Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Inactivation Of Nanocrystalline C60 Cytotoxicity By γ-irradiation

A. Isakovic, Z. Marković, N. Nikolic, B. Todorovic-Markovic, Sanja D. Vranješ-Djurić, L. Harhaji, N. Raičević, N. Romcevic, D. Vasiljević-Radović, M. Dramićanin, V. Trajkovic
Published 2006 · Chemistry

Save to my Library
Download PDF
Analyze on Scholarcy
Share
We investigated the effect of γ-irradiation on the cytotoxicity of pure C60 solubilized in water by using tetrahydrofuran (THF/n-C60 or THF/n-C60). In contrast to THF/n-C60, its γ-irradiated counterpart failed to generate oxygen radicals and cause extracellular signal-regulated kinase (ERK)-dependent necrotic cell death in various types of mammalian cells. Moreover, γ-irradiated THF/n-C60 protected cells from the oxidative stress induced by native THF/n-C60 or hydrogen peroxide. The observed biological effects were associated with γ-irradiation-mediated decomposition of THF and subsequent derivatization of the n-C60 surface. These results for the first time demonstrate γ-irradiation-mediated changes in the physico-chemical properties of THF-prepared nanocrystalline C60, resulting in a complete loss of its cytotoxic effect and its conversion to a cytoprotective agent.
This paper references
10.1016/J.CARBON.2005.11.008
Ecotoxicology of carbon-based engineered nanoparticles: Effects of fullerene (C60) on aquatic organisms
E. Oberdörster (2006)
10.1111/j.1471-4159.2004.02744.x
Role of extracellular signal‐regulated protein kinase in neuronal cell death induced by glutathione depletion in neuron/glia mesencephalic cultures
S. de Bernardo (2004)
10.1016/S0009-2614(02)01305-2
Comparative analysis of two aqueous-colloidal solutions of C60 fullerene with help of FTIR reflectance and UV–Vis spectroscopy
G. Andrievsky (2002)
10.1016/S0887-2333(02)00127-3
Phagocytosis of titanium particles and necrosis in TNF-α-resistant mouse sarcoma L929 cells
E. Osano (2003)
10.1016/J.EJMECH.2003.09.005
Fullerene derivatives: an attractive tool for biological applications.
S. Bosi (2003)
10.1038/nbt875
The potential environmental impact of engineered nanomaterials
V. Colvin (2003)
10.1016/j.neulet.2004.04.034
Cholinergic modulation of baker’s yeast cell phagocytosis by rat astrocytes
R. M. Gómez (2004)
10.1016/J.CEB.2004.09.011
Death by design: apoptosis, necrosis and autophagy.
A. Edinger (2004)
10.1523/JNEUROSCI.19-04-01284.1999
Distinct Mechanisms Underlie Neurotoxin-Mediated Cell Death in Cultured Dopaminergic Neurons
J. Lotharius (1999)
10.1002/JBT.20062
Low levels of arsenite activates nuclear factor‐κB and activator protein‐1 in immortalized mesencephalic cells
K. Felix (2005)
10.1093/TOXSCI/KFJ127
Distinct cytotoxic mechanisms of pristine versus hydroxylated fullerene.
A. Isakovic (2006)
10.1038/350158A0
Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF
D. Kaplan (1991)
10.1042/BJ3500717
A new phosphospecific cell-based ELISA for p42/p44 mitogen-activated protein kinase (MAPK), p38 MAPK, protein kinase B and cAMP-response-element-binding protein.
H. Versteeg (2000)
10.1021/ES048099N
C60 in water: nanocrystal formation and microbial response.
J. Fortner (2005)
10.1289/ehp.7021
Manufactured Nanomaterials (Fullerenes, C60) Induce Oxidative Stress in the Brain of Juvenile Largemouth Bass
E. Oberdörster (2004)
10.1021/ES050090D
Comparison of electrokinetic properties of colloidal fullerenes (n-C60) formed using two procedures.
J. Brant (2005)
10.1016/S1359-6446(02)02563-1
Anticancer drugs of tomorrow: apoptotic pathways as targets for drug design.
M. Los (2003)
10.1042/BJ20031253
Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis.
J. Rejman (2004)
10.1080/15363830500237267
Is the C60 Fullerene Molecule Toxic?!
