Online citations, reference lists, and bibliographies.
← Back to Search

Radiation Therapy In The Management Of Patients With Mesothelioma.

W. Gordon, K. H. Antman, J. Greenberger, R. Weichselbaum, J. Chaffey
Published 1982 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
The results of radiation therapy in the management of 27 patients with malignant mesothelioma were reviewed. Eight patients were treated with a curative intent combining attempted surgical excision of tumor (thoracic in 6 and peritoneal in 2), aggressive radiation therapy, and combination chemotherapy using an adriamycin-containing regimen. One patient achieved a 2-year disease-free interval followed by recurrence of tumor above the thoracic irradiation field. This patient was retreated with localized irradiation and is disease-free after 5 years of initial diagnosis. One patient has persistent abdominal disease at 18 months; the other 6 patients suffered local recurrence within 8-13 months of initiation of treatment. Radiation therapy was used in 19 other patients who received 29 courses for palliation of dyspnea, superior vena cava syndrome, dysphagia, or neurological symptoms of brain metastasis. A palliation index was used to determine the effectiveness of irradiation and revealed that relief of symptoms was complete or substantial in 5 treatment courses, moderately effective in 6 courses and inadequate in 18 treatment courses. Adequate palliation strongly correlated with a dose at or above 4,000 rad in 4 weeks. The management of patients with mesothelioma requires new and innovative approaches to increase the effectiveness of radiation therapy and minimize the significant potential combined toxicity of pulmonary irradiation and adriamycin.
This paper references
10.1002/1097-0142(197309)32:3<656::AID-CNCR2820320319>3.0.CO;2-U
Long‐term survival in patients with malignant peritoneal mesothelioma treated with irradiation
E. Rogoff (1973)
10.1016/S0003-4975(10)62906-2
Surgical management of malignant mesothelioma.
G. A. Delaria (1978)
10.1002/JSO.2930080503
Radiation‐induced peritoneal mesothelioma
T. Babcock (1976)
Pathologic basis of disease
S. L. Robbins (1974)
10.1002/1097-0142(195907/08)12:4<799::AID-CNCR2820120425>3.0.CO;2-L
Prolonged survival in diffuse pleural mesothelioma treated with AU198
R. Richart (1959)
10.1016/0002-9343(80)90103-5
Multimodality therapy for malignant mesothelioma based on a study of natural history.
K. H. Antman (1980)
10.1016/S0012-3692(15)37393-1
Malignant mesothelioma. Current status and future prospects.
J. Aisner (1978)
10.1056/NEJM196503182721104
RELATION BETWEEN EXPOSURE TO ASBESTOS AND MESOTHELIOMA.
I. Selikoff (1965)
10.7326/0003-4819-87-5-613
Pleural mesothelioma: clinical features and therapeutic implications.
S. Legha (1977)
10.1136/thx.31.1.15
Pleuropneumonectomy in the management of diffuse malignant mesothelioma of the pleura. Experience with 29 patients.
E. Butchart (1976)
Treatment of diffuse malignant mesothelioma: a review.
A. Chahinian (1978)
10.1056/NEJM198007243030407
Current concepts: malignant mesothelioma.
K. Antman (1980)
10.1016/S0305-7372(77)80016-9
Therapeutic approaches in malignant mesothelioma.
S. Legha (1977)
10.1378/CHEST.64.5.641
Mesothelioma following exposure to asbestos: a review of 72 cases.
M. Borow (1973)



