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The Enzymatic Degradation And Swelling Properties Of Chitosan Matrices With Different Degrees Of N-acetylation.

Dongwen Ren, H. Yi, W. Wang, X. Ma
Published 2005 · Chemistry, Medicine

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In the design of chitosan-based drug delivery systems and implantable scaffolds, the biodegradation rate of the chitosan matrix represents a promising strategy for drug delivery and the function of carriers. In this study, we have investigated the degradation of chitosan with different degrees of N-acetylation, with respect to weight loss, water absorption, swelling behavior, molecular weight loss of bulk materials, and reducing sugar content in the media. Chitosan matrices were prepared by compression molding. The results revealed that the initial degradation rate, equilibrium water absorption, and swelling degree increased with decreasing degree of deacetylation (DD) and a dramatic rise began as DD of the chitosan matrix decreased to 62.4%. Chitosan matrices with DD of 52.6%, 56.1%, and 62.4% had the weight half-life of 9.8, 27.3, and more than 56 days, respectively, and the weight half-life of average molecular weight 8.4, 8.8, and 20.0 days, respectively. For chitosan matrices with DD of 71.7%, 81.7%, and 93.5%, both types of half-life exceeded 84 days because of the much slower degradation rate. The dimension of chitosan matrices during degradation was determined by the process of swelling and degradation. These findings may help to design chitosan-based biomedical materials with predetermined degradation timed from several days to months and proper swelling behaviors.
This paper references
Solid state characterization of the structure of chitosan films
R. Samuels (1981)
Effects of the controlled-released TGF-beta 1 from chitosan microspheres on chondrocytes cultured in a collagen/chitosan/glycosaminoglycan scaffold.
J. Lee (2004)
Chitin: Fulfilling a Biomaterials Promise
E. Khor (2001)
Scaffolds in tissue engineering bone and cartilage.
D. Hutmacher (2000)
Heterogeneous N-deacetylation of chitin in alkaline solution
K. Chang (1997)
Microcapsules of alginate-chitosan--I. A quantitative study of the interaction between alginate and chitosan.
O. Gåserød (1998)
Solid state structure of chitosan prepared under different N-deacetylating conditions
K. H. Prashanth (2002)
Host response to tissue engineered devices.
Mikos (1998)
Blood compatibility and biodegradability of partially N-acylated chitosan derivatives.
K. Lee (1995)
The chitosan prepared from crab tendons: II. The chitosan/apatite composites and their application to nerve regeneration.
I. Yamaguchi (2003)
Tear lysozyme levels in contact lens wearers.
A. Temel (1991)
The importance of physicochemical swelling in cartilage illustrated with a model hydrogel system.
N. Broom (1998)
In vitro and in vivo degradation of films of chitin and its deacetylated derivatives.
K. Tomihata (1997)
Why degradable polymers undergo surface erosion or bulk erosion.
F. von Burkersroda (2002)
Porous chitosan scaffold containing microspheres loaded with transforming growth factor-beta1: implications for cartilage tissue engineering.
S. Kim (2003)
Degradation of partially N-acetylated chitosans with hen egg white and human lysozyme
Ragnhild J. Nordtveit (1996)
N-acetylation in chitosan and the rate of its enzymic hydrolysis.
S. Hirano (1989)
Chitosan and its use as a pharmaceutical excipient.
L. Illum (1998)
Recent advances on chitosan-based micro- and nanoparticles in drug delivery.
S. Agnihotri (2004)
Clinical diagnosis and management by laboratory methods
J. Henry (1979)
Novel injectable neutral solutions of chitosan form biodegradable gels in situ.
A. Chenite (2000)
Studies on chitosan: 4. Lysozymic hydrolysis of partially N-acetylated chitosans.
Satoshi Aiba (1992)
In vitro degradation rates of partially N-acetylated chitosans in human serum.
K. M. Vårum (1997)
The chitosan prepared from crab tendon I: the characterization and the mechanical properties.
I. Yamaguchi (2003)
Biodegradation and distribution of water-soluble chitosan in mice.
Hayato Onishi (1999)
Studies on chitosan: 3. Evidence for the presence of random and block copolymer structures in partially N-acetylated chitosans.
Satoshi Aiba (1991)
Controlling cell adhesion and degradation of chitosan films by N-acetylation.
T. Freier (2005)
Degradation of fully water-soluble, partially N-acetylated chitosans with lysozyme
Ragnhild J. Nordtveit (1994)
Swelling behavior and the release of protein from chitosan–pectin composite particles
K. Chang (2000)
Fast setting calcium phosphate-chitosan scaffold: mechanical properties and biocompatibility.
H. Xu (2005)

