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Stable Drug Encapsulation In Micelles And Microemulsions.
A. Narang, D. Delmarre, Danchen Gao
Published 2007 · Chemistry, Medicine
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Oral absorption of hydrophobic drugs can be significantly improved using lipid-based non-particulate drug delivery systems, which avoid the dissolution step. Micellar and microemulsion systems, being the most dispersed of all, appear the most promising. While these systems show high drug entrapment and release under sink conditions, the improvement in oral drug bioavailability is often unpredictable. The formulation and drug-related biopharmaceutical aspects of these systems that govern oral absorption have been widely studied. Among these, preventing drug precipitation upon aqueous dilution could play a predominant role in many cases. Predictive ability and quick methods for assessment of such problems could be very useful to the formulators in selecting lead formulations. This review will attempt to summarize the research work that could be useful in developing these tools.
This paper references
Crystallization of hydrocortisone acetate: influence of polymers.
S. Raghavan (2001)
Enhanced Oral Bioavailability of a Poorly Water Soluble Drug PNU‐91325 by Supersaturatable Formulations
Ping Gao (2004)
Influence of lipolysis and droplet size on tocotrienol absorption from self-emulsifying formulations.
S. P. Yap (2004)
Light-scattering studies of testosterone enanthate containing soybean oil/C18:1E10/water oil-in-water microemulsions.
C. Malcolmson (2002)
Excess of Solubilization and Curvature in Nonionic Microemulsions.
Solubilization of flavopiridol by pH control combined with cosolvents, surfactants, or complexants.
P. Li (1999)
Formulation of self-emulsifying drug delivery systems
C. Pouton (1997)
Monodisperse colloids of transition metal and lanthanide compounds
J. Beattie (1989)
Improved oil solubilization in oil/water food grade microemulsions in the presence of polyols and ethanol.
N. Garti (2001)
Absorption of cyclosporin from conventional and new microemulsion oral formulations in liver transplant recipients with external biliary diversion.
A. Trull (1995)
Factors limiting the oral bioavailability of N-acetylglucosaminyl-N-acetylmuramyl dipeptide (GMDP) and enhancement of absorption in rats by delivery in a water-in-oil microemulsion.
K. Lyons (2000)
Partition Behaviour of Drugs in Microemulsions Measured by Electrokinetic Chromatography
Y. Mrestani (2004)
Amino acids in AOT reversed micelles. 2. The hydrophobic effect and hydrogen bonding as driving forces for interfacial solubilization
E. B. Leodidis (1990)
Effect of oil on the level of solubilization of testosterone propionate into nonionic oil-in-water microemulsions.
C. Malcolmson (1998)
Improved bioavailability of vitamin E with a self emulsifying formulation.
T. Julianto (2000)
Microemulsions: A Potential Delivery System for Bioactives in Food
J. Flanagan (2006)
Amino acids in AOT reversed micelles. 1. Determination of interfacial partition coefficients using the phase-transfer method
E. B. Leodidis (1990)
Effects of epidermal growth factor microemulsion formulation on the healing of stress-induced gastric ulcers in rats.
N. Çelebi (2002)
Crystallisation of oil-in-water emulsions: Amphiphile directed nucleation in aqueous emulsions of m-chloronitrobenzene
R. Davey (1996)
Self-diffusion nuclear magnetic resonance, microstructure transitions, and solubilization capacity of phytosterols and cholesterol in Winsor IV food-grade microemulsions.
Aviram Spernath (2003)
Preparation and evaluation of self‐microemulsifying drug delivery systems (SMEDDS) containing atorvastatin
Hai-rong Shen (2006)
Structural characterisation of water-Tween 40/Imwitor 308-isopropyl myristate microemulsions using different experimental methods.
F. Podlogar (2004)
Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems.
C. Pouton (2000)
Membrane transport of hydrocortisone acetate from supersaturated solutions; the role of polymers.
S. Raghavan (2001)
Amphotericin B in oil-water lecithin-based microemulsions: formulation and toxicity evaluation.
B. Brime (2002)
Effects of molecular structure of the interface and continuous phase on solubilization of water in water / oil microemulsions
M. J. ou (1987)
In vitro assessment of oral lipid based formulations.
C. J. Porter (2001)
Thermosetting microemulsions and mixed micellar solutions as drug delivery systems for periodontal anesthesia.
M. Scherlund (2000)
Lecithin-based oil-in-water microemulsions for parenteral use: pseudoternary phase diagrams, characterization and toxicity studies.