This paper is referenced by
10.1007/978-1-4615-1589-0_13
Malignant pleural mesothelioma.
L. Ho (2001)
10.1016/S1470-2045(17)30459-X
Radiotherapy for the treatment of malignant pleural mesothelioma.
M. Perrot (2017)
10.1200/JCO.1993.11.6.1172
Node status has prognostic significance in the multimodality therapy of diffuse, malignant mesothelioma.
D. Sugarbaker (1993)
10.21037/apm-19-495
The role of palliative radiation therapy in treating pleural or peritoneal disseminated tumors: 22 cases and a review of the literature.
N. Ishibashi (2020)
10.1016/J.EJCTS.2005.10.008
Multimodality approach in management of malignant pleural mesothelioma.
S. Neragi-Miandoab (2006)
10.1016/B978-0-323-24098-7.00046-0
Chapter 46 – Uncommon Thoracic Tumors
J. Zeng (2016)
10.1007/978-3-319-28761-4_20
Modern Radiotherapy Techniques in Malignant Pleural Mesothelioma
G. Ozyigit (2016)
10.1016/J.IJROBP.2006.08.026
Feasibility of boron neutron capture therapy (BNCT) for malignant pleural mesothelioma from a viewpoint of dose distribution analysis.
M. Suzuki (2006)
10.1016/S1040-8428(86)80059-2
Asbestos-related malignancy.
K. Antman (1986)
10.1183/09031936.99.13370699
Malignant pleural mesothelioma.
H. Schouwink (1999)
10.1016/j.ijrobp.2009.06.037
Radiotherapy in malignant pleural mesothelioma.
M. McAleer (2009)
10.1016/S0360-3016(02)04151-2
Intensity-modulated radiation therapy: a novel approach to the management of malignant pleural mesothelioma.
A. Ahamad (2003)
LA TERAPIA MULTIMODALE NEL TRATTAMENTO DEL
Mesotelioma Pleurico Maligno (2006)
10.1016/j.rpor.2012.07.015
Radiotherapy applications of patients with malignant mesothelioma: A single center experience.
M. Akmansu (2012)
10.1136/thx.40.1.72
Pleural mesothelioma treated by fast neutron therapy.
P. Blake (1985)
10.1002/1097-0142(19851101)56:9<2170::AID-CNCR2820560905>3.0.CO;2-L
A prospective study of detorubicin in malignant mesothelioma
Nicolas Colbert (1985)
10.1007/BF01054270
Cerebral metastases in pleural mesothelioma: Case report and review of the literature
M. Wroński (2005)
10.5772/55292
Mesothelioma: An Evidence-Based Review
J. Goudreault (2013)
10.1183/09031936.98.12040972
Malignant pleural mesothelioma.
C. Boutin (1998)
10.1088/0031-9155/46/7/310
Wedge-shaped applicator for additional light delivery and dosimetry in the diaphragmal sinus during photodynamic therapy for malignant pleural mesothelioma.
P. V. Van Veen (2001)
10.1378/CHEST.126.4.1318
Malignant pleural mesothelioma: update, current management, and newer therapeutic strategies.
M. Pistolesi (2004)
10.1097/MAJ.0b013e318039c7d1
A Large Abdominal Wall Mass as an Initial Manifestation of Malignant Mesothelioma
T. Takeda (2007)
10.3978/j.issn.2072-1439.2013.11.28
Guidelines for the diagnosis and treatment of malignant pleural mesothelioma.
N. van Zandwijk (2013)
10.1136/thx.39.4.255
Malignant mesothelioma of the pleura: a study of 52 treated and 64 untreated patients.
M. Law (1984)
10.1136/thorax.56.4.250
Statement on malignant mesothelioma in the United Kingdom
T. British (2001)
10.1111/1759-7714.12008
Role of new radiation techniques in the treatment of pleural mesothelioma
M. Amichetti (2013)
10.1378/CHEST.106.6_SUPPLEMENT.359S
Trials in malignant mesothelioma. LCSG 851 and 882.
V. Rusch (1994)
10.1016/J.JARE.2011.02.004
European guidelines for the management of malignant pleural mesothelioma
E. Thiel (2011)
10.1378/CHEST.96.1_SUPPLEMENT.93S
Natural history and staging of malignant mesothelioma.
K. Antman (1989)
10.1378/CHEST.107.6_SUPPLEMENT.332S
Current approach to malignant mesothelioma of the pleura.
J. Aisner (1995)
10.1081/CNV-120023766
Cisplatin and Irinotecan (CPT-11) for Peritoneal Mesothelioma
D. T. Le (2003)
10.1093/ANNONC/MDH356
The palliative benefits of MVP (mitomycin C, vinblastine and cisplatin) chemotherapy in patients with malignant mesothelioma.
E. Andreopoulou (2004)
See more
Semantic Scholar Logo Some data provided by SemanticScholar