Online citations, reference lists, and bibliographies.
← Back to Search

Solid Lipid Nanoparticles For Targeting And Delivery Of Drugs And Genes

Rakesh K Tekade, Rahul Maheshwari, M. Tekade, M. Chougule
Published 2017 · Materials Science

Cite This
Download PDF
Analyze on Scholarcy
Share
Most of the biologically active compounds are struggle with low solubility and therefore low bioavailability, biological degradation and inadvertent intrinsic side effects. To overcome such difficulties, the emergence of potential and novel drug carrier system is of supreme importance in terms of their efficient applicability through different routes of administration like skin, oral, topical, parenteral and pulmonary. Considering this, Solid lipid nanoparticles have attracted huge attention for the successful delivery of drugs and genes and also employed as an effective strategy for targeting therapeutics. The potential advantages of solid lipid nanoparticles over other nanoparticles are because of their high biocompatibility, higher drug loading capacity and scalability. In this chapter, we summarize the complete understanding about morphology, methodology, characterization, hybridization and biomedical applications of solid lipid nanoparticles.
This paper references
10.1016/j.ejps.2013.02.011
DNA delivery via cationic solid lipid nanoparticles (SLNs).
C. Carrillo (2013)
10.2174/1573413711309010010
Nanoparticulate Carrier Mediated Intranasal Delivery of Insulin for the Restoration of Memory Signaling in Alzheimer’s Disease
Pankaj Dwivedi (2013)
10.1016/j.yrtph.2016.10.020
Comparative biodistribution and safety profiling of olmesartan medoxomil oil-in-water oral nanoemulsion.
Bapi Gorain (2016)
10.1016/J.EJPB.2003.10.015
Effect of cationic lipid and matrix lipid composition on solid lipid nanoparticle-mediated gene transfer.
K. Tabatt (2004)
10.1111/jphp.12136
Formulation and evaluation of metoclopramide solid lipid nanoparticles for rectal suppository
R. A. Mohamed (2013)
10.1039/C4RA15802D
Characterization of solid lipid nanoparticles produced with carnauba wax for rosmarinic acid oral delivery
A. R. Madureira (2015)
10.1016/J.JFOODENG.2016.01.014
Formation of solid lipid microparticles from fully hydrogenated canola oil using supercritical carbon dioxide
O. Çiftçi (2016)
10.1166/JNN.2015.9039
Glycyrrhizin Conjugated Dendrimer and Multi-Walled Carbon Nanotubes for Liver Specific Delivery of Doxorubicin.
Prashant K Chopdey (2015)
10.1007/s13346-016-0349-0
Whether a novel drug delivery system can overcome the problem of biofilms in respiratory diseases?
K. Dua (2016)
10.17352/IJPSDR.000003
Advancements in Microemulsion Based Drug Delivery Systems for Better Therapeutic Effects
G. Sahu (2015)
10.1023/A:1011939323560
Efficacy and Pharmacokinetics of Site-Specific Cefazolin Delivery Using Biodegradable Implants in the Prevention of Post-operative Wound Infections
S. Allababidi (2004)
10.1166/JBN.2012.1383
Development of cationic solid lipid nanoparticles with factorial design-based studies for topical administration of doxorubicin.
S. F. Taveira (2012)
10.1007/s10544-008-9192-5
Iron-oxide embedded solid lipid nanoparticles for magnetically controlled heating and drug delivery
Ming-Huang Hsu (2008)
10.1093/JAC/DKL128
Oral nanoparticle-based antituberculosis drug delivery to the brain in an experimental model.
R. Pandey (2006)
10.1080/02652040802312572
Exploring dendrimer towards dual drug delivery: pH responsive simultaneous drug-release kinetics
Rakesh K Tekade (2009)
10.1021/mp500403b
Designing hybrid onconase nanocarriers for mesothelioma therapy: a Taguchi orthogonal array and multivariate component driven analysis.
Rakesh K Tekade (2014)
10.2174/157016311796799062
20 Years of Lipid Nanoparticles (SLN & NLC): Present State of Development & Industrial Applications
R. Mueller (2011)
10.1021/BC0601166
Employment of cationic solid-lipid nanoparticles as RNA carriers.
G. Montana (2007)
10.1155/2013/858946
STAT6 siRNA Matrix-Loaded Gelatin Nanocarriers: Formulation, Characterization, and Ex Vivo Proof of Concept Using Adenocarcinoma Cells
Susanne R. Youngren (2013)
10.1155/2013/712678
Formulation Development and Evaluation of Hybrid Nanocarrier for Cancer Therapy: Taguchi Orthogonal Array Based Design
Rakesh K Tekade (2013)
10.1021/mp8002489
Dendimer-mediated solubilization, formulation development and in vitro-in vivo assessment of piroxicam.
R. N. Prajapati (2009)
10.2147/IJN.S20849
New surface-modified solid lipid nanoparticles using N-glutaryl phosphatidylethanolamine as the outer shell
S. Kashanian (2011)
10.1007/s11095-007-9514-y
Solid Lipid Nanoparticles as Delivery Systems for Bromocriptine
E. Esposito (2007)
10.1016/j.addr.2012.06.013
Immunotoxicity derived from manipulating leukocytes with lipid-based nanoparticles.
D. Peer (2012)
10.1016/S0378-5173(02)00080-7
Solid lipid nanoparticles (SLN) as ocular delivery system for tobramycin.
R. Cavalli (2002)
10.1208/s12249-014-0073-3
Dendrimer, Liposomes, Carbon Nanotubes and PLGA Nanoparticles: One Platform Assessment of Drug Delivery Potential
N. Mody (2014)
10.1002/CHIN.201524284
Physicochemical Characterization Techniques for Solid Lipid Nanoparticles: Principles and Limitations
N. Kathe (2015)
10.1016/j.jconrel.2012.01.026
Antibody-drug conjugates: basic concepts, examples and future perspectives.
G. Casi (2012)
10.1002/9781118444726.CH13
Dendrimers for Enhanced Drug Solubilization
N. Jain (2013)
10.1016/j.jcis.2016.07.020
Augmented delivery of gemcitabine in lung cancer cells exploring mannose anchored solid lipid nanoparticles.
N. Soni (2016)
10.1016/j.biomaterials.2010.12.029
Tailoring nanostructured solid-lipid carriers for time-controlled intracellular siRNA kinetics to sustain RNAi-mediated chemosensitization.
H. Xue (2011)
10.1211/jpp.61.08.0002
Dendrimers as therapeutic agents: a systematic review
V. Gajbhiye (2009)
10.1007/s11095-014-1506-0
Dendrimer-stabilized smart-nanoparticle (DSSN) platform for targeted delivery of hydrophobic antitumor therapeutics
Rakesh K Tekade (2014)
10.1016/j.colsurfb.2014.01.055
Formulation, characterization and cytotoxicity studies of alendronate sodium-loaded solid lipid nanoparticles.
Jafar Ezzati Nazhad Dolatabadi (2014)
10.3109/1061186X.2012.747529
Preparation, characterization, in vivo and biochemical evaluation of brain targeted Piperine solid lipid nanoparticles in an experimentally induced Alzheimer’s disease model
Mohammad Yusuf (2013)
10.1038/152102A0
Transparent Water-in-Oil Dispersions: the Oleopathic Hydro-Micelle
T. Hoar (1943)
10.2217/nnm.16.19
Luteinizing hormone-releasing hormone peptide tethered nanoparticulate system for enhanced antitumoral efficacy of paclitaxel.
Raksha Ghanghoria (2016)
10.1016/0378-5173(95)04388-8
Thymopentin in solid lipid nanoparticles
S. Morel (1996)
SOLID LIPID NANOPARTICLES: A REVIEW
P. Ekambaram (2012)
10.1016/j.jconrel.2013.03.033
Just getting into cells is not enough: mechanisms underlying 4-(N)-stearoyl gemcitabine solid lipid nanoparticle's ability to overcome gemcitabine resistance caused by RRM1 overexpression.
Piyanuch Wonganan (2013)
10.1016/j.jconrel.2014.09.001
Nanocarrier mediated delivery of siRNA/miRNA in combination with chemotherapeutic agents for cancer therapy: current progress and advances.
N. S. Gandhi (2014)
10.2147/IJN.S31711
Solid lipid nanoparticles modified with stearic acid–octaarginine for oral administration of insulin
Z. Zhang (2012)
10.1016/J.VACCINE.2005.07.053
Lipid microparticles for mucosal immunization against hepatitis B.
Surbhi Saraf (2006)
10.2174/1567201811310040012
Cancer targeting potential of folate targeted nanocarrier under comparative influence of tretinoin and dexamethasone.
