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Protein-based Signaling Systems In Tissue Engineering.

T. Boontheekul, D. Mooney
Published 2003 · Biology, Medicine

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Tissue engineering aims to replace damaged tissues or organs using either transplanted cells or host cells recruited to the target site. Protein signaling is crucial to regulate cell phenotype and thus engineered tissue structure and function. Biomaterial vehicles are being designed to incorporate and locally deliver various molecules involved in this signaling, including both growth factors and peptides that mimick whole proteins. Controlling the concentration, local duration and spatial distribution of these factors is key to their utility and efficacy. Recent advances have been made in the development of polymeric delivery systems intended to achieve this control.
This paper references
10.1002/JBM.10267
Loading of collagen-heparan sulfate matrices with bFGF promotes angiogenesis and tissue generation in rats.
J. S. Pieper (2002)
10.1007/s10380-002-0686-5
Intramyocardial sustained delivery of basic fibroblast growth factor improves angiogenesis and ventricular function in a rat infarct model
A. Iwakura (2003)
10.1016/S0003-2697(02)00396-2
Protein-heparin interactions measured by BIAcore 2000 are affected by the method of heparin immobilization.
R. Osmond (2002)
10.1016/S0142-9612(02)00231-4
Growth of human endothelial cells on photochemically grafted Gly-Arg-Gly-Asp (GRGD) chitosans.
Tze-Wen Chung (2002)
Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus.
Lily Y Koo (2002)
10.1073/pnas.192291499
Engineering growing tissues
E. Alsberg (2002)
10.1002/JBM.A.10427
Controlled release of fibroblast growth factors and heparin from photocrosslinked chitosan hydrogels and subsequent effect on in vivo vascularization.
M. Ishihara (2003)
10.1038/86715
A biodegradable polymer as a cytokine delivery system for inducing bone formation
N. Saito (2001)
10.1002/1097-4636(20010905)56:3<390::AID-JBM1108>3.0.CO;2-L
Immobilized RGD peptides on surface-grafted dextran promote biospecific cell attachment.
S. Massia (2001)
10.2106/00004623-200100002-00002
TGF-&bgr;1 Release from Biodegradable Polymer Microparticles: Its Effects on Marrow Stromal Osteoblast Function
L. Lu (2001)
10.1097/00007890-200205270-00011
Local delivery of basic fibroblast growth factor increases both angiogenesis and engraftment of hepatocytes in tissue-engineered polymer devices1
H. Lee (2002)
10.1016/B978-012436630-5/50004-0
TISSUE ENGINEERING IN PERSPECTIVE
E. Bell (2000)
10.1038/nbt1101-1029
Polymeric system for dual growth factor delivery
T. P. Richardson (2001)
10.1111/j.1749-6632.2002.tb03068.x
Molecular Signaling in Bioengineered Tissue Microenvironments
D. Bottaro (2002)
10.1016/S8756-3282(03)00028-0
Local bone formation by injection of recombinant human bone morphogenetic protein-2 contained in polymer carriers.
N. Saito (2003)
10.1016/S0142-9612(02)00570-7
Engineering cell adhesive surfaces that direct integrin α5β1 binding using a recombinant fragment of fibronectin
S. Cutler (2003)
10.1089/107632703762687636
Novel approach to regeneration of periodontal tissues based on in situ tissue engineering: effects of controlled release of basic fibroblast growth factor from a sandwich membrane.
T. Nakahara (2003)
10.1021/BM005584B
Nanoscale clustering of RGD peptides at surfaces using Comb polymers. 1. Synthesis and characterization of Comb thin films.
D. J. Irvine (2001)
10.1002/JPS.10556
Surface modification of poly(glycolic acid) (PGA) for biomedical applications.
Kyung-Bok Lee (2003)
10.1007/BF03179936
Growth factor releasing porous poly (ɛ-caprolactone)-chitosan matrices for enhanced bone regenerative rherapy
S. Im (2003)
10.1089/10763270260424213
Release of bioactive transforming growth factor beta(3) from microtextured polymer surfaces in vitro and in vivo.
J. T. Parker (2002)
10.1038/nbt818
Repair of bone defects using synthetic mimetics of collagenous extracellular matrices
M. Lutolf (2003)
10.1007/s00402-003-0493-0
Hypoxia and PDGF have a synergistic effect that increases the expression of the angiogenetic peptide vascular endothelial growth factor in Achilles tendon fibroblasts
W. Petersen (2003)
10.1002/JBM.1256
Effect of experimental parameters on the in vitro release kinetics of transforming growth factor beta1 from coral particles.
C. Demers (2002)
10.1038/415234a
Myocardial gene therapy
J. Isner (2002)
10.1016/0092-8674(87)90707-0
Identification of an amino acid sequence in laminin mediating cell attachment, chemotaxis, and receptor binding
J. Graf (1987)
10.1073/PNAS.90.4.1513
Perivascular and intravenous administration of basic fibroblast growth factor: vascular and solid organ deposition.
E. Edelman (1993)
10.1002/1521-4095(20020618)14:12<886::AID-ADMA886>3.0.CO;2-I
Biomaterials to Spatially Regulate Cell Fate
J. Rowley (2002)
10.1038/309030A0
Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule
M. Pierschbacher (1984)
10.1016/S1050-1738(02)00259-1
Insights from angiogenesis trials using fibroblast growth factor for advanced arteriosclerotic disease.
Rohit Khurana (2003)
10.1002/JBM.A.10396
Effect of chitosan film containing basic fibroblast growth factor on wound healing in genetically diabetic mice.
K. Mizuno (2003)
10.1038/nm0603-669
The biology of VEGF and its receptors
N. Ferrara (2003)
10.1073/pnas.0737381100
Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: Engineering cell-invasion characteristics
M. Lutolf (2003)
10.1073/pnas.051626998
Nerve growth factor control of neuronal expression of angiogenetic and vasoactive factors
L. Calzà (2001)
10.1177/00220345010800111501
Cell-interactive Alginate Hydrogels for Bone Tissue Engineering
E. Alsberg (2001)
10.1002/1521-4095(200106)13:11<837::AID-ADMA837>3.0.CO;2-D
Controlled Drug Delivery from Polymers by Mechanical Signals
K. Lee (2001)
10.1038/71916
Stabilization of proteins encapsulated in injectable poly (lactide-co-glycolide)
Gaozhong Zhu (2000)
10.1055/S-0037-1613389
Fibrin-based biomaterials to deliver human growth factors.
C. Wong (2003)
10.1046/J.1525-1594.2003.07009.X
Delivery of a growth factor fusion protein having collagen-binding activity to wound tissues.
T. Ishikawa (2003)
10.1016/S0142-9612(00)00250-7
Poly(L-lysine)-GRGDS as a biomimetic surface modifier for poly(lactic acid).
R. Quirk (2001)
10.1111/j.1749-6632.2002.tb04870.x
Placental Growth Factor (PlGF) and Its Receptor Flt‐1 (VEGFR‐1)
A. Luttun (2002)
10.1002/JBM.10169
Experimental studies on bone induction using low-molecular-weight poly (DL-lactide-co-glycolide) as a carrier for recombinant human bone morphogenetic protein-2.
K. Bessho (2002)
10.1016/S8756-3282(01)00617-2
Human osteoprogenitor growth and differentiation on synthetic biodegradable structures after surface modification.
X. Yang (2001)
10.1517/14712598.2.2.211
Becaplermin: recombinant platelet derived growth factor, a new treatment for healing diabetic foot ulcers
J. Embil (2002)
10.1517/14712598.2.8.805
Tissue engineering strategies for in vivo neovascularisation
Alessandra B. Ennett (2002)
10.1038/nm848
Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2
R. Cao (2003)
10.1016/S0142-9612(00)00287-8
EGF containing gelatin-based wound dressings.
K. Ulubayram (2001)
10.1097/00007632-200208150-00006
IGF-I and TGF-beta1 application by a poly-(D,L-lactide)-coated cage promotes intervertebral bone matrix formation in the sheep cervical spine.
F. Kandziora (2002)
10.1126/SCIENCE.2218494
New methods of drug delivery.
R. Langer (1990)
10.1152/AJPHEART.00621.2002
Expression of VEGF and angiopoietins-1 and -2 during ischemia-induced coronary angiogenesis.
T. Matsunaga (2003)
10.1097/00007632-200208151-00002
Overview of Bone Morphogenetic Proteins
J. Wozney (2002)
10.1016/S0168-3659(02)00350-4
A novel method to obtain protein release from porous polymer scaffolds: emulsion coating.
J. Sohier (2003)
10.1016/S0923-1811(00)00141-9
Regulation of keratinocyte function by growth factors.
K. Hashimoto (2000)
10.1083/JCB.131.3.791
Integrin function: molecular hierarchies of cytoskeletal and signaling molecules
S. Miyamoto (1995)
10.1021/BM0255950
In situ immobilization of proteins and RGD peptide on polyurethane surfaces via poly(ethylene oxide) coupling polymers for human endothelial cell growth.
D. Wang (2002)
10.1038/74473
Enzymatic incorporation of bioactive peptides into fibrin matrices enhances neurite extension
J. C. Schense (2000)
10.1097/01.BRS.0000048644.91330.14
Simple Carrier Matrix Modifications Can Enhance Delivery of Recombinant Human Bone Morphogenetic Protein-2 for Posterolateral Spine Fusion
T. Akamaru (2003)
10.1038/nm0603-702
Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration
S. Rafii (2003)
10.1146/ANNUREV.CELLBIO.17.1.463
How matrix metalloproteinases regulate cell behavior.
M. Sternlicht (2001)
10.1016/S0168-3659(02)00181-5
Delivery of osteoinductive growth factors from degradable PEG hydrogels influences osteoblast differentiation and mineralization.
J. Burdick (2002)



This paper is referenced by
10.1007/s10856-015-5494-3
A glass polyalkenoate cement carrier for bone morphogenetic proteins
Adel M F Alhalawani (2015)
10.1016/J.BIOMATERIALS.2004.09.021
Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migration.
Solitaire A. DeLong (2005)
Colloidal gel and its application in tissue engineering
Baojun Xie (2005)
10.2741/2554
Notch signaling pathway and tissue engineering.
M. Carlson (2007)
10.1002/jbm.a.32140
Micropatterned surfaces with controlled ligand tethering.
T. Petrie (2009)
10.1016/J.JCONREL.2006.04.011
Microsphere-integrated collagen scaffolds for tissue engineering: effect of microsphere formulation and scaffold properties on protein release kinetics.
F. Ungaro (2006)
10.1007/S11684-008-0043-9
Current progress on scaffolds of tissue engineering heart valves
N. Dong (2008)
10.1016/j.biomaterials.2010.06.013
Enhanced angiogenesis of gene-activated dermal equivalent for treatment of full thickness incisional wounds in a porcine model.
R. Guo (2010)
Chapter 1 Titanium Alloys in Orthopaedics
W. Wang (2013)
10.1039/B514174P
Inductive tissue engineering with protein and DNA-releasing scaffolds.
D. Salvay (2006)
10.1002/jbm.a.34252
In vitro characterizations of mesoporous hydroxyapatite as a controlled release delivery device for VEGF in orthopedic applications.
Chye Khoon Poh (2012)
10.1201/9781439823989
Tissue engineering using ceramics and polymers
J. E. Gough (2007)
10.1016/j.biomaterials.2009.11.042
The effect of VEGF functionalization of titanium on endothelial cells in vitro.
Chye Khoon Poh (2010)
10.1533/9781845693817.1.129
Combining tissue engineering and drug deliveryTissue Engineering Using Ceramics and Polymers
N. Tirelli (2007)
10.1126/science.1169494
Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties
April M Kloxin (2009)
The Molecular Toolbox: Dendrimer Decorated Biomaterials for Musculoskeletal Regeneration
Ryan J Seelbach (2015)
10.1111/J.1601-6343.2005.00335.X
Advances in skeletal tissue engineering with hydrogels.
J. Elisseeff (2005)
10.3109/10717544.2010.509357
Hyaluronic acid/Chitosan nanoparticles as delivery vehicles for VEGF and PDGF-BB
Yolanda Parajó (2010)
10.1016/j.msec.2020.111220
Micro-patterned surface construction on BCP ceramics and the regulation on inflammation-involved osteogenic differentiation.
J. Wang (2020)
10.1111/J.1600-0757.2006.00156.X
Principles and applications of cell delivery systems for periodontal regeneration.
P. Bartold (2006)
10.1021/BK-2012-1120.CH003
Protein−Bioceramic Interactions at the Interface
Sunita Prem Victor (2012)
DEVELOPMENT AND CHARACTERISATION OF PHOTOCROSSLINKABLE POLY(ETHYLENE CARBONATE) ELASTOMERS FOR LOCAL PROTEIN DELIVERY
L. Cornacchione (2016)
Ortsgerichtete Immobilisierung fluoreszenzmarkierter IL-6-Typ-Zytokine und Analyse ihrer Signaltransduktion
T. Recker (2011)
10.1007/978-3-540-75645-3_8
Polymer Hydrogels to Enable New Medical Therapies
P. Welzel (2009)
10.1016/J.COPBIO.2004.08.010
Current strategies for cell delivery in cartilage and bone regeneration.
M. Sittinger (2004)
10.1098/rsif.2010.0223
Growth factor delivery-based tissue engineering: general approaches and a review of recent developments
Kangwon Lee (2010)
10.1002/term.309
Biosilicate® and low‐level laser therapy improve bone repair in osteoporotic rats
Paulo Sérgio Bossini (2011)
10.1089/107632703762687636
Novel approach to regeneration of periodontal tissues based on in situ tissue engineering: effects of controlled release of basic fibroblast growth factor from a sandwich membrane.
T. Nakahara (2003)
10.1007/S10856-006-0433-Y
The surface functionalization of 45S5 Bioglass®-based glass-ceramic scaffolds and its impact on bioactivity
Q. Chen (2006)
10.1038/sj.gt.3302940
Localized viral vector delivery to enhance in situ regenerative gene therapy
W. Hu (2007)
10.1016/J.TIBTECH.2003.10.002
Molecular farming in plants: host systems and expression technology.
R. Twyman (2003)
10.1016/j.biomaterials.2010.08.006
An in vitro assessment of titanium functionalized with polysaccharides conjugated with vascular endothelial growth factor for enhanced osseointegration and inhibition of bacterial adhesion.
X. Hu (2010)
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