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In Vivo Measurement Of Human Tibial Strains During Vigorous Activity.

D. Burr, C. Milgrom, D. Fyhrie, M. Forwood, M. Nyska, A. Finestone, S. Hoshaw, E. Saiag, A. Simkin
Published 1996 · Biology, Medicine

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Our understanding of mechanical controls on bone remodeling comes from studies of animals with surgically implanted strain gages, but in vivo strain measurements have been made in a single human only once. That study showed that strains in the human tibia during walking and running are well below the fracture threshold. However, strains have never been monitored in vivo during vigorous activity in people, even though prolonged strenuous activity may be responsible for the occurrence of stress fractures. We hypothesized that strains > 3000 microstrain could be produced on the human tibial midshaft during vigorous activity. Strains were measured on the tibiae of two subjects via implanted strain gauges under conditions similar to those experienced by Israeli infantry recruits. Principal compressive and shear strains were greatest for uphill and downhill zigzag running, reaching nearly 2000 microstrain in some cases, about three times higher than recorded during walking. Strain rates were highest during sprinting and downhill running, reaching 0.050/sec. These results show that strain is maintained below 2000 microstrain even under conditions of strenuous activity. Strain rates are higher than previously recorded in human studies, but well within the range reported for running animals.
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This paper is referenced by
10.1007/BF02351006
Mechanotransduction of bone cellsin vitro: Mechanobiology of bone tissue
M. Mullender (2006)
10.1016/B978-0-08-100752-5.00003-2
Hard tissue applications of biocomposites
K. Tanner (2010)
10.1016/J.JBIOMECH.2005.04.032
Osteocyte lacunae tissue strain in cortical bone.
D. Nicolella (2006)
10.1038/boneres.2016.32
A multiscale 3D finite element analysis of fluid/solute transport in mechanically loaded bone
Lixia Fan (2016)
10.1146/ANNUREV.FLUID.010908.165136
Fluid and Solute Transport in Bone: Flow-Induced Mechanotransduction.
S. Fritton (2009)
10.1016/J.BONE.2006.05.025
Exercise distance and speed affect the risk of fracture in racehorses.
K. Verheyen (2006)
10.3934/bioeng.2020002
Bone remodeling and biological effects of mechanical stimulus
Chao Hu (2020)
Quantitative Computed-Tomography Based Bone-Strength Indicators for the Identification of Low Bone-Strength Individuals in a Clinical Environment
B. Varghese (2011)
10.1016/j.msec.2012.12.069
Effect of stress and temperature on the micromechanics of creep in highly irradiated bone and dentin.
A. Singhal (2013)
10.1016/S8756-3282(99)00205-7
In vivo matrix microdamage in a naturally occurring canine fatigue fracture.
P. Muir (1999)
10.1002/(SICI)1096-8644(199805)106:1<87::AID-AJPA6>3.0.CO;2-A
Patterns of strain in the macaque ulna during functional activity.
B. Demes (1998)
10.1002/(SICI)1520-6300(1999)11:4<437::AID-AJHB4>3.0.CO;2-K
An approach to estimating bone and joint loads and muscle strength in living subjects and skeletal remains
H. Frost (1999)
10.1016/B978-0-323-05460-7.00026-0
CHAPTER 26 – Mechanotransduction of Orthodontic Forces
S. Wadhwa (2010)
10.1016/j.jbiomech.2015.06.021
Peak strain magnitudes and rates in the tibia exceed greatly those in the skull: An in vivo study in a human subject
Richard A Hillam (2015)
10.1016/j.mbs.2020.108411
A structural-based computational model of tendon-bone insertion tissues.
S. Kuznetsov (2020)
Intragrade intramedullary nailing of an open tibial shaft fracture in a patient with concomitant ipsilateral total knee arthroplasty.
N. Greco (2015)
10.1016/J.BIOMATERIALS.2006.08.026
Synthesis of two-component injectable polyurethanes for bone tissue engineering.
Ian C Bonzani (2007)
10.1016/J.BIOMATERIALS.2004.05.024
Aspects of in vitro fatigue in human cortical bone: time and cycle dependent crack growth.
R. K. Nalla (2005)
10.1016/J.JBIOMECH.2004.05.008
Influence of phase angle between axial and torsional loadings on fatigue fractures of bone.
W. T. George (2005)
Expression of alkaline phosphatase in immortalized murine cementoblasts in response to compression-force.
Y. Tian (2011)
Bone response to cyclooxygenase inhibition and mechanical loading
Bryan T. Hackfort (2014)
What do we currently know from in vivo bone strain measurements in humans?
P. yang (2011)
10.1007/S12018-008-9014-6
Osteocytes: Mechanosensors of Bone and Orchestrators of Mechanical Adaptation
J. Klein-Nulend (2007)
10.1201/9781420042191.ch14
Rabbits as an animal model for stress fractures
D. Burr (2000)
Investigation of Biomechanical Risk Factors of Medial Tibial Stress Syndrome through Finite Element Analysis
R. Wesley (2015)
Micro-Mechanical Modeling of the Mechanosensation of Bone Cells
A. Lodygowski (2016)
10.14288/1.0077253
Ground reaction force analysis of a variety of jumping activities in growing children
Garry C K Tsang (2000)
10.1359/JBMR.041222
Bone Adaptation to a Mechanical Loading Program Significantly Increases Skeletal Fatigue Resistance
S. Warden (2005)
10.1002/JOR.1100150522
Dependence of trabecular damage on mechanical strain
E. Wachtel (1997)
10.1016/S0021-9290(99)00129-3
An in vitro comparison of bone deformation measured with surface and staple mounted strain gauges.
A. Arndt (1999)
10.1016/S8756-3282(01)00488-4
Modulation of appositional and longitudinal bone growth in the rat ulna by applied static and dynamic force.
A. Robling (2001)
10.3795/KSME-A.2009.33.7.629
Development of a Tensile Cell Stimulator to Study the Effects of Uniaxial Tensile Stress on Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells
H. Shin (2009)
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