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Albumin-stabilized Epirubicin Nanocarriers Of Core–shell Type Based On Poly(butyl Cyanoacrylate) And Poly(styrene-co-maleic Acid)
Published 2015 · Chemistry
Abstract This article describes a facile approach for preparation of novel albumin-stabilized polymer nanoparticles of core–shell type based on poly(butyl cyanoacrylate) (PBCA) and poly(styrene-co-maleic acid) (PSMA) as carriers for the anticancer drug epirubicin. The PBCA/PSMA particles were obtained by nanoprecipitation and were found to be spherical in shape, with monomodal size distribution and negative zeta-potentials. Particles of increasing average sizes between 100 and 200 nm were prepared by increasing the PBCA/PSMA ratio. Even 5 wt% of PSMA in the PBCA/PSMA particles resulted in increased electrostatic stabilization of the drug-free colloids and larger absolute value of the zeta potential. This effect on the electrokinetic behavior was attributed to enhanced deposition of the amphiphilic PSMA component at the particle surface and formation of a PSMA-enriched shell over the PBCA-enriched particle core. Epirubicin was loaded to the PBCA/PSMA particles by sorption. Only 5 wt% of PSMA in the PBCA/PSMA particles was enough to increase drug loading efficiency to ∼95% and to improve albumin adsorption on the particle surface leading to increased colloidal stability. The obtained albumin-stabilized PBCA/PSMA epirubicin carriers did not cause any significant hemolysis (tested in vitro), neither affected the osmotic fragility of erythrocytes, which is an important prerequisite for biomedical applications.