Online citations, reference lists, and bibliographies.
← Back to Search

Positively Charged Submicron Emulsions — A New Type Of Colloidal Drug Carrier

E. Elbaz, A. Zeevi, S. Klang, S. Benita
Published 1993 · Chemistry

Cite This
Download PDF
Analyze on Scholarcy
Share
A positively charged submicron emulsion was prepared and stabilized by forming a mixed film comprising phospholipids, poloxamer and stearylamine at the o/w interface of the oil droplets. This was confirmed concomitantly by the selective adsorption of the thiocyanate anion and the lack of adsorption of Ca2+ onto the emulsified oil droplets of the actual emulsions. The incorporation of various drugs in the new type of submicron emulsions altered neither the nature of the surface charge nor the mean droplet size. These results clearly demonstrated that the positively charged submicron emulsion can be used as a new type of colloidal drug carrier.
This paper references
10.1111/j.1749-6632.1987.tb45793.x
Lipid Emulsions as Drug Delivery Systems
S. Davis (1987)
10.1016/0378-5173(86)90134-1
Physostigmine emulsion: a new injectable controlled release delivery system
S. Benita (1986)
10.1002/JPS.2600800706
In vitro release and intestinal absorption of physostigmine salicylate from submicron emulsions.
A. Rubinstein (1991)
10.1016/0142-9612(87)90066-4
Calcium and thiocyanate interactions with crosslinked albumin microcapsules: influence of the reticulation rate.
A. Sawaya (1987)
10.1080/02681219380000261
Efficacy evaluation of a novel submicron amphotericin B emulsion in murine candidiasis.
M. Y. Levy (1993)
10.1016/0378-5173(88)90273-6
Development of parenteral formulations of experimental cytotoxic agents. I. Rhizoxin (NSC-332598)
V. Stella (1988)
10.1042/BJ1290123
Lysosomal localization of -fructofuranosidase-containing liposomes injected into rats.
G. Gregoriadis (1972)
Preliminary development and evaluation of a parenteral emulsion formulation of penclomedine (NSC-338720; 3,5-dichloro-2,4-dimethoxy-6-trichloromethylpyridine): a novel, practically water insoluble cytotoxic agent.
R. Prankerd (1988)
10.1016/0378-5173(82)90138-7
Stability of a fat emulsion based intravenous feeding mixture
W. R. Burnham (1982)
10.1159/000267160
A submicron emulsion as ocular vehicle for delta-8-tetrahydrocannabinol: effect on intraocular pressure in rabbits.
S. Muchtar (1992)
10.1093/INFDIS/158.5.1065
An emulsion formulation of amphotericin B improves the therapeutic index when treating systemic murine candidiasis.
R. Kirsh (1988)
10.1016/S0006-291X(75)80433-5
The effect of particle size and charge on the clearance rates of liposomes and liposome encapsulated drugs.
R. Juliano (1975)
10.1016/0378-5173(92)90374-B
Systemic bioavailability of penclomedine (NSC-338720) from oil-in-water emulsions administered intraduodenally to rats
R. A. Myers (1992)



