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Proximal Femoral Density And Geometry Measurements By Quantitative Computed Tomography: Association With Hip Fracture.

X. Cheng, J. Li, Y. Lu, J. Keyak, T. Lang
Published 2007 · Biology, Medicine

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INTRODUCTION Bone mineral density and geometry measurements by volumetric quantitative computed tomography (vQCT) have been utilized in clinical research studies of aging, pharmacologic intervention and mechanical unloading, but there is relatively little information about the association of these measures with hip fracture. To address this issue, we have carried out a study comparing vQCT parameters in elderly Chinese women with hip fractures with measurements in age-matched controls. MATERIALS AND METHODS Forty-five women (mean age 74.71+/-5.94) with hip fractures were compared to 66 age-matched control subjects (mean age 70.70+/-4.66). vQCT was employed to characterize the volumetric bone mineral density in cortical, trabecular, and integral volumes of interest in the proximal femur. In addition to the volume of interest measurements, we computed the cross-sectional areas of the femoral neck and intertrochanteric planes, the femoral neck axis length, indices of femoral neck bending and compressive strength, and measures of femoral neck cortical geometry. To determine if cortical geometry measures were associated with hip fracture independently of trabecular vBMD, we carried out multi-variate analyses including these parameters in a logistic regression model. RESULTS AND CONCLUSIONS All vQCT measurements discriminated between fractured subjects and age-matched controls. There was no significant difference in predictive strength between volumetric and areal representations of BMD and trabecular and integral vBMD showed comparable discriminatory power, although both of these measures were more correlated to fracture status than cortical vBMD. We found that fractured subjects had larger femoral neck cross-sectional areas, consistent with adaptation to lower BMD in these osteoporotic subjects. The larger neck cross-sectional areas resulted in bending strength indices in the fractured subjects that were comparable or larger than those of the control subjects. In multi-variate analyses, reduced femoral neck cortical thickness and buckling ratio indices were associated with fracture status independently of trabecular vBMD.
This paper references
Volumetric quantitative computed tomography of the proximal femur: precision and relation to bone strength.
T. Lang (1997)
Relation between age, femoral neck cortical stability, and hip fracture risk
Paul M. Mayhew (2005)
One year of alendronate after one year of parathyroid hormone (1-84) for osteoporosis.
D. Black (2005)
Predicting Proximal Femoral Strength Using Structural Engineering Models
J. Keyak (2005)
The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis.
D. Black (2003)
Correlations between orthogonal mechanical properties and density of trabecular bone: use of different densitometric measures.
J. Keyak (1994)
Femoral structure and stiffness in patients with femoral neck fracture
D. Cody (2000)
Assessment of vertebral bone mineral density using volumetric quantitative CT.
T. Lang (1999)
Predictive value of proximal femoral bone densitometry in determining local orthogonal material properties.
D. Cody (1996)
Prediction of hip fractures from pelvic radiographs: The study of osteoporotic fractures
C. Glüer (1994)
Bone density distribution and gender dominate femoral neck fracture risk predictors
D. D. Cody (2000)
Does estimating volumetric bone density of the femoral neck improve the prediction of hip fracture? A prospective study
S. Cummings (1994)
Population‐Based Study of Age and Sex Differences in Bone Volumetric Density, Size, Geometry, and Structure at Different Skeletal Sites
B. Riggs (2004)
Accuracy of CT-based thickness measurement of thin structures: modeling of limited spatial resolution in all three dimensions.
S. Prevrhal (2003)
Non-invasive measurement of long bone cross-sectional moment of inertia by photon absorptiometry.
R. B. Martin (1984)
Femoral strength is better predicted by finite element models than QCT and DXA.
D. Cody (1999)
How Hip and Whole-Body Bone Mineral Density Predict Hip Fracture in Elderly Women: The EPIDOS Prospective Study
A. Schott (1998)
Bone density at various sites for prediction of hip fractures
S. Cummings (1993)
Cortical and Trabecular Bone Mineral Loss From the Spine and Hip in Long‐Duration Spaceflight
T. Lang (2004)
Assessment of bone mineral at appendicular sites in females with fractures of the proximal femur.
P. Augat (1998)
Accuracy of cortical and trabecular bone measurements with peripheral quantitative computed tomography (pQCT).
P. Augat (1998)
System for the analysis of whole-bone strength from helical CT images
J. Camp (2004)

