Online citations, reference lists, and bibliographies.
← Back to Search

Dendrimers In Biomedical Applications--reflections On The Field.

Sönke Svenson, D. Tomalia
Published 2005 · Biology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
The formation of particulate systems with well-defined sizes and shapes is of eminent interest in certain medical applications such as drug delivery, gene transfection, and imaging. The high level of control possible over the architectural design of dendrimers; their size, shape, branching length/density, and their surface functionality, clearly distinguishes these structures as unique and optimum carriers in those applications. The bioactive agents may be encapsulated into the interior of the dendrimers or chemically attached/physically adsorbed onto the dendrimer surface, with the option of tailoring the carrier to the specific needs of the active material and its therapeutic applications. In this regard, the high density of exo-presented surface groups allows attachment of targeting groups or functionality that may modify the solution behavior or toxicity of dendrimers. Quite remarkably, modified dendrimers have been shown to act as nano-drugs against tumors, bacteria, and viruses. Recent successes in simplifying and optimizing the synthesis of dendrimers such as the 'lego' and 'click' approaches, provide a large variety of structures while at the same time reducing the cost of their production. The reflections on biomedical applications of dendrimers given in this review clearly demonstrate the potential of this new fourth major class of polymer architecture and indeed substantiate the high hopes for the future of dendrimers.
This paper references
10.1016/S0168-3659(02)00087-1
Transepithelial transport of poly(amidoamine) dendrimers across Caco-2 cell monolayers.
M. Elsayed (2002)
10.1021/MA010363Z
Location of the Outer Shell and Influence of pH on Carboxylic Acid-Functionalized Poly(propyleneimine) Dendrimers
I. Rietveld (2001)
10.1021/BC0000583
Synthesis of polyamidoamine dendrimers having poly(ethylene glycol) grafts and their ability to encapsulate anticancer drugs.
C. Kojima (2000)
10.1021/BM010079F
Poly(amidoamine)s as potential nonviral vectors: ability to form interpolyelectrolyte complexes and to mediate transfection in vitro.
S. Richardson (2001)
10.1007/3-540-45010-6_7
Artificial Multivalent Sugar Ligands to Understand and Manipulate Carbohydrate-Protein Interactions
T. Lindhorst (2002)
10.1021/CR960373B
Steroids in Molecular Recognition.
P. Wallimann (1997)
10.1021/BC990036K
DNA complexing with polyamidoamine dendrimers: implications for transfection.
A. Bielinska (1999)
10.1016/S0021-9673(98)00419-1
Slab-gel and capillary electrophoretic characterization of polyamidoamine dendrimers
L. Piehler (1998)
10.1016/0730-725X(94)00100-H
Biodistribution and metabolism of targeted and nontargeted protein-chelate-gadolinium complexes: evidence for gadolinium dissociation in vitro and in vivo.
F. N. Franano (1995)
10.1021/JA00120A032
The dendritic box, shape-selective liberation of encapsulated guests
J. Jansen (1995)
10.1124/MOL.58.5.1100
Polyanionic (i.e., polysulfonate) dendrimers can inhibit the replication of human immunodeficiency virus by interfering with both virus adsorption and later steps (reverse transcriptase/integrase) in the virus replicative cycle.
M. Witvrouw (2000)
10.1081/MC-120023912
Dendrimeric Supramolecular and Supramacromolecular Assemblies
D. Tomalia (2003)
10.1016/J.JCONREL.2003.09.005
Synthesis and characterization of branched poly(L-glutamic acid) as a biodegradable drug carrier.
W. Tansey (2004)
10.1016/S0040-4020(03)00435-6
Dendritic encapsulation-roles of cores and branches
T. L. Chasse (2003)
10.1021/BC0498572
Multimodality in vivo molecular-genetic imaging.
M. Doubrovin (2004)
10.1021/JA963874N
Synthesis of New α-Thiosialodendrimers and Their Binding Properties to the Sialic Acid Specific Lectin from Limax flavus
D. Zanini (1997)
10.1016/S0168-3659(99)00246-1
Dendrimers: relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of 125I-labelled polyamidoamine dendrimers in vivo.