M. A. Moreno (2003)
Examination of the impact of a range of Pluronic surfactants on the in‐vitro solubilisation behaviour and oral bioavailability of lipidic formulations of atovaquone
L. Sek (2006)
Enhanced rates of electrolytic styrene epoxidation catalyzed by cross-linked myoglobin-poly(L-lysine) films in bicontinuous microemulsions.
A. Vaze (2004)
Microemulsions for dermal drug delivery studied by dynamic light scattering: effect of interparticle interactions in oil-in-water microemulsions.
Anuj Shukla (2003)
Supersaturation mechanism of drugs from solid dispersions with enteric coating agents.
A. Hasegawa (1988)
Microemulsions for topical delivery of estradiol.
S. Peltola (2003)
Fully dilutable microemulsions embedded with phospholipids and stabilized by short-chain organic acids and polyols.
Aviram Spernath (2006)
Preparation and evaluation of self - microemulsifying drug delivery systems ( SMEDDS ) containing atorvastatin
H. hen (2006)
Amino acids in reversed micelles. 4. Amino acids as cosurfactants
E. B. Leodidis (1991)
Solubilization of ionized and un-ionized flavopiridol by ethanol and polysorbate 20.
P. Li (1999)
Comparative bioavailability of Neoral and Sandimmune in cardiac transplant recipients over 1 year.
G. J. Cooney (1998)
Inhibition of sulfathiazole crystal growth by polyvinylpyrrolidone.
A. Simonelli (1970)
Evaluation of in vitro precipitation methods.
P. Li (1998)
Theory, Production and Mechanism of Formation of Monodispersed Hydrosols
V. Lamer (1950)
Recent applications of microemulsion electrokinetic chromatography
S. Hansen (2003)
Formulation design and bioavailability assessment of lipidic self-emulsifying formulations of halofantrine
Shui-Mei Khoo (1998)
Effect of cellulose polymers on supersaturation and in vitro membrane transport of hydrocortisone acetate.
S. Raghavan (2000)
Entrapment of enzyme in water-restricted microenvironment for enzyme-mediated catalysis under microemulsion-based organogels
D. Madamwar (2004)
Intestinal absorption of penclomedine from lipid vehicles in the conscious rat: contribution of emulsification versus digestibility.
P. C. de Smidt (2004)
A lecithin-based microemulsion of rh-insulin with aprotinin for oral administration: Investigation of hypoglycemic effects in non-diabetic and STZ-induced diabetic rats.
A. Cilek (2005)
Lipid Microemulsions for Improving Drug Dissolution and Oral Absorption: Physical and Biopharmaceutical Aspects
P. Constantinides (2004)
Investigation of Pharmaceutical Oil/Water Microemulsions by Small-Angle Scattering
Anuj Shukla (2004)
Crystallization from microemulsions – a novel method for the preparation of new crystal forms of aspartame
H. Füredi-Milhofer (1999)
Lipid-based delivery systems for improving the bioavailability and lymphatic transport of a poorly water-soluble LTB4 inhibitor.
D. Hauss (1998)
ORAL DELIVERY OF INSULIN
YoughW. Cho (1989)
Improved solubilization of Celecoxib in U-type nonionic microemulsions and their structural transitions with progressive aqueous dilution.
N. Garti (2006)
Evaluation of the in‐vitro digestion profiles of long and medium chain glycerides and the phase behaviour of their lipolytic products
L. Sek (2002)
Crystallization of Organic Compounds in Reversed Micelles. I. Solubilization of Amino Acids in Water−Isooctane−AOT Microemulsions
J. Yano (2000)
Estimation of the effect of NaCl on the solubility of organic compounds in aqueous solutions.
N. Ni (2000)
Sodium ascorbyl phosphate in topical microemulsions.
P. Spiclin (2003)
Microemulsions as colloidal vehicle systems for dermal drug delivery. Part V: Microemulsions without and with glycolipid as penetration enhancer.
R. Neubert (2005)
Microemulsion-based media as novel drug delivery systems.
M. Lawrence (2000)
Food-grade microemulsions based on nonionic emulsifiers: media to enhance lycopene solubilization.
Aviram Spernath (2002)
Development of a supersaturable SEDDS (S-SEDDS) formulation of paclitaxel with improved oral bioavailability.
