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Preparation Of Chitosan-reinforced Alginate Gel Beads — Effects Of Chitosan On Gel Matrix Erosion

Y. Murata, T. Maeda, E. Miyamoto, S. Kawashima
Published 1993 · Chemistry

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Abstract Chitosan-reinforced alginate gel beads were prepared and the release patterns of coloring matter (Brilliant Blue G, BB) held within them were investigated. The release rates of BB from the gel beads were much slower after an initial lag time when they were incubated with chitosan compared with the original intact gels prepared without chitosan. These differences were observed irrespective of the β- d -mannuronic acid/α- l -guluronic acid (M/G) ratio of the alginate used and an additive effect on the release rate was observed when two species of alginates were combined. The initial release rates were reduced gradually in proportion to the increases in the chitosan concentration and/or incubation times used when preparing the gel beads. Furthermore, erosion of the gel beads was suppressed by chitosan treatment. The release of phenytoin from alginate gel beads showed the same characteristics as that of BB.
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