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Ionic Liquids-Prompted Synthesis Of Biologically Relevant Five- And Six-Membered Heterocyclic Skeletons: An Update

B. Mishra, D. Kumar, Anoop S. Singh, R. Tripathi, V. K. Tiwari
Published 2015 · Chemistry

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Abstract Since last two decades it has seen a proliferation in the number of ionic liquids that have found extensive uses in organic synthesis as solvents and/or catalysts, simply due to their interesting and attractive features viz. simple handling, tunable properties, benign environmental character, catalytic activity, and excellent recyclability, whereas their interest in various different branches of science is expanding exponentially. Heterocyclic skeletons are known for their wide range of pharmacological activities and have led to the increased demand for significant amounts of five- and six-membered heterocycles for complete chemical and pharmacological investigations. Therefore, tremendous efforts have been made to develop facile procedures for the synthesis of diverse heterocycles of great biological interest. This chapter highlights the rapid increase in widespread applications of discovered room temperature ionic liquids in heterocyclic synthesis of great chemotherapeutic potential.
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