← Back to Search
Nanoparticle And Targeted Systems For Cancer Therapy.
L. Brannon-Peppas, J. Blanchette
Published 2004 · Medicine
Download PDFAnalyze on Scholarcy
This review explores recent work directed towards more targeted treatment of cancer, whether through more specific anti-cancer agents or through methods of delivery. These areas include delivery by avoiding the reticuloendothelial system, utilizing the enhanced permeability and retention effect and tumor-specific targeting. Treatment opportunities using antibody-targeted therapies are summarized. The ability to treat cancer by targeting delivery through angiogenesis is also discussed and antiangiogenic drugs in clinical trials are presented. Delivery methods that specifically use nanoparticles are also highlighted, including both degradable and nondegradable polymers.
This paper references
Molecular targets and cancer therapeutics: discovery, development and clinical validation.
B. Teicher (2000)
Therapeutic efficacy of anti-ErbB2 immunoliposomes targeted by a phage antibody selected for cellular endocytosis.
U. Nielsen (2002)
Renaissance of cancer therapeutic antibodies.
M. Glennie (2003)
Fibronectin controls capillary endothelial cell growth by modulating cell shape.
D. Ingber (1990)
In vitro cellular accumulation of gadolinium incorporated into chitosan nanoparticles designed for neutron-capture therapy of cancer.
Futoshi Shikata (2002)
Chemotherapeutic engineering: Application and further development of chemical engineering principles for chemotherapy of cancer and other diseases
S. Feng (2003)
An overview of targeted treatments in cancer.
R. Abou-Jawde (2003)
Endothelial cells and angiogenesis
N. Sepp (1997)
Successful treatment of an angiogenic disease.
J. Folkman (1989)
Tumor Regression by Targeted Gene Delivery to the Neovasculature
J. Hood (2002)
A PEGylated dendritic nanoparticulate carrier of fluorouracil.
D. Bhadra (2003)
Effects of emulsifiers on the controlled release of paclitaxel (Taxol) from nanospheres of biodegradable polymers.
S. Feng (2001)
A novel controlled release formulation for the anticancer drug paclitaxel (Taxol): PLGA nanoparticles containing vitamin E TPGS.
L. Mu (2003)
Toward selection of internalizing antibodies from phage libraries.
B. Becerril (1999)
Surface modification of nanoparticles to oppose uptake by the mononuclear phagocyte system
G. Storm (1995)
Preparation and characterization of poly(lactic-co-glycolic acid) microspheres for targeted delivery of a novel anticancer agent, taxol.
Y. Wang (1996)
Transport of molecules, particles, and cells in solid tumors.
R. Jain (1999)
Nanoparticles in cancer therapy and diagnosis.
I. Brigger (2002)
Nanoparticle drug delivery system for intravenous delivery of topoisomerase inhibitors.
J. Williams (2003)
Thrombospondin-1 expression in patients with pathologic stage T3 prostate cancer undergoing radical prostatectomy: association with p53 alterations, tumor angiogenesis, and tumor progression.
G. Grossfeld (2002)
Relationship of endothelial cell proliferation to tumor vascularity in human breast cancer.
S. Fox (1993)
Tumor-targeted gene therapy: strategies for the preparation of ligand-polyethylene glycol-polyethylenimine/DNA complexes.
M. Ogris (2003)
Enhanced tumor cell selectivity of adriamycin-monoclonal antibody conjugate via a poly(ethylene glycol)-based cleavable linker.
T. Suzawa (2002)
Coupling of cell-binding ligands to polyethylenimine for targeted gene delivery
R. Kircheis (1997)
Nanoparticle-mediated gene delivery to tumour neovasculature.
A. Reynolds (2003)
Immunotherapy of folate receptor-expressing tumors: review of recent advances and future prospects.
Y. Lu (2003)
Different strategies for formation of pegylated EGF-conjugated PEI/DNA complexes for targeted gene delivery.
T. Blessing (2001)
Targeted delivery of chemotherapeutics: tumor-activated prodrug therapy.
Paclitaxel and its formulations.
A. K. Singla (2002)
Continuous cultures of fused cells secreting antibody of predefined specificity
G. Köhler (1975)
In vitro and in vivo anti-tumor activities of nanoparticles based on doxorubicin-PLGA conjugates.
H. Yoo (2000)
IgG2a induced by interleukin (IL) 12-producing tumor cell vaccines but not IgG1 induced by IL-4 vaccine is associated with the eradication of experimental metastases.
M. Rodolfo (1998)
Paclitaxel-loaded PLGA nanoparticles: preparation, physicochemical characterization and in vitro anti-tumoral activity.
Cristina Fonseca (2002)
Exploiting the hallmarks of cancer: the future conquest of breast cancer.
G. Sledge (2003)
Targeting tumor angiogenesis with gene therapy.
Q. Chen (2001)
VIP grafted sterically stabilized liposomes for targeted imaging of breast cancer: in vivo studies.
