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Antioxidant Properties Of High Molecular Weight Dietary Chitosan In Vitro And In Vivo

M. Anraku, Takeshi Fujii, Y. Kondo, E. Kojima, T. Hata, N. Tabuchi, Daiju Tsuchiya, Takeshi Goromaru, H. Tsutsumi, D. Kadowaki, T. Maruyama, M. Otagiri, Hisao Tomida
Published 2011 · Chemistry

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Abstract The effect of high molecular weight chitosan supplement (HMCS), a natural polymer derived from chitin, on indices of oxidative stress was investigated in normal volunteers. The use of HMCS for 8 weeks resulted in a significant decrease in total cholesterol levels and atherogenic index, and increased levels of high density lipoprotein (HDL) cholesterol. HMCS treatment also resulted in a lowered ratio of oxidized to reduced albumin and an increase in total plasma antioxidant activity. A good correlation between the atherogenic index and oxidized albumin ratio was found. The results suggest that the ratio of oxidized to reduced albumin ratio represents a potentially useful marker of the metabolic syndrome. In in vitro studies, HMCS slightly reduced the levels of two stable radicals in a dose- and time-dependent manner. The strong binding capacity of indoxyl sulfate and low density lipoprotein (LDL) cholesterol was also observed with HMCS. These results suggest that HMCS reduces significant levels of pro-oxidants such as cholesterol and uremic toxins in the gastrointestinal tract, thereby inhibiting the subsequent development of oxidative stress in the systemic circulation in humans.
This paper references
Antimicrobial Activity of Hetero-Chitosans and Their Oligosaccharides with Different Molecular Weights
P. Park (2004)
Antioxidant protection of human serum albumin by chitosan.
M. Anraku (2008)
The relative contributions of vitamin E, urate, ascorbate and proteins to the total peroxyl radical-trapping antioxidant activity of human blood plasma.
D. D. Wayner (1987)
Indoxyl sulfate increases the gene expressions of TGF-beta 1, TIMP-1 and pro-alpha 1(I) collagen in uremic rat kidneys.
T. Miyazaki (1997)
Antioxidant activity of water-soluble chitosan derivatives.
W. Xie (2001)
Chitosan induces different L-arginine metabolic pathways in resting and inflammatory macrophages.
C. Porporatto (2003)
Reduction in fat storage during chitin-chitosan treatment in mice fed a high-fat diet
L-K Han (1999)
Cholesterol reduction by glucomannan and chitosan is mediated by changes in cholesterol absorption and bile acid and fat excretion in rats.
C. Gallaher (2000)
Role for "uremic toxin" in the progressive loss of intact nephrons in chronic renal failure.
M. Motojima (1991)
The effect of chitosan and other polycations on tight junction permeability in the human intestinal Caco-2 cell line(1).
G. Ranaldi (2002)
Intravenous iron administration induces oxidation of serum albumin in hemodialysis patients.
M. Anraku (2004)
Effect of Dietary Chitosans with Different Viscosity on Plasma Lipids and Lipid Peroxidation in Rats Fed on A Diet Enriched with Cholesterol
M. Chiang (2000)
Lipoproteins in atherogenesis.
G. Schonfeld (1979)
A novel use of chitosan as a hypocholesterolemic agent in rats.
M. Sugano (1980)
Quantitative evaluation of the antioxidant properties of garlic and shallot preparations.
Nuttakaan Leelarungrayub (2006)
Antioxidative activities of several marine polysaccharides evaluated in a phosphatidylcholine-liposomal suspension and organic solvents.
C. Xue (1998)
Potential Immuno-Stimulating Effect of Antitumoral Fraction of Chitosan Oligosaccharides
전유진 (2001)
Effect of chitosan supplementation on antitubercular drugs-induced hepatotoxicity in rats.
S. Santhosh (2006)
Chitosan supplementation and fat absorption in men and women.
M. D. Gades (2005)
Potent antiperoxidation activity of the bisbenzylisoquinoline alkaloid cepharanthine: the amine moiety is responsible for its pH-dependent radical scavenge activity.
K. Kogure (1999)
Plasma lipids and apolipoproteins as discriminators for presence and severity of angiographically defined coronary artery disease.
A. Noma (1983)
Effects of chitosan oligosaccharide (COS) on the glycerol-induced acute renal failure in vitro and in vivo.
H. Yoon (2008)
Deoxycholic acid-conjugated chitosan oligosaccharide nanoparticles for efficient gene carrier.
S. Chae (2005)
Antioxidant effects of a dietary supplement: reduction of indices of oxidative stress in normal subjects by water-soluble chitosan.
M. Anraku (2009)
Effect of Olmesartan on Oxidative Stress in Hemodialysis Patients
D. Kadowaki (2007)
Albumin--an important extracellular antioxidant?
B. Halliwell (1988)
Antioxidant properties of some different molecular weight chitosans.
Hisao Tomida (2009)
Indoxyl sulfate induces complex redox alterations in mesangial cells.
A. Gelasco (2006)
Renal disposition of a furan dicarboxylic acid and other uremic toxins in the rat.
Y. Tsutsumi (2002)
Evaluating Efficacy of a Chitosan Product Using a Double-Blinded, Placebo-Controlled Protocol
G. Kaats (2006)
Dietary chitosan inhibits hypercholesterolaemia and atherogenesis in the apolipoprotein E-deficient mouse model of atherosclerosis.
D. Ormrod (1998)
Chitosans as absorption enhancers of poorly absorbable drugs. 3: Influence of mucus on absorption enhancement.
N. G. Schipper (1999)
Antitumor effect of hexa-N-acetylchitohexaose and chitohexaose.
K. Suzuki (1986)