This paper is referenced by
10.1023/A:1016090420759
Evidence for Phospholipid Bilayer Formation in Solid Lipid Nanoparticles Formulated with Phospholipid and Triglyceride
H. Heiati (2004)
10.1016/S0378-5173(02)00461-1
Positively charged nanoparticles for improving the oral bioavailability of cyclosporin-A.
M. H. El-Shabouri (2002)
10.1016/j.ijpharm.2009.08.001
Formulation of multifunctional oil-in-water nanosized emulsions for active and passive targeting of drugs to otherwise inaccessible internal organs of the human body.
S. Tamilvanan (2009)
10.1016/j.colsurfb.2008.11.034
Comparative effects of different cosurfactants on sterile prednisolone acetate ocular submicron emulsions stability and release.
Shaimaa S Ibrahim (2009)
10.1201/9781420006636.SEC7
Nanoemulsion Formulations for Tumor-Targeted Delivery
M. Amiji (2006)
10.1016/0378-5173(94)90416-2
The design and characterization of a positively charged submicron emulsion containing a sunscreen agent
A. Zeevi (1994)
Investigations on the transfer of lipophilic drug models from lipid nanoparticles to lipophilic acceptor compartments using different techniques
Mohamed rer. nat. Dawound (2011)
10.1023/A:1018806425667
Submicron Cationic Emulsions as a New Delivery System for Oligonucleotides
H. Teixeira (2004)
10.1081/PDT-100102035
Influence of Emulsion Droplet Surface Charge on Indomethacin Ocular Tissue Distribution
S. Klang (2000)
10.1016/S0939-6411(01)00191-6
A new lipid emulsion formulation with high antimicrobial efficacy using chitosan.
M. Jumaa (2002)
UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL FACULDADE DE FARMÁCIA PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS FARMACÊUTICAS Nanoemulsões catiônicas como sistemas de liberação de oligonucleotídeos: Formulação e caracterização físico-química
P. Alegre (2005)
10.1111/j.2042-7158.1994.tb03254.x
Physicochemical Characterization and Acute Toxicity Evaluation of a Positively‐charged Submicron Emulsion Vehicle
S. Klang (1994)
10.1002/1098-2299(200007/08)50:3/4<476::AID-DDR31>3.0.CO;2-6
Enhanced absorption and drug targeting by positively charged submicron emulsions
S. C. Yang (2000)
10.1016/J.COCIS.2008.03.003
Mono- and multilayer covered drops as carriers
D. Grigoriev (2009)
10.1016/j.ijpharm.2012.03.040
Penetration and release studies of positively and negatively charged nanoemulsions--is there a benefit of the positive charge?
Yücel Başpınar (2012)
10.1016/S1773-2247(10)50043-1
Chitosan-coated lipid nanocarriers for therapeutic applications
F. Oyarzun-Ampuero (2010)
10.1016/J.PLIPRES.2004.09.001
Oil-in-water lipid emulsions: implications for parenteral and ocular delivering systems.
S. Tamilvanan (2004)
Etude de systèmes lipidiques de délivrance de principes actifs
A. Ramadan (2010)
10.1081/DDC-100000124
Polymeric Controlled Drug-Delivery Systems: Perspective Issues and Opportunities
M. N. R. Ravi Kumar (2001)
10.1002/9781119962977.CH14
Chitosan‐Based Systems for Ocular Delivery of Biopharmaceuticals
Suresh P. Vyas (2012)
10.1007/3-540-45362-8_2
Pharmaceutical Polymeric Controlled Drug Delivery Systems
M. Kumar (2002)
10.1016/J.ADDR.2012.09.021
Solid lipid nanoparticles
W. Mehnert (2012)
10.1080/10717540802321792
Effect of Oil-in-Water Submicron Emulsion Surface Charge on Oral Absorption of a Poorly Water-Soluble Drug in Rats
S. Poullain-Termeau (2008)
10.1007/S11051-009-9648-4
Enhanced gastrointestinal absorption of N3-O-toluyl-fluorouracil by cationic solid lipid nanoparticles
Donghua Liu (2010)
10.1016/S1773-2247(11)50006-1
Lecithin-based nanoemulsions
V. Klang (2011)
10.1016/S0168-3659(98)00107-2
Evaluation of a positively charged submicron emulsion of piroxicam on the rabbit corneum healing process following alkali burn.
S. Klang (1999)
10.1016/J.IJPHARM.2007.05.065
Positively charged microemulsions for topical application.
E. Peira (2008)
10.1081/E-ENN3-120014180
DNA Interactions with Functionalized Emulsions
Thierry Delair (2014)
10.1016/0378-5173(95)04324-1
The stability of piroxicam incorporated in a positively-charged submicron emulsion for ocular administration
S. Klang (1996)
10.1016/S1350-9462(01)00017-9
Microemulsions as ocular drug delivery systems: recent developments and future challenges
T. Vandamme (2002)
A REVIEW: METHODS FOR ENHANCING BIOAVAILABILITY OF DRUG
Mr. Rajkumar S Moon (2011)
10.1007/S003960050050
Development of positively charged colloidal drug carriers: Chitosan-coated polyester nanocapsules and submicron-emulsions
P. Calvo (1997)
See more
Semantic Scholar Logo Some data provided by SemanticScholar