Online citations, reference lists, and bibliographies.
← Back to Search

Characterization Of Peptide Coatings Adhered To Synthetic Fibers: A Versatile Model For Peptide Nucleic Acids

Allison M. Pekkanen, Ryan J Mondschein, Denis Guenette, Nrusingh Mohaptra, T. Long
Published 2017 · Materials Science

Save to my Library
Download PDF
Analyze on Scholarcy
Abstract Peptide nucleic acids (PNAs) are an emerging family of biomaterials designed to specifically target and treat diseased cells, most commonly in the antimicrobial-resistant bacteria MRSA. While PNAs offer great promise for the elimination of these bacteria, they are significantly more expensive than traditional peptides and often do not provide functionality for analysis. In this work, a model peptide (KFFCCQ) was developed to evaluate peptide coatings adhered to fibrous surfaces with multiple functional handles, i.e. the presence of a sulfur atom in cysteine and an aromatic ring in phenylalanine, to predict the durability of PNA coatings on 50/50 nylon/cotton blends (NyCo), which are commonly used in clothing such as combat and medical attire. Following elemental analysis through XPS and EDX-SEM, rinses were performed on the fabrics and the subsequent release of peptide was evaluated with UV–vis. As expected, elevated temperature and increased time resulted in higher KFFCCQ release levels from the NyCo fibers. Finally, EDX-SEM examined the presence of KFFCCQ following rinse cycles, revealing that a higher level of KFFCCQ released from nylon fibers compared to cotton fibers. This evaluation proves the utility of KFFCCQ as a preliminary model to evaluate adhesion and release of peptides from nylon and cotton fibrous surfaces.
This paper references
Atomic layer deposition TiO2/Al2O3 nanolayer of dyed polyamide/aramid blend fabric for high intensity UV light protection
Xingfang Xiao (2015)
Plasma treatment applied in the pad-dry-cure process for making rechargeable antimicrobial cotton fabric that inhibits S. Aureus
Chang-E Zhou (2016)
Initiated chemical vapor deposition of antimicrobial polymer coatings.
T. Martin (2007)
Cell Penetrating Peptides for Chemical Biological Studies.
I. Nakase (2015)
Characteristics of Cell-Penetrating Peptide/Nucleic Acid Nanoparticles.
Helerin Margus (2016)
Synthesis and characterization of poly(ethylene glycol)-glutathione conjugate self-assembled nanoparticles for antioxidant delivery.
S. Williams (2009)
Peptide nucleic acid (PNA). A DNA mimic with a peptide backbone.
P. Nielsen (1994)
Peptide Nucleic Acid Probes for Sequence-Specific DNA Biosensors
J. Wang (1996)
Diagnosis of bacterial vaginosis by a new multiplex peptide nucleic acid fluorescence in situ hybridization method
A. Machado (2015)
Superhydrophobic conductive textiles with antibacterial property by coating fibers with silver nanoparticles
Chao-Hua Xue (2012)
Ultrasonic Coating of Textiles by Antibacterial and Antibiofilm Nanoparticles
I. Perelshtein (2016)
A study of surface morphology and structure of cotton fibres with soluble immobilized-cellulase treatment
Yuanyuan Yu (2014)
Antisense Growth Inhibition of Methicillin-Resistant Staphylococcus aureus by Locked Nucleic Acid Conjugated with Cell-Penetrating Peptide as a Novel FtsZ Inhibitor
Jingru Meng (2014)
Surface and Adhesion Properties of Polypyrrole-Coated Textiles
C. Heisey (1993)
Sonochemical coating of silver nanoparticles on textile fabrics (nylon, polyester and cotton) and their antibacterial activity.
I. Perelshtein (2008)
Antibacterial cotton treated with N-halamine and quaternary ammonium salt
Y. Liu (2013)
Fluorescence imaging of siRNA delivery by peptide nucleic acid-based probe.
T. Sato (2015)
Amination of Poly(ethylene-terephthalate) polymer surface for biochemical applications
C. Girardeaux (1996)
Silver-coated nylon fiber as an antibacterial agent.
P. C. Mackeen (1987)
DNA detection using water-soluble conjugated polymers and peptide nucleic acid probes
B. Gaylord (2002)

This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar