Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Myogenic Cell Specification During Somitogenesis

M. Buckingham, S. Tajbakhsh
Published 1999 · Biology

Save to my Library
Download PDF
Analyze on Scholarcy
Publisher Summary The formation of skeletal muscle has provided a paradigm for the study of tissue differentiation since the 1970s. The availability of mammalian muscle cell lines as well as primary cultures, in which dividing myoblasts spontaneously form muscle fibers, facilitated investigation of the battery of muscle-specific genes that are activated during this process. It also led to the isolation of the MyoD family of myogenic regulatory factors (MRFs) in the late 1980s. An initial wave of primary myogenesis leads to the formation of primary fibers that will contribute mainly to the slow fibers of adult skeletal muscle. Subsequently, a second wave of myogenesis occurs, which is characterized by the proliferation of previously quiescent myoblasts, and the formation of secondary fibers, which mature into the different fast fibers of the adult. This process is associated with the onset of innervations, although not entirely dependent on it, and will continue throughout the fetal period. The fiber type and hence the transcriptional status of different muscle genes are affected by physiological parameters such as exercise, and adult muscles retain a precursor cell population, the satellite cells, which permit regeneration to take place. In this chapter, the early stages of skeletal myogenesis in the embryo are discussed—taking the mouse as a model—in the context of the genes and the signaling molecules that lead to the acquisition of myogenic identity.
This paper references
Pax3 modulates expression of the c-Met receptor during limb muscle development.
J. Epstein (1996)
A novel myoblast enhancer element mediates MyoD transcription.
S. Tapscott (1992)
Identification of separate slow and fast muscle precursor cells in vivo, prior to somite formation.
S. Devoto (1996)
Two molecules related to the VEGF receptor are expressed in early endothelial cells during avian embryonic development
A. Eichmann (1993)
Specific muscle identities are regulated by Krüppel during Drosophila embryogenesis.
M. Ruiz-Gómez (1997)
Alterations in somite patterning of Myf-5-deficient mice: a possible role for FGF-4 and FGF-6.
S. Grass (1996)
Consequences of neural tube and notochord excision on the development of the peripheral nervous system in the chick embryo.
M. Teillet (1983)
Phenotype of adult mouse muscle myoblasts reflects their fiber type of origin.
J. D. Rosenblatt (1996)
Muscle pioneers: large mesodermal cells that erect a scaffold for developing muscles and motoneurones in grasshopper embryos
R. Ho (1983)
Mouse Lbx1 and human LBX1 define a novel mammalian homeo☐ gene family related to the Drosophila lady bird genes
K. Jagla (1995)
Targeted inactivation of the muscle regulatory gene Myf-5 results in abnormal rib development and perinatal death
T. Braun (1992)
Myogenic cell lineages.
F. Stockdale (1992)
Redefining the Genetic Hierarchies Controlling Skeletal Myogenesis: Pax-3 and Myf-5 Act Upstream of MyoD
S. Tajbakhsh (1997)
Pax-3 is necessary for migration but not differentiation of limb muscle precursors in the mouse.
G. Daston (1996)
How is myogenesis initiated in the embryo?
G. Cossu (1996)
Frzb, a Secreted Protein Expressed in the Spemann Organizer, Binds and Inhibits Wnt-8
S. Wang (1997)
N-cadherin is involved in myoblast migration and muscle differentiation in the avian limb bud.
B. Brand-Saberi (1996)
Skeletal myogenesis: the preferred pathway of chick embryo epiblast cells in vitro.
M. George-Weinstein (1996)
Diversity and Pattern in the Developing Spinal Cord
Y. Tanabe (1996)
The world according to bedgebog
M. Hammerschmidt (1997)
Scatter factor/hepatocyte growth factor (SF/HGF) induces emigration of myogenic cells at interlimb level in vivo.
B. Brand-Saberi (1996)
Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos
C. Coffman (1993)
Isolated sequences from the linked Myf-5 and MRF4 genes drive distinct patterns of muscle-specific expression in transgenic mice.
A. Patapoutian (1993)
Myogenin is required for late but not early aspects of myogenesis during mouse development
J. Venuti (1995)
The role of the neural crest in patterning of avian cranial skeletal, connective, and muscle tissues.
D. Noden (1983)
Notochord signals control the transcriptional cascade of myogenic bHLH genes in somites of quail embryos.
