Online citations, reference lists, and bibliographies.
← Back to Search

The Results Of Amniotic Membrane Transplantation For Primary Pterygium Compared With Conjunctival Autograft.

N. Tananuvat, Tada Martin
Published 2004 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
PURPOSE To study the efficacy and safety of amniotic membrane transplantation as an adjunctive therapy after surgical excision of primary pterygium and to compare the clinical outcome with that of conjunctival autograft. METHODS Eighty-six eyes of 78 patients with primary pterygium were operated on by a single surgeon (N.T.). All patients were randomized to undergo amniotic membrane or conjunctival autograft transplantation as an adjuvant therapy after pterygium excision. Forty-four eyes in 39 patients were treated with amniotic membrane transplantation (AM group), and 42 eyes of 41 patients were treated with conjunctival autograft (CG group). Patients were followed up at 1 week, 1, 3, 6, and 12 months postoperation. The main outcome measurement was a recurrence rate after surgery. RESULTS The mean follow-up was 14.40 +/- 5.4 months in the AM group and 12.35 +/- 3.13 months in the CG group. There were 18 recurrences (40.9%) in the AM group and two (4.76%) in the CG group, which was significantly different among both groups (P < 0.007). The cumulative proportion that were recurrence-free at 12 months was 0.6 +/- 0.15 for the AM group and 0.95 +/- 0.07 for the CG group (P = 0.0003, Log-rank test). The cumulative nonrecurrence rate at 6 and 12 months in all patients stratified by age and sex was not significantly different (P = 0.28 and P = 0.9, Log-rank test). No major complications were observed in either group. CONCLUSION The surgical results of primary pterygium excision followed by amniotic membrane and conjunctival autograft transplantation were compared. It was found that amniotic membrane transplantation for pterygium surgery has an unacceptably high recurrence rate.
This paper references
Immunogenicity of human amniotic membrane epithelial cells after transplantation into volunteers
CA Akle (1981)
A randomized trial of conjunctival autograft transplantation for pterygium in the tropics
S. Lewallen (1989)
10.1056/NEJM200007133430202
Reconstruction of damaged corneas by transplantation of autologous limbal epithelial cells.
R. J. Tsai (2000)
10.1001/ARCHOPHT.1992.01080130101035
The long-term effects of visible light on the eye.
H. Taylor (1992)
10.1016/S0161-6420(95)30842-1
Cytologlogic Evidence of Corneal Diseases with Limbal Stem Cell Deficiency
V. Puangsricharern (1995)
Ocular surface transplantation techniques for pterygium surgery
Tan DTH (2000)
10.1016/S0161-6420(01)00599-1
Amniotic membrane transplantation in entropion surgery.
S. Ti (2001)
10.1016/S0161-6420(02)01160-0
Limbal versus conjunctival autograft transplantation for advanced and recurrent pterygium
Mashhoor F. Al Fayez (2002)
10.1073/PNAS.93.8.3509
Suppression of apoptosis by basement membrane requires three-dimensional tissue organization and withdrawal from the cell cycle.
N. Boudreau (1996)
10.1016/S0161-6420(00)00026-9
Amniotic membrane transplantation for ocular surface reconstruction in Stevens-Johnson syndrome.
S. Honavar (2000)
10.1111/J.1442-9071.2006.01195.X
Mitomycin C in the treatment of pterygium
L. Hirst (2006)
10.1016/s0161-6420(02)01160-0
Limbal versus conjunctival autograft transplantation for advanced and recurrent pterygium.
Mashhoor F Al Fayez (2002)
10.1136/bjo.84.9.973
Amniotic membrane graft for primary pterygium: comparison with conjunctival autograft and topical mitomycin C treatment
D. Ma (2000)
10.1902/JOP.1986.57.5.311
Chemotaxis of human gingival epithelial cells to laminin. A mechanism for epithelial cell apical migration.
V. P. Terranova (1986)
Expression of HLA antigens, B2microglobulin and enzymes by human amniotic membrane
M Adinofli (1982)
Personal approach to pterygium
RI Barraquer (2000)
Integrin a6/b4 complex is located in hemidesmosomes, suggesting a major role in epidermal cellbasement membrane adhesion
A Sonnenberg (1991)
10.1016/S0161-6420(00)00567-4
Amniotic membrane transplantation after extensive removal of primary and recurrent pterygia.
A. Solomon (2001)
Amniotic membrane transplantation for acute chemical and thermal burns
D Meller (2000)
10.1016/0002-9394(68)93082-1
Adhesion of regenerating corneal epithelium. The role of basement membrane.
A. Khodadoust (1968)
10.1001/ARCHOPHT.1940.00860130586006
PLASTIC REPAIR OF CONJUNCTIVAL DEFECTS WITH FETAL MEMBRANES
A. D. Rötth (1940)
10.1126/science.7531366
Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix
N. Boudreau (1995)
10.3928/1542-8877-20011101-05
Preserved human amniotic membrane transplantation in the treatment of primary pterygium.
N. Tekin (2001)
Conjunctival epithelial cell differentiation on amniotic membrane.
D. Meller (1999)
10.1016/S0161-6420(97)30057-8
Amniotic membrane transplantation for ocular surface reconstruction in patients with chemical and thermal burns.
J. Shimazaki (1997)
10.1016/S0161-6420(00)00024-5
Amniotic membrane transplantation for acute chemical or thermal burns.
D. Meller (2000)
10.1002/(SICI)1097-4652(199906)179:3<325::AID-JCP10>3.0.CO;2-X
Suppression of transforming growth factor‐beta isoforms, TGF‐β receptor type II, and myofibroblast differentiation in cultured human corneal and limbal fibroblasts by amniotic membrane matrix
S. C. Tseng (1999)
10.1016/S0002-9394(14)71962-2
Surgical reconstruction of the ocular surface in advanced ocular cicatricial pemphigoid and Stevens-Johnson syndrome.
K. Tsubota (1996)
10.1016/S0161-6420(89)32667-4
A randomized trial of conjunctival autografting for pterygium in the tropics.
S. Lewallen (1989)
10.1038/295325A0
Expression of HLA antigens, β2-microglobulin and enzymes by human amniotic epithelial cells
M. Adinolfi (1982)
10.1136/bjo.85.6.658
Amniotic membrane transplantation in the management of conjunctival malignant melanoma and primary acquired melanosis with atypia
D. Paridaens (2001)
10.1136/bjo.64.3.154
Aetiology of climatic droplet keratopathy and pterygium.
H. Taylor (1980)
Overexpression of collagenase (MMP-1) and stromelysin (MMP-3) by pterygium head fibroblasts.
D. Li (2001)
10.1001/ARCHOPHT.1997.01100160530001
Impression cytology study of epithelial phenotype of ocular surface reconstructed by preserved human amniotic membrane.
P. Prabhasawat (1997)
10.1016/S0002-9394(14)72602-9
A randomized trial comparing mitomycin C and conjunctival autograft after excision of primary pterygium.
P. Chen (1995)
10.1016/S0161-6420(97)30197-3
Comparison of conjunctival autografts, amniotic membrane grafts, and primary closure for pterygium excision.
P. Prabhasawat (1997)
10.1136/bjo.82.3.235
Transplantation of amniotic membrane and limbal autograft for patients with recurrent pterygium associated with symblepharon
J. Shimazaki (1998)
10.3109/02713689408999878
Immunohistochemical evidence that human pterygia originate from an invasion of vimentin-expressing altered limbal epithelial basal cells.
N. Dushku (1994)
10.1001/ARCHOPHT.1997.01100160405001
Effect of pterygium morphology on pterygium recurrence in a controlled trial comparing conjunctival autografting with bare sclera excision.
D. Tan (1997)
10.1016/S0002-9394(14)70125-4
Amniotic membrane transplantation for persistent epithelial defects with ulceration.
S. Lee (1997)
10.1001/ARCHOPHT.119.5.695
Pterygia pathogenesis: corneal invasion by matrix metalloproteinase expressing altered limbal epithelial basal cells.
N. Dushku (2001)
10.1083/JCB.113.4.907
Integrin alpha 6/beta 4 complex is located in hemidesmosomes, suggesting a major role in epidermal cell-basement membrane adhesion
A. Sonnenberg (1991)
The human amniotic membrane is a site MHC class 1b expression: evidence for the expression of HLA-E and HLA-G
JM Houlihan (1995)
Amniotic membrane transplantation after extensive removal of primary and recurrent pterygium
A Solomon (2001)
Cytologic evidence of corneal diseases with limbal stem cell deficiency.
V. Puangsricharern (1995)
10.1016/S0161-6420(99)90006-4
Conjunctival rotation autograft for pterygium. An alternative to conjunctival autografting.
A. Jap (1999)
The human amnion is a site of MHC class Ib expression: evidence for the expression of HLA-E and HLA-G.
J. Houlihan (1995)



This paper is referenced by
10.1177/112067210601600203
Limbal Conjunctival Mini-Autografting for Preventing Recurrence after Pterygium Surgery
H. Oğuz (2006)
Estudio de la película lagrimal y la superficie conjuntival después de la excisión del pterigion
Bibiana Calviño Louzao (2012)
10.4103/1119-3077.113463
Short term results of pterygium surgery with adjunctive amniotic membrane graft.
O. Okoye (2013)
[Amniotic membrane transplantation associated with conjunctival autograft for primary pterygium treatment].
