← Back to Search
Self-emulsifying Drug Delivery Systems: Assessment Of The Efficiency Of Emulsification
Published 1985 · Chemistry
Download PDFAnalyze on Scholarcy
Abstract Self-emulsifying formulations have potential uses as vehicles for the administration of lipophilic drugs by the oral route. In this study model oil-surfactant mixtures were allowed to self-emulsify under conditions of gentle agitation. During emulsification the relative intensity of light scattered by the dispersion was monitored continuously which enabled the rates of emulsification to be compared. The particle sizes of resultant emulsions were compared by light microscopy and using a Coulter Nano-Sizer. Efficient self-emulsifying formulations were produced by the oils Miglyol 812 or Miglyol 840 in combination with the surfactant Tween 85. The properties of these systems have been studied over a range of mixture compositions. The finest dispersions were produced rapidly and in reproducible time by a mixture of 30% w/w Tween 85 and 70% w/w Miglyol 812.
This paper references
The Scattering of Light and Other Electromagnetic Radiation ~Academic
M. Kerker (1969)
Aspects of surfactant toxicity
D. Attwood (1983)
Measurement of the ‘spontaneity’ of self‐emulsifiable oils
M. Groves (1974)
The mesaurement of polymer latex particle size with the coulter® Nano-Sizer™
R. W. Lines (1979)
Entropy-induced dispersion of bulk liquids
H. Reiss (1975)
Drug release from lipid-based dosage forms. I
N. Armstrong (1980)
Emulsions as carriers of pesticides.
Hartley Gs (1967)
The self-emulsifying action of mixed surfactants in oil.
Groves Mj (1976)
This paper is referenced by
Application of Box–Behnken design in the preparation and optimization of fenofibrate-loaded self-microemulsifying drug delivery system (SMEDDS)
D. Lee (2014)
PREPARATION AND EVALUATION OF SELF EMULSIFYING DRUG DELIVERY SYSTEM OF ROSUVASTATIN CALCIUM
Amit K. Vishwakarma (2016)
Formulation Strategies to Improve the Bioavailability of Poorly Absorbed Drugs with Special Emphasis on Self-Emulsifying Systems
S. Gupta (2013)
SMEDDS: A NOVEL APPROACH FOR LIPOPHILIC DRUGS
V. Sharma (2012)
Self emulsifying drug delivery system (SEDDS) for phytoconstituents: a review.
N. Chouhan (2015)
Nanophytomedicine: Concept to Clinic
Md. Abul Barkat (2020)
DESIGN, DEVELOPMENT & EVALUATION OF SELF EMULSIFYING DRUG DELIVERY SYSTEM OF AMLODIPINE
Jograna M.B (2019)
Triple antioxidant SNEDDS formulation with enhanced oral bioavailability: Implication of chemoprevention of breast cancer.
S. Tripathi (2016)
Enhancing intestinal drug solubilisation using lipid-based delivery systems.
C. H. Porter (2008)
Response surface methodology for the optimization of ubiquinone self-nanoemulsified drug delivery system
S. Nazzal (2008)
Development and Evaluation of Nanoemulsifying Preconcentrate of Curcumin for Colon Delivery
J. Wadhwa (2015)
Drug Solubility and Solubilization
Ching-Chiang Su (2019)
Nanoemulsion: An Advanced Vehicle For Efficient Drug Delivery.
A. Ali (2017)
The Influence of Surfactant HLB and Oil/Surfactant Ratio on the Formation and Properties of Self-emulsifying Pellets and Microemulsion Reconstitution
Irini Matsaridou (2012)
Optimization of the fabrication, stability, and performance of food grade nanoemulsions with low and high energy methods
Jennifer Komaiko (2016)
Liquid spray formulations of xibornol by using self-microemulsifying drug delivery systems.
M. Cirri (2007)
Self microemulsifying drug delivery system as a potential drug delivery system for protease inhibitors in the treatment of AIDS
A. Patel (2011)
Physicochemical Characterization and Oral Dosage Form Selection Based on the Biopharmaceutics Classification System
G. E. Amidon (2010)
Understanding Biorelevant Drug Release from a Novel Thermoplastic Capsule by Considering Microstructural Formulation Changes During Hydration
Zdravka Misic (2013)
Lipids as Biological Materials for Nanoparticulate Delivery
I. P. Kaur (2014)
Lipid-based oral multiparticulate formulations – advantages, technological advances and industrial applications
Dali Shukla (2011)
Impact of emulsion-based drug delivery systems on intestinal permeability and drug release kinetics.
Fulden Buyukozturk (2010)
An investigation into the physico-chemical properties of self-emulsifying systems using low frequency dielectric spectroscopy, surface tension measurements and particle size analysis
D. Craig (1993)
Recent Advances in Particle Size Measurements: A Critical Review
B. Miller (1988)
Bioavailability of seocalcitol II: development and characterisation of self-microemulsifying drug delivery systems (SMEDDS) for oral administration containing medium and long chain triglycerides.
M. Grove (2006)
Enhancement of solubility and therapeutic potential of poorly soluble lovastatin by SMEDDS formulation adsorbed on directly compressed spray dried magnesium aluminometasilicate liquid loadable tablets: A study in diet induced hyperlipidemic rabbits
M. Qureshi (2015)
Preparation and evaluation of floating risedronate sodium Gelucire 39/01 matrices.
B. Chauhan (2004)
Formulation and Evaluation of Furosemide Solid Self-emulsifying Drug Delivery System
J. Renuka (2018)
Design and evaluation of prostaglandin E1 (PGE1) intraurethral liquid formulation employing self-microemulsifying drug delivery system (SMEDDS) for erectile dysfunction treatment.
Sangkil Lee (2008)
Developing early formulations: practice and perspective.
P. Li (2007)
Comparative bioavailability of L-683,453, a 5α-reductase inhibitor, from a self-emulsifying drug delivery system in Beagle dogs
B. Matuszewska (1996)
Positively charged self-emulsifying oil formulation for improving oral bioavailability of progesterone.
T. Gershanik (1996)See more