M. Pownall (1996)
Positive and Negative Regulation of Muscle Cell Identity by Members of the hedgehog and TGF-β Gene Families
S. Du (1997)
Two myogenic lineages within the developing somite.
C. Ordahl (1992)
Muscle Differentiation: Which myogenic factors make muscle?
M. Buckingham (1994)
The fub-1 mutation blocks initial myofibril formation in zebrafish muscle pioneer cells.
A. Felsenfeld (1991)
Myogenic cell migration from somites is induced by tissue contact with medial region of the presumptive limb mesoderm in chick embryos.
K. Hayashi (1995)
Embryonic activation of the myoD gene is regulated by a highly conserved distal control element.
D. J. Goldhamer (1995)
Expression of two myogenic regulatory factors myogenin and MyoDl during mouse embryogenesis
D. Sassoon (1989)
Pax-3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle progenitor cells.
E. Bober (1994)
Severe defects in the formation of epaxial musculature in open brain (opb) mutant mouse embryos.
R. Spörle (1996)
Control of dorsoventral pattern in the chick paraxial mesoderm.
S. Dietrich (1997)
Maintenance of somite borders in mice requires the Delta homologue Dll1
M. Angelis (1997)
Somite subdomains, muscle cell origins, and the four muscle regulatory factor proteins
T. Smith (1994)
Actin and myosin multigene families: their expression during the formation of skeletal muscle.
Buckingham Me (1985)
Mammalian muscle cells bear a cell-autonomous, heritable memory of their rostrocaudal position
M. Donoghue (1992)
Determination of somite cells: independence of cell differentiation and morphogenesis.
H. Aoyama (1988)
Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development
M. Rudnicki (1992)
Regulation of muscle differentiation by the MEF2 family of MADS box transcription factors.
E. Olson (1995)
Vertebrate limb development
C. Tickle (1996)
Differential activation of Myf5 and MyoD by different Wnts in explants of mouse paraxial mesoderm and the later activation of myogenesis in the absence of Myf5.
S. Tajbakhsh (1998)
Frzb-1 Is a Secreted Antagonist of Wnt Signaling Expressed in the Spemann Organizer
L. Leyns (1997)
Specification of the hypaxial musculature.
S. Dietrich (1998)
Distinct signal/response mechanisms regulate pax1 and QmyoD activation in sclerotomal and myotomal lineages of quail somites.
A. Borycki (1997)
MyoD or Myf-5 is required for the formation of skeletal muscle
M. Rudnicki (1993)
Ectopic expression of Sonic hedgehog alters dorsal-ventral patterning of somites
R. Johnson (1994)
Krüppel target gene knockout participates in the proper innervation of a specific set of Drosophila larval muscles
C. Hartmann (1997)
Myogenesis in paraxial mesoderm: preferential induction by dorsal neural tube and by cells expressing Wnt-1.
H. Stern (1995)
Muscle pattern diversification in Drosophila is determined by the autonomous function of homeotic genes in the embryonic mesoderm.
A. Michelson (1994)
Expression of Hox-7.1 in myoblasts inhibits terminal differentiation and induces cell transformation
K. Song (1992)
Expression of the met receptor tyrosine kinase in muscle progenitor cells in somites and limbs is absent in Splotch mice.
X. Yang (1996)
Myogenin gene disruption results in perinatal lethality because of severe muscle defect
Y. Nabeshima (1993)
Induction of a specific muscle cell type by a hedgehog-like protein in zebrafish
P. Currie (1996)
Scatter factor/hepatocyte growth factor as a regulator of skeletal muscle and neural crest development.
H. Takayama (1996)
Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite.
A. Münsterberg (1995)
Pax-3 expression in segmental mesoderm marks early stages in myogenic cell specification.
B. Williams (1994)
Notochord induction of zebrafish slow muscle mediated by Sonic hedgehog.
C. S. Blagden (1997)
Gene targeting the myf‐5 locus with nlacZ reveals expression of this myogenic factor in mature skeletal muscle fibres as well as early embryonic muscle
S. Tajbakhsh (1996)
The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD.
R. Kopan (1994)
Interaction Between Wingless and Notch Signaling Pathways Mediated by Dishevelled
J. Axelrod (1996)
Angiogenic potential of the avian somite
J. Wilting (1995)
The myoD gene family: nodal point during specification of the muscle cell lineage.
H. Weintraub (1991)
Wingless signaling induces nautilus expression in the ventral mesoderm of the Drosophila embryo.