R. S. Dhakad (2013)
10.4028/www.scientific.net/JNanoR.32.106
Hollow Gold Nanoparticals as Biocompatible Radiosensitizer: An In Vitro Proof of Concept Study
Chien Wen Huang (2015)
10.2967/jnumed.113.136044
Tumor-Absorbed Dose Predicts Progression-Free Survival Following 131I-Tositumomab Radioimmunotherapy
Y. Dewaraja (2014)
10.1166/SAM.2015.2245
Chitosan Encrusted Nonionic Surfactant Based Vesicular Formulation for Topical Administration of Ofloxacin
R. S. Maheshwari (2015)
10.1016/j.ejpb.2015.10.015
Lyophilized mucoadhesive-dendrimer enclosed matrix tablet for extended oral delivery of albendazole.
Shakir Mansuri (2016)
10.1016/j.drudis.2014.12.015
Dendrimer generational nomenclature: the need to harmonize.
P. Kesharwani (2015)
10.1016/j.colsurfb.2013.03.037
Drug resistance reversal activity of anticancer drug loaded solid lipid nanoparticles in multi-drug resistant cancer cells.
J. Miao (2013)
10.2174/138161282130151007150300
Nanocarriers Assisted siRNA Gene Therapy for the Management of Cardiovascular Disorders.
Rahul Maheshwari (2015)
10.1023/A:1018888927852
Body Distribution of Camptothecin Solid Lipid Nanoparticles After Oral Administration
Shicheng Yang (2004)
10.1016/j.colsurfb.2012.05.006
Preparation and stability study of norfloxacin-loaded solid lipid nanoparticle suspensions.
Yan Wang (2012)
10.1016/j.nano.2010.06.008
Pulmonary toxicity of carbon nanotubes: a systematic report.
Jitendra Kayat (2011)
10.1166/JBN.2009.036
Solid lipid nanoparticles as insulin inhalation carriers for enhanced pulmonary delivery.
R. C. Bi (2009)
10.1016/J.ADDR.2007.04.012
Nanostructured lipid carriers (NLC) in cosmetic dermal products.
R. Mueller (2007)
10.1016/j.drudis.2016.06.029
RNAi-combined nano-chemotherapeutics to tackle resistant tumors.
Rakesh K Tekade (2016)
10.1016/j.ejps.2012.10.022
Development of solid lipid nanoparticles (SLNs) of lopinavir using hot self nano-emulsification (SNE) technique.
J. S. Negi (2013)
10.1016/J.IJPHARM.2004.10.014
Solid lipid micro-particles carrying insulin formed by solvent-in-water emulsion-diffusion technique.
M. Trotta (2005)
10.1016/j.jconrel.2012.06.002
Improvement of drug safety by the use of lipid-based nanocarriers.
S. B. Lim (2012)
10.2174/138161282131151013192116
siRNA Therapy, Challenges and Underlying Perspectives of Dendrimer as Delivery Vector.
Rakesh K Tekade (2015)
Preparation and characterization of magnetic solid lipid nanoparticles loaded with ibuprofen
Xiujuan Pang (2009)
10.1016/j.jsps.2011.10.001
Ethosomes and ultradeformable liposomes for transdermal delivery of clotrimazole: A comparative assessment.
Rahul Maheshwari (2012)
10.1016/j.colsurfb.2011.07.060
Solid lipid nanoparticles comprising internal Compritol 888 ATO, tripalmitin and cacao butter for encapsulating and releasing stavudine, delavirdine and saquinavir.
Y. Kuo (2011)
10.1016/j.colsurfb.2011.07.036
Formulation design, preparation and physicochemical characterizations of solid lipid nanoparticles containing a hydrophobic drug: effects of process variables.
S. Das (2011)
10.2174/1381612821999150911093912
Editorial: Contemporary siRNA Therapeutics and the Current State-of-Art.
Rakesh K Tekade (2015)
10.1007/s11095-014-1549-2
Generation Dependent Safety and Efficacy of Folic Acid Conjugated Dendrimer Based Anticancer Drug Formulations
P. Kesharwani (2014)
10.1016/j.ijpharm.2015.10.043
Effect of sterilization on the physical stability of brimonidine-loaded solid lipid nanoparticles and nanostructured lipid carriers.
Noha S. El-Salamouni (2015)
10.1158/1538-7445.AM2015-3680
Abstract 3680: Albumin-chitosan hybrid onconase nanocarriers for mesothelioma therapy
Rakesh K Tekade (2015)
10.1021/cr068212n
Dendrimers in oncology: an expanding horizon.
