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Antioxidant Properties Of High Molecular Weight Dietary Chitosan In Vitro And In Vivo

M. Anraku, Takeshi Fujii, Y. Kondo, E. Kojima, T. Hata, N. Tabuchi, Daiju Tsuchiya, Takeshi Goromaru, H. Tsutsumi, D. Kadowaki, T. Maruyama, M. Otagiri, Hisao Tomida
Published 2011 · Chemistry

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Abstract The effect of high molecular weight chitosan supplement (HMCS), a natural polymer derived from chitin, on indices of oxidative stress was investigated in normal volunteers. The use of HMCS for 8 weeks resulted in a significant decrease in total cholesterol levels and atherogenic index, and increased levels of high density lipoprotein (HDL) cholesterol. HMCS treatment also resulted in a lowered ratio of oxidized to reduced albumin and an increase in total plasma antioxidant activity. A good correlation between the atherogenic index and oxidized albumin ratio was found. The results suggest that the ratio of oxidized to reduced albumin ratio represents a potentially useful marker of the metabolic syndrome. In in vitro studies, HMCS slightly reduced the levels of two stable radicals in a dose- and time-dependent manner. The strong binding capacity of indoxyl sulfate and low density lipoprotein (LDL) cholesterol was also observed with HMCS. These results suggest that HMCS reduces significant levels of pro-oxidants such as cholesterol and uremic toxins in the gastrointestinal tract, thereby inhibiting the subsequent development of oxidative stress in the systemic circulation in humans.
This paper references
Antimicrobial Activity of Hetero-Chitosans and Their Oligosaccharides with Different Molecular Weights
P. Park (2004)
10.1016/j.ijbiomac.2008.04.006
Antioxidant protection of human serum albumin by chitosan.
M. Anraku (2008)
10.1016/0304-4165(87)90155-3
The relative contributions of vitamin E, urate, ascorbate and proteins to the total peroxyl radical-trapping antioxidant activity of human blood plasma.
D. D. Wayner (1987)
Indoxyl sulfate increases the gene expressions of TGF-beta 1, TIMP-1 and pro-alpha 1(I) collagen in uremic rat kidneys.
T. Miyazaki (1997)
10.1016/S0960-894X(01)00285-2
Antioxidant activity of water-soluble chitosan derivatives.
W. Xie (2001)
10.1016/S0006-291X(03)00579-5
Chitosan induces different L-arginine metabolic pathways in resting and inflammatory macrophages.
C. Porporatto (2003)
10.1038/sj.ijo.0800806
Reduction in fat storage during chitin-chitosan treatment in mice fed a high-fat diet
L-K Han (1999)
10.1093/JN/130.11.2753
Cholesterol reduction by glucomannan and chitosan is mediated by changes in cholesterol absorption and bile acid and fat excretion in rats.
C. Gallaher (2000)
10.1038/KI.1991.233
Role for "uremic toxin" in the progressive loss of intact nephrons in chronic renal failure.
M. Motojima (1991)
10.1016/S0955-2863(01)00208-X
The effect of chitosan and other polycations on tight junction permeability in the human intestinal Caco-2 cell line(1).
G. Ranaldi (2002)
10.1111/J.1523-1755.2004.00813.X
Intravenous iron administration induces oxidation of serum albumin in hemodialysis patients.
M. Anraku (2004)
10.1271/bbb.64.965
Effect of Dietary Chitosans with Different Viscosity on Plasma Lipids and Lipid Peroxidation in Rats Fed on A Diet Enriched with Cholesterol
M. Chiang (2000)
Lipoproteins in atherogenesis.
G. Schonfeld (1979)
10.1093/AJCN/33.4.787
A novel use of chitosan as a hypocholesterolemic agent in rats.
M. Sugano (1980)
10.1016/J.NUT.2005.05.010
Quantitative evaluation of the antioxidant properties of garlic and shallot preparations.
Nuttakaan Leelarungrayub (2006)
10.1271/BBB.62.206
Antioxidative activities of several marine polysaccharides evaluated in a phosphatidylcholine-liposomal suspension and organic solvents.
C. Xue (1998)
Potential Immuno-Stimulating Effect of Antitumoral Fraction of Chitosan Oligosaccharides
전유진 (2001)
10.1016/J.TOX.2005.11.001
Effect of chitosan supplementation on antitubercular drugs-induced hepatotoxicity in rats.