G. Ranganayakulu (1996)
MSX1 inhibits MyoD expression in fibroblast × 10T½ cell hybrids
P. Woloshin (1995)
MyoD is required for myogenic stem cell function in adult skeletal muscle.
L. Megeney (1996)
Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds.
B. Parr (1993)
Muscle progenitor cells failing to respond to positional cues adopt non-myogenic fates in myf-5 null mice
S. Tajbakhsh (1996)
Patterning of mammalian somites by surface ectoderm and notochord: Evidence for sclerotome induction by a hedgehog homolog
C. Fan (1994)
Control of dorsoventral patterning of somitic derivatives by notochord and floor plate.
O. Pourquié (1993)
Emergence of determined myotome precursor cells in the somite.
B. Williams (1997)
Somite Development: Constructing the Vertebrate Body
S. Tajbakhsh (1998)
Segregation of myogenic lineages in Drosophila requires numb.
M. Ruíz Gómez (1997)
Developmental regulation of zebrafish MyoD in wild-type, no tail and spadetail embryos.
E. Weinberg (1996)
Embryonic development of the larval body wall musculature of Drosophila melanogaster.
S. Abmayr (1995)
Jagged: A mammalian ligand that activates notch1
C. Lindsell (1995)
Insertional mutation of the mouse Msx1 homeobox gene by an nlacZ reporter gene
D. Houzelstein (1997)
Lateral and Axial Signals Involved in Avian Somite Patterning: A Role for BMP4
O. Pourquié (1996)
Know Your Neighbors: Three Phenotypes in Null Mutants of the Myogenic bHLH Gene MRF4
E. Olson (1996)
Mouse limb muscle is determined in the absence of the earliest myogenic factor myf-5.
S. Tajbakhsh (1994)
Slow and fast muscle fibers are preferentially derived from myoblasts migrating into the chick limb bud at different developmental times.
J. Van Swearingen (1995)
Pax3 Inhibits Myogenic Differentiation of Cultured Myoblast Cells (*)
J. Epstein (1995)
A transgene target for positional regulators marks early rostrocaudal specification of myogenic lineages
U. Grieshammer (1992)
Uncoupling of Grb2 from the Met Receptor In Vivo Reveals Complex Roles in Muscle Development
F. Maina (1996)
A role for the Drosophila neurogenic genes in mesoderm differentiation
V. Corbin (1991)
Differential response of embryonic and fetal myoblasts to TGF beta: a possible regulatory mechanism of skeletal muscle histogenesis.
M. G. Cusella-De Angelis (1994)
A role for WNT proteins in induction of dermomyotome.
C. Fan (1997)
Mutations in a novel gene, myoblast city, provide evidence in support of the founder cell hypothesis for Drosophila muscle development.
E. Rushton (1995)
Coordinate actions of BMPs, Wnts, Shh and noggin mediate patterning of the dorsal somite.
C. Marcelle (1997)
The in vivo expression of the FGF receptor FREK mRNA in avian myoblasts suggests a role in muscle growth and differentiation.
C. Marcelle (1995)
Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
F. Bladt (1995)
Regulation of Pax-3 expression in the dermomyotome and its role in muscle development.
M. Goulding (1994)
A new Drosophila homeo box gene is expressed in mesodermal precursor cells of distinct muscles during embryogenesis.
C. Dohrmann (1990)
Ectopic Pax-3 Activates MyoD and Myf-5 Expression in Embryonic Mesoderm and Neural Tissue
M. Maroto (1997)
Regulation and function of SF/HGF during migration of limb muscle precursor cells in chicken.
S. Heymann (1996)
The prospero gene encodes a divergent homeodomain protein that controls neuronal identity in Drosophila.
Q. Chu-LaGraff (1991)
Activation of different myogenic pathways: myf-5 is induced by the neural tube and MyoD by the dorsal ectoderm in mouse paraxial mesoderm.
G. Cossu (1996)
Expression of a dominant-negative Wnt blocks induction of MyoD in Xenopus embryos.
S. Hoppler (1996)
Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene
P. Hasty (1993)
Myoblast differentiation during mammalian somitogenesis is dependent upon a community effect.
G. Cossu (1995)
Pax: genes for mice and men.
P. Tremblay (1994)
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
C. Chiang (1996)
Location and growth of epaxial myotome precursor cells.
W. Denetclaw (1997)

This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar