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3D Fiber-deposited Scaffolds For Tissue Engineering: Influence Of Pores Geometry And Architecture On Dynamic Mechanical Properties.

L. Moroni, J. D. de Wijn, C. V. van Blitterswijk
Published 2006 · Materials Science, Medicine

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One of the main issues in tissue engineering is the fabrication of scaffolds that closely mimic the biomechanical properties of the tissues to be regenerated. Conventional fabrication techniques are not sufficiently suitable to control scaffold structure to modulate mechanical properties. Within novel scaffold fabrication processes 3D fiber deposition (3DF) showed great potential for tissue engineering applications because of the precision in making reproducible 3D scaffolds, characterized by 100% interconnected pores with different shapes and sizes. Evidently, these features also affect mechanical properties. Therefore, in this study we considered the influence of different structures on dynamic mechanical properties of 3DF scaffolds. Pores were varied in size and shape, by changing fibre diameter, spacing and orientation, and layer thickness. With increasing porosity, dynamic mechanical analysis (DMA) revealed a decrease in elastic properties such as dynamic stiffness and equilibrium modulus, and an increase of the viscous parameters like damping factor and creep unrecovered strain. Furthermore, the Poisson's ratio was measured, and the shear modulus computed from it. Scaffolds showed an adaptable degree of compressibility between sponges and incompressible materials. As comparison, bovine cartilage was tested and its properties fell in the fabricated scaffolds range. This investigation showed that viscoelastic properties of 3DF scaffolds could be modulated to accomplish mechanical requirements for tailored tissue engineered applications.
This paper references
10.1016/S0736-0266(02)00050-5
Rheology of joint fluid in total knee arthroplasty patients
D. Mazzucco (2002)
10.1016/S0142-9612(01)00232-0
Fused deposition modeling of novel scaffold architectures for tissue engineering applications.
I. Zein (2002)
10.1016/S0142-9612(02)00139-4
Rapid prototyping of scaffolds derived from thermoreversible hydrogels and tailored for applications in tissue engineering.
R. Landers (2002)
10.1109/TBME.2003.821041
Implementation of an optical method for the real-time determination of uniaxial strain and vessel mechanics
S. Elhadj (2004)
10.1016/S0021-9290(96)00133-9
Optical and mechanical determination of Poisson's ratio of adult bovine humeral articular cartilage.
J. Jurvelin (1997)
10.1016/J.BIOMATERIALS.2004.02.046
The effect of PEGT/PBT scaffold architecture on the composition of tissue engineered cartilage.
J. Malda (2005)
10.1002/1097-4636(200105)55:2<203::AID-JBM1007>3.0.CO;2-7
Mechanical properties and cell cultural response of polycaprolactone scaffolds designed and fabricated via fused deposition modeling.
D. Hutmacher (2001)
10.1163/156856297X00588
Mechanical properties of dense polylactic acid structures fabricated by three dimensional printing.
R. A. Giordano (1996)
10.1016/S0378-5173(02)00328-9
A comparison between the use of dynamic mechanical analysis and oscillatory shear rheometry for the characterisation of hydrogels.
T. Meyvis (2002)
10.1097/00000658-199807000-00002
Survival and function of hepatocytes on a novel three-dimensional synthetic biodegradable polymer scaffold with an intrinsic network of channels.
S. Kim (1998)
10.1002/JBM.A.10520
Gas plasma etching of PEO/PBT segmented block copolymer films.
M. B. Olde Riekerink (2003)
10.1016/S0168-3659(99)00170-4
A controlled release system for proteins based on poly(ether ester) block-copolymers: polymer network characterization.
J. Bezemer (1999)
The Effect of PEO Ratio on Degradation, Calcification and Bone Bonding of PEO/PBT Copolymer (Polyactive)
C. Blitterswijk (1993)
10.1023/A:1024674325253
Effectiveness and Safety of the PEGT/PBT Copolymer Scaffold as Dermal Substitute in Scar Reconstruction Wounds (Feasibility Trial)
I. Menšík (2004)
10.1023/A:1016189724389
Fabrication of soft tissue engineering scaffolds by means of rapid prototyping techniques
R. Landers (2002)
10.1163/156856201744489
Scaffold design and fabrication technologies for engineering tissues — state of the art and future perspectives
D. Hutmacher (2001)
Biomechanical properties of knee articular cartilage.
M. Laasanen (2003)
10.1016/0142-9612(94)90022-1
Degradative behaviour of polymeric matrices in (sub)dermal and muscle tissue of the rat: a quantitative study.
G. Beumer (1994)
10.1016/J.BIOMATERIALS.2003.10.056
Design of porous scaffolds for cartilage tissue engineering using a three-dimensional fiber-deposition technique.