S. Santhosh (2006)
10.1016/J.JADA.2004.10.004
Chitosan supplementation and fat absorption in men and women.
M. D. Gades (2005)
10.1016/S0304-4165(98)00146-9
Potent antiperoxidation activity of the bisbenzylisoquinoline alkaloid cepharanthine: the amine moiety is responsible for its pH-dependent radical scavenge activity.
K. Kogure (1999)
10.1016/0021-9150(83)90002-3
Plasma lipids and apolipoproteins as discriminators for presence and severity of angiographically defined coronary artery disease.
A. Noma (1983)
10.1016/J.FCT.2007.09.111
Effects of chitosan oligosaccharide (COS) on the glycerol-induced acute renal failure in vitro and in vivo.
H. Yoon (2008)
10.1016/J.JCONREL.2005.09.040
Deoxycholic acid-conjugated chitosan oligosaccharide nanoparticles for efficient gene carrier.
S. Chae (2005)
10.1016/j.fct.2008.10.015
Antioxidant effects of a dietary supplement: reduction of indices of oxidative stress in normal subjects by water-soluble chitosan.
M. Anraku (2009)
10.1291/hypres.30.395
Effect of Olmesartan on Oxidative Stress in Hemodialysis Patients
D. Kadowaki (2007)
10.1016/0006-2952(88)90126-8
Albumin--an important extracellular antioxidant?
B. Halliwell (1988)
10.1016/j.carres.2009.05.006
Antioxidant properties of some different molecular weight chitosans.
Hisao Tomida (2009)
10.1152/AJPRENAL.00281.2004
Indoxyl sulfate induces complex redox alterations in mesangial cells.
A. Gelasco (2006)
10.1124/JPET.303.2.880
Renal disposition of a furan dicarboxylic acid and other uremic toxins in the rat.
Y. Tsutsumi (2002)
10.1080/07315724.2006.10719550
Evaluating Efficacy of a Chitosan Product Using a Double-Blinded, Placebo-Controlled Protocol
G. Kaats (2006)
10.1016/S0021-9150(98)00045-8
Dietary chitosan inhibits hypercholesterolaemia and atherogenesis in the apolipoprotein E-deficient mouse model of atherosclerosis.
D. Ormrod (1998)
10.1016/S0928-0987(99)00032-9
Chitosans as absorption enhancers of poorly absorbable drugs. 3: Influence of mucus on absorption enhancement.
N. G. Schipper (1999)
10.1016/S0008-6215(00)90359-8
Antitumor effect of hexa-N-acetylchitohexaose and chitohexaose.
K. Suzuki (1986)



This paper is referenced by
10.1002/9781119143802.ch40
Chitosan–Antioxidant Conjugates
Vivien Nagy (2020)
10.1063/1.4894224
Towards bio-silicon interfaces: formation of an ultra-thin self-hydrated artificial membrane composed of dipalmitoylphosphatidylcholine (DPPC) and chitosan deposited in high vacuum from the gas-phase.
M. J. Retamal (2014)
10.1016/j.carbpol.2020.116782
Designing, structural determination and biological effects of rifaximin loaded chitosan- carboxymethyl chitosan nanogel.
S. Algharib (2020)
10.1016/j.carbpol.2018.07.016
Antioxidant activities of chitosans and its derivatives in in vitro and in vivo studies.
M. Anraku (2018)
10.1002/9781118412893.CH10
Biological effects and extraction processes used to obtain marine chitosan.
A. Montilla (2013)
10.1016/J.POSTHARVBIO.2013.07.025
Chitosan based powder coating technique to enhance phytochemicals and shelf life quality of radish shreds
R. Pushkala (2013)
10.1016/j.carbpol.2012.03.014
Antioxidant and renoprotective activity of chitosan in nephrectomized rats.
M. Anraku (2012)
10.1007/s13726-020-00875-9
Functionalization of carboxymethyl chitosan with chlorogenic acid: preparation, characterization, and antioxidant capacity
Chaohong Zhang (2020)
10.1016/j.carbpol.2012.10.005
Self-assembled nanoparticles of modified-chitosan conjugates for the sustained release of DL-α-tocopherol.