N. Malik (2000)
10.1002/(SICI)1522-2586(199902)9:2<348::AID-JMRI30>3.0.CO;2-J
Synthesis and relaxometry of high‐generation (G = 5, 7, 9, and 10) PAMAM dendrimer‐DOTA‐gadolinium chelates
L. Bryant (1999)
10.1038/nature00877
Synthetic hosts by monomolecular imprinting inside dendrimers
S. Zimmerman (2002)
10.1021/BK-2004-0879
Carrier-based drug delivery
Sönke Svenson (2004)
10.1016/S0939-6411(00)00088-6
Cellular delivery of antisense oligonucleotides.
I. Lebedeva (2000)
10.1021/JA001225C
Folding Dendrons: The Development of Solvent-, Temperature-, and Generation-Dependent Chiral Conformational Order in Intramolecularly Hydrogen-Bonded Dendrons
Janosch Recker (2000)
10.1083/JCB.149.4.825
DNA Dendrimers Localize Myod mRNA in Presomitic Tissues of the Chick Embryo
J. Gerhart (2000)
10.1128/AAC.44.9.2471-2474.2000
Dendrimers, a New Class of Candidate Topical Microbicides with Activity against Herpes Simplex Virus Infection
N. Bourne (2000)
10.1002/1521-3765(20020301)8:5<1040::AID-CHEM1040>3.0.CO;2-D
The impact of rigidity and water exchange on the relaxivity of a dendritic MRI contrast agent.
G. Nicolle (2002)
10.1162/153535003765276237
Dendrimer-based macromolecular MRI contrast agents: characteristics and application.
Hisataka Kobayashi (2003)
10.1016/S1359-6446(01)01757-3
Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications.
R. Esfand (2001)
10.1021/BM025562K
Stepwise self-assembled poly(amidoamine) dendrimer and poly(styrenesulfonate) microcapsules as sustained delivery vehicles.
A. J. Khopade (2002)
10.1002/1521-3773(20010105)40:1<74::AID-ANIE74>3.0.CO;2-C
Dendritic Encapsulation of Function: Applying Nature's Site Isolation Principle from Biomimetics to Materials Science.
S. Hecht (2001)
10.1211/0022357021771887
Vehicles for oligonucleotide delivery to tumours
C. Dass (2002)
10.1152/PHYSIOLGENOMICS.2000.3.2.93
A novel, sensitive detection system for high-density microarrays using dendrimer technology.
R. Stears (2000)
10.1002/(SICI)1521-3773(19990401)38:7<884::AID-ANIE884>3.0.CO;2-K
Dendrimers: From Design to Application-A Progress Report.
M. Fischer (1999)
10.1016/S0168-3659(01)00357-1
Evaluation of polyplexes as gene transfer agents.
C. Gebhart (2001)
10.1021/LA030004S
Protein−Ligand Interactions at Poly(amidoamine) Dendrimer Monolayers on Gold
Mi-Young Hong (2003)
10.1023/A:1016458104359
The Lower-Generation Polypropylenimine Dendrimers Are Effective Gene-Transfer Agents
Bernd H. Zinselmeyer (2004)
10.1021/CR970414J
Dendrimers containing heteroatoms (si, p, B, ge, or bi).
J. Majoral (1999)
10.1021/BC0155824
Dendrimers as carrier protein mimetics for IgE antibody recognition. Synthesis and characterization of densely penicilloylated dendrimers.
F. Sánchez-Sancho (2002)
10.1021/NL034957M
Designed Dendrimer Syntheses by Self-Assembly of Single-Site, ssDNA Functionalized Dendrons
C. Demattei (2004)
10.1016/S0168-3659(03)00200-1
Dendrimer-mediated transdermal delivery: enhanced bioavailability of indomethacin.
A. Chauhan (2003)
10.1016/S0070-2137(01)80007-8
Thiol-based antioxidants.
S. M. Deneke (2000)
10.1097/00001813-199909000-00010
Dendrimer-platinate: a novel approach to cancer chemotherapy.
N. Malik (1999)
10.1021/CR980440X
Gadolinium(III) Chelates as MRI Contrast Agents: Structure, Dynamics, and Applications.
P. Caravan (1999)
10.1023/A:1020398624602
Design and Function of a Dendrimer-Based Therapeutic Nanodevice Targeted to Tumor Cells Through the Folate Receptor
A. Quintana (2004)
10.1021/JA047864V
Optimizing saccharide-directed molecular delivery to biological receptors: design, synthesis, and biological evaluation of glycodendrimer-cyclodextrin conjugates.
J. M. Benito (2004)
10.1016/J.PROGPOLYMSCI.2004.04.001
Chemically modified chitin and chitosan as biomaterials
H. Sashiwa (2004)
10.1016/S0925-8388(96)02830-7
Gadolinium(III) DO3A macrocycles and polyethylene glycol coupled to dendrimers : Effect of molecular weight on physical and biological properties of macromolecular magnetic resonance imaging contrast agents
L. Margerum (1997)
10.1002/MRM.1910310102
Dendrimer‐based metal chelates: A new class of magnetic resonance imaging contrast agents
E. C. Wiener (1994)
10.1021/NL020246X
Novel Iodinated Dendritic Nanoparticles for Computed Tomography (CT) Imaging
A. Yordanov (2002)
10.1081/DIS-120030657
Self‐Assembly and Self‐Organization: Important Processes, But Can We Predict Them?
Sönke Svenson (2004)
Comparative study of the photosensitization of Jurkat cells in vitro by pheophorbide-a and a pheophorbide-a diaminobutane poly-propylene-imine dendrimer complex
A. Paul (2003)
10.1002/1097-0142(19940501)73:9<2432::AID-CNCR2820730929>3.0.CO;2-S
Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications
J. Ross (1994)
10.1002/mrm.1214
Novel intravascular macromolecular MRI contrast agent with generation‐4 polyamidoamine dendrimer core: Accelerated renal excretion with coinjection of lysine
H. Kobayashi (2001)
10.1002/(SICI)1097-4636(199601)30:1<53::AID-JBM8>3.0.CO;2-Q
Preliminary biological evaluation of polyamidoamine (PAMAM) Starburst dendrimers.
J. Roberts (1996)
10.1021/MA035983+
Multivalent Contrast Agents Based on Gadolinium-Diethylenetriaminepentaacetic Acid-Terminated Poly(propylene imine) Dendrimers for Magnetic Resonance Imaging
S. Langereis (2004)
10.1016/S0040-4020(03)00437-X
Dendrimers as potential drug carriers; encapsulation of acidic hydrophobes within water soluble PAMAM derivatives
A. Beezer (2003)
10.1016/S1461-5347(00)00273-X
The use of PAMAM dendrimers in the efficient transfer of genetic material into cells.
Eichman (2000)
10.1002/ANIE.200453707
Multivalency in the gas phase: the study of dendritic aggregates by mass spectrometry.
M. Broeren (2004)
10.1002/HLCA.19960790320
Dendrophanes: Novel Steroid‐Recognizing Dendritic Receptors. Preliminary Communication
Peter Wallimann (1996)
10.1016/S0040-4039(00)01488-X
Utilization of dendritic framework as a multivalent ligand: a functionalized gadolinium(III) carrier with glycoside cluster periphery
M. Takahashi (2000)
10.1021/BC025663F
Synthesis of novel cationic lipids having polyamidoamine dendrons and their transfection activity.
Toshinari Takahashi (2003)
10.1021/JA002824M
Structure and conformation of DAB dendrimers in solution via multidimensional NMR techniques.
M. Chai (2001)
10.1021/BC025586O
Synthesis and biological evaluation of folate receptor-targeted boronated PAMAM dendrimers as potential agents for neutron capture therapy.
Supriya Shukla (2003)
10.1021/BC025633C
Macromolecular MRI contrast agents with small dendrimers: pharmacokinetic differences between sizes and cores.