This paper is referenced by
Chitosan–Antioxidant Conjugates
Vivien Nagy (2020)
Towards bio-silicon interfaces: formation of an ultra-thin self-hydrated artificial membrane composed of dipalmitoylphosphatidylcholine (DPPC) and chitosan deposited in high vacuum from the gas-phase.
M. J. Retamal (2014)
Designing, structural determination and biological effects of rifaximin loaded chitosan- carboxymethyl chitosan nanogel.
S. Algharib (2020)
Antioxidant activities of chitosans and its derivatives in in vitro and in vivo studies.
M. Anraku (2018)
Biological effects and extraction processes used to obtain marine chitosan.
A. Montilla (2013)
Chitosan based powder coating technique to enhance phytochemicals and shelf life quality of radish shreds
R. Pushkala (2013)
Antioxidant and renoprotective activity of chitosan in nephrectomized rats.
M. Anraku (2012)
Functionalization of carboxymethyl chitosan with chlorogenic acid: preparation, characterization, and antioxidant capacity
Chaohong Zhang (2020)
Self-assembled nanoparticles of modified-chitosan conjugates for the sustained release of DL-α-tocopherol.
Javier Pérez Quiñones (2013)
Biological effects of chitosan and its derivatives
Dai-Hung Ngo (2015)
Polyphenol-chitosan conjugates: Synthesis, characterization, and applications.
Qiaobin Hu (2016)
Development of a low fat fresh pork sausage based on chitosan with health claims: impact on the quality, functionality and shelf-life.
Deborah S. do Amaral (2015)
Carboxymethyl chitosan modulates the genotoxic risk and oxidative stress of perfluorooctanoic acid in Nile tilapia (Oreochromis niloticus)
F. K. Abdel-Gawad (2016)
Recent Advances of Chitosan and Its Derivatives for Novel Applications in Food Science
Y. Luo (2013)
The preparation and validation of chitosan tablets that rapidly disperse and disintegrate as an oral adsorbent in the treatment of lifestyle-related diseases
M. Anraku (2020)
An oral absorbent, surface-deacetylated chitin nano-fiber ameliorates renal injury and oxidative stress in 5/6 nephrectomized rats.
M. Anraku (2017)
Effects of chitosan on oxidative stress and related factors in hemodialysis patients.
M. Anraku (2014)
In Vitro Antioxidant Activity of Chitosan Aqueous Solution: Effect of Salt Form
Natthan Charernsriwilaiwat (2012)
Antimicrobial and antioxidant properties of chitosan and its derivatives and their applications: A review.
M. A. Abd El-Hack (2020)
Effect of Chitosan on the Properties of Electrospun Fibers From Mixed Poly(Vinyl Alcohol)/Chitosan Solutions
R. Gonçalves (2017)
Green synthesis of Cefadroxil loaded chitosan/PVA nanofibers by freeze drying
Haroon Iqbal (2019)
Free radical-mediated conjugation of chitosan with tannic acid: Characterization and antioxidant capacity
Yingjun Jing (2019)
Chitosan powder coating, a novel simple technique for enhancement of shelf life quality of carrot shreds stored in macro perforated LDPE packs
R. Pushkala (2012)
Improved Chemical Stability and Antiproliferative Activities of Curcumin-Loaded Nanoparticles with a Chitosan Chlorogenic Acid Conjugate.
Y. Fan (2017)
Chitosan Nanoparticles Attenuate Hydrogen Peroxide-Induced Stress Injury in Mouse Macrophage RAW264.7 Cells
Z. Wen (2013)
Poly (Vinyl Alcohol)/Chitosan/Akermanite Nanofibrous Scaffolds Prepared by Electrospinning
M. Bafandeh (2019)
Methods of reducing the level of indoxyl sulfate – one of the most potent protein-bound uremic toxins
Malgorzata Karbowska (2016)
ORAC of chitosan and its derivatives
L. Casettari (2012)
Preparation and in vitro antioxidant activities of 6‐amino‐6‐deoxychitosan and its sulfonated derivatives
J. Yang (2015)
Antioxidative activity of chitosan and chitosan based biopolymer film
M. N. Hromis (2017)
Chitosan-based luminescent/magnetic hybrid nanogels for insulin delivery, cell imaging, and antidiabetic research of dietary supplements.
J. Shen (2012)
Razvoj biorazgradivog aktivnog ambalažnog materijala na bazi hitozana: sinteza, optimizacija svojstava, karakterizacija i primena
Nevena Hromiš (2015)
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