Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Biostability Of γ-Fe2O3 Nano Particles Evaluated Using An In Vitro Cytotoxicity Assays On Various Tumor Cell Lines

Kwon-Jai Lee, Jeung-Hee An, Jae-Soo Shin, D. Kim, H. Yoo, Chong-kwan Cho
Published 2011 · Chemistry

Save to my Library
Download PDF
Analyze on Scholarcy
Abstract This study examined the cytotoxic effects of the γ-Fe 2 O 3 magnetic nanoparticles (GMNs) on a range of tumor cell lines. GMNs, approximately 20 nm in diameter, were prepared using a chemical coprecipitation technique, and coated with two surfactants to obtain a water-based product. A 3-(4, 5-dimethylthiazol-2-yl) −2, 5-diphenyltetrazolium bromide assay revealed the GMNs to be non-toxic to human fibroblast cells and most of the tumor cell lines tested. However, the magnetic nanoparticles coated with the anti-cancer drugs exhibited cytotoxic activity against tumor cells. These results suggest that GMNs are not cytotoxic to the tumor cells and normal human cells tested in this study. In addition, the magnetic nanoparticles are biostable and magnetic nanoparticles coated with anti-cancer drugs are effective drug delivery vehicles. These results highlight the potential of drug-coated Fe 2 O 3 magnetic nanoparticles as new anti-tumor agents.
This paper references
Clinical applications of magnetic drug targeting.
A. Lübbe (2001)
Changes in adsorption and permeability of mitoxantrone on plasma membrane of BCRP/MXR resistant cells.
G. Breuzard (2005)
In vivo investigation of cobalt ferrite-based magnetic fluid and magnetoliposomes using morphological tests
S. A. Kuckelhaus (2004)
The influence of surface functionalization on the enhanced internalization of magnetic nanoparticles in cancer cells.
Ángeles Villanueva (2009)
Raman microspectroscopy of some iron oxides and oxyhydroxides
D. L. A. Faria (1997)
The effect of magnetic targeting on the uptake of magnetic-fluid-loaded liposomes by human prostatic adenocarcinoma cells.
Marie-Sophie Martina (2008)
Biocompatibility of various ferrite nanoparticles evaluated by in vitro cytotoxicity assays using HeLa cells
A. Tomitaka (2009)
Magnetic relaxation switches capable of sensing molecular interactions
J. M. Pérez (2002)
Self-Assembled Magnetic Matrices for DNA Separation Chips
P. Doyle (2002)
Magnetic nanoparticle-peptide conjugates for in vitro and in vivo targeting and extraction of cancer cells.
K. E. Scarberry (2008)
Magnetic nanoparticles as a catalyst vehicle for simple and easy recycling
Tae-Jong Yoon (2003)
Raman scattering study of liquid ethylene glycol confined to nanoporous silica glasses
Ren‐Sheng Luo (2001)
Electrochemical biosensors utilising electron transfer in heme proteins immobilised on Fe3O4 nanoparticles.
Dongfang Cao (2003)
Raman Investigation of Uncoated and Coated Magnetic Fluids
P. Morais (2000)
A new approach for the in vitro identification of the cytotoxicity of superparamagnetic iron oxide nanoparticles.
M. Mahmoudi (2010)
Protective effect of maghemite nanoparticles on ultraviolet-induced photo-damage in human skin fibroblasts.
Kwon-Jai Lee (2007)
Interdigitated array microelectrode based impedance biosensor coupled with magnetic nanoparticle-antibody conjugates for detection of Escherichia coli O157:H7 in food samples.
M. Varshney (2007)
Studies of cell toxicity of complexes of magnetic fluids and biological macromolecules
P. P. Macaroff (2005)
Nanoscaled biocompatible magnetic drug-delivery system: preparation and characterization
P. Morais (2009)
Preparation of photosensitizer-coated magnetic fluid for treatment of tumor
Sang-Im Park (2004)

This paper is referenced by
Effects of a Nonthermal Atmospheric Pressure Plasma Jet on Human Gingival Fibroblasts for Biomedical Application
J. Lee (2016)
Ferrite-based magnetic nanofluids used in hyperthermia applications
I. Sharifi (2012)
Transfection efficiency influenced by aggregation of DNA/polyethylenimine max/magnetic nanoparticle complexes
Satoshi Ota (2013)
Synthesis and characterization of new branched magnetic nanocomposite for loading and release of topotecan anti-cancer drug
Tuba Tarhan (2019)
Effects of a Nonthermal Atmospheric Pressure Plasma Discharged in Cell Culture Medium on Melanoma Cell
Yun-Ju Chuang (2019)
Magnetic Nanoparticles: Synthesis, Surface Modifications and Application in Drug Delivery
S. Bucak (2012)
Synthesis of (Mn(1−x)Znx)Fe2O4 nanoparticles for magnetocaloric applications
V. Balanov (2020)
Spectroscopic and quantum chemical studies of interaction between the alginic acid and Fe3O4 nanoparticles.
Małgorzata Śmiłowicz (2017)
Synthesis and Characterization of Magnetic γ-Fe2O3/Al2O3 Core-Shell Nanocomposites
H. Ding (2011)
The effect of polyvinyl alcohol (PVA) coating on structural, magnetic properties and spin dynamics of Ni0.3Zn0.7Fe2O4 ferrite nanoparticles
M. Rahimi (2013)
Magnetic nanoparticles-based drug and gene delivery systems for the treatment of pulmonary diseases.
I. ElSherbiny (2017)
Hydroxy, carboxylic and amino acid functionalized superparamagnetic iron oxide nanoparticles: Synthesis, characterization and in vitro anti-cancer studies
Dilaveez Rehana (2015)
γ-Fe2O3/polyaniline-lonidamine prepared by doping/dedoping method
Han Huang (2014)
Magnetically Driven Multifunctional Nanorobots for Biomedical Applications
M. Hoop (2017)
Semantic Scholar Logo Some data provided by SemanticScholar