Rakesh K Tekade (2009)
10.2174/1381612822666161201143600
Pharmacokinetic and Pharmacodynamic Features of Nanoemulsion Following Oral, Intravenous, Topical and Nasal Route.
H. Choudhury (2017)
10.2217/nnm.11.52
Methotrexate-loaded SLNs prepared by coacervation technique: in vitro cytotoxicity and in vivo pharmacokinetics and biodistribution.
L. Battaglia (2011)
10.1016/j.ijpharm.2012.07.058
Long-term stability, biocompatibility and oral delivery potential of risperidone-loaded solid lipid nanoparticles.
A. Silva (2012)
10.1016/J.BFOPCU.2015.11.002
Diflucortolone valerate loaded solid lipid nanoparticles as a semisolid topical delivery system
Fatma S. Abdel-Salam (2016)
10.7555/JBR.27.20120123
Extraction and RP-HPLC determination of taxol in rat plasma, cell culture and quality control samples
Rakesh K Tekade (2013)
10.1080/02652040500162436
SLN and NLC for topical delivery of ketoconazole
E. Souto (2005)
10.1016/S0378-5173(02)00688-9
Preparation and purification of cationic solid lipid nanospheres--effects on particle size, physical stability and cell toxicity.
A. V. Heydenreich (2003)
10.1080/10611860802473154
Surface-engineered dendrimers for dual drug delivery: A receptor up-regulation and enhanced cancer targeting strategy
Rakesh K Tekade (2008)
10.1016/j.ejpb.2013.01.029
Biodistribution of Nanostructured Lipid Carriers (NLCs) after intravenous administration to rats: influence of technological factors.
A. Beloqui (2013)
10.1016/j.colsurfb.2011.12.006
Rheological studies on solid lipid nanoparticle based carbopol gels of aceclofenac.
Viney Chawla (2012)
10.1016/j.ijpharm.2008.01.008
Solid lipid nanoparticles for pulmonary delivery of insulin.
J. Liu (2008)
10.2174/138161207780162999
Pharmaceutical and Biomedical Potential of PEGylated Dendrimers
V. Gajbhiye (2007)
Solid lipid nanoparticles of anticancer drugs against MCF-7 cell line and a murine breast cancer model.
Y. Zhuang (2012)
10.1201/B17191-12
Nanomaterial-Based Gene and Drug Delivery: Pulmonary Toxicity Considerations
Mahavir Bhupal Chougule (2014)
10.1016/S0168-3659(99)00223-0
Vitamin A-loaded solid lipid nanoparticles for topical use: drug release properties.
V. Jenning (2000)
10.2174/1381612821666150910113031
Nanomaterial Based Approaches for the Diagnosis and Therapy of Cardiovascular Diseases.
P. Sharma (2015)
10.1016/j.ejps.2012.10.025
New approach to improve encapsulation and antitumor activity of doxorubicin loaded in solid lipid nanoparticles.
S. Mussi (2013)
10.1016/j.biomaterials.2013.03.013
Targeting delivery of saquinavir to the brain using 83-14 monoclonal antibody-grafted solid lipid nanoparticles.
Y. Kuo (2013)
10.1211/jpp.59.8.0002
Solid lipid nanoparticles (SLN) as carriers for the topical delivery of econazole nitrate: in‐vitro characterization, ex‐vivo and in‐vivo studies
V. Sanna (2007)
10.1016/j.ejps.2013.03.013
Development of solid lipid nanoparticles based controlled release system for topical delivery of terbinafine hydrochloride.
H. Vaghasiya (2013)
10.1016/j.ijpharm.2013.02.012
Encapsulation of Rifampicin in a solid lipid nanoparticulate system to limit its degradation and interaction with Isoniazid at acidic pH.
H. Singh (2013)
10.1373/CLINCHEM.2007.090795
Applications of nanobiotechnology in clinical diagnostics.
K. Jain (2007)
10.1080/09205063.2015.1133155
Dendrimer-mediated approaches for the treatment of brain tumor
N. Dwivedi (2016)
10.1517/17425247.2010.492212
Micro- and nanocarrier-mediated lung targeting
B. D. Kurmi (2010)
10.1021/J150580A027
Mechanism of Formation and Structure of Micro Emulsions by Electron Microscopy
J. H. Schulman (1959)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar