Online citations, reference lists, and bibliographies.
← Back to Search

Study Of The Mechanisms Of Formation Of Nanoparticles And Nanocapsules Of Polyisobutyl-2-cyanoacrylate

M. Gallardo, G. Couarraze, B. Denizot, L. Treupel, P. Couvreur, F. Puisieux
Published 1993 · Chemistry

Cite This
Download PDF
Analyze on Scholarcy
Share
Abstract Biodegradable colloids suitable for use as drug delivery systems can be formed by in situ polymerization of isobutylcyanoacrylate monomers. In this work we have studied the mechanisms of formation of colloidal systems of PIBCA obtained in the presence of oil and ethanol. For this different analytical techniques have been used (TEM, PCS, GPC). The results have shown that the diffusing ethanol was the most important factor which leads to the structure and colloidal characteristics of the particles by convective effects, the oil playing the role of a monomer support. The existence of an ideal oil/ethanol ratio (2:100) seems to result from the combination of both mechanisms. In the absence of oil and ethanol, IBCA polymerization occurs within micelles appearing in the aqueous phase. However, in the case of nanocapsule formation, owing to the solubility of the monomer in the organic phase and the diffusibility of ethanol, polymerization can develop at the interface. In this latter case, the formation of a double population of nanocapsules and nanoparticles probably arises from the breakdown of the same interfacial polymer.
This paper references
Caractérisations physico-chimiques de systèmes nanoparticulaires de polyisobutyl-2-cyanoacrylate
Marie-Madeleine Gallardo (1991)
10.1111/j.2042-7158.1976.tb02790.x
Interfacial properties of polymethyl α‐cyanoacrylate and polybutyl α‐cyanoacrylate *
A. Florence (1976)
Nanoparticles--a new colloidal drug delivery system.
J. Marty (1978)
10.1111/j.2042-7158.1979.tb13510.x
Polycyanoacrylate nanocapsules as potential lysosomotropic carriers: preparation, morphological and sorptive properties
P. Couvreur (1979)
10.1177/088391158900400202
Surface Pressure and Surface Potential Studies of Poly(Isobutylcyanoacrylate)-Ampicillin Interactions at the Water-Air Interface
A. Baszkin (1989)
10.1023/A:1016366022712
Molecular Weights of Free and Drug-Loaded Nanoparticles
Luc Vansnick (2004)
10.1016/0021-9797(85)90230-9
Sorption of ammonia in cation-exchanged Y zeolites: Isotherms and state of sorbed molecules
V. P. Shiralkar (1985)
10.1007/978-1-4615-7966-3_5
Stability of Interfaces
C. Miller (1978)
10.1002/MACP.1989.021900713
Water effects on the zwitterionic polymerization of cyanoacrylates
I. C. Eromosele (1989)
10.1007/BFB0116767
Measurement of low interfacial tensions by capillary wave spectroscopy. Study of an oil-water-surfactant system near its phase inversion
D. Wielebinski (1988)
10.1016/0378-5173(90)90024-X
Design of nanoparticles of less than 50 nm diameter: preparation, characterization and drug loading
B. Seijo (1990)
10.1111/j.2042-7158.1987.tb03143.x
Monolayer studies on poly(isobutylcyanoacrylate)‐ampicillin association
A. Baszkin (1987)
10.1002/JPS.2600750408
Physicochemical and morphological characterization of polyisobutyl cyanoacrylate nanocapsules.
J. Rollot (1986)
10.1002/AIC.690050421
Interfacial turbulence: Hydrodynamic instability and the marangoni effect
C. V. Sternling (1959)
10.1021/I160044A017
Spontaneous Emulsification in Ternary Systems with Mass Transfer
K. J. Ruschak (1972)
10.1002/POL.1977.130150703
Ionic and zwitterionic polymerization of n-alkyl 2-cyanoacrylates
E. Donnelly (1977)
10.1016/0021-9797(85)90260-7
Marangoni convection in liquid films with a deformable open surface
J. L. Castillo (1985)
10.1016/0378-5173(86)90236-X
Development of a new process for the manufacture of polyisobutylcyanoacrylate nanocapsules
N. A. K. Fallouh (1986)
10.1016/0021-9797(89)90345-7
Estimation of the polar parameters of the surface tension of liquids by contact angle measurements on gels
C. J. Oss (1989)
10.2118/81-32-40
Spontaneous Emulsification Aspect Of Enhanced Oil Recovery
E. O. Egbogah (1981)



This paper is referenced by
10.1016/0142-9612(96)81411-6
Preparation and characterization of polyethyl-2-cyanoacrylate nanocapsules containing antiepileptic drugs.
M. Fresta (1996)
10.1016/S0939-6411(03)00191-7
Evidence for restrictive parameters in formulation of insulin-loaded nanocapsules.
F. Cournarie (2004)
10.17675/2305-6894-2019-8-2-2
Microencapsulation of corrosion inhibitors and active additives for anticorrosive protective polymer coatings
V. A. Golovin (2019)
10.1002/9783527610419.NTLS0116
Solid Lipid and Polymeric Nanoparticles for Drug Delivery
J. Pedraz (2007)
10.3109/10837459609029889
Positively charged self-emulsifying oil formulation for improving oral bioavailability of progesterone.
T. Gershanik (1996)
10.1016/J.COLSURFA.2017.02.055
Experimental design approach applied to the development of chitosan coated poly(isobutylcyanoacrylate) nanocapsules encapsulating copaiba oil
F. H. Xavier-Júnior (2018)
10.1002/9780470571224.PSE350
Controlled-Release Dosage Forms
Anil Kumar Anal (2010)
10.1007/BF00656891
Activity and stability studies of ultrafine nanoencapsulated catalase and penicillinase
N. Munshi (1995)
10.1063/1.480970
Cross polarization induced by temporary adsorption: NMR investigations on nanocapsule dispersions
D. Hoffmann (2000)
10.1002/3527600035.BPOL9021
Biodegradation of Poly(alkylcyanoacrylates)
C. Vauthier (2002)
10.1201/B11035-4
Nanocapsules as Carriers for the Transport and Targeted Delivery of Bioactive Molecules
P. Hervella (2011)
10.3109/02652048.2013.843600
Artificial oxygen carriers based on perfluorodecalin-filled poly(n-butyl-cyanoacrylate) nanocapsules
C. Stephan (2014)
10.1007/978-1-4471-4213-3_2
Synthesis of Organic and Bioorganic Nanoparticles: An Overview of the Preparation Methods
J. Allouche (2013)
10.1177/039139880502801114
Nanocapsules as Drug Delivery Systems
C. Mayer (2005)
10.1016/0378-5173(95)00142-6
Influence of the preparation conditions on poly(ethylcyanoacrylate) nanocapsule formation
G. Puglisi (1995)
Synthesis of poly(alkyl cyanoacrylate)-based colloidal
Patrick Couvreur (2009)
10.1016/j.colsurfb.2008.10.003
Poly(n-butyl cyanoacrylate) nanoparticles via miniemulsion polymerization. 2. PEG-based surfactants.
M. Wu (2009)
10.1006/JCIS.1999.6381
Aluminum Polyphosphate Nanoparticles: Preparation, Particle Size Determination, and Microchemistry.
do Rego Monteiro VA (1999)
10.1007/978-3-642-19792-5_3
Polymeric Nanocapsules: Concepts and Applications
Fernanda S. Poletto (2011)
10.1016/S0021-9797(03)00019-5
Pulsed field gradient NMR on polybutylcyanoacrylate nanocapsules.
M. Wohlgemuth (2003)
Controle da liberação do éster etílico de indometacina a partir de nanocápsulas poliméricas através da variação da concentração do monoestearato de sorbitano.
P. D. Pós-graduação (2008)
10.1021/jp5003098
Polyalkylcyanoacrylate nanocapsules: variation of membrane permeability by chemical cross-linking.
Christoph Groß-Heitfeld (2014)
10.1080/026520400405697
Improved preparation and physical studies of polybutylcyanoacrylate nanocapsules
M. Wohlgemuth, W. MacHtle, C. Mayer (2000)
10.1201/9780203913338-26
From Polymer Chemistry and Physicochemistry to Nanoparticulate Drug Carrier Design and Applications
C. Vauthier (2003)
10.1002/9783527610419
Polymeric nanomaterials – synthesis, functionalization and applications in diagnosis and therapy
J. Rieger (2007)
10.1016/J.PROGPOLYMSCI.2011.01.001
Polymer nanoparticles: Preparation techniques and size-control parameters
J. D. Rao (2011)
10.1006/JCIS.1998.6053
Synthesis of Iron Oxide Nanoparticles Used as MRI Contrast Agents: A Parametric Study.
Babes (1999)
10.1016/S0169-409X(03)00041-3
Poly(alkylcyanoacrylates) as biodegradable materials for biomedical applications.
C. Vauthier (2003)
10.1080/08927022.2019.1609671
Theoretical study on the stability of insulin within poly-isobutyl cyanoacrylate (PIBCA) nanocapsule
Eunhye Shin (2019)
10.1002/CPHC.200400527
Nanoparticles and nanocapsules created using the Ouzo effect: spontaneous emulisification as an alternative to ultrasonic and high-shear devices.
Ganachaud François (2005)
10.1002/MASY.200950705
Well-Defined Poly(butyl cyanoacrylate) Nanoparticles via Miniemulsion Polymerization
M. Wu (2009)
10.14356/kona.2017005
Aerosol Delivery of siRNA to the Lungs. Part 2: Nanocarrier-based Delivery Systems.
Susanne R. Youngren-Ortiz (2017)
See more
Semantic Scholar Logo Some data provided by SemanticScholar