A. G. Castellano (2005)
10.1007/s00417-011-1820-8
Comparison of conjunctival autograft transplantation and amniotic membrane transplantation for pterygium: a meta-analysis
Meiyan Li (2011)
10.1097/ICO.0000000000001453
Comparison of Pterygium Recurrence Rates Among Different Races and Ethnicities After Primary Pterygium Excision by Surgeons in Training
G. Campagna (2018)
10.4103/1596-3519.84695
Treatment of pterygium.
I. Mohammed (2011)
10.1016/j.ophtha.2012.06.021
Recurrence and complications after 1,000 surgeries using pterygium extended removal followed by extended conjunctival transplant.
L. Hirst (2012)
10.3341/JKOS.2012.53.2.215
Effectiveness of Wide Excision of Subconjucntival Fibrovascular Tissue with Conjunctivo-Limbal Autograft in Pterygium Surgery
S. Bae (2012)
10.1097/ICO.0b013e31823cbecb
Comparison of Pterygium Recurrence Rates After Limbal Conjunctival Autograft Transplantation and Other Techniques: Meta-analysis
Kangkeng Zheng (2012)
10.5152/JAREM.2015.550
New Limboconjunctival Flap Technique in the Surgical Treatment of Primary Pterygium: A Preliminary Report
Fadime Nuhoğlu (2015)
Comparison of the surgical outcome between Wet Amniotic Membrane Graft (Wet AMG), Conjunctival Autograft (CAG) and Topical Mitomycin C (MMC)
S. Daigavane (2017)
10.3341/JKOS.2009.50.12.1780
Recurrence Rates of Amniotic Membrane Transplantation, Conjunctival Autograft and Conjunctivolimbal Autograft in Primary Pterygium
C. Kim (2009)
10.1080/08820530902801106
Pterygia: Pathogenesis and the Role of Subconjunctival Bevacizumab in Treatment
J. Mauro (2009)
10.1159/000137670
Comparison of Mini-Flap Technique and Conjunctival Autograft Transplantation without Mitomycin C in Primary and Recurrent Pterygium
M. Kim (2008)
10.1111/aos.13176
Role of artificial tears in reducing the recurrence of pterygium after surgery: a prospective randomized controlled trial
Kosol Kampitak (2017)
10.3341/JKOS.2012.53.2.200
The Effectiveness of Mitomycin C on Pterygium Surgery with Amniotic Membrane Transplantation
S. Bae (2012)
10.17925/USOR.2007.03.00.35
Preserved Amniotic Membrane Transplantation for Ocular Surface Reconstruction
Alisa Kim (2012)
Excisão de Pterígio Primário com Autotransplante Conjuntival e Cola Biológica
F. Trincão (2011)
A Comparative Study of Complications and Recurrence of Pterygiumafter Primary Pterygium Excision with Auto- Conjunctival Graft versus Amniotic Membrane Graft
Dr N. Lakshmi Pradeesha (2020)
Efficacy and safety of conjunctival auto graft and amniotic membrane graft after primary pterygium
Dhuwadhapare Pravinkumar (2014)
10.1097/ICU.0b013e3281a7ecbb
Current concepts and techniques in pterygium treatment
L. Ang (2007)
10.1016/B978-0-323-04332-8.00055-X
Surgical Ocular Surface Reconstruction
V. Feiz (2009)
10.1089/jop.2011.0022
Preoperative subpterygial mitomycin C injection versus limbal conjunctival autograft transplantation for prevention of pterygium recurrence.
Sameh S Mandour (2011)
10.1016/S0246-0343(10)51825-2
Chirurgie des pathologies sévères de la surface oculaire
V. Borderie (2010)
10.1111/j.1442-9071.2006.01408.x
Amniotic membrane transplantation for ocular surface reconstruction: indications and outcomes
V. Maharajan (2007)
10.18240/ijo.2018.03.08
Clinical outcome of combined conjunctival autograft transplantation and amniotic membrane transplantation in pterygium surgery.
Tejsu Malla (2018)
10.3341/JKOS.2016.57.12.1866
The Effect of Inferior Conjunctival Transposition Flap for Recurrent Pterygium
S. Y. Kim (2016)
10.1159/000336452
Corneal Melting Two Weeks after Pterygium Excision with Topical Mitomycin C: Successfully Treated with Lamellar Keratoplasty and Amnion Membrane Transplantation
M. Menghini (2012)
10.1097/ICO.0000000000000597
Low Recurrence Rate of Pterygium After Excision With Conjunctival Limbal Autograft: A Retrospective Study With Long-Term Follow-Up
J. Masters (2015)
A Novel Technique - Pterygium excision followed by sutureless and gluefree conjunctival autografting
Poonam Bhargava (2015)
10.1097/OPX.0b013e3181baac1a
Treatment of Primary Pterygium
Y. Ozkurt (2009)
See more
Semantic Scholar Logo Some data provided by SemanticScholar