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Characterization Of Peptide Coatings Adhered To Synthetic Fibers: A Versatile Model For Peptide Nucleic Acids

Allison M. Pekkanen, Ryan J Mondschein, Denis Guenette, Nrusingh Mohaptra, T. Long
Published 2017 · Materials Science

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Abstract Peptide nucleic acids (PNAs) are an emerging family of biomaterials designed to specifically target and treat diseased cells, most commonly in the antimicrobial-resistant bacteria MRSA. While PNAs offer great promise for the elimination of these bacteria, they are significantly more expensive than traditional peptides and often do not provide functionality for analysis. In this work, a model peptide (KFFCCQ) was developed to evaluate peptide coatings adhered to fibrous surfaces with multiple functional handles, i.e. the presence of a sulfur atom in cysteine and an aromatic ring in phenylalanine, to predict the durability of PNA coatings on 50/50 nylon/cotton blends (NyCo), which are commonly used in clothing such as combat and medical attire. Following elemental analysis through XPS and EDX-SEM, rinses were performed on the fabrics and the subsequent release of peptide was evaluated with UV–vis. As expected, elevated temperature and increased time resulted in higher KFFCCQ release levels from the NyCo fibers. Finally, EDX-SEM examined the presence of KFFCCQ following rinse cycles, revealing that a higher level of KFFCCQ released from nylon fibers compared to cotton fibers. This evaluation proves the utility of KFFCCQ as a preliminary model to evaluate adhesion and release of peptides from nylon and cotton fibrous surfaces.
This paper references
10.1002/PEN.24068
Atomic layer deposition TiO2/Al2O3 nanolayer of dyed polyamide/aramid blend fabric for high intensity UV light protection
Xingfang Xiao (2015)
10.1177/0040517515622147
Plasma treatment applied in the pad-dry-cure process for making rechargeable antimicrobial cotton fabric that inhibits S. Aureus
Chang-E Zhou (2016)
10.1016/J.BIOMATERIALS.2006.10.009
Initiated chemical vapor deposition of antimicrobial polymer coatings.
T. Martin (2007)
10.1007/978-1-4939-2806-4_26
Cell Penetrating Peptides for Chemical Biological Studies.
I. Nakase (2015)
10.1021/acs.molpharmaceut.5b00598
Characteristics of Cell-Penetrating Peptide/Nucleic Acid Nanoparticles.
Helerin Margus (2016)
10.1021/bm801058j
Synthesis and characterization of poly(ethylene glycol)-glutathione conjugate self-assembled nanoparticles for antioxidant delivery.
S. Williams (2009)
10.1021/BC00025A001
Peptide nucleic acid (PNA). A DNA mimic with a peptide backbone.
P. Nielsen (1994)
10.1021/JA9608050
Peptide Nucleic Acid Probes for Sequence-Specific DNA Biosensors
J. Wang (1996)
10.7717/peerj.780
Diagnosis of bacterial vaginosis by a new multiplex peptide nucleic acid fluorescence in situ hybridization method
A. Machado (2015)
10.1016/J.APSUSC.2011.10.074
Superhydrophobic conductive textiles with antibacterial property by coating fibers with silver nanoparticles
Chao-Hua Xue (2012)
10.1007/978-981-287-470-2_20-1
Ultrasonic Coating of Textiles by Antibacterial and Antibiofilm Nanoparticles
I. Perelshtein (2016)
10.1007/s12221-014-1609-6
A study of surface morphology and structure of cotton fibres with soluble immobilized-cellulase treatment
Yuanyuan Yu (2014)
10.1128/AAC.03781-14
Antisense Growth Inhibition of Methicillin-Resistant Staphylococcus aureus by Locked Nucleic Acid Conjugated with Cell-Penetrating Peptide as a Novel FtsZ Inhibitor
Jingru Meng (2014)
10.1177/004051759306300501
Surface and Adhesion Properties of Polypyrrole-Coated Textiles
C. Heisey (1993)
10.1088/0957-4484/19/24/245705
Sonochemical coating of silver nanoparticles on textile fabrics (nylon, polyester and cotton) and their antibacterial activity.
I. Perelshtein (2008)
10.1007/s10570-013-0056-7
Antibacterial cotton treated with N-halamine and quaternary ammonium salt
Y. Liu (2013)
10.2116/analsci.31.315
Fluorescence imaging of siRNA delivery by peptide nucleic acid-based probe.
T. Sato (2015)
10.1007/BF02532829
Amination of Poly(ethylene-terephthalate) polymer surface for biochemical applications
C. Girardeaux (1996)
10.1128/AAC.31.1.93
Silver-coated nylon fiber as an antibacterial agent.
P. C. Mackeen (1987)
10.1073/pnas.162375999
DNA detection using water-soluble conjugated polymers and peptide nucleic acid probes
B. Gaylord (2002)



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