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Cytotoxicity Of Magnetite-loaded Polylactide, Polylactide/glycolide Particles And Solid Lipid Nanoparticles

R. Mueller, S. Maaβen, H. Weyhers, F. Specht, J. S. Lucks
Published 1996 · Chemistry

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Particles from polylactide (PLA), polylactide/glycolide (PLA/GA) and solid lipid nanoparticles (SLN) were produced and loaded with different amounts of magnetite. The in vitro cytotoxicity was determined to assess their toxicological acceptance as intravenous formulation for magnetic resonance imaging and as potential carrier for drug targeting. Viability determinations were performed in suspensions of human granulocytes using the dimethylthiazolyldiphenyltetrazolium (MTT) test. Particle internalization by the granulocytes was followed using luminol enhanced chemiluminescence (CL). The effective concentrations to reduce the viability to 50% (ED 50%) were 0.38% and 0.30% for high and low molecular weight PLA, 0.15% for PLA/GA. The mechanism of toxicity is the intracellular uptake, with the highest toxicity being observed for the faster degrading polymers, low molecular weight PLA and PLA/GA. The solid lipid nanoparticles proved to be the least cytotoxic preparation with an effective concentration (ED 50%) above 10%.
This paper references
10.1016/0378-5173(93)90315-7
In vitro uptake of polystyrene latex particles and parenteral fat emulsions by human granulocytes
S. Rudt (1993)
10.1016/0168-3659(92)90101-V
In vitro phagocytosis assay of nano- and microparticles by chemiluminescence. I. Effect of analytical parameters, particle size and particle concentration
S. Rudt (1992)
10.1002/CYTO.990110203
High gradient magnetic cell separation with MACS.
S. Miltenyi (1990)
10.1016/0168-3659(94)90047-7
Solid lipid nanoparticles (SLN) for controlled drug delivery. I. Production, characterization and sterilization
C. Schwarz (1994)
10.1016/0022-1759(83)90303-4
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.
T. Mosmann (1983)
In vitro release of biologically active adriamycin by magnetically responsive albumin microspheres.
K. Widder (1980)
Comparative measurements of nanoparticle degradation velocity using an accelerated hydrolysis test
K. H. Wallis (1993)
10.1016/0928-0987(93)90015-3
In vitro phagocytosis assay of nano- and microparticles by chemiluminescence. III. Uptake of differently sized surface-modified particles, and its correlation to particle properties and in vivo distribution
S. Rudt (1993)
10.1016/0378-5173(92)90210-S
Alkylcyanoacrylate drug carriers: II. Cytotoxicity of cyanoacrylate nanoparticles with different alkyl chain length
C. Lherm (1992)
Some aspects of the use of contrast agents in magnetic resonance imaging.
H. P. Niendorf (1986)
Solid lipid nanoparticles (SLN) : an alternative colloidal carrier system for controlled drug delivery
R. Mueller (1995)
10.1016/0168-3659(93)90094-L
In vitro phagocytosis assay of nano- and microparticles by chemiluminescence. II: Effect of surface modification by coating of particles with poloxamer on the phagocytic uptake
S. Rudt (1993)
10.1002/MACP.1981.020051981103
Stereoregular bioresorbable polyesters for orthopaedic surgery
M. Vert (1981)



This paper is referenced by
10.3109/03639045.2010.522193
Preparation and evaluation of solid lipid nanoparticles of baicalin for ocular drug delivery system in vitro and in vivo
Zhidong Liu (2011)
10.1080/026520400417685
Effect of solid lipid nanoparticles (SLN) on cytokine production and the viability of murine peritoneal macrophages
N. Schöler, E. Zimmermann, U. Katzfey, H. Hahn, R. (2000)
10.1016/J.IJPHARM.2006.07.042
PVP magnetic nanospheres: biocompatibility, in vitro and in vivo bleomycin release.
Ding Guo-wei (2007)
10.1016/j.colsurfb.2008.08.018
Effect of PLGA as a polymeric emulsifier on preparation of hydrophilic protein-loaded solid lipid nanoparticles.
Shuyu Xie (2008)
10.1081/E-EBPP-120050077
Inhaler Systems: Dry Powder
Aysu Yurdasiper (2015)
10.1016/J.JDDST.2016.10.012
Development and evaluation of insulin-loaded cationic solid lipid nanoparticles for oral delivery
J. Hecq (2016)
10.1016/j.colsurfb.2014.07.025
Surface modification of HSA containing magnetic PLGA nanoparticles by poloxamer to decrease plasma protein adsorption.
Quazi T. H. Shubhra (2014)
Sistemas poliméricos coloidais como meios de contraste em Imageologia por Ressonância Magnética
S. Gameiro (2004)
10.1007/S11771-016-3341-4
Synthesis of size-controllable Fe3O4 magnetic submicroparticles and its biocompatible evaluation in vitro
Qing-hua Tian (2016)
10.1007/978-1-4419-9745-6_12
Polymers for Pulmonary Drug Delivery
P. Sheth (2011)
10.1080/02652040500444198
DEET-loaded solid lipid particles for skin delivery: In vitro release and skin permeation characteristics in different vehicles
Y. Işcan (2006)
Synthesis , kinetics and functionalization of PLA and PLA based biomaterials
Xia Meng (2012)
10.1201/B17191
Nanotoxicity of polymeric and solid lipid nanoparticles
D. Prasad (2014)
10.1016/j.ijbiomac.2012.01.024
In vitro and in vivo evaluation of oridonin-loaded long circulating nanostructured lipid carriers.
Lejiao Jia (2012)
10.1016/S0075-7535(06)32007-4
The biocompatibility and toxicity of magnetic particles
U. Häfeli (2007)
10.2147/IJN.S1045
Nanocarriers as pulmonary drug delivery systems to treat and to diagnose respiratory and non respiratory diseases
Malgorzata Smola (2008)
10.1186/1476-511X-11-72
Formulation and evaluation of chitosan solid lipid nanoparticles of carbamazepine
Rahul S. Nair (2012)
10.1124/pr.115.012070
Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come
Phatsapong Yingchoncharoen (2016)
10.1016/j.ijantimicag.2014.02.009
Nanocarriers for antibiotics: a promising solution to treat intracellular bacterial infections.
N. Abed (2014)
10.1208/s12249-015-0439-1
Drug Targeting to Macrophages With Solid Lipid Nanoparticles Harboring Paromomycin: an In Vitro Evaluation Against L. major and L. tropica
Maryam Heidari Kharaji (2015)
Programa de Pós-graduação em Ciências Farmacêuticas Área de Pesquisa e Desenvolvimento de Fármacos e Medicamentos
Câmpus de Araraquara (2013)
Development of a Novel Drug Delivery System to Enhance the Oral Bioavailability of Lactoferrin
Xudong Yao (2015)
Etude de systèmes lipidiques de délivrance de principes actifs
A. Ramadan (2010)
10.1002/9783527610419.NTLS0116
Solid Lipid and Polymeric Nanoparticles for Drug Delivery
J. Pedraz (2007)
10.1134/S0020168506080140
Fe-containing nanoparticles on the surface of silica microgranules
G. Yurkov (2006)
10.1002/CHIN.201202274
SOLID LIPID NANOPARTICLES: COLLOIDAL CARRIER SYSTEMS FOR DRUG DELIVERY
G. Swathi (2010)
10.1080/10837450.2019.1638398
Development and characterization of PLGA nanoparticles containing 1,3-dihydroxy-2-methylxanthone with improved antitumor activity on a human breast cancer cell line
Maribel Teixeira (2019)
10.2174/1567201813666160101120452
Nanosuspension: Principles, Perspectives and Practices.
S. Singh (2016)
10.1007/978-1-4614-8993-1_10
Cytotoxicity and Genotoxicity of Solid Lipid Nanoparticles
Priscyla D. Marcato (2014)
10.1016/J.IJPHARM.2007.07.025
Nimodipine loaded lipid nanospheres prepared by solvent diffusion method in a drug saturated aqueous system.
F. Hu (2008)
10.1002/ADFM.200700456
Formulation of Superparamagnetic Iron Oxides by Nanoparticles of Biodegradable Polymers for Magnetic Resonance Imaging
Y. Wang (2008)
10.1016/S1773-2247(08)50034-7
Assessment of drug permeation from lipid nanoparticles formulated with a novel structured lipid matrix through artificial skin construct bio-engineered from HDF and HaCaT cell lines
A. Attama (2008)
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