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AUGMENTATION OF HUMAN NATURAL KILLER CELLS WITH HUMAN LEUKOCYTE AND HUMAN RECOMBINANT LEUKOCYTE INTERFERON

J. Ortaldo, R. Herberman, S. Pestka
Published 1982 · Biology

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Publisher Summary This chapter highlights the determination of all or some of the various homogeneous leukocyte interferons that had regulatory activity as measured by their ability to augment natural killer (NK) cells. Ten species of human leukocyte interferon, eight purified to homogeneity, were tested for their ability to modulate cytolytic activity of NK cells. Because the dosage of the leukocyte interferon species was titrated, the ability to augment cytolytic activity varied considerably among the various species, although all preparations were tested at equivalent antiviral titers. In contrast, significant augmentation of activity from large granular lymphocytes (LGL), and human peripheral blood NK activity was seen at very low interferon titers. Pure human leukocyte and recombinant leukocyte interferons were shown to be able to augment appreciably cytolytic activity of NK cells. Because the various species and the recombinant forms, at the same number of antiviral units, demonstrated large differences in their functional efficacy. It might be of clinical importance to utilize for therapeutic trials species or mixtures of species of interferon that have high potency for augmenting a variety of functions.
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