101/lm.1855610
Emotional and cognitive information processing: relations to behavioral performance and hippocampal long-term potentiation in vivo during a spatial water maze training in rats.
K. Schulz (2010)
10.1016/0165-1781(85)90071-X
Disturbed cortisol secretion in man: Contrasting cushing's disease and endogenous depression
K. Voigt (1985)
THE EFFECTS OF STRESS AND APOLIPOPROTEIN Ε4 ON ODOR MEMORY AND LEARNING IN YOUNG AND OLDER ADULTS
Emily S Bower (2011)
10.1007/BF01953268
Effect of orchidectomy and estradiol on acetylcholinesterase activity in rat brain areas and adenohypophysis
C. Iramain (2005)
Behavioral Neuroscience
D. M. Wilson (2009)
10.1007/978-1-4684-3396-8_22
Sexual Differentiating Actions of Steroids on the Hypothalamopituitary-Liver Axis
J. Gustafsson (1979)
10.1037/0894-4105.18.4.646
Inter- and intraindividual variability in recognition memory: effects of aging and estrogen use.
D. J. Wegesin (2004)
10.1016/B978-0-12-452807-9.50008-5
CHAPTER 2 – The Hypothalamo–Pituitary–Liver Axis: A New Hormonal System in Control of Hepatic Steroid and Drug Metabolism
J. Gustafsson (1980)
10.1016/S0163-1047(81)92306-2
Androgenic influences on apomorphine-induced yawning in rats.
H. G. Berendsen (1981)
10.1038/315059A0
Co-localization of corticotropin releasing factor and vasopressin mRNA in neurones after adrenalectomy
B. Wolfson (1985)
10.1016/0006-8993(78)90138-5
Chromatin binding of estradiol in the hypothalamus and cortex of male and female rats
R. Whalen (1978)
10.1006/hbeh.1998.1445
The Role of Gonadal Steroid Receptor Activation in the Restoration of Sociosexual Behavior in Adult Male Rats
M. Vagell (1998)
Semantic Scholar Logo Some data provided by SemanticScholar