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Polybutylcyanoacrylate Nanoparticles For The Delivery Of [75Se]norcholestenol

J. Kreuter, S. Mills, S. Davis, C. Wilson
Published 1983 · Chemistry

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Abstract Polybutylcyanoacrylate nanoparticles have been used for the intravenous and intramuscular administration of a steroidal material ([ 75 Se]norcholestenol) to the rabbit. Whole body profiles of 75 Se, obtained using a gamma camera over a period of 30 days, show that the [ 75 Se]norcholestenol is retained for a longer period of time with the nanoparticle system than for the control system where the drug was dissolved in a micellar system. In vitro dialysis experiments indicate that the thermodynamic activity of the drug can be increased by its incorporation within nanoparticles. This increased activity may affect the distribution of the drug into body tissues.
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