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Natural And Synthetic Polymers For Drug Delivery And Targeting

G. D. Mogoșanu, A. Grumezescu, L. Bejenaru, C. Bejenaru
Published 2016 · Materials Science

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During recent decades, interdisciplinary research has led to the development of modern generations of pharmaceutical systems with improved performance in terms of active principle release, such as: pharmaceutical systems with prolonged or sustained release, with controlled release, and with targeted delivery (to the specific site of action), respectively. By the ability to control and manipulate some biological structures, at nanometric, molecular or even atomic level, pharmaceutical nanobiotechnology paved the way for both the treatment and diagnosis of diseases and for real-time monitoring of biosystems. In this respect, the use of liposomes, niosomes, polymeric nanoparticles, and therapeutic polymers (e.g., polymeric micelles, dendrimers, colloidal nanogels, polymeric artificial cells), as “intelligent,” biocompatible and biodegradable systems for targeted drug delivery, are highly topical and perspective guidelines for biomedical area. In this context, benefiting from the advances of molecular medicine, genomics and proteomics, pharmaceutical nanobiotehnology has significantly contributed to the development of nanomedicine (nanoimmunology, nanooncology, nanocardiology, etc.) and personalized therapy.
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