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Experimental Design Approach Applied To The Development Of Chitosan Coated Poly(isobutylcyanoacrylate) Nanocapsules Encapsulating Copaiba Oil

F. H. Xavier-Júnior, F. H. Xavier-Júnior, E. S. T. Egito, A. R. V. Morais, A. R. V. Morais, É. N. Alencar, A. Maciuk, C. Vauthier
Published 2018 · Chemistry

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Abstract The aim of this work was to develop, characterize and optimize the natural copaiba oil-loaded chitosan decorated poly(isobutylcyanoacrylate) nanocapsules. These innovatively obtained natural-based systems were developed by an original method of interfacial polymerization of isobutylcyanoacrylate using chitosan as a stabilizer for the nanocapsules. A preliminary study investigated the influence of the molecular weight of chitosan, the type of copaiba oil extract and the solvent phase. Nanocapsules could only be produced with copaiba resin oil, with size ranging from 300 to 1200 nm. Nanocapsule size and zeta potential were then optimized by two-level three-variable full-factorial experimental design. Samples showed spherical objects when analyzed by transmission electron microscopy. The copaiba oil encapsulated in the nanocapsules showed all compounds of the parent oil. Nanocapsules with positive zeta potential were obtained consistently with the expected distribution of chitosan on the nanocapsule surface. Optimal nanocapsules showed a diameter of 473 nm, a zeta potential of +34 mV and an encapsulation efficiency of the oil of 74% including 55.5 μg of β- caryophyllene/mg of nanocapsules. The obtained nanocapsules can be suggested as oral delivery system for anticancer molecules including paclitaxel assuming a synergistic effect with anticancer active components of the oil.
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