G. Andrievsky (2005)
10.1002/jnr.10049
Toxic effect of L‐2‐chloropropionate on cultured rat cerebellar granule cells is ameliorated after inhibition of reactive oxygen species formation
O. Myhre (2001)
10.1021/NL051866B
[60]fullerene is a powerful antioxidant in vivo with no acute or subacute toxicity.
N. Gharbi (2005)
10.1073/PNAS.94.17.9434
Carboxyfullerenes as neuroprotective agents.
L. Dugan (1997)
10.1897/04-503R3.1
Extracellular signal-regulated kinase-signaling-dependent G2/M arrest and cell death in murine macrophages by cadmium.
J. Kim (2005)
10.1021/NL0507966
Single-Walled Carbon Nanotube Induces Oxidative Stress and Activates Nuclear Transcription Factor-κB in Human Keratinocytes
S. Manna (2005)
10.1016/0020-7055(70)90014-8
Hydrogen and ion yields in the γ-radiolysis of tetrahydrofuran
J. H. Baxendale (1970)
10.1002/1097-4547(20001115)62:4<600::AID-JNR15>3.0.CO;2-F
Polyhydroxylated C60, fullerenols, as glutamate receptor antagonists and neuroprotective agents
H. Jin (2000)
10.1006/nbdi.1996.0013
Buckminsterfullerenol Free Radical Scavengers Reduce Excitotoxic and Apoptotic Death of Cultured Cortical Neurons
L. Dugan (1996)
10.1016/J.ASR.2003.07.001
Stability of interstellar fullerenes under high-dose γ-irradiation
G. Albarrán (2004)
10.1016/S0165-5728(01)00391-5
Interleukin-17 stimulates inducible nitric oxide synthase activation in rodent astrocytes
V. Trajkovič (2001)
10.1148/RADIOLOGY.197.2.7480707
MR imaging of phagocytosis in experimental gliomas.
C. Zimmer (1995)
10.1046/j.1365-2362.2003.01219.x
Resveratrol modulates apoptosis and oxidation in human blood mononuclear cells
G. Losa (2003)
10.1016/0022-1759(84)90147-9
Comparison of in vitro cell cytotoxic assays for tumor necrosis factor.
D. A. Flick (1984)
10.1002/ijc.21080
Novel platinum(IV) complexes induce rapid tumor cell death in vitro
Goran N. Kaludjerović (2005)
10.1021/NL0489586
The Differential Cytotoxicity of Water-Soluble Fullerenes
C. Sayes (2004)
10.1016/J.BIOMATERIALS.2005.05.027
Nano-C60 cytotoxicity is due to lipid peroxidation.
C. Sayes (2005)
10.1021/NL051748O
Molecular characterization of the cytotoxic mechanism of multiwall carbon nanotubes and nano-onions on human skin fibroblast.
L. Ding (2005)
10.1016/S1353-8020(00)00064-X
Fullerene-based antioxidants and neurodegenerative disorders.
L. Dugan (2001)



This paper is referenced by
Fullerene nanoparticles operating the apoptosis and cell proliferationprocesses in normal and malignant cells
M. Orlova (2013)
10.1186/1556-276X-7-433
Spectroscopic study on the interaction of pristine C60 and serum albumins in solution
S. Liu (2012)
10.1016/B978-0-12-385089-8.00009-1
Chapter 9 – Conclusions
Zoraida P. Aguilar (2013)
PHOTOACTIVE NANOPARTICLES FOR ONCOLOGY FOTOAKTIVNE NANO^ESTICE U ONKOLOGIJI
Zoran S. Markovi (2010)
10.1021/es202269r
Escherichia coli Inactivation by UVC-Irradiated C60: kinetics and mechanisms.
M. Cho (2011)
10.1016/J.APSUSC.2008.09.043
Atomic force microscopy study of fullerene-based colloids
B. Todorovic-Markovic (2008)
10.1007/s12403-015-0190-6
Assessing Exposure of Fullerenes/Functionalized Fullerenes from Water: Risk, Challenges, and Knowledge Gaps
J. Chawla (2015)
10.1016/B978-0-08-100716-7.00005-2
[60]Fullerene and derivatives for biomedical applications
F. Moussa (2018)
10.1016/J.RADPHYSCHEM.2014.05.057
Rate constants of highly hydroxylated fullerene C60 interacting with hydroxyl radicals and hydrated electrons. Pulse radiolysis study
J. Grębowski (2014)
10.1109/ICBEB.2012.304
Preparation and Radical Scavenging Activity of Nano-Fuller-Serine
J. Zhang (2012)
10.1016/j.biomaterials.2008.05.005
Biomedical potential of the reactive oxygen species generation and quenching by fullerenes (C60).