Hisataka Kobayashi (2003)
10.1021/JA002596W
Synthesis of N,N'-bis(acrylamido)acetic acid-based T-antigen glycodendrimers and their mouse monoclonal IgG antibody binding properties.
R. Roy (2001)
10.1021/BC000111N
Enhancement of gene expression by polyamidoamine dendrimer conjugates with α-, β-, and γ-cyclodextrins
Hidetoshi Arima (2001)
10.1038/SCIENTIFICAMERICAN0295-62
Manic-depressive illness and creativity.
K. Jamison (1995)
10.1021/JA980619P
Dendritic Nucleic Acid Probes for DNA Biosensors
J. Wang (1998)
10.1021/BC970048A
Terminal groups in Starburst dendrimers: activation and reactions with proteins.
P. Singh (1998)
10.1002/ANIE.200250827
Dendrimer design: how to circumvent the dilemma of a reduction of steps or an increase of function multiplicity?
V. Maraval (2003)
10.1021/NL005502P
Dendrimer−Silver Complexes and Nanocomposites as Antimicrobial Agents
L. Balogh (2001)
DENDRONS, DENDRIMERS AND DENDRIGRAFTS
D. Tomalia (1997)
10.1021/BC010027N
Synthesis and biological studies of 5-aminolevulinic acid-containing dendrimers for photodynamic therapy.
S. Battah (2001)
10.1002/1439-7633(20020902)3:9<836::AID-CBIC836>3.0.CO;2-2
Inhibition of Adhesion of Type 1 Fimbriated Escherichia coli to Highly Mannosylated Ligands
N. Nagahori (2002)
10.1093/NAR/28.21.4225
Enhanced delivery of antisense oligonucleotides with fluorophore-conjugated PAMAM dendrimers.
H. Yoo (2000)
10.1021/BC990082K
Design of dendritic macromolecules containing folate or methotrexate residues.
K. Kono (1999)
10.1021/JO0344438
"Lego" chemistry for the straightforward synthesis of dendrimers.
V. Maraval (2003)
10.1038/sj.gt.3300886
Activated polyamidoamine dendrimers, a non-viral vector for gene transfer to the corneal endothelium
T. Hudde (1999)
10.1021/JO001573X
Synthesis and properties of new thiourea-functionalized poly(propylene imine) dendrimers and their role as hosts for urea functionalized guests.
U. Boas (2001)
10.1016/S0959-440X(96)80037-6
Syntheses and some applications of chemically defined multivalent glycoconjugates.
R. Roy (1996)
10.1016/S0928-0987(00)00068-3
A lipid carrier with a membrane active component and a small complex size are required for efficient cellular delivery of anti-sense phosphorothioate oligonucleotides.
I. Jääskeläinen (2000)
10.1002/HLCA.19970800603
Dendrimers with Porphyrin Cores: Synthetic models for globular heme proteins
P. J. Dandliker (1997)
10.1021/CR970069Y
About Dendrimers: Structure, Physical Properties, and Applications.
A. W. Bosman (1999)
10.1016/S0040-4039(98)02680-X
The synthesis of water soluble dendrimers, and their application as possible drug delivery systems
L. Twyman (1999)
10.1016/S0378-5173(00)00534-2
DNA transfection and transfected cell viability using amphipathic asymmetric dendrimers.
D. Shah (2000)
10.1021/MA010354Q
Structural Molecular Dynamics Studies on Polyamidoamine Dendrimers for a Therapeutic Application: Effects of pH and Generation
I. Lee (2002)
10.1021/BM034051A
Synthesis and properties of star-shaped polylactide attached to poly(amidoamine) dendrimer.
Q. H. Cai (2003)
10.1002/(SICI)1521-3773(19991102)38:21<3215::AID-ANIE3215>3.0.CO;2-S
Dendritic Iron Porphyrins with Tethered Axial Ligands: New Model Compounds for Cytochromes.
Weyermann (1999)
10.1016/S0142-9612(02)00445-3
In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis.
D. Fischer (2003)
10.1007/3-540-44924-8_5
Structure of Dendrimers in Dilute Solution
M. Ballauff (2001)
10.1002/jgm.319
Optimisation of dendrimer‐mediated gene transfer by anionic oligomers
A. Maksimenko (2003)
10.1002/ANIE.199001381
Starburst Dendrimers: Molecular‐Level Control of Size, Shape, Surface Chemistry, Topology, and Flexibility from Atoms to Macroscopic Matter
D. Tomalia (1990)
10.1021/MA00163A029
Dendritic macromolecules: synthesis of starburst dendrimers
D. Tomalia (1986)
10.1021/JA035515F
Structural effects on encapsulation as probed in redox-active core dendrimer isomers.
T. L. Chasse (2003)
10.1016/J.IJPHARM.2004.07.006
The effect of PAMAM dendrimer generation size and surface functional group on the aqueous solubility of nifedipine.
B. Devarakonda (2004)
10.1002/ANIE.200454078
Efficiency and fidelity in a click-chemistry route to triazole dendrimers by the copper(i)-catalyzed ligation of azides and alkynes.
P. Wu (2004)
10.1021/JA031698U
Glycodendriproteins: a synthetic glycoprotein mimic enzyme with branched sugar-display potently inhibits bacterial aggregation.
P. M. Rendle (2004)
10.1002/(SICI)1522-2586(199902)9:2<204::AID-JMRI8>3.0.CO;2-M
MRI of acute myocardial ischemia: Comparing a new contrast agent, Gd‐DTPA‐24‐cascade‐polymer, with Gd‐DTPA
H. Roberts (1999)
10.1021/LA9620263
Dendrimers with Hydrophobic Cores and the Formation of Supramolecular Dendrimer−Surfactant Assemblies
D. Watkins (1997)
10.1039/A806596I
Dendritic hydrogen bonding receptors: enantiomerically pure dendroclefts for the selective recognition of monosaccharides
D. Smith (1998)
10.1016/S0040-4020(03)00431-9
A new class of protein mimics: preparation and electrophoretic properties of polycationic β-alanine-based dendrimers
H. Chow (2003)
10.1021/BC0340464
Poly(l-glutamic acid) Gd(III)-DOTA conjugate with a degradable spacer for magnetic resonance imaging.
Zheng-Rong Lu (2003)
10.1016/S0040-4020(03)00461-7
Peptide-functionalized polyphenylene dendrimers
Andreas Herrmann (2003)
10.1021/JA028100N
Designing macromolecules for therapeutic applications: polyester dendrimer-poly(ethylene oxide) "bow-tie" hybrids with tunable molecular weight and architecture.
E. Gillies (2002)
10.1021/AR000044C
Structure-property relationships in dendritic encapsulation.
C. Gorman (2001)
10.1016/S0968-0896(01)00248-6
Synthesis and protein binding properties of T-antigen containing GlycoPAMAM dendrimers.
Myung-Gi Baek (2002)
10.1016/S1389-0352(01)00065-4
Glycodendrimers: novel glycotope isosteres unmasking sugar coding. case study with T-antigen markers from breast cancer MUC1 glycoprotein.
R. Roy (2002)
10.1023/A:1016044609972
Evaluation of Adjuvants that Enhance the Effectiveness of Antisense Oligodeoxynucleotides
J. Hughes (2004)
10.1038/nbt995
Polyvalent dendrimer glucosamine conjugates prevent scar tissue formation
S. Shaunak (2004)
10.1016/S0378-5173(02)00623-3
The influence of surface modification on the cytotoxicity of PAMAM dendrimers.
R. Jevprasesphant (2003)
10.1002/1521-3773(20020415)41:8<1329::AID-ANIE1329>3.0.CO;2-P
Dendritic polymers in biomedical applications: from potential to clinical use in diagnostics and therapy.