T. Woodfield (2004)
10.1615/CRITREVEUKARYOTGENEEXPR.V12.I3.40
Scaffolds for tissue engineering of cartilage.
T. Woodfield (2002)
10.1016/S0378-5173(98)00337-8
Dynamic mechanical analysis of polymeric systems of pharmaceutical and biomedical significance.
D. Jones (1999)
10.1089/107632702753503009
The design of scaffolds for use in tissue engineering. Part II. Rapid prototyping techniques.
S. Yang (2002)
10.1016/S0142-9612(02)00361-7
Microarchitectural and mechanical characterization of oriented porous polymer scaffolds.
A. Lin (2003)
10.1016/S0142-9612(03)00052-8
Fabrication of PLGA scaffolds using soft lithography and microsyringe deposition.
G. Vozzi (2003)
10.1016/S0142-9612(01)00286-1
Control of vitamin B12 release from poly(ethylene glycol)/poly(butylene terephthalate) multiblock copolymers.
R. van Dijkhuizen-Radersma (2002)
10.1016/0142-9612(92)90001-5
Cartilage and diarthrodial joints as paradigms for hierarchical materials and structures.
V. Mow (1992)
10.1016/S0168-3659(01)00497-7
Design of segmented poly(ether ester) materials and structures for the tissue engineering of bone.
A. A. Deschamps (2002)
10.22203/ECM.V005A03
Making tissue engineering scaffolds work. Review: the application of solid freeform fabrication technology to the production of tissue engineering scaffolds.
E. Sachlos (2003)
10.1302/0301-620X78B6.6806
FEMORAL CANAL OCCLUSION IN TOTAL HIP REPLACEMENT USING A RESORBABLE AND FLEXIBLE CEMENT RESTRICTOR
S. K. Bulstra (1996)
10.1002/JBM.820280504
Biocompatibility of a biodegradable matrix used as a skin substitute: an in vivo evaluation.
G. Beumer (1994)
10.1016/S0142-9612(02)00223-5
A three-dimensional osteochondral composite scaffold for articular cartilage repair.
J. Sherwood (2002)
10.1016/S0142-9612(02)00276-4
Indirect solid free form fabrication of local and global porous, biomimetic and composite 3D polymer-ceramic scaffolds.
J. M. Taboas (2003)
10.1016/S0142-9612(00)00121-6
Scaffolds in tissue engineering bone and cartilage.
D. Hutmacher (2000)
10.1201/9781420049183
Dynamic Mechanical Analysis: A Practical Introduction
K. Menard (1997)
10.1002/JBM.A.20128
Apparent viscoelastic anisotropy as measured from nondestructive oscillatory tests can reflect the presence of a flaw in cortical bone.
Y. Yeni (2004)
10.1002/JBM.1026
Dynamic mechanical characterization of biodegradable composites of hydroxyapatite and polylactides.
S. Nazhat (2001)
10.1089/107632702320934182
Microsyringe-based deposition of two-dimensional and three-dimensional polymer scaffolds with a well-defined geometry for application to tissue engineering.
G. Vozzi (2002)
10.1002/JBM.B.10485
Use of stereolithography to manufacture critical-sized 3D biodegradable scaffolds for bone ingrowth.
Malcolm N. Cooke (2003)
10.1002/JBM.1267
Biomimetic calcium phosphate coatings on Polyactive 1000/70/30.
C. Du (2002)
10.1023/B:ABME.0000012742.01261.b0
The Effect of Strain Rate on the Viscoelastic Response of Aortic Valve Tissue: A Direct-Fit Approach
T. Doehring (2004)
10.1002/JBM.10300
Key issues involved with the use of miniature specimens in the characterization of the mechanical behavior of polymeric biomaterials--a review.
G. Lewis (2002)
10.1016/J.YEXCR.2004.07.027
Adhesion-mediated signal transduction in human articular chondrocytes: the influence of biomaterial chemistry and tenascin-C.
T. Mahmood (2004)
10.1016/S0142-9612(02)00148-5
Optimal design and fabrication of scaffolds to mimic tissue properties and satisfy biological constraints.
S. Hollister (2002)
10.1016/0142-9612(88)90064-6
Effect of implantation site on phagocyte/polymer interaction and fibrous capsule formation.
D. Bakker (1988)



This paper is referenced by
10.1007/s10856-018-6071-3
3D fiber deposited polymeric scaffolds for external auditory canal wall
C. Mota (2018)
10.1163/092050610X494604
Novel Melt-Processable Chitosan–Polybutylene Succinate Fibre Scaffolds for Cartilage Tissue Engineering
J. T. Oliveira (2011)
10.1093/rb/rbaa001
A tarsus construct of a novel branched polyethylene with good elasticity for eyelid reconstruction in vivo
P. Xu (2020)
10.1016/j.ijbiomac.2020.09.018
An In vitro evaluation of zinc silicate fortified chitosan scaffolds for bone tissue engineering.
