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Occlusive Hydrocolloid Dressings Decrease Keratinocyte Population Growth Fraction And Clinical Scale And Skin Thickness In Active Psoriatic Plaques.

A. Gottlieb, L. Staiano-Coico, S. Cohen, M. Varghese, D. M. Carter
Published 1990 · Medicine

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Clinical studies suggest a therapeutic role for occlusion in the treatment of psoriasis. Previous studies, using multiparameter RNA/DNA flow cytometric analysis of epidermal suspensions obtained from active plaques, demonstrated increased keratinocyte growth fraction which reversed with successful medical treatment. Because keratinocyte growth fraction reflected disease activity, it was used in this study in addition to clinical evaluations in order to determine the efficacy of occlusion in the treatment of psoriatic plaques. In each of 9 patients, scale, skin thickness and erythema were compared in one occluded and one control plaque using an analog scale. Both scale and skin thickness, but not erythema, were decreased after 2 weeks of occlusion. However after 10 weeks, no additional differences were seen when compared with assessments made after 2 weeks, suggesting that the benefits of occlusive therapy occurred early. After 10 weeks of occlusion, the keratinocyte growth fraction was significantly decreased in occluded plaques. This study demonstrates that occlusion plays a synergistic role with other therapeutic modalities in ameliorating psoriatic plaques.
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This paper is referenced by
Occlusion enhances the efficacy of topical calcipotriol in the treatment of psoriasis vulgaris
J. Bourke (1993)
Combination therapy of psoriasis vulgaris with a hydrocolloid occlusive dressing and Goeckerman therapy.
H. Ohtsubo (1991)
New Developments in Topical Psoriasis Therapy
C. Lee (2006)
Effects and Uses of Occlusion on Human Skin: An Overview
Nicholas J Golda (2005)
Endogenous Growth Factor Pathways May Regulate Epidermal Hyperplasia in Chronic Venous Wounds: Modulation by Hydrocolloid Dressings
J. Krueger (1995)
Hydrogel Patch: A New Occlusive Device for the Treatment of Psoriasis—Patient Feedback from a Bilaterally Controlled Study
B. Koo (2007)
The epidermis as a target for antipsoriatic treatment; the Nijmegen view
P. V. Kerkhof (1997)
Epidermal kinetic alterations required to generate the psoriatic phenotype: a reappraisal
T. Simonart (2010)
Diagnostic and therapeutic innovations of phototherapy in psoriasis and (pre)malignancies of the skin
M. M. Kleinpenning (2007)
The effects of keratolytic pretreatment prior to fluorescence diagnosis and photodynamic therapy with aminolevulinic acid-induced porphyrins in psoriasis
M. M. Kleinpenning (2010)
Effects of Occlusion on Human Skin
Nicholas J Golda (2005)
Evaluating the efficacy and safety of calcipotriene/betamethasone ointment occluded with a hydrogel patch: a 6-week bilaterally controlled, investigator-blinded trial.
Tejas Patel (2011)
Clobetasol-17-propionate lotion under hydrocolloid dressing (Duoderm ET) once weekly versus unoccluded clobetasol-17-propionate ointment twice daily in psoriasis: an immunohistochemical study on remission and relapse
C. Vleuten (1999)
Non-invasive Approaches for the Diagnosis of Autoimmune/Autoinflammatory Skin Diseases—A Focus on Psoriasis and Lupus erythematosus
Anna Berekméri (2019)
A hyperosmotic stimulus elevates intracellular calcium and inhibits proliferation of a human keratinocyte cell line.
A. Dascalu (2000)
Signal transduction pathways in epidermal proliferation and cutaneous inflammation.
F. van Ruissen (1995)
Treatment of dry skin syndrome
M. Lodén (2012)
Wound Healing and Skin Physiology
P. Altmeyer (1995)
Epidermal vascular endothelial growth factor production is required for permeability barrier homeostasis, dermal angiogenesis, and the development of epidermal hyperplasia: implications for the pathogenesis of psoriasis.
P. Elias (2008)
Skin permeability barrier and occlusion: no delay of repair in irritated human skin *
J. Welzel (1996)
The value of colloid dressings in psoriasis.
A. Agius (1999)
Genetics of psoriasis: evidence for epistatic interaction between skin barrier abnormalities and immune deviation.
J. Bergboer (2012)
The role of occlusion in corticosteroid therapy of psoriasis
Y. Leow (1997)
Corneobiology and Corneotherapy – a final chapter
A. Kligman (2011)
Prolonged occlusion in the treatment of psoriasis: a clinical and immunohistologic study.
C. E. Griffiths (1995)
Origin of Threshold Behaviour in Psoriatic Skin
O. Lejeune (2008)
A Review of its Pharmacological Properties and Therapeutic Efficacy in the Management of Psoriasis
M. Bagot (1996)
Multi Parameter Flow Cytometric Assessment of Regenerative Epidermis with Special Reference to the Antiproliferative Effect of Occlusion
M. V. van Rossum (1998)
Sauerstoffversorgung der Haut
M. Stücker (2003)
Skin changes induced by a zinc oxide dressing compared with a hydrocolloid dressing in healthy individuals
L. F. Nielsen (2005)
Abnormal Epidermal Barrier Recovery in Uninvolved Skin supports the Notion of an Epidermal Pathogenesis of Psoriasis
L. Ye (2014)
Evaluation der okklusiven Effekte von Hydrokolloidfolien bei chronischer stationärer Psoriasis vulgaris
M. Stuecker (2001)
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