Javier Pérez Quiñones (2013)
10.1016/J.FOODHYD.2015.05.023
Biological effects of chitosan and its derivatives
Dai-Hung Ngo (2015)
10.1016/j.carbpol.2016.05.109
Polyphenol-chitosan conjugates: Synthesis, characterization, and applications.
Qiaobin Hu (2016)
10.1039/c5fo00303b
Development of a low fat fresh pork sausage based on chitosan with health claims: impact on the quality, functionality and shelf-life.
Deborah S. do Amaral (2015)
10.1016/J.JSSAS.2014.04.005
Carboxymethyl chitosan modulates the genotoxic risk and oxidative stress of perfluorooctanoic acid in Nile tilapia (Oreochromis niloticus)
F. K. Abdel-Gawad (2016)
Recent Advances of Chitosan and Its Derivatives for Novel Applications in Food Science
Y. Luo (2013)
10.1016/j.carbpol.2020.117246
The preparation and validation of chitosan tablets that rapidly disperse and disintegrate as an oral adsorbent in the treatment of lifestyle-related diseases
M. Anraku (2020)
10.1016/j.carbpol.2016.12.057
An oral absorbent, surface-deacetylated chitin nano-fiber ameliorates renal injury and oxidative stress in 5/6 nephrectomized rats.
M. Anraku (2017)
10.1016/j.carbpol.2014.05.078
Effects of chitosan on oxidative stress and related factors in hemodialysis patients.
M. Anraku (2014)
10.4314/TJPR.V11I2.9
In Vitro Antioxidant Activity of Chitosan Aqueous Solution: Effect of Salt Form
Natthan Charernsriwilaiwat (2012)
10.1016/j.ijbiomac.2020.08.153
Antimicrobial and antioxidant properties of chitosan and its derivatives and their applications: A review.
M. A. Abd El-Hack (2020)
10.1590/1980-5373-MR-2016-0618
Effect of Chitosan on the Properties of Electrospun Fibers From Mixed Poly(Vinyl Alcohol)/Chitosan Solutions
R. Gonçalves (2017)
10.1088/2053-1591/ab5c8c
Green synthesis of Cefadroxil loaded chitosan/PVA nanofibers by freeze drying
Haroon Iqbal (2019)
10.1016/J.REACTFUNCTPOLYM.2018.12.005
Free radical-mediated conjugation of chitosan with tannic acid: Characterization and antioxidant capacity
Yingjun Jing (2019)
10.1016/J.IFSET.2012.03.003
Chitosan powder coating, a novel simple technique for enhancement of shelf life quality of carrot shreds stored in macro perforated LDPE packs
R. Pushkala (2012)
10.1021/acs.jafc.7b04451
Improved Chemical Stability and Antiproliferative Activities of Curcumin-Loaded Nanoparticles with a Chitosan Chlorogenic Acid Conjugate.
Y. Fan (2017)
10.3390/md11103582
Chitosan Nanoparticles Attenuate Hydrogen Peroxide-Induced Stress Injury in Mouse Macrophage RAW264.7 Cells
Z. Wen (2013)
10.1080/00222348.2019.1587883
Poly (Vinyl Alcohol)/Chitosan/Akermanite Nanofibrous Scaffolds Prepared by Electrospinning
M. Bafandeh (2019)
10.1080/15569543.2016.1222442
Methods of reducing the level of indoxyl sulfate – one of the most potent protein-bound uremic toxins
Malgorzata Karbowska (2016)
10.1016/J.FOODHYD.2012.01.005
ORAC of chitosan and its derivatives
L. Casettari (2012)
10.1002/bip.22656
Preparation and in vitro antioxidant activities of 6‐amino‐6‐deoxychitosan and its sulfonated derivatives
J. Yang (2015)
10.5937/FFR1702091H
Antioxidative activity of chitosan and chitosan based biopolymer film
M. N. Hromis (2017)
10.1016/j.ijpharm.2012.01.059
Chitosan-based luminescent/magnetic hybrid nanogels for insulin delivery, cell imaging, and antidiabetic research of dietary supplements.
J. Shen (2012)
Razvoj biorazgradivog aktivnog ambalažnog materijala na bazi hitozana: sinteza, optimizacija svojstava, karakterizacija i primena
Nevena Hromiš (2015)
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