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Silica-Based Amorphous Drug Delivery Systems
X. Zhang, M. Cresswell
Published 2016 · Materials Science
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This chapter reviews and introduces some of the most important fundamental concepts in the design, production, processing and application of amorphous silica materials as drug delivery systems for the controlled release of drug molecules. A distinction is made between silicate-based drug delivery systems that have ordered internal porous structures and those that have disordered porous structures. The formation of these two different types of carrier systems is controlled in fundamentally different ways. Ordered systems require the use of template-forming agents. These can be based on block copolymers, ionic or non-ionic surfactant molecules and are typically mesoporous in nature (2-50 nm). Disordered silica drug delivery systems require no such pore-forming agents and are typically microporous (< 2 nm). Strategies for controlling active release from these systems are introduced, and the specific use of porous silica for the topical delivery of a pharmaceutical active is highlighted.
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