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Influence Of Enzymes On The Stability Of Polybutylcyanoacrylate Nanoparticles

D. Scherer, J. Robinson, J. Kreuter
Published 1994 · Chemistry

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Abstract The influence of three different enzymes (amylase, pepsin and esterase) on the stability of polybutylcyanoacrylate (PBCA) nanoparticles was studied. The study was performed as an in vitro investigation using side-by-side diffusion cells. A suspension of 14C-labelled PBCA nanoparticles was placed into the donor chamber of the diffusion cell and incubated with the above-mentioned enzymes. Esterase caused a highly significant degradation of the nanoparticles that was proportional to the amount of the enzyme put into the donor chamber. Amylase and pepsin had no significant effect on the stability of the PBCA nanoparticles.
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