Ajita Jindal (2020)
10.1016/J.BIOMATERIALS.2006.09.024
Culture of dermal fibroblasts and protein adsorption on block conetworks of poly(butyl methacrylate-block-(2,3 propandiol-1-methacrylate-stat-ethandiol dimethacrylate)).
Y. Sun (2007)
10.1007/978-3-642-39802-5_43
Biomimetic Spatial and Temporal (4D) Design and Fabrication
Veronika Kapsali (2013)
10.1002/bip.21701
Extrusion based rapid prototyping technique: An advanced platform for tissue engineering scaffold fabrication
M. E. Hoque (2012)
10.1155/2016/1239842
3D-Printed Scaffolds and Biomaterials: Review of Alveolar Bone Augmentation and Periodontal Regeneration Applications
Farah Asa'ad (2016)
10.1115/SBC2011-53407
Effects of Freezing-Induced Cell-Fluid-Matrix Interactions on Cells and Extracellular Matrix of Engineered Tissues
Ka Yaw Teo (2011)
10.1002/jbm.b.33926
Multiscale regeneration scaffold in vitro and in vivo.
H. Chen (2018)
Fabrication of composite scaffolds impregnated with an optimized fibrin-alginate hydrogel for cartilage tissue engineering
C. J. Little (2012)
10.1089/ten.TEA.2008.0355
Processing of polycaprolactone and polycaprolactone-based copolymers into 3D scaffolds, and their cellular responses.
M. E. Hoque (2009)
10.1177/2041731414541850
Strategies for osteochondral repair: Focus on scaffolds
Seog-Jin Seo (2014)
10.1089/ten.2006.0397
Critical Steps toward a Tissue-Engineered Cartilage Implant Using Embryonic Stem Cells
Jojanneke M. Jukes (2008)
10.1039/C5TB01188D
Understanding cell homing-based tissue regeneration from the perspective of materials.
D. Zhao (2015)
10.1016/j.msec.2016.11.019
Robust formulation for the design of tissue engineering scaffolds: A comprehensive study on structural anisotropy, viscoelasticity and degradation of 3D scaffolds fabricated with customized desktop robot based rapid prototyping (DRBRP) system.
M. E. Hoque (2017)
10.1002/PEN.20732
Design and fabrication of 3D‐plotted polymeric scaffolds in functional tissue engineering
Azizeh-Mitra Yousefi (2007)
10.1155/2014/501275
Scaffolds Reinforced by Fibers or Tubes for Tissue Repair
Xiaoming Li (2014)
Fatigue and cyclic loading of 3D printed soft polymers for orthopedic applications
A. Miller (2017)
10.1371/journal.pone.0064772
Microwell Scaffolds for the Extrahepatic Transplantation of Islets of Langerhans
M. Buitinga (2013)
10.1016/J.JMST.2016.01.007
3D Bioplotting of Gelatin/Alginate Scaffolds for Tissue Engineering: Influence of Crosslinking Degree and Pore Architecture on Physicochemical Properties
T. Pan (2016)
10.1089/ten.TEC.2012.0383
Three-dimensional printing of soy protein scaffolds for tissue regeneration.
K. Chien (2013)
Bioresorbable scaffold as a dermal substitute.
L. Cardoso (2017)
10.1002/adma.200802977
Scaffold design and manufacturing: from concept to clinic.
S. Hollister (2009)
Development of Novel Scaffolds for Skeletal Muscle Tissue Engineering Applications
Biswadeep Chaudhuri (2016)
Microstereolithography of tissue scaffolds using a biodegradable photocurable polyester
Nicholas A. Chartrain (2016)
10.1016/j.msec.2017.03.079
Effects of plasma electrolytic oxidation process on the mechanical properties of additively manufactured porous biomaterials.
Z. Gorgin Karaji (2017)
10.1101/2020.06.23.165605
A hybrid additive manufacturing platform to create bulk and surface composition gradients on scaffolds for tissue regeneration
R. Sinha (2020)
10.1016/J.ACTAMAT.2012.01.044
Effect of pore geometry and loading direction on deformation mechanism of rapid prototyped scaffolds
Soodeh Amirkhani (2012)
10.1016/J.POLYMERTESTING.2017.07.026
Preparation and characterization of 3D collagen materials with magnetic properties
A. Sionkowska (2017)
10.1007/s11948-017-9918-y
3D Bioprinting Technology: Scientific Aspects and Ethical Issues
Sara Patuzzo (2018)
10.1002/adhm.201701095
Design and Structure-Function Characterization of 3D Printed Synthetic Porous Biomaterials for Tissue Engineering.
Cambre N Kelly (2018)
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