This paper is referenced by
Current State of the Potential Use of Chitosan as Pharmaceutical Excipient
A. R. Madureira (2015)
Dextran Microspheres as a Potential Carrier for Vincristine Sulphate Incorporated with Thermosensitive Gel offered Prolonged Release
Vivek Thakur (2016)
Properties and Biocompatibility of Chitosan and Silk Fibroin Blend Films for Application in Skin Tissue Engineering
Witoo Luangbudnark (2012)
The effect of degree of deacetylation on the radiation induced degradation of chitosan
Pınar Taşkın (2014)
Thermosensitive chitosan/glycerophosphate-based hydrogel and its derivatives in pharmaceutical and biomedical applications
Stéphanie Supper (2014)
In-situ forming thermosensitive hydroxypropyl chitin-based hydrogel crosslinked by Diels-Alder reaction for three dimensional cell culture.
B. Bi (2019)
Fabrication and characterization of hydrothermal cross-linked chitosan porous scaffolds for cartilage tissue engineering applications.
Mohammad Amin Shamekhi (2017)
Development and Implementation of Multi-Cued Guidance Strategies for Axonal Regeneration
Aleesha M. McCormick (2014)
Preparation and evaluation of lysozyme-loaded nanoparticles coated with poly-γ-glutamic acid and chitosan.
Y. Liu (2013)
Methods of N-acetylated chitosan scaffolds and its in vitro biodegradation by lysozyme
Thazin Han (2012)
Influence of Polycation Functional Properties on Polyanion Micro/Nanoparticles for NSAIDs Reinforced Via Polyelectrolyte Complexation: Alginate–Chitosan Case Study
B. Čalija (2017)
Tailorable Trimethyl chitosans as adjuvant for intranasal immunization
Rolf J. Verheul (2010)
Chitin and Chitosan for Tissue Engineering Application
S. Park (2012)
Properties of chitosan-collagen sponges and osteogenic differentiation of rat-bone-marrow stromal cells.
P. Arpornmaeklong (2008)
Collagen/Chitosan Complexes: Preparation, Antioxidant Activity, Tyrosinase Inhibition Activity, and Melanin Synthesis
Yingying Hua (2020)
Chitosan scaffolds for in vitro buffalo embryonic stem-like cell culture: an approach to tissue engineering.
W. W. Thein-Han (2007)
An injectable enzymatically crosslinked tyramine-modified carboxymethyl chitin hydrogel for biomedical applications.
B. Bi (2019)
Fast degrading polymer networks based on carboxymethyl chitosan
M. A. Gámiz-González (2017)
Biodegradable and synthetic membranes for the expansion and functional differentiation of rat embryonic liver cells.
Antonella Piscioneri (2011)
Rapid, guanosine 5'-diphosphate-induced, gelation of chitosan sponges as novel injectable scaffolds for soft tissue engineering and drug delivery applications.
Mina Mekhail (2013)
Biodegradable Chitosan Decreases the Immune Response to Trichinella spiralis in Mice
K. Brodaczewska (2017)
Polymeric Nanoparticles for Cancer Photodynamic Therapy.
C. Conte (2016)
Biotinylated N-palmitoyl chitosan for design of drug loaded self-assembled nanocarriers
V. Balan (2016)
Development of chitosan-tripolyphosphate non-woven fibrous scaffolds for tissue engineering application
Falguni Pati (2012)
Degradation and compatibility behaviors of poly(glycolic acid) grafted chitosan.
L. Zhang (2013)
Design of deformable chitosan microspheres loaded with superparamagnetic iron oxide nanoparticles for embolotherapy detectable by magnetic resonance imaging.
Eun-Young Chung (2012)
In vitro assessment of three dimensional dense chitosan-based structures to be used as bioabsorbable implants.
Nuno Guitian Oliveira (2014)
Preparation and Functional Assessment of Composite Chitosan-Nano-Hydroxyapatite Scaffolds for Bone Regeneration
B. Reves (2012)
Porous chitosan microspheres for application as quick in vitro and in vivo hemostat.
J. Li (2017)
Fabrication of biodegradable nano test tubes by template synthesis.
Jillian L. Perry (2010)
An investigation on the short-term biodegradability of chitosan with various molecular weights and degrees of deacetylation
S. Bagheri-khoulenjani (2009)
Chitosan nanoparticles: a promising system in novel drug delivery.
K. Nagpal (2010)
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