Ping Gao (2003)
Struc - tural characterisation of water - Tween 40 / Imwitor 308 - isopropyl myristate T of Pharmaceutics 345 ( 2007 ) 9 – 25 microemulsions using different experimental methods
F. odlogar (2004)
Use of a Dynamic in Vitro Lipolysis Model to Rationalize Oral Formulation Development for Poor Water Soluble Drugs: Correlation with in Vivo Data and the Relationship to Intra-Enterocyte Processes in Rats
A. Dahan (2006)
Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs.
R. N. Gursoy (2004)
Crystallization of Organic Compounds in Reversed Micelles. III. Solubilization of Aspartame
H. Füredi-Milhofer (2003)
Correlation of octanol-water partition coefficients with capacity factors measured by micellar electrokinetic chromatography.
Y. Ishihama (1994)
Decrease of genital organ weights and plasma testosterone levels in rats following oral administration of leuprolide microemulsion.
J. Y. Zheng (2006)
Aqueous microemulsions of a fluorinated surfactant and oil studied by PFG-NMR: transformation from threadlike to spherical micelles.
Espen Johannessen (2004)
Susceptibility to Lipase-Mediated Digestion Reduces the Oral Bioavailability of Danazol After Administration as a Medium-Chain Lipid-Based Microemulsion Formulation
C. H. Porter (2004)
A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P-glycoprotein activity in vitro.
Erin D. Hugger (2002)
Lipid-based vehicles for the oral delivery of poorly water soluble drugs
A. Humberstone (1997)
Effect of Adding an Amphiphilic Solubilization Improver, Sucrose Distearate, on the Solubilization Capacity of Nonionic Microemulsions.
K. Aramaki (2001)
Microemulsion-based media as novel drug delivery systems
M. J. Lawrence (2000)
Enzyme immobilization in silica-hardened organogels.
M. Schuleit (2001)
Classification of orally administered drugs on the World Health Organization Model list of Essential Medicines according to the biopharmaceutics classification system.
Marc Lindenberg (2004)
Development of a colonic release capsule dosage form and the absorption of insulin.
M. Kraeling (1992)
Microemulsions versus micelles
L. M. Prince (1975)
Solubilizing Excipients in Oral and Injectable Formulations
R. Strickley (2004)
Effects of the molecular structure of the interface and continuous phase on solubilization of water in water/oil microemulsions
M. Hou (1987)
Amino acids in reversed micelles. 3. Dependence of the interfacial partition coefficient on excess phase salinity and interfacial curvature
E. B. Leodidis (1991)
This paper is referenced by
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S. Kollipara (2014)
ANTI-INFLAMMATORY AND ANTIBACTERIAL POTENTIAL OF CARISSA CARANDAS AND CARISSA SPINARUM NANOEMULSIONS
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J. Brouwers (2009)
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Sheo Datta Maurya (2017)
Improved human bioavailability of vemurafenib, a practically insoluble drug, using an amorphous polymer-stabilized solid dispersion prepared by a solvent-controlled coprecipitation process.
N. Shah (2013)
Surfactant for better tomorrow: applied aspect of surfactant aggregates from laboratory to industry
P. Sar (2019)
Interactions of diazepam with sodium dodecylsulfate and hexadecyl trimethyl ammonium bromide: Conductometric, UV–visible spectroscopy, fluorescence and NMR studies
T. S. Banipal (2017)
Self-emulsifying bifendate pellets: preparation, characterization and oral bioavailability in rats
X. Yan-Yu (2013)
Einsatzmöglichkeiten eines saponinreichen Extrakts aus Quillaja saponaria Molina zur Formulierung und Stabilisierung von funktionellen Lebensmittelinhaltsstoffen
Janine Tippel (2017)
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M. Bergonzi (2014)
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Nurin Afiqah Zairul Azman (2019)
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Amir Biriaee (2018)
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Wang Zi-heng (2015)
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H. Kulhari (2015)
Application of smart organic nanocontainers in feedback active coatings
D. Shchukin (2010)
Thiomers--from bench to market.
S. Bonengel (2014)
Microsoft Word-File no 10 vol 5 issue 2
Javed Ahmad (2013)
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R. S. Kumar (2014)
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Javed Ahmad (2013)
Development of microemulsion systems for Thai herbal extract
P. Maneewattanapinyo (2016)
Prototropism and dynamics of an anticancer drug in reverse micelles: Focus on the variation of pH in reverse micelles having w0 ≥ 10
R. Sett (2017)
Preparation, physicochemical characterization and antioxidant activity of diphenyl diselenide-loaded poly(lactic acid) nanoparticles.
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