Salah-Eddine Stiriba (2002)
10.1039/A801510D
Synthesis of highly functionalised dendrimers based on polyhedral silsesquioxane cores
P. Jaffrès (1998)
10.1002/mrm.1257
Positive effects of polyethylene glycol conjugation to generation‐4 polyamidoamine dendrimers as macromolecular MR contrast agents
H. Kobayashi (2001)
10.1002/MASY.19961010128
Starburstr̀ dendrimers — Nanoscopic supermolecules according to dendritic rules and principles
D. Tomalia (1996)
10.1021/JA00188A079
Starburst dendrimers. 5. Molecular shape control
Adel M. Naylor (1989)
10.1021/MA000791P
Unusual pH-Dependent Polarity Changes in PAMAM Dendrimers: Evidence for pH-Responsive Conformational Changes
Wei Chen (2000)
10.1016/S0040-4020(03)00432-0
Dendrimers with tetrabenzoporphyrin cores: near infrared phosphors for in vivo oxygen imaging
I. Rietveld (2003)
10.1016/J.PROGPOLYMSCI.2005.01.007
Birth of a new macromolecular architecture: dendrimers as quantized building blocks for nanoscale synthetic polymer chemistry
D. Tomalia (2005)
10.1002/ANIE.200250284
Amphiphilic dendrimers: novel self-assembling vectors for efficient gene delivery.
Derk Joester (2003)
10.1021/BC0498370
Estimating the number of bound waters in Gd(III) complexes revisited. Improved methods for the prediction of q-values.
B. Hay (2004)
10.1016/S0040-4020(03)00459-9
Synthesis and chiroptical properties of a new type of chiral depsipeptide dendrons
Boris Buschhaus (2003)
10.4052/TIGG.16.243
Interference with Lectin Binding and Bacterial Adhesion by Multivalent Carbohydrates and Peptidic Carbohydrate Mimics
R. Pieters (2004)
10.1021/BM030021W
Synthesis of a chitosan-dendrimer hybrid and its biodegradation.
H. Sashiwa (2003)
10.1016/J.COCIS.2004.06.008
Controlling surfactant self-assembly
Sönke Svenson (2004)
10.1016/S1389-0352(01)00064-2
Design, functional evaluation and biomedical applications of carbohydrate dendrimers (glycodendrimers).
K. Bezouška (2002)
10.1016/S1461-5347(99)00203-5
Designing dendrimers for drug delivery.
Liu (1999)
10.1016/S0142-9612(02)00036-4
Interactions between dendrimer biocides and bacterial membranes.
C. Chen (2002)
10.1002/1439-7633(20011105)2:11<822::AID-CBIC822>3.0.CO;2-W
Wedgelike Glycodendrimers as Inhibitors of Binding of Mammalian Galectins to Glycoproteins, Lactose Maxiclusters, and Cell Surface Glycoconjugates
S. André (2001)
10.1016/S0378-5173(03)00225-4
Drug complexation, in vitro release and cellular entry of dendrimers and hyperbranched polymers.
P. Kolhe (2003)
10.1021/BC010103M
Polyester dendritic systems for drug delivery applications: in vitro and in vivo evaluation.
O. L. Padilla De Jesús (2002)
10.1016/J.TET.2003.10.070
Antibacterial single-bead screening
S. Lebreton (2003)
10.1039/CC9960001523
A dendritic iron porphyrin as a novel haemoprotein mimic: effects of the dendrimer cage on dioxygen-binding activity
Donglin Jiang (1996)
10.1021/JA970859P
Di-, Tri-, and Tetravalent Dendritic Galabiosides That Inhibit Hemagglutination by Streptococcus suis at Nanomolar Concentration
H. C. Hansen (1997)
10.1039/B309043B
Dendrimers in drug research.
U. Boas (2004)
10.1126/science.266.5188.1226
Encapsulation of Guest Molecules into a Dendritic Box
J. Jansen (1994)
10.1016/S0378-5173(03)00391-0
Transport mechanism(s) of poly (amidoamine) dendrimers across Caco-2 cell monolayers.
M. Elsayed (2003)
10.1016/S0378-5173(03)00132-7
A PEGylated dendritic nanoparticulate carrier of fluorouracil.
