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Use Of Nanostructured Materials In Drug Delivery

F. Vázquez-Hernández, D. A. Granada-Ramírez, J. S. Arias-Cerón, P. Rodríguez-Fragoso, J. Mendoza-Álvarez, E. Ramón-Gallegos, A. Cruz-Orea, J. Luna-Arias
Published 2017 · Materials Science

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Nanostructured materials are those in which at least one of their dimensions is between 1 and 100 nm. This kind of materials has been used in diagnostics, therapeutics, and drug delivery applications during the last three decades. Drug delivery takes advantage of the affinity that nucleic acids, proteins, peptides, vaccines, and drugs present for the attachment to several nanostructured materials as well as the improvement in their bioavailability, rapid clearance, and reduced toxicity. These materials are also known as nanocarriers, which may be functionalized and bioconjugated to increase selective targeting, uptake, solubility, and circulation time, making them more efficient drug delivery tools. In this review, synthesis, functionalization, bioconjugation and drug loading for chitosan, dendrimers, liposomes, carbon nanotubes, hydroxyapatite nanoparticles, semiconductor quantum dots, metallic quantum dots, ferromagnetic quantum dots, and gold nanoparticles are described. Additionally, the use of some of them in photodynamic therapy and their cytotoxicity will be described as well.
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