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Inactivation Of Nanocrystalline C60 Cytotoxicity By γ-irradiation
A. Isakovic, Z. Marković, N. Nikolic, B. Todorovic-Markovic, Sanja D. Vranješ-Djurić, L. Harhaji, N. Raičević, N. Romcevic, D. Vasiljević-Radović, M. Dramićanin, V. Trajkovic
Published 2006 · Chemistry
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We investigated the effect of γ-irradiation on the cytotoxicity of pure C60 solubilized in water by using tetrahydrofuran (THF/n-C60 or THF/n-C60). In contrast to THF/n-C60, its γ-irradiated counterpart failed to generate oxygen radicals and cause extracellular signal-regulated kinase (ERK)-dependent necrotic cell death in various types of mammalian cells. Moreover, γ-irradiated THF/n-C60 protected cells from the oxidative stress induced by native THF/n-C60 or hydrogen peroxide. The observed biological effects were associated with γ-irradiation-mediated decomposition of THF and subsequent derivatization of the n-C60 surface. These results for the first time demonstrate γ-irradiation-mediated changes in the physico-chemical properties of THF-prepared nanocrystalline C60, resulting in a complete loss of its cytotoxic effect and its conversion to a cytoprotective agent.
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