D. Bhadra (2003)
10.1007/s002590000293
Monoclonal antibody-dendrimer conjugates enable radiolabeling of antibody with markedly high specific activity with minimal loss of immunoreactivity
Hisataka Kobayashi (2000)
10.1021/BM0055495
Quaternary ammonium functionalized poly(propylene imine) dendrimers as effective antimicrobials: structure-activity studies.
C. Chen (2000)
10.1039/A700860K
Hydrophobically modified poly(amidoamine) (PAMAM) dendrimers: their properties at the air–water interface and use as nanoscopic container molecules
Yasmin Sayed-Sweet (1997)
10.1002/(SICI)1099-1387(199905)5:5<203::AID-PSC181>3.0.CO;2-N
Peptide and glycopeptide dendrimers. Part II
P. Vepr̆ek (1999)
10.1016/J.JCONREL.2003.05.002
Polyion complex micelles entrapping cationic dendrimer porphyrin: effective photosensitizer for photodynamic therapy of cancer.
Guo-Dong Zhang (2003)
10.1002/1521-3927(20020401)23:5/6<332::AID-MARC332>3.0.CO;2-I
Poly(amido‐amine)s: Biomedical Applications
P. Ferruti (2002)
10.1021/BC025597H
Light-harvesting ionic dendrimer porphyrins as new photosensitizers for photodynamic therapy.
N. Nishiyama (2003)
10.1038/sj.gt.3300454
The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes
M. Tang (1997)
10.1023/A:1011958726518
Antisense Pharmacodynamics: Critical Issues in the Transport and Delivery of Antisense Oligonucleotides
R. Juliano (2004)
10.1021/BC015525A
In vitro gene transfection using dendritic poly(L-lysine).
M. Ohsaki (2002)
10.1016/S0166-3542(02)00054-2
Evidence of dual sites of action of dendrimers: SPL-2999 inhibits both virus entry and late stages of herpes simplex virus replication.
Y. Gong (2002)
10.1021/CR000418F
The cluster glycoside effect.
J. J. Lundquist (2002)
10.1002/(SICI)1522-2675(19990804)82:8<1225::AID-HLCA1225>3.0.CO;2-V
Dendroclefts: Optically Active Dendritic Receptors for the Selective Recognition and Chiroptical Sensing of Monosaccharide Guests
D. Smith (1999)
10.1021/JA9536126
MOLECULAR DYNAMICS OF ION-CHELATE COMPLEXES ATTACHED TO DENDRIMERS
E. Wiener (1996)
10.1021/JA00177A027
Preparation of polymers with controlled molecular architecture. A new convergent approach to dendritic macromolecules
C. Hawker (1990)



This paper is referenced by
Synthesis and cytotoxic activity of G3 PAMAM-NH(2) dendrimer-modified digoxin and proscillaridin A conjugates in breast cancer cells.
K. Winnicka (2010)
10.1016/j.ijpharm.2009.06.035
Ethylendiamine core PAMAM dendrimers/siRNA complexes as in vitro silencing agents.
A. Perez (2009)
Etude de l'interaction de dendrimères phosphorés avec les monocytes humains : recherche de récepteur (s)
Jérémy Le Dall (2015)
6 Dendrimers as Antibacterial Agents
M. Tülü (2018)
10.1039/C5PY01283J
Multifaceted glycodendrimers with programmable bioactivity through convergent, divergent, and accelerated approaches using polyfunctional cyclotriphosphazenes
Leïla Abbassi (2015)
10.1039/c3dt53535e
Porphyrins with a carbosilane dendrimer periphery as synthetic components for supramolecular self-assembly.
Zakariyya N. Ishtaiwi (2014)
10.1016/j.bmc.2016.11.028
Synthesis and binding monitoring of a new nanomolar PAMAM-based matrix metalloproteinases inhibitor (MMPIs).
L. Cerofolini (2017)
10.1080/21655979.2020.1736240
Advanced in developmental organic and inorganic nanomaterial: a review.