This paper is referenced by
Trabecular bone score is associated with volumetric bone density and microarchitecture as assessed by central QCT and HRpQCT in Chinese American and white women.
B. C. Silva (2013)
Quantitative computed tomography.
T. Lang (2010)
Comparison of DXA hip structural analysis with volumetric QCT.
S. Prevrhal (2008)
Associations between fluoride intakes, bone outcomes and dental fluorosis
R. Oweis (2018)
Inhibition of antigen presentation and T cell costimulation blocks PTH‐induced bone loss
B. Bedi (2010)
Identify fracture-critical regions inside the proximal femur using statistical parametric mapping.
W. Li (2009)
Discrimination of Cervical and Trochanteric Hip Fractures Using Radiography-Based Two-Dimensional Finite Element Models
J. Thevenot (2009)
Hip fracture discrimination from dual-energy X-ray absorptiometry by statistical model registration.
Tristan Whitmarsh (2012)
Bone fracture risk estimation based on image similarity.
W. Li (2009)
Proximal femur lag screw placement based on bone mineral density determined by quantitative computed tomography.
Gang Liu (2020)
Proximal Femoral Structure and the Prediction of Hip Fracture in Men: A Large Prospective Study Using QCT
D. Black (2008)
Distribution of bone density in the proximal femur and its association with hip fracture risk in older men: The osteoporotic fractures in men (MrOS) study
L. Yang (2012)
Contribution of Trochanteric Soft Tissues to Fall Force Estimates, the Factor of Risk, and Prediction of Hip Fracture Risk*
M. Bouxsein (2007)
CTXA hip: the effect of partial volume correction on volumetric bone mineral density data for cortical and trabecular bone
Y. Liu (2020)
Balance performance and related soft tissue components across three age groups.
Y. Lee (2019)
Women and men with hip fractures have a longer femoral neck moment arm and greater impact load in a sideways fall
Q. Wang (2008)
Structural Parameters of the Proximal Femur by 3-Dimensional Dual-Energy X-ray Absorptiometry Software: Comparison With Quantitative Computed Tomography.
Jordi Clotet (2018)
Pelvic body composition measurements by quantitative computed tomography: association with recent hip fracture.
T. Lang (2008)
Bone mass and architecture determination: state of the art.
J. Griffith (2008)
Osteoporosis y osteopenia en mujeres trabajadoras de la salud en la Ciudad de México
F. Gómez-García (2008)
Fracture risk assessment in older adults using a combination of selected quantitative computed tomography bone measures: a subanalysis of the Age, Gene/Environment Susceptibility-Reykjavik Study.
N. Rianon (2014)
Trabecular Homogeneity Index Derived From Plain Radiograph to Evaluate Bone Quality
J. Thevenot (2013)
Hip load capacity and yield load in men and women of all ages.
J. H. Keyak (2020)
Age trends in proximal femur geometry in men: variation by race and ethnicity
T. Travison (2007)
Next-generation imaging of the skeletal system and its blood supply
A. Grüneboom (2019)
Morphometric Evaluation of Korean Femurs by Geometric Computation: Comparisons of the Sex and the Population
Ho-Jung Cho (2015)
Considerations for Development of Surrogate Endpoints for Antifracture Efficacy of New Treatments in Osteoporosis: A Perspective
M. Bouxsein (2008)
A local reference frame for describing the proximal human femur: application in clinical settings
M. Masjedi (2013)
The immune system and bone.
R. Pacifici (2010)
Assessment of Operational Factors, Structural Properties and Disease Associations Influencing Bone Mineral Density Variation
S Lekamwasam (2012)
X-Ray Based Imaging Methods to Assess Bone Quality
Klaus Engelke (2014)
Structural patterns of the proximal femur in relation to age and hip fracture risk in women.
J. Carballido-Gamio (2013)
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