S. Dagar (2003)
Development of polymeric nanoparticulate drug delivery systems: evaluation of nanoparticles based on biotinylated poly(ethylene glycol) with sugar moiety.
I. Kim (2003)
Tumour targeted delivery of encapsulated dextran-doxorubicin conjugate using chitosan nanoparticles as carrier.
S. Mitra (2001)
Biodistribution of fluoresceinated dextran using novel nanoparticles evading reticuloendothelial system.
U. Gaur (2000)
New developments in angiogenesis: a major mechanism for tumor growth and target for therapy.
A. Jones (1998)
Endothelial proliferation in tumours and normal tissues: continuous labelling studies.
B. Hobson (1984)
Tumour vasculature as a target for anticancer therapy.
M. Eatock (2000)
This paper is referenced by
Synthesis and characterization of novel core-shell colloidal particles ZnO/poly(ethylcyanoacrylate)
G. Yordanov (2009)
Idarubicin-loaded folic acid conjugated magnetic nanoparticles as a targetable drug delivery system for breast cancer.
U. Gunduz (2014)
Bioactive and Therapeutic ROMP Polymers
D. Smith (2007)
Quantitative estimation of gold nanoshell concentrations in whole blood using dynamic light scattering.
H. Xie (2007)
Pharmacokinetics and biodistribution of nanoparticles.
Shyh-Dar Li (2008)
Polysaccharide-gold nanoparticles as anticancer drugs carriers
Mireia Vila Gasull (2011)
A Liposomal Formulation Able to Incorporate a High Content of Paclitaxel and Exert Promising Anticancer Effect
P. Kan (2011)
INTRACELLULAR TRANSPORT IN CANCER TREATMENTS: CARBON NANOHORNS CONJUGATED TO QUANTUM DOTS AND CHEMOTHERAPEUTIC AGENTS
Kristen A. Zimmermann (2012)
Design and synthesis of multifunctional polymeric micelles for gene-directed enzyme prodrug therapy
Alicia J. Sawdon (2014)
Caractérisation physico-chimique, au niveau nanométrique, des surfaces de biomatériaux utilisés pour la délivrance de médicaments et pour la croissance osseuse
Rodrigo de Oliveira França (2014)
TARGETING OF ANTI CANCER DRUGS THROUGH NANOPARTICLES
B. S. H. Sagar (2015)
Synthesis of polymeric nanoparticles for the controlled release of hydrophobic and hydrophillic therapeutic compounds
Jiang Xu (2016)
Trimethyl chitosan nanoparticles for the delivery of monoclonal antibodies against hepatocellular carcinoma cells
Preeyanat Vongchana (2011)
Advances in the synthesis and application of nanoparticles for drug delivery.
W. Park (2015)
Plasmid pORF-hTRAIL targeting to glioma using transferrin-modified polyamidoamine dendrimer
S. Gao (2016)
"NANOTECHNOLOGY" THE NEW FATE OF THERAPY IN CANCER”
Rajeev Kumar Jha (2017)
Potential applications of boron nitride nanotubes as drug delivery systems
G. Ciofani (2010)
Modification of a DNA Vaccine for Oral Administration in Fish for Aquaculture by Using Non-Microbial Nanoparticles
A. Mandal (2010)
Bionano Electronics: Magneto-Electric Nanoparticles for Drug Delivery, Brain Stimulation and Imaging Applications
R. Guduru (2013)
Polyelectrolyte coated PLGA nanoparticles: templation and release behavior.
J. Zhou (2009)
Nanotechnology in cancer treatment
M. Mironidou-Tzouveleki (2011)
NUMERICAL SIMULATION ON THE EFFECTS OF DRUG RELEASE POSITIONS IN HEPATIC PORTAL VEIN FOR TARGETING THERAPY
Y. Chen (2015)
Stored luminescence computed tomography.
Wenxiang Cong (2014)
A concise review on cancer treatment methods and delivery systems
Elham Bidram (2019)
PLGA-Loaded Gold-Nanoparticles Precipitated with Quercetin Downregulate HDAC-Akt Activities Controlling Proliferation and Activate p53-ROS Crosstalk to Induce Apoptosis in Hepatocarcinoma Cells
Kausik Bishayee (2015)
Advances in Dental Materials through Nanotechnology: Facts, Perspectives and Toxicological Aspects.
G. C. Padovani (2015)
Multifunctional Magnetic Liposomes for Cancer Imaging and Therapeutic Applications
Manashjit Gogoi (2016)
Nanotechnology for cancer therapy
K. C. Patil (2016)
Folate-targeted star-shaped cationic copolymer co-delivering docetaxel and MMP-9 siRNA for nasopharyngeal carcinoma therapy
T. Liu (2016)
Recent advances in physiologically based pharmacokinetic and pharmacodynamic models for anticancer nanomedicines
J. Byun (2020)
Nanocristaux à luminescence persistante : nouveaux concepts pour l'imagerie in vivo
T. Maldiney (2012)
Anti-CD8 conjugated nanoparticles to target mammalian cells expressing CD8.
A. Bicho (2010)See more