K. Khalid (2020)
Title Photoinduced Electron Transfer of PAMAM Dendrimer-Zinc ( II ) PorphyrinAssociates at Polarized Liquid ¦ Liquid Interfaces
Hirohisa Nagatani (2017)
10.1021/bm200658b
Sonoproduction of liposomes and protein particles as templates for delivery purposes.
R. Silva (2011)
10.1186/1556-276X-9-247
Dendrimers: synthesis, applications, and properties
E. Abbasi (2014)
10.1002/ANGE.200902672
Anwendung von Poly(ethylenglycol) beim Wirkstoff‐Transport: Vorteile, Nachteile und Alternativen
K. Knop (2010)
10.1517/17425247.5.5.593
Polymer conjugates as therapeutics: future trends, challenges and opportunities
M. J. Vicent (2008)
10.2147/IJN.S7681
Progress in antiretroviral drug delivery using nanotechnology
R. Mallipeddi (2010)
10.1002/POLA.24784
Versatile synthesis of asymmetrical dendron‐like/dendron‐like poly(ε‐caprolactone)‐b‐poly(γ‐benzyl‐L‐glutamate) block copolymers
Wei Liu (2011)
10.1016/j.addr.2011.06.016
The effects of polymeric nanostructure shape on drug delivery.
Shrinivas Venkataraman (2011)
10.1021/JP2093077
Photodynamic Behavior of Heteroleptic Ir(III) Complexes with Carbazole-Functionalized Dendrons Associated with Efficient Electron Transfer Processes
A. R. Hwang (2012)
10.1039/C1NJ20481E
Dendrimers as bactericides
A. Castonguay (2012)
10.1517/17425247.2012.668522
Advancement in multifunctional nanoparticles for the effective treatment of cancer
Mahfoozur Rahman (2012)
10.1016/J.COLSURFA.2013.01.047
Analytical model study of complexation of dendrimer as an ion penetrable sphere with DNA
Khawla Qamhieh (2014)
10.1517/17425247.2015.970162
Potential nanotechnologies and molecular targets in the quest for efficient chemotherapy in ovarian cancer
Khadija Rhoda (2015)
Quantificação eletroquímica de analitos de interesse ambiental e biológico, empregando novos materiais preparados a partir de silsesquioxanos funcionalizados
Daniela Silvestrini Fernandes (2015)
10.1002/CNMA.201500018
Amino Acid‐Dependent Host–Guest Interaction: Polyglycerol Dendrimer of Generation 3 Encapsulates Amino Acids Bearing Two Amino Groups
Tooru Ooya (2015)
10.1016/J.JCIS.2007.02.087
Conformation and distribution of groups on the surface of amphiphilic polyether-co-polyester dendrimers: effect of molecular architecture.
R. S. Dhanikula (2007)
Dendrimers : Synthesis, Characterization and Use in Thiol-Ene Networks
C. Nilsson (2008)
10.1016/J.CATCOM.2008.01.009
The application of novel dendritic nickel catalysts in the oligomerization of ethylene
R. Malgas (2008)
10.2174/156802608785849012
Dendrimers as biopharmaceuticals: synthesis and properties.
C. Villalonga-Barber (2008)
10.1038/ncpcardio1242
Multimodality nanotracers for cardiovascular applications
W. J. Mulder (2008)
10.1021/nn800098j
Self-assembly and electrochemical oxidation of polyamidoamine-carbazole dendron surfmer complexes: nanoring formation.
Chatthai Kaewtong (2008)
10.1016/J.ELECTACTA.2008.04.081
Spectroelectrochemical analysis of ion-transfer and adsorption of the PAMAM dendrimer at a polarized liquid|liquid interface
H. Nagatani (2008)
10.1016/j.niox.2009.11.002
Reduced ischemia/reperfusion injury via glutathione-initiated nitric oxide-releasing dendrimers.
T. A. Johnson (2010)
10.1517/17425240903530651
Design of stimuli-responsive dendrimers
Chie Kojima (2010)
See more
Semantic Scholar Logo Some data provided by SemanticScholar