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Restenosis And The Proportional Neointimal Response To Coronary Artery Injury: Results In A Porcine Model.

Robert S. Schwartz, Kenneth C. Huber, Joseph G. Murphy, William D. Edwards, Allan R. Camrud, Ronald E. Vlietstra, D R Holmes
Published 1992 · Medicine
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Restenosis is a reparative response to arterial injury occurring with percutaneous coronary revascularization. However, the quantitative characteristics of the relation between vessel injury and the magnitude of restenotic response remain unknown. This study was thus performed to determine the relation between severity of vessel wall injury and the thickness of resulting neointimal proliferation in a porcine model of coronary restenosis. Twenty-six porcine coronary artery segments in 24 pigs were subjected to deep arterial injury with use of overexpanded, percutaneously delivered tantalum wire coils. The vessels were studied microscopically 4 weeks after coil implantation to measure the relation between the extent of injury and the resulting neointimal thickness. For each wire site, a histopathologic score proportional to injury depth and the neointimal thicknesses at that site were determined. Mean injury scores were compared with both mean neointimal thickness and planimetry-derived area percent lumen stenosis. The severity of vessel injury strongly correlated with neointimal thickness and percent diameter stenosis (p less than 0.001). Neointimal proliferation resulting from a given wire was related to injury severity in adjacent wires, suggesting an interaction among effects at injured sites. If the results in this model apply to human coronary arteries, restenosis may depend on the degree of vessel injury sustained during angioplasty.



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O'Neill Ww (1999)
10.4244/EIJV12I9A188
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Yanping Cheng (2016)
10.1172/JCI117133
Modulation by beta-aminopropionitrile of vessel luminal narrowing and structural abnormalities in arterial wall collagen in a rabbit model of conventional balloon angioplasty versus laser balloon angioplasty.
James Richard Spears (1994)
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Damian J. Kelly (2010)
Decoy oligodeoxynucleotide against activator protein-1 reduces neointimal proliferation after coronary angioplasty in hypercholesterolemic minipigs.
Arnd B. Buchwald (2002)
10.12729/jbtr.2019.20.4.091
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Kang Jin Jeong (2019)
The involvement of modified lipids in vascular injury and disease
Fiona H. Greig (2013)
10.1016/S0735-1097(97)00450-6
In-stent restenosis: contributions of inflammatory responses and arterial injury to neointimal hyperplasia.
Ran Kornowski (1998)
10.2459/01.JCM.0000247319.65159.47
Clinical outcome of patients undergoing low aggressive angioplasty combined with brachytherapy and short-term dual antiplatelet therapy for in-stent restenosis
Francesco di Pede (2006)
10.2147/IJN.S51258
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Cheng-Hung Lee (2014)
10.1016/j.jcin.2013.04.013
Tissue uptake, distribution, and healing response after delivery of paclitaxel via second-generation iopromide-based balloon coating: a comparison with the first-generation technology in the iliofemoral porcine model.
Piotr P. Buszman (2013)
10.1007/s00380-013-0465-4
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Takafumi Kurosawa (2013)
10.1007/s10237-019-01279-2
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Ran He (2020)
10.1016/j.acvd.2012.10.004
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Junying Kong (2013)
10.4070/kcj.2011.41.9.535
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Young Joon Hong (2011)
10.1583/10-3353.1
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Haiwei Li (2011)
10.1142/S1758825110000718
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Tae Hong Lee (2005)
10.1111/1755-5922.12267
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Jacek Bil (2017)
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Tré R Welch (2009)
10.1016/j.yjmcc.2018.07.007
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Jarkko P. Hytönen (2018)
10.1016/j.jcin.2017.06.059
Endothelial Barrier Protein Expression in Biodegradable Polymer Sirolimus-Eluting Versus Durable Polymer Everolimus-Eluting Metallic Stents.
Hiroyoshi Mori (2017)
10.1109/TMI.2002.806289
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Gerhard Koning (2002)
10.1159/000080891
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Bas Langeveld (2004)
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Zuned Hajiali (2014)
10.1253/CIRCJ.CJ-14-0315
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Noritoshi Hiranuma (2014)
10.1097/00019501-200009000-00002
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