Z. Markovic (2008)
10.1016/j.msec.2017.03.178
Facile synthesis of fluorescence carbon dots from sweet potato for Fe3+ sensing and cell imaging.
J. Shen (2017)
10.9734/BJMMR/2013/3453
Perspectives of fullerene derivatives in PDT and radiotherapy of cancers.
M. Orlova (2013)
10.1088/0957-4484/24/20/205601
Ultraviolet radiation synthesis of water dispersed CdTe/CdS/ZnS core-shell-shell quantum dots with high fluorescence strength and biocompatibility.
B. Xu (2013)
10.1021/cr3005026
Fullerenes in liquid media: an unsettling intrusion into the solution chemistry.
N. Mchedlov-Petrossyan (2013)
10.1016/j.biomaterials.2009.01.023
The protection of cells from nitric oxide-mediated apoptotic death by mechanochemically synthesized fullerene (C(60)) nanoparticles.
Maja S Misirkic (2009)
10.1016/j.biomaterials.2008.09.029
The cytotoxicity of cadmium based, aqueous phase - synthesized, quantum dots and its modulation by surface coating.
Yuanyuan Su (2009)
10.1016/j.actbio.2013.10.037
A tumoral acidic pH-responsive drug delivery system based on a novel photosensitizer (fullerene) for in vitro and in vivo chemo-photodynamic therapy.
Jinjin Shi (2014)
10.1007/978-0-387-76713-0_13
Toxicity studies of fullerenes and derivatives.
Jelena Kolosnjaj (2007)
10.1016/J.MATTOD.2017.03.017
Fullerene: biomedical engineers get to revisit an old friend
Saba Goodarzi (2017)
Regulation and Risk Assessment of Nanomaterials - Too Little, Too Late?
S. Hansen (2009)
10.1088/0957-4484/21/37/375102
Oxidative stress-mediated hemolytic activity of solvent exchange-prepared fullerene (C60) nanoparticles.
Andreja Trpković (2010)
Pharmacophore Superfamily to Operate the Cell Proliferation and Apoptosis Processes
M. Orlova (2012)
10.1007/s11062-009-9044-9
Disorders in the Cytoskeleton of Astroglia and Neurons in the Rat Brain Induced by Long-Lasting Exposure to Ethanol and Correction of These Shifts by Hydrated Fullerene С60
А. Tikhomirov (2009)
10.1016/j.biomaterials.2009.09.007
Opposite effects of nanocrystalline fullerene (C(60)) on tumour cell growth in vitro and in vivo and a possible role of immunosupression in the cancer-promoting activity of C(60).
Nevena Zogovic (2009)
10.1016/j.jconrel.2011.07.002
"Nanoantibiotics": a new paradigm for treating infectious diseases using nanomaterials in the antibiotics resistant era.
Ae Jung Huh (2011)
10.4236/JBNB.2012.33037
Cytotoxicity of Pristine C 60 Fullerene on Baby Hamster Kidney Cells in Solution
S. Liu (2012)
10.1093/toxsci/kfp265
The biological mechanisms and physicochemical characteristics responsible for driving fullerene toxicity.
H. Johnston (2010)
10.1016/j.biomaterials.2014.10.031
Transferrin-mediated fullerenes nanoparticles as Fe(2+)-dependent drug vehicles for synergistic anti-tumor efficacy.
H. Zhang (2015)
10.1016/j.biomaterials.2014.03.071
A fullerene-based multi-functional nanoplatform for cancer theranostic applications.
Jinjin Shi (2014)
10.1007/s11051-014-2599-4
Physicochemical characterization of fullerenol and fullerenol synthesis by-products prepared in alkaline media
Paul A. Indeglia (2014)
10.1016/B978-0-12-385089-8.00008-X
Nanotoxicology and Remediation
Zoraida P. Aguilar (2013)
See more
Semantic Scholar Logo